• Safety and Health at Work
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• v.1 no.2
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• pp.140-148
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• 2010

Objectives: Determining the work-relatedness of lung cancer developed through occupational exposures is very difficult. Aims of the present study are to develop a decision tree of occupational lung cancer. Methods: 153 cases of lung cancer surveyed by the Occupational Safety and Health Research Institute (OSHRI) from 1992-2007 were included. The target variable was whether the case was approved as work-related lung cancer, and independent variables were age, sex, pack-years of smoking, histological type, type of industry, latency, working period and exposure material in the workplace. The Classification and Regression Test (CART) model was used in searching for predictors of occupational lung cancer. Results: In the CART model, the best predictor was exposure to known lung carcinogens. The second best predictor was 8.6 years or higher latency and the third best predictor was smoking history of less than 11.25 pack-years. The CART model must be used sparingly in deciding the work-relatedness of lung cancer because it is not absolute. Conclusion: We found that exposure to lung carcinogens, latency and smoking history were predictive factors of approval for occupational lung cancer. Further studies for work-relatedness of occupational disease are needed.

• Toxicological Research
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• v.18 no.1
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• pp.43-46
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• 2002

A 61 Year-old female patient was hospitalized for lung cancer. Her Occupational history indicated that she had worked for an asbestos company for 9 years from 1976. The histopathology of the lung revealed malignant bronchioalveolar adenocarcima (stage III) in the lower-left lobe, and a lung sample was found to cantion an unusually high level of asbestos, 218.9$\times$$10^6$ asbestos fibers/g of dry lung tissue. The majority of asbestos fibers found was chrusotile. yet no asbestos body was detected. When compared with Korean male (0.3$\times$$10^6$ fibers/g of dry lung tissue) and female subjects (0.15$\times$$10^6$ fibers/g of dry lung tissue) with no known history of occupational asbestos exposure, the apparent cause of the lung cancer in the current patient was occupational exposure to asbestos.

• Safety and Health at Work
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• v.1 no.2
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• pp.134-139
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• 2010

Objectives: The lung cancer mortality in Korea has increased remarkably during the last 20 years, and has been the first leading cause of cancer-related deaths since 2000. The aim of the current study was to examine the time trends of occupational lung cancer and carcinogens exposure during the period 2006-2009 in South Korea, by assessing the proportion of occupational burden. Methods: We defined occupational lung cancer for surveillance, and developed a reporting protocol and reporting website for the surveillance of occupational lung cancer. The study patients were chosen from 9 participating university hospitals in the following 7 areas: Seoul, Incheon, Wonju, Daejeon, Daegu, Busan, and Gwangju. Results: The combined proportion of definite and probable occupational lung cancer among all lung cancers investigated in this study was 10.0%, 8.6%, 10.7%, and 15.8% in the years 2006 to 2009, respectively, with an average of 11.7% over the four-year study period. The main carcinogens were asbestos, crystalline silica, radon, polyaromatic hydrocarbons (PAHs), diesel exhaust particles, chromium, and nickel. Conclusion: We estimated that about 11.7% of the incident lung cancer was preventable. This reveals the potential to considerably reduce lung cancer by intervention in occupational fields.

• Proceedings of the Korea Contents Association Conference
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• 2010.05a
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• pp.216-217
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• 2010

• Safety and Health at Work
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• v.4 no.1
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• pp.71-74
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• 2013

Here, we present a case of lung cancer in a 48-year-old male horse trainer. To the best of our knowledge, this is the first such case report to include an exposure assessment of respirable crystalline silica (RCS) as a quartz. The trainer had no family history of lung cancer. Although he had a 15 pack/year cigarette-smoking history, he had stopped smoking 12 years prior to his diagnosis. For the past 23 years, he had performed longeing, and trained 7-12 horses per day on longeing arena surfaces covered by recycled sands, the same surfaces used in race tracks. We investigated his workplace RCS exposure, and found it to be the likely cause of his lung cancer. The 8-hour time weight average range of RCS was 0.020 to $0.086mg/m^3$ in the longeing arena. Horse trainers are exposed to RCS from the sand in longeing arenas, and the exposure level is high enough to have epidemiological ramifications for the occupational risk of lung cancer.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.4
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• pp.378-384
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• 2021

Objectives: Horse trainers ensure the horses they are training and monitor horse's health, hygiene. While most of the studies on horse trainer's health focused on musculoskeletal disorders, few studies have examined the health effect of occupational exposure. This study aimed to investigate the risk of lung cancer in Korean Horse trainers. Methods: Among the largest health screening program of health screening service of the National Health Insurance Corporation, 2,246 workers were selected for study. We utilized data from the National Health Insurance Service (NHIS) National Cohort Data Base 2005-2017. We performed analyses using a Cox's proportional hazards model to identify the risk of lung cancer in Horse trainers. Results: This study found that the horse trainers group had a higher risk of lung cancer 10.07 (95% CI :2.38-42.64) compared to other occupational group. Additionally, there was 6.5 times higher risk of lung cancer in non-smoker horse trainers group. Conclusions: We, thus, verified horse trainers could have relation with increase of lung cancer risk. As lung cancer is known as a cancer with a high contribution of occupational factors compared to other cancers, it is necessary to determine the efficacy of continuous attention and active management of occupational exposure.

• Safety and Health at Work
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• v.4 no.4
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• pp.216-220
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• 2013

A 46-year-old man who had worked as a bumper spray painter in an automobile body shop for 15 years developed lung cancer. The patient was a nonsmoker with no family history of lung cancer. To determine whether the cancer was related to his work environment, we assessed the level of exposure to carcinogens during spray painting, sanding, and heat treatment. The results showed that spray painting with yellow paint increased the concentration of hexavalent chromium in the air to as much as $118.33{\mu}g/m^3$. Analysis of the paint bulk materials showed that hexavalent chromium was mostly found in the form of lead chromate. Interestingly, strontium chromate was also detected, and the concentration of strontium chromate increased in line with the brightness of the yellow color. Some paints contained about 1% crystalline silica in the form of quartz.

• Toxicological Research
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• v.25 no.4
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• pp.217-224
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• 2009

Inhaled inorganic dusts such as coal can cause inflammation and fibrosis in the lung called pneumoconiosis. Chronic inflammatory process in the lung is associated with various cytokines and reactive oxygen species (ROS) formation. Expression of some cytokines mediates inflammation and leads to tissue damage or fibrosis. The aim of the present study was to compare the levels of blood cytokines interleukin (IL)-$1\beta$, IL-6, IL-8, tumor necrosis factor (TNF)-$\alpha$ and monocyte chemoatlractant protein (MCP)-1 among 124 subjects (control 38 and pneumoconiosis patient 86) with category of chest x-ray according to International Labor Organization (ILO) classification. The levels of serum IL-8 (p= 0.003), TNF-$\alpha$ (p=0.026), and MCP-1 (p=0.010) of pneumoconiosis patients were higher than those of subjects with the control. The level of serum IL-8 in the severe group with the small opacity (ILO category II or III) was higher than that of the control (p=0.035). There was significant correlation between the profusion of radiological findings with small opacity and serum levels of IL-$1\beta$(rho=0.218, p<0.05), IL-8 (rho=0.224, p<0.05), TNF-$\alpha$ (rho=0.306, p<0.01), and MCP-1 (rho=0.213, p<0.01). The serum levels of IL-6 and IL-8, however, did not show significant difference between pneumoconiosis patients and the control. There was no significant correlation between serum levels of measured cytokines and other associated variables such as lung function, age, BMI, and exposure period of dusts. Future studies will be required to investigate the cytokine profile that is present in pneumoconiosis patient using lung specific specimens such as bronchoalveolar lavage fluid (BALF), exhaled breath condensate, and lung tissue.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.1 no.2
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• pp.238-245
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• 1991

This study was analysis of ${\alpha}$-quartz in the 37 worker's lung died of coal workers' pneumoconiosis(CWP) and in the 9 normal's lung by Fourier transform infrared spectrophotometer. The results were as follows : 1. The dried lung weight percents in wet lung weight were 24.4%, 25.4%, coal workers' pneumoconiosis and normal lungs, respectively. Ash weight percents in dried lung weight were 7.7%, 5.0%, coal workers' pneumoconiosis and normal lungs, respectively. 2. The presision (as of coefficient of variation) for the ${\alpha}$-quartz determination were 2.6% in standard quartz (ranged from 9.9 to $198.0{\mu}g$) and 3.7% in ashed lung samples. 3. The characterstic ${\alpha}$-quartz absorption spectra in lungs of CWP were only shawn by LTA ashing. 4. Geometric mean of ${\alpha}$-quartz concentration in CWP lung was 173mg/100g dried lung. 5. The concentrations of ${\alpha}$-quartz in Korean CWP lungs were similar to those of foreign coal miner's lungs.

• Toxicological Research
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• v.17 no.3
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• pp.163-165
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• 2001

A patient,58 years of age, with suspected 0/l pneumoconiosis since 1993, complained of a dry cough and exertioning dyspnea for 6 months. He had worked in an asbestos company for more than 20 years from 1974. He was subsequently diagnosed with an interstitial lung disease during an annual special health check-up for asbestos workers. h chest X-ray showed an interstitial lung disease and high-resolution computed tomography (HRCT) showed a round opaque asbestosis with chronic hypersensitivity pneumonitis. A pulmonary function test indicated that the patient had a mild restrictive lung disease with FEV1 1.67 litters and 82% FEVl/FVC. The bronchoalveloar larvage fluid included many asbestos bodies, indicating previous exposure to asbestos. Transmission electron microscopy (TEM) using an energy dispersive X-ray analyzer (EDX) revealed many asbestos bodies consisting of mainly crocidolite fibers (6,071$\times$$10^6$fibers/g of dry lung). The patient had an unusually high asbestos content of 6,112$\times$$10^6$ asbestos fibers/9 of dry lung.