• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.1057-1067
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• 2014

Many genetic variants have been identified to be associated with complex diseases such as hypertension, diabetes and cancers throughout genome-wide association studies (GWAS). However, there still exist a serious missing heritability problem since the proportion explained by genetic variants from GWAS is very weak less than 10~15%. Gene-gene interaction study may be helpful to explain the missing heritability because most of complex disease mechanisms are involved with more than one single SNP, which include multiple SNPs or gene-gene interactions. This paper focuses on gene-gene interactions with the survival phenotype by extending the multifactor dimensionality reduction (MDR) method to the accelerated failure time (AFT) model. The standardized residual from AFT model is used as a residual score for classifying multiple geno-types into high and low risk groups and algorithm of MDR is implemented. We call this method AFT-MDR and compares the power of AFT-MDR with those of Surv-MDR and Cox-MDR in simulation studies. Also a real data for leukemia Korean patients is analyzed. It was found that the power of AFT-MDR is greater than that of Surv-MDR and is comparable with that of Cox-MDR, but is very sensitive to the censoring fraction.

• Journal of KIISE:Information Networking
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• v.30 no.6
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• pp.729-742
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• 2003

Mobile Communication has a possibility of eavesdropping by nature of wireless channel. It is known that eavesdropping of CDMA system is impossible because the voice data spreads with the PN. First of all, we show that it is possible to eavesdrop the CDMA channel by analysis of the forward channel in case that we know the ESN and the MIN. We can monitor the forward traffic channel with easy since ESN and MIN are exposed during the call processing in CDMA service in Korea. In this paper, we will show security weakness and propose an enhanced mechanism for CDMA service. We consider the problem of security in the CDMA service. CDMA system has wireless channels to transmit voice or data. By this reason, CDMA communication has a possibility of being eavesdropped by someone. It is known that eavesdropping in CDMA system is impossible because the voice data spreads with the PN. However, we can eavesdrop the CDMA data in FCM protocol in case that we know the ESN and the MIN. In CDMA system, ESN and MIN are exposed to the wireless channel. In this paper, we analyze the flow of the voice and signal in the CDMA system and monitor the forward traffic channel by the FCM protocol. The FCM protocol is proposed to monitor the forward channel in CDMA system. We can show the possibility of monitoring in one-way channel of CDMA system by the FCM protocol. The test instrument based on the FCM protocol is proposed to monitor the CDMA forward channel. We will show the system architecture of the test instrument to monitor the forward channel in CDMA.

• Archives of design research
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• v.18 no.3 s.61
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• pp.45-54
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• 2005

Visual messages are fundamental elements for performing communication and indicate the signs which are delivered from the communicator to the communicatee via channels, Generally, we can classify visual messages into two groups; linguistic factors which are rational and deliver abstract concepts and unlinguistic factors which are mental and can be expressed concretely. Especially, web site with receivers' low attention and concentration need images which can attract their attention to visual messages. That is, web site is a medium which allows us to feel visual and emotional experiences. We can call it a standard of sign systems which are consisted of various styles of digital texts. The main purpose of this study lies in that we'll analyze how homepage introductory page as one of the forms of digital text conduces a meaning action to the receivers and that we'll apprehend the structures of images and different types of signs via a semiotic approach and analyze the underlying meaning of the messages. In order to survey the structures of images we'll look into the attitude toward perceiving messages by using semantic differential method which has been developed mostly by Osgood and analyze the visual images by adopting sign types of Fuss. As the signification is created by combining signs, it is significant that we'll analyze the meaning of sings between the transmitters and receivers from the semiotic viewpoint and study the signification systems.

• Journal of KIISE:Information Networking
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• v.30 no.5
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• pp.581-594
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• 2003

Recently, a location management is being more important in mobile communication systems due to an explosive increase of mobile users. Current systems have used a concept of location area. Based on this concept, a mobile user performs a location update whenever it moves into a new location area. However, this scheme can not avoid unnecessary location updates when a mobile user moves around with high movement rate as compared to call arrival rate. That results in tremendous location management cost. To overcome this drawback, our proposal divides service areas into two sets: One is a set of areas that mobile users move with high speed and another is a set of areas that they move with low speed. After establishing these two sets, this paper employs different location tracking schemes for each sets. Generally, most mobile users with high speed have a low CMR and a regular direction until they arrive at their destination. Using such the moving behavior, systems can predict a mobile user's next location area in advance. When the mobile user moves into the predicted location, our proposal does not perform a location update. Thus, it can reduce overall location management cost. The Markov model is used to analyze the performance of our proposal. Using the model, this paper compares our proposal with IS-41 and TLA. The analytic results show that as CMR grows lower, an overall cost of our proposal becomes less, particularly if a mobile user frequently moves into the specific location are predicted by mobile systems. Also, our proposal has a better performance than other two schemes when the communication cost between HLR and VLR is high.

• Journal of Information Technology Services
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• v.1 no.1
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• pp.57-66
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• 2002

We are looking at the two different kinds of IT on this paper. One is VoIP and the other is VR (voice recognition). We are more interesting at the evolving techniques and services produced by combining the two techniques mentioned above. Recently, there are so many services and products appeared in the market using voice recognition technique. Now the technique has progressed on the level that can even replace the user interfaces using the QUI or general DTMF. Therefore, we are expecting so many various new services showed UP In the market which is combination of the VoIP and VR. Up until now, three models are available in the field which are wired telephone, wireless telephone, and wireless internet. We know the effectiveness of the VoIP is maximized more when this technique is combined with others rather than used alone without other techniques.

• Journal of KIISE:Databases
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• v.31 no.3
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• pp.261-273
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• 2004

Advances in information and communication technologies have been creating new classes of applications in the area of databases. For example, in moving object databases, which track positions of a lot of objects, or stream databases, which process data streams from a lot of sensors, data Processed in such database systems are usually changed very rapidly and continuously. However, traditional database systems have a problem in processing these rapidly and continuously changing data because they suppose that a data item stored in the database remains constant until It is explicitly modified. The problem becomes more serious in the R-tree, which is a typical index structure for multidimensional data, because modifying data in the R-tree can generate cascading node splits or merges. To process frequent updates more efficiently, we propose a novel update technique for the R-tree, which we call the leaf-update technique. If a new value of a data item lies within the leaf MBR that the data item belongs, the leaf-update technique changes the leaf node only, not whole of the tree. Using this leaf-update manner and the leaf-access hash table for direct access to leaf nodes, the proposed technique can reduce update cost greatly. In addition, the leaf-update technique can be adopted in diverse variants of the R-tree and various applications that use the R-tree since it is based on the R-tree and it guarantees the correctness of the R-tree. In this paper, we prove the effectiveness of the leaf-update techniques theoretically and present experimental results that show that our technique outperforms traditional one.

• Journal of Korean Society of Transportation
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• v.19 no.6
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• pp.75-87
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• 2001

Inter-port competition is fiercer than in the past because of technological evolution in transport systems : the increasing side of containerships implies only a few calls in three or four ports at each end of the trade and the rest of the traffic being served by smaller feederships. It is therefore essential for big ports to be selected as one of these calls by the main shipowners, consortia and alliances to avoid rmarginalisation. In order to compete effectively, many ports have been obliged to modernise and extend considerably its existing ports or to build new port facilities. With the advent of major environmental legislation around the world, however, amenities such as fish and wildlife, clean air and water, access to the waterfront, and view protection took on greater importance. Ports are now being forced to incorporate environmental considerations into their planning and management functions in order to avoid additional costs or timing delays. The aim of this paper is to analyse the port value by which port comparison(or selection) will be made with HFP(Hierarchical Fuzzy Process) method. This was done by extracting and grouping the evaluation factors of port value by port experts : facility and location factor, logistics service factor environment and amenity factor, city and economic factor, and human and system factor. For empirical test of this method, 6 major ports in Northeast Asia were chosen and analysed. The order of importance for five evaluation factors were 1) facility and location factor 2) logistics service factor 3) human and system factor, 4) city and economic factor, and 5) environment and amenity factor. This means that geographical location and logistics services are still being considered as the most important factor to call the port by port users. even though environment and amenity factor shows relatively low figure. Among 6 major ports, Port of Kobe was ranked the first position in a comprehensive evaluation, while Ports of Busan and Kwangyang were 4th and 5th respectively. This implies that Port of Busan should make much efforts to enhance the existing facilities as well as management system.

• Korean Journal of Organic Agriculture
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• v.22 no.4
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• pp.855-868
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• 2014

Synthetic agro-chemicals have been widely used to control diseases on paprika but these days negative attention has been increasing to use of them because of several adverse effects. This research was conducted to isolate and to characterize the antagonistic microorganism to control major paprika diseases, gray mold rot, fruit and stem rot, phytophthora blight, sclerotium rot, and wilt disease. Analysis of the fatty acid and analysis of the 16S rDNA gene sequence revealed that YKJ1 isolated in this research belongs to a group of Serratia marcescens. Specially, 16S rDNA gene sequence of YKJ1 showed 99% of sequence similarity with S. marcescens. Observation through the optical microscope revealed that YKJ1 suppressed the spore germination and the hyphal growth of pathogens. YKJ1 treatment on pathogens induced marked morphological changes like hyphal swelling and degradation of cell wall. In the case of phytophthora blight, the zoosporangium formation was restrained. S. marcescens found in this study call as S. marcescens-YKJ1 and it may be valuable as one of biological control agents against major diseases of paprika in the future even though it is require to be tested with more study on field test.

• Journal of Korea Spatial Information System Society
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• v.10 no.3
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• pp.93-106
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• 2008

For agriculture is very highly dependent on climate and weather condistions, global warming seems to have a great impact on it, including its productivity, cultivation condition, product quality, and optimum cultivation location. In this study, we adopted geographical information system (GIS) in order to investigate the changes of Korea's cultivation area which are caused by global warming, especially with the examples of such tropical and sub-tropical fruits as lemon, fig, kiwi, orange, pomegranate, and mandarin. In terms of GIS techniques, we utilized the interpolate function for temperature changes, surface analysis function for slope, and raster calculator. Currently, these fruits's cultivation areas are in Jeju island and southern part of Korea. But these areas will be expanded according as our GIS model assumes $3^{\circ}C$ and $4.5^{\circ}$ increases of average and lowest temperature by the global warming in Korea. Optimum cultivation areas of these six fruits have two patterns; one is expansion and the other is belt shape shift. From the results of the study, we call for an urgent need of Korea government's policy and farmers' reasonable responses about global warming, which will be able to give more opportunities and better foods to Korea society in general.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.1-19
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• 2002

The use of herbals has increased considerably while their efficacy and safety remain untested. This unsupported surge in demand has prompted a call for their clinical evaluation. One area in which evaluations are emerging is ginseng and diabetes. Growing evidence is accumulating from in vitro and animal models indicating that various ginseng species, American (Panax quinquefolius L), Asian (Panax ginseng C.A. Meyer), Korean Red, San-chi (Panax notoginseng [Burk.] P.R. Chen), and the non-panax species Siberian (Eleutherococcus senticossus) ginsing, and their fractions, saponins (ginsenosides) and peptidoglycans (panaxans for panax species and eleutehrans for Siberian ginseng), might affect carbohydrate metabolism and related signaling molecules. Recent human studies from our laboratory have also shown a blood glucose lowering effect of American ginseng (AG) and some other ginseng spices postprandially after acute administration and chronically after administration for 8-weeks in people with type 2 diabetes. Although generally encouraging, these data only indicate a need for more evaluations of ginsengs safety and efficacy. Because of poor industry standardization, it is not known whether all ginsengs will affect blood glucose. In this regards some ginseng batches have demonstrated null effects while others have even raised postprandial glycemia. Clinical research should therefore focus on components involved in its glucose lowering effects.