• Parasites, Hosts and Diseases
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• v.43 no.1 s.133
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• pp.27-32
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• 2005

Toxoplasma gondii tachyzoites were isolated from an ocular patient in the Republic of Korea and maintained in the laboratory (designated KI-1). In the present study, its genotype was determined by analyzing dense granule antigen 6 (GRA6) gene and surface antigen 2 (SAG2) gene as typing markers. Digestion of the amplification products of GRA6 and of the 5' and 3' ends of SAG2, respectively, with Mse I, Sau3A I, and Hha I, revealed that KI-1 is included in the genotype I, which includes the worldwide virulent RH strain. In addition, when the whole sequences of the coding regions of SAG1, rhoptry antigen 1 (ROP1), and GRA8 genes of KI-1 were compared with those of RH, minor nucleotide polymorphisms and amino acid substitutions were identified. These results show that KI-1 is a new geographical strain of T. gondii that can be included in the genotype I.

• Current Optics and Photonics
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• v.6 no.2
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• pp.151-160
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• 2022

Fundus images can reflect ocular diseases and systemic diseases such as glaucoma, diabetes mellitus, and hypertension. Thus, research on fundus-detection equipment is of great importance. The fundus camera has been widely used as a kind of noninvasive detection equipment. Most existing devices can only obtain two-dimensional (2D) retinal-image information, yet the fundus of the human eye also has spectral characteristics. The fundus has many pigments, and their different distributions in the eye lead to dissimilar tissue penetration for light waves, which can reflect the corresponding fundus structure. To obtain more abundant information and improve the detection level of equipment, a snapshot nonmydriatic fundus imaging spectral system, including fundus-imaging spectrometer and illumination system, is studied in this paper. The system uses a microlens array to realize snapshot technology; information can be obtained from only a single exposure. The system does not need to dilate the pupil. Hence, the operation is simple, which reduces its influence on the detected object. The system works in the visible and near-infrared bands (550-800 nm), with a volume less than 400 mm × 120 mm × 75 mm and a spectral resolution better than 6 nm.

• Childhood Kidney Diseases
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• v.27 no.1
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• pp.40-45
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• 2023

Tubulointerstitial nephritis and uveitis (TINU) syndrome is defined as the occurrence of tubulointerstitial nephritis and uveitis in the absence of other systemic diseases. Three pediatric cases have been reported in the Republic of Korea, and we now report a fourth case. A 15-year-old girl presented to the ophthalmology department with a 1-week history of bilateral ocular discomfort that worsened on the day of presentation with redness and pain in both eyes. She was diagnosed with bilateral uveitis, and her baseline examination revealed moderate renal dysfunction and mild proteinuria. A renal biopsy was performed and confirmed the diagnosis of TINU syndrome. She was started on steroid eye drops and a 12-week course of oral steroids at a dose of 40 mg/m²/day, which completely resolved the proteinuria and mild renal function to an estimated glomerular filtration rate of 60 mL/min/1.73 m². However, the uveitis did not improve, and despite the addition of oral methotrexate as a second-line treatment, the uveitis remains unresponsive to treatment over 21 months. Further evaluation and treatment are ongoing, and active therapeutic intervention is suggested even at a pediatric age, considering the lack of improvement in renal function and uveitis to date.

• IMMUNE NETWORK
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• v.19 no.1
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• pp.3.1-3.17
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• 2019

Aging is a complex process associated with dysregulation of the immune system and low levels of inflammation, often associated with the onset of many pathologies. The lacrimal gland (LG) plays a vital role in the maintenance of ocular physiology and changes related to aging directly affect eye diseases. The dysregulation of the immune system in aging leads to quantitative and qualitative changes in antibodies and cytokines. While there is a gradual decline of the immune system, there is an increase in autoimmunity, with a reciprocal pathway between low levels of inflammation and aging mechanisms. Elderly C57BL/6J mice spontaneously show LGs infiltration that is characterized by Th1 but not Th17 cells. The aging of the LG is related to functional alterations, reduced innervation and decreased secretory activities. Lymphocytic infiltration, destruction, and atrophy of glandular parenchyma, ductal dilatation, and secretion of inflammatory mediators modify the volume and composition of tears. Oxidative stress, the capacity to metabolize and eliminate toxic substances decreased in aging, is also associated with the reduction of LG functionality and the pathogenesis of autoimmune diseases. Although further studies are required for a better understanding of autoimmunity and aging of the LG, we described anatomic and immunology aspects that have been described so far.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.4
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• pp.375-380
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• 2005

To assess convergence and accommodation at a short distance, 92 selected subjects without any ocular diseases by apperatuses of visual chart(Shinnippon CT30) and phoropter(Shinnippon VT 10) at a short distance(40 cm) were tested upon MEM retinoscopy(Welch Allyn, USA). BELL retinoscopy(Welch Allyn, USA), binocular accommodative facility (${\pm}2.00$ D flipper. Bernell Co., USA), vergence facility(prism flipper, Bernell Co., USA). There were such test results as MEM retinoscopy(R/L)($+1.05{\pm}0.87/1.02{\pm}0.80$ D). BELL retinoscopy ($17.89{\pm}12.12/17.94{\pm}11.72cm$), binocular accommodative facility (R/G)($7.69{\pm}6.48cpm$). binocular accommodative facility(polaroid)($11.76{\pm}5.22cpm$), monocular accommodative facility(R/L) ($13.9{\pm}6.27/13.8{\pm}5.96cpm$), vergence facility($13.5{\pm}6.40cpm$).

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.3
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• pp.293-297
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• 2011

Purpose: This study was to know the correlation among refractive error and the dimensions of ocular components on older adults. Methods: The subjects were 95 older age who had no eye diseases. The refractive error, corneal radius, corneal diopter, axial length, anterior chamber depth and lens thickness were measured and analysed. Results: The axial length(AL)/corneal radius(CR) ratio was positively correlated with the corneal diopter, axial length, the anterior chamber depth. Then it was negatively correlated with corneal radius. It was shown that the highest correlation was between the corneal diopter and axial length (r = -0.545, p = 0.000). The spherical equivalent of the refractive error was negatively correlated with the AL/CR ratio. Conclusions: It was shown that the AL/CR ratio was a very important indicator for diagnosing the refractive error of the old age.

• Journal of Medicine and Life Science
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• v.18 no.2
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• pp.35-39
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• 2021

Exaggerated acute and late toxicities following radiotherapy have been reported in patients with pre-existing connective tissue diseases, such as systemic lupus and scleroderma. Behcet's disease (BD) is a relapsing multisystem connective tissue disease characterized by vasculitis in the mucocutaneous, ocular, gastrointestinal, respiratory, neurologic, urogenital, articular, and cardiovascular systems. Data concerning the relationship between radiotherapy toxicity and BD are limited in the literature. Here, we report a case of lung cancer treated with radiotherapy (60 Gy) in a patient with BD. No severe radiation-induced toxicity was observed. Radiation-induced toxicity in patients with BD has also been discussed.

• Clinical and Experimental Pediatrics
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• v.65 no.3
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• pp.115-126
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• 2022

Retinopathy of prematurity (ROP) is among the most common causes of childhood blindness. Three phases of ROP epidemics have been observed worldwide since ROP was first described in the 1940s. Despite advances in neonatal care, the occurrence of ROP and associated visual impairment has been increasing somewhere on Earth and remains difficult to control. Conventional treatment options for preventing ROP progression include retinal ablation using cryotherapy or laser therapy. With the emergence of anti-vascular endothelial growth factor (anti-VEGF) treatment for ocular diseases, the efficacy and safety of anti-VEGF therapy for ROP have recently been actively discussed. In the advanced stage of ROP with retinal detachment, surgical treatment including scleral buckling or vitrectomy is needed to maintain or induce retinal attachment. At this stage, the visual outcome is usually poor despite successful anatomical retinal attachment. Therefore, preventing ROP progression by timely screening examinations and treatment remains the most important part of ROP management.

• Parasites, Hosts and Diseases
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• v.60 no.6
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• pp.429-432
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• 2022

Inflammatory eyelid symptoms are common in primary care and there have been several reports on Demodex blepharitis. In the present study, we evaluate the 9 patients with Demodex blepharitis, who showed inflammation of the eyelids, dry eye, and cylindrical dandruff at the base of the eyelashes. The causative species from all patients was Demodex folliculorum of either the adult or nymph stage. Two patients had recurrent chalazion and 3 patients had keratitis. Weekly lid scrubs with 50% tee tree oil were performed for 6 weeks. After treatment, the symptoms of blepharitis and keratitis had improved in all patients. This case report provides clinical reference source for the proper treatment of ocular demodicosis.

• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.580-581
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• 2024

고령화 사회에 접어들면서 황반 변성과 당뇨 망막 병증 등 시야결손을 동반하는 안구 질환의 발병률은 증가하지만 이러한 질환의 조기 발견에 인공지능을 접목시킨 연구는 부족한 실정이다. 본 논문은 안구 질환 자가 검사용 인공 신경망을 학습시키기 위한 데이터 베이스 구축 방법을 제안한다. MNIST와 CIFAR-10을 합성하여 중첩 이미지 데이터셋인 G-Dataset을 생성하였고, 7개의 인공신경망에 학습시켜 최종적으로 90% 이상의 정확도를 얻음으로 그 유효성을 입증하였다. G-Dataset을 안구 질환 자가 검사용 딥러닝 모델에 학습시켜 모바일 어플에 적용하면 사용자가 주기적인 검사를 통해 안구 질환을 조기에 진단하고 치료할 수 있을 것으로 기대된다.