• 한국식품위생안전성학회지
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• 제11권4호
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• pp.291-297
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• 1996

The role of cytochrome P-450 2E1 (P450 2E1) in the early phase of alcoholic fatty liver was examined. Female rats were pretreated with either allyl sulfide (200 mg/kg, po), disulfiram (500 mg/kg, po), YH 439 (250 mg/kg, po) or pyrazine (200 mg/kg/day$\times$2 days, ip). Marked changes in carbon tetrachloride-induced hepatotoxicity and caboxyhemoglobin (COHb) elevation due to dichloromethane administration were observed in rats treated with one of the P450 2E1 modulators. A single dose of ethanol (6 g/kg, po) increased the hepatic triglyceride contents approximately 2 fold, which was inhibited completely by YH 439 pretreatment. However, the other P450 2E1 modulators failed to alter the ethanol-induced hepatic triglyceride accumulation. In vitro hepatic microsomal enzyme activity was determined in 4 week old premature and 12 week old adult rats. Aminopyrine-N demethylation was not different, but p-nitrophenol hydroxylation and p-nitroanisole O-demethylation were significantly higher in premature rats. However, no difference in the triglyceride accumulation induced by an intraperitoneal dose of ethanol (3 g/kg) was noted between premature and adult rats. The results suggest that the P450 2E1 activity dose not play an important role in the induction of acute alcoholic fatty liver.

• 가정과삶의질연구
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• 제3권1호
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• pp.107-125
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• 1985

This paper investigated adult's consciousness with a view to establishing basic data about set-up any concrete plan and provision for elderly life in hoe and society. In this paper, the study of concerned reference and social survey by questionnaire are used. The data is obtained from 326 espondents who are 30 to 4 years old in Seoul and Andong. As to consciousness to the provision for elderly life and situation of set-up any concrete plan, the x2(chi-square) is applied to the analysis of regional, socio-economical, demographic difference. The conclusion of this study are as follows; 1) Although the respondents show positive attitude toward consciousness to the provision for elderly. life, their behavior does not show any sing of translating it into reality. 2) The consciousness to the provision for elderly life varies according to regional, socio-economical, demographic variance. Those who are in their 30's more-educated, and high-income want to be more independent from their children and express strong desire to set-up provision for elderly life in advance. This is also true of those living in city. As a results, as adults(30-54) recognize the importance of provision for elderly life, so the support by the society or governmental policy for the solution of better-life for old people is important. however, mental , physical, economical preparation in family life according to the family life cycle can basic solution.

• 복식문화연구
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• 제13권1호
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• pp.1-5
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• 2005

The objective of this paper is to provide fundamental data to establish measuring system of clothing that is more accurate. For the objective, stature and ration of height items, stature and ratio of circumference item, stature and ratio of length item on the children are investigated to obtain the interrelation of each item. Data for the research are selected from 52 people of 6 years old on boys and 49 people of 6 years old on girls who dwell in Seoul. The results of the research are as follows. Because ratio of the body on the stature of children is different from ratio of the adult, the same method for the adult cloth is not appropriate when producing the cloth of the children. observing the interrelation of each measurement item, measurement system of the children cloth that is indicated by the stature and the breast circumference, the stature and the waist circumference is not reasonable. Because the value of correlation of back length and circumference item was, it is not suitable that the back length is graded by the breast circumference when producing the cloth of the children.

• 한국축산식품학회지
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• 제39권6호
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• pp.988-999
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• 2019

To investigate the relationship between muscle fiber characteristics and meat quality traits by age of Korean native black goat (KNBG), four muscles (longissimus dorsi, LD; psoas major, PM; semimembranosus, SM; gluteus medius, GM) were obtained from five adult goat (AG; 18 months old) and five young goat (YG; 9 months old). PM muscle had the highest fiber number percentage (FNP) and fiber area percentage (FAP) of type I, followed by SM, GM, and LD muscles. FNP and FAP of type IIB were significantly (p<0.001) higher in AG than those in YG. YG had higher L^* values but lower b^* values than AG. The highest L^* and b^* values were observed in LD muscle (p<0.001). Age and muscle type had detrimental (p<0.001) effect on shear force and collagen content for all muscle in AG as compared to YG. YG had significantly (p<0.001) higher myofibrillar fragmentation index (MFI) than AG for all four muscles. These results suggest that muscle fiber compositions of different muscle types of KNBG depend on age, resulting in variations of meat color, MFI, collagen content, and shear force.

• 생명과학회지
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• 제10권1호
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• pp.45-51
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• 2000

Ovarian development and yolk protein (YP) of mushroom fly, Coboldia fuscipes, were characterized. C. fuscipes has a pair of ovaries, composed of 130∼140 ovarioles, respectively. Ovarian development begins at 1 day of pupa, and growth of the ovaries continued to become a matured shape at 1 day after emergence. The YP of C. fuscipes identified by SDS-PAGE analysis revealed that the protein is composed of three subunits, designated YP1 (61 kDa), YPS(50 kDa), and YP3 (47 kDa). These three subunits of YP gradually decreased during embryogenesis. The YP was first detected in the 3 day-old pupal ovary and was continually detected up to 2 day-old adult, but not in the hemolymph. Furthermore, Western blot analysis of male and female adult hemolymph and ovary revealed that the antibodies against YP1, YP2, and YP3 reacted with three YP bands in ovary and egg extract, respectively. However, this reactivity was not observed in the male and female hemolymps. Therefore, it is assumed that the UP of C. fuscipes is synthesized in the ovary at 3 days after pupation.

• 지역사회간호학회지
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• 제17권3호
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• pp.315-325
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• 2006

Purpose: The Purpose of this study was to build up guidelines for preventing constipation in the Korean elderly based on the National Guideline $Clearinghouse^{TM}$ Guideline. Method: The process is composed of four steps: first. the composition of an expert group; second, the evaluation by the expert group about the appropriateness and applicability of each recommendation in the guideline; third, systematic literature review for evidence searching; and fourth. the formation of guidelines for Preventing constipation in the Korean elderly according to experts' opinions and literature review. Result: The appropriateness and applicability of each recommendation showed high scores, but the score of applicability was lower than that of appropriateness. The reasons for lower score of applicability were lack of cognition on the importance of constipation management and lack of recent information and evidence-based knowledge on constipation. There were some inadequate recommendations in Korean clinical setting. So the modified and replaced recommendations were added to the guidelines for preventing constipation in the old adult population to improve the applicability in Korea. Conclusion: The results of this study can be used as fundamental baseline data for future study to develope guidelines for management of constipation in the elderly and will be adapted locally for Korean clinical setting.

• International journal of advanced smart convergence
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• 제8권3호
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• pp.1-6
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• 2019

Adults in their middle age are being held back by their roles through economic activities, but their rapid retirement and job sharing are adding to their anxiety. Also, it is very important to establish welfare policies for the elderly in the future because it can predict the economic situation in the old age through the economic activities of middle-aged adults. My study analyzed the 6th data of Kreis of the National Pension Research Institute's. The number of people studied is 2,552 employed people aged 40 or over 64 across the country. According to the analysis, there were more men than women. There were many high school graduates and 50s. There were many people who had spouses and who lived in the province. Wage workers represented 53.1% of the total. The lower the age, the higher the level of education, the higher the number of wage earners. Only 29% of standard workers and 30.8% of regular workers were employed. There were many economically unstable middle-aged adults. Economic instability in the middle age requires social attention because it can lead to poverty in old age. Therefore, measures should be taken to ensure stable jobs for middle-aged adults, whose spending increases more than their income.

• 대한수의학회지
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• 제61권2호
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• pp.12.1-12.9
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• 2021

The mosquito-borne pathogen Zika virus may result in neurological disorders such as Guillain-Barré syndrome and microcephaly. The virus is classified as a member of the Flaviviridae family and its wide spread in multiple continents is a significant threat to public health. So, there is a need to develop animal models to examine the pathogenesis of the disease and to develop vaccines. To examine the clinical profile during Zika virus infection, we infected neonatal and adult wild-type mice (C57BL/6 and Balb/c) and compared the clinical signs of African-lineage strain (MR766) and Asian-lineage strain (PRVABC59, MEX2-81) of Zika virus. Consistent with previous reports, eight-week-old female Balb/c mice infected with these viral strains showed no changes in body weight, survival rate, and neurologic signs, but demonstrated increases in the weights of spleens and hearts. However, one-day-old neonates showed significantly lower survival rate and body weight with the African-lineage strain than the Asian-lineage strain. These results confirmed the pathogenic differences between Zika virus strains. We also evaluated the clinical responses in neonatal and adult mice of different strains. Our findings suggest that these are useful mouse models for characterization of Zika virus for vaccine development.

• 한국임상보건과학회지
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• 제11권1호
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• pp.1632-1638
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• 2023

Purpose: The aim of this study was to determine the distribution of the cornea thickness and intra ocular pressure Korean adult of 20 to 24 year old using the Pentacam and tonometer. Methods: The subjects of this study were 43 Korean adults with healthy eyes. Corneal thickness was measured with Pentacam device. The intra ocular pressure was measured with tonometer. Data was analyzed by means of the Pearson's correlation cofficient. P-values<0.001 were considered statistically significant. Results: Mean age of subjects was 20.41±0.86 years. The mean +/- intra ocular pressure of the right eye and left eye were 16.236±2.523mmHg and 16.971±1.992mmHg, respectively. The mean central corneal thickness of the right eye and left eye was 545.324±38.682㎛ and 547.442±33.778㎛, respectively. No significant difference in central corneal thickness was found between the right and left eyes. But, there was a statistically significant difference between central cornea thickness and peripheral cornea thickness around 4 mm of central cornea(p<0.001, Pearson's correlation). However there was no statistically significant difference between central cornea thickness and intra ocular pressure. Conclusion: The results of this study could be used as a clinical reference data for diagnosis and treatment of cornea in Korean adult.

• Molecules and Cells
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• 제20권1호
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• pp.51-56
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• 2005

Excitation-contraction coupling (ECC) proteins in the human heart were characterized using human atrial tissues from different age groups. The samples were classified into one infant group (Group A: 0.2-7 years old) and three adult groups (Group B: 21-30; Group C: 41-49; Group D: 60-66). Whole homogenates (WH) of atrial tissues were assayed for ligand binding, $^{45}Ca^{2+}$ uptake and content of ECC proteins by Western blotting. Equilibrium [$^3H$]ryanodine binding to characterize the ryanodine receptor (RyR) of the sarcoplasmic reticulum (SR) showed that the maximal [$^3H$]ryanodine binding ($B_{max}$) to RyR was similar in all the age groups, but the dissociation constant ($k_d$) of ryanodine was higher in the infant group than the adult groups. Oxalate-supported $^{45}Ca^{2+}$ uptake into the SR, a function of the SR SERCA2a activity, was lower in the infant group than in the adult groups. Similarly, [$^3H$]PN200-110 binding, an index of dihydropyridine receptor (DHPR) density, was lower in the infant group. Expression of calsequestrin and triadin assessed by Western blotting was similar in the infant and adult groups, but junctin expression was considerably higher in the adult groups. These differences in key ECC proteins could underlie the different $Ca^{2+}$ handling properties and contractility of infant hearts.