• Journal of Broadcast Engineering
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• v.22 no.5
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• pp.589-599
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• 2017

This paper introduces a system to reproduce the olfactory effect using the MPEG-V (ISO / IEC 23005) standard to verify the reliability of the fragrance used in the olfactory experiment Using the implemented system, with experiment participant wearing HMD(Head Mounted Display), we carried out one-to-one matching of aroma and scent object images, matching images of aroma and many scent objects, matching of aroma and fragrance object images, and analyzing distance preference. The results of the experiment showed that aroma of coffee, cocoa, banana, and peach aroma is suitable scent for testing. In case of coffee aroma with high matching accuracy, 10 ~ 20cm distance between smell and participant was more effective in image matching than 30cm. In the future, we can conduct the olfactory research for enhancing the sense of immersion and presence of virtual reality contents using the selected fragrance.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.137.2-137
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• 2001

We have been developed an intelligent mobile robot with an artificial olfactory function to recognize odours and to track odour source location. This mobile robot also has been installed an engine for speech recognition and synthesis, and is controlled by wireless communication. An artificial olfactory system based on array of 7 gas sensors has been installed in the mobile robot for odour recognition, and 11 gas sensors also are located in the bottom of robot to track odour sources. 3 optical sensors are also included in the intelligent mobile robot, which is driven by 2 D.C. motors, for clash avoidance in a way of direction toward an odour source. Throughout the experimental trails, it is confirmed that the intelligent mobile robot is capable of not only the odour recognition using artificial neural network algorithm, but also the tracking odour source using the step-by-step approach method ...

• The Korean Journal of Zoology
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• v.34 no.4
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• pp.491-499
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• 1991

The present experiment was carried out 1) to study the developmental topography of GnRH neuronal system and 2) to characterize the cellular localization of GnRH neurons in the prenatal brain development of the rat. At embryonic day (I) 14.5, immunoreactive cell bodies of GnRH were first seen in the nasal septum and in the ganglion terminate located in the ventral protion of the caudal olfactory bulb. Two days later (E 16.5), GnRH-containing neurons were observed at the level of olfactory tubercle and diagonal band of Broca, which is the first appearance in the intracerebral region. From 118.5, the topographic pattern of immunoreactive GnRH perikarya was similar to that of adult rats. The present data suggest that GnRH neurons were originated from the nasal septum and gradually extended to the hvpothalamic regions with increasing fetal age.

• Molecules and Cells
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• v.40 no.12
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• pp.954-965
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• 2017

Mammalian genomes are well established, and highly conserved regions within odorant receptors that are unique from other G-protein coupled receptors have been identified. Numerous functional studies have focused on specific conserved amino acids motifs; however, not all conserved motifs have been sufficiently characterized. Here, we identified a highly conserved 18 amino acid sequence motif within transmembrane domain seven (CAS-TM7) which was identified by aligning odorant receptor sequences. Next, we investigated the expression pattern and distribution of this conserved amino acid motif among a broad range of odorant receptors. To examine the localization of odorant receptor proteins, we used a sequence-specific peptide antibody against CAS-TM7 which is specific to odorant receptors across species. The specificity of this peptide antibody in recognizing odorant receptors has been confirmed in a heterologous in vitro system and a rat-based in vivo system. The CAS-TM7 odorant receptors localized with distinct patterns at each region of the olfactory epithelium; septum, endoturbinate and ectoturbinate. To our great interests, we found that the CAS-TM7 odorant receptors are primarily localized to the dorsal region of the olfactory bulb, coinciding with olfactory epithelium-based patterns. Also, these odorant receptors were ectopically expressed in the various non-olfactory tissues in an evolutionary constrained manner between human and rats. This study has characterized the expression patterns of odorant receptors containing particular amino acid motif in transmembrane domain 7, and which led to an intriguing possibility that the conserved motif of odorant receptors can play critical roles in other physiological functions as well as olfaction.

• Journal of the Korea Computer Graphics Society
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• v.30 no.4
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• pp.31-39
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• 2024

This study applied virtual reality systems for forest therapy to reduce motion sickness and enhance immersion using multi-sensory elements. In applying virtual reality systems, multi-sensory elements were utilized to reduce motion sickness while providing a more immersive experience. Among these elements, tactile and olfactory devices utilizing wind and scent were developed and employed. The program was developed using Unity3D's HDRP (High Definition Render Pipeline), and both HMD (Head Mounted Display) and non-HMD systems were established to determine if visual motion induces motion sickness. An air circulator was placed to provide a sense of wind and allow users to smell scents through the olfactory device. An experiment was designed to examine whether tactile and olfactory stimuli influence user satisfaction with the virtual reality forest therapy system. The results showed that the tactile device significantly reduced motion sickness, while the developed olfactory device did not yield significant results in reducing motion sickness for participants.

• Toxicological Research
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• v.31 no.1
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• pp.17-23
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• 2015

Excessive manganese (Mn) in the brain promotes a variety of abnormal behaviors, including memory deficits, decreased motor skills and psychotic behavior resembling Parkinson's disease. Hereditary hemochromatosis (HH) is a prevalent genetic iron overload disorder worldwide. Dysfunction in HFE gene is the major cause of HH. Our previous study has demonstrated that olfactory Mn uptake is altered by HFE deficiency, suggesting that loss of HFE function could alter manganese-associated neurotoxicity. To test this hypothesis, Hfe-knockout ($Hfe^{-/-}$) and wild-type ($Hfe^{+/+}$) mice were intranasally-instilled with manganese chloride ($MnCl_2$ 5 mg/kg) or water daily for 3 weeks and examined for memory function. Olfactory Mn diminished both short-term recognition and spatial memory in $Hfe^{+/+}$ mice, as examined by novel object recognition task and Barnes maze test, respectively. Interestingly, $Hfe^{-/-}$ mice did not show impaired recognition memory caused by Mn exposure, suggesting a potential protective effect of Hfe deficiency against Mn-induced memory deficits. Since many of the neurotoxic effects of manganese are thought to result from increased oxidative stress, we quantified activities of anti-oxidant enzymes in the prefrontal cortex (PFC). Mn instillation decreased superoxide dismutase 1 (SOD1) activity in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice. In addition, Hfe deficiency up-regulated SOD1 and glutathione peroxidase activities. These results suggest a beneficial role of Hfe deficiency in attenuating Mn-induced oxidative stress in the PFC. Furthermore, Mn exposure reduced nicotinic acetylcholine receptor levels in the PFC, indicating that blunted acetylcholine signaling could contribute to impaired memory associated with intranasal manganese. Together, our model suggests that disrupted cholinergic system in the brain is involved in airborne Mn-induced memory deficits and loss of HFE function could in part prevent memory loss via a potential up-regulation of anti-oxidant enzymes in the PFC.

• Molecules and Cells
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• v.41 no.2
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• pp.150-159
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• 2018

Animals use their odorant receptors to receive chemical information from the environment. Insect odorant receptors differ from the G protein-coupled odorant receptors in vertebrates and nematodes, and very little is known about their protein-protein interactions. Here, we introduce a mass spectrometric platform designed for the large-scale analysis of insect odorant receptor protein-protein interactions. Using this platform, we obtained the first Orco interactome from Drosophila melanogaster. From a total of 1,186 identified proteins, we narrowed the interaction candidates to 226, of which only two-thirds have been named. These candidates include the known olfactory proteins Or92a and Obp51a. Around 90% of the proteins having published names likely function inside the cell, and nearly half of these intracellular proteins are associated with the endomembrane system. In a basic loss-of-function electrophysiological screen, we found that the disruption of eight (i.e., Rab5, CG32795, Mpcp, Tom70, Vir-1, CG30427, Eaat1, and CG2781) of 28 randomly selected candidates affects olfactory responses in vivo. Thus, because this Orco interactome includes physiologically meaningful candidates, we anticipate that our platform will help guide further research on the molecular mechanisms of the insect odorant receptor family.

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.6
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• pp.698-703
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• 2006

This paper proposes an approach to search for the odor source using an autonomous mobile robot equipped with vision and odor sensors. The robot is initially navigating around the specific area with vision system until it looks for an object in the camera image. The robot approaches the object found in the field of view and checks it with the odor sensors if it is releasing odor. If so, the odor is classified and localized with the classification algorithm based on neural network The AMOR(Autonomous Mobile Olfactory Robot) was built up and used for the experiments. Experimental results on the classification and localization of odor sources show the validity of the proposed algorithm.

• Journal of Sensor Science and Technology
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• v.28 no.1
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• pp.52-57
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• 2019

Studies to augment emotion and immersion in multimedia content through olfactory stimulation are being increasingly conducted in the past two decades, and a variety of scent devices have been developed. Most of the scent devices are very large and heavy; consequently, they are installed on a table rather than being attached to the Head-mounted Display (HMD). Even if such devices are mounted on the HMD, it is not possible to control the scent density because of the size limitation, and it is not easy to be immersed in the experience because of the noise caused by the scent device. In order for an actual virtual reality or an augmented reality system to work efficiently with the scent device, three conditions - noiseless, a compact design, and concentration control- must be satisfied. In this study, we design a scent device that satisfies these three conditions. By using a miniature piezoelectric pump, a small size scent device is designed so that it can be easily attached to the lower end of the HMD, and hardly any noise is generated. Moreover, it is possible to control the concentration of the scent by controlling the piezoelectric pump using amplitude and frequency.

• Korean journal of applied entomology
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• v.61 no.1
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• pp.1-14
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• 2022

Moths have a well-developed sex pheromone communication system. Male moths exhibit an extremely sensitive and selective sex pheromone detection system so that they can detect the sex pheromone produced by conspecific females and locate them for successful mating. Using the pheromone detection system, male moths display characteristic stereotypic behavioral responses, flying upwind to follow intermittent filamentous pheromone strands in pheromone plume. The chemical composition of female sex pheromone in moths, typically comprised of multiple compounds, is species-specific. Male moths contain specialized pheromone receptor neurons on the antennae to detect conspecific sex pheromone accurately, and distinguish it from the pheromones produced by other species. The signals from pheromone receptor neurons are integrated and induce relevant behavior from the male moths. Male moths also contain olfactory sensory neurons in pheromone sensilla, specialized for pheromone-related behavioral antagonist compounds, which can enhance discrimination between conspecific and heterospecific pheromones. Here we review reports on the sex pheromone detection system in male moths and their related responses, and suggest future research direction.