• 한방비만학회지
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• 제4권1호
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• pp.201-211
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• 2004

The treatment of obesity is increasingly becoming important to effective medical treatment, especially in case involving a degradation of the lower joints. A recent case placed two osteoarthritic obese patients who underwent arthroscopic surgery in a regiment of herbal diet. Alter 3-5 months of receiving this oriental treatment, the patients not only lost weight, but also showed significant reduction of joint inflammation and pain. It is true that obese patients with lower limb or osteoarthritis who have undergone normal obesity treatment regularly for 5 years or more will find the treatment becomes less effective over times. However, for patients suffering from lower limb pain or osteoarthristis, oriental obesity treatment, on the whole was effective in decreasing five key areas(5D). For this reason, it is necessary for oriental medicine to be given further study and consideration as an effective treatment of obesity.

• 비만대사연구학술지
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• 제1권1호
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• pp.39-42
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• 2022

Obesity is a chronic disease associated with severe complications. A major complication of obesity is depression, which can worsen obesity and vice versa. In addition, most antidepressants or antipsychotics cause weight gain, and the relationship between obesity and depression is clinically critical. However, treatment of obese patients with major depressive disorder is complicated. Bariatric physicians should provide appropriate behavioral interventions alongside pharmacological treatment, considering psychiatric symptoms, drug side effects, and drug interactions. Two successful cases of moderate-to-severe obese patients with major depressive disorder who had been treated for obesity using behavioral intervention therapy along with liraglutide will be discussed. This report highlights the safety and efficacy of liraglutide treatment of obesity in patients with depression who take antidepressants and antipsychotics.

• 한방비만학회지
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• 제23권2호
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• pp.86-97
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• 2023

Objectives: The purpose of this study is to review clinical studies related to the effect of Traditional Chinese Medicine (TCM) on moderate to severe obese patients with hypertension. Methods: Clinical studies from the China National Knowledge Infrastructure (CNKI) were searched by specific keywords and criteria. Total of 7 randomized controlled trials were selected and analyzed. Results: Various evaluation methods were used to see the effect of TCM compared to conventional western medicine. Most of the studies used herbal medicine combined with conventional anti-hypertensive western medicine. The effective rate of anti-hypertension was higher when TCM was added to conventional anti-hypertensive medicine. Traditional medicine treatment showed significant effect on lowering blood pressure and body mass index. Conclusions: Based on the results of the clinical studies from China, TCM can be a valuable option for moderate to severe obese patients with hypertension. Applying Traditional medicine has a significant effect on lowering blood pressure and weight loss. Combining herbal medicine can be worthy of clinical promotion and application for moderate and severe obese patients with hypertension.

• Molecules and Cells
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• 제40권9호
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• pp.685-695
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• 2017

Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood. In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese patients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation. Two dimensional difference in-gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was carried out. A total of 28 proteins were identified with a statistically significant difference in abundance and a 1.5-fold change (ANOVA, $p{\leq}0.05$) between the groups. 11 proteins showed increased abundance while 17 proteins were decreased in the metabolically unhealthy obese compared to the healthy obese. The differentially expressed proteins belonged broadly to three functional categories: (i) protein and lipid metabolism (ii) cytoskeleton and (iii) regulation of other metabolic processes. Network analysis by Ingenuity pathway analysis identified the $NF{\kappa}B$, IRK/MAPK and PKC as the nodes with the highest connections within the connectivity map. The top network pathway identified in our protein data set related to cellular movement, hematological system development and function, and immune cell trafficking. The VAT proteome between the two groups differed substantially between the groups which could potentially be the reason for metabolic dysfunction.

• Journal of Nutrition and Health
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• 제28권7호
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• pp.629-635
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• 1995

Obese children have increaed in Korean in recent years as socieconomic status have got more higher than past years. Obese children have many health problems and some kinds of complications. Obese patients who have fatty liver with abnormal liver function should be managed with weight control. This study was intended to investigate the effect of weight control on hepatic abnormalities of obese children with fatty liver. We managed 6 obese children who had fatty liver with abnormal liver finction for weight control containing behavior modification, diet and exercise during 3 months. After 3 months, we compared body weight, liver function test, dietary intake and exercise. Body mass index(BMI) showed significant decrease from 28.1$\pm$2.3kg/$m^2$ to 26.2$\pm$1.7kg/$m^2$ (p<0.01). Aspartate aminotransferase(AST) showed significant improvement from 56$\pm$15IU/l(p<0.01). Alanine aminotransferase(ALT) also showed significant improvement from 108$\pm$38IU/l to 33$\pm$9IU/l(p<0.01). Therefore if we can rule out the other causes of hepatic abnormalities in obese children with fatty liver, these patients showed benefit by weight control as it can improve both obesity and liver functions.

• Journal of Chest Surgery
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• 제53권6호
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• pp.417-419
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• 2020

Surgeons avoid creating arteriovenous fistulae in obese patients owing to deep vessels, cannulation complications, and inconsistent outcomes. We describe placing an arteriovenous polytetrafluoroethylene (PTFE) graft between the brachial artery and axillary vein to avoid these complications. A 39-year-old super-obese woman with end-stage renal disease had undergone several hemodialysis access procedures on both arms. We traced the course of the arteriovenous graft course with the patient sitting and lying down. The ideal course was more accurate with the patient sitting; thus, the patient sat when the course was drawn, before lying on the operating bed. The PTFE graft was placed between the right brachial artery and axillary vein, according to the course in the opposite arm. No anastomotic dehiscence or pseudoaneurysm has taken place during 2 years of follow-up. In super-obese patients, the ideal course for arteriovenous grafts should be drawn while they are sitting, avoiding skin folds. This tip could avoid anastomotic dehiscence and pseudoaneurysm between the axillary vein and a PTFE graft.

• 한방비만학회지
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• 제6권1호
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• pp.51-59
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• 2006

Objectives : This study was designed to evaluate the relationship with abdominal visceral fat area in obese patients identified as phlegm type. Methods : This research were performed in 201 cases, visited Kirin Oriental Hospital from March 2005 to February 2006 for weight loss. We measured body mass index(BMI), abdominal CT, and classified all patients into two groups, normal and obesity group. And then we differentiated patients with phlegm-retention symptom from patients without it through questionnaire made by Korea Institute of Oriental Medicine. Results and Conclusions : Phlegm type was significantly higher than them of no symptom of phlegm in the abdominal visceral areas(P=0.036) and ratio(P=0.007), in obesity group$(BMI{\geq}25)$. On the other hand, there is little difference between abdominal visceral fat areas of phlegm type and no symptom of phlegm in normal group. According to the above results, if obese patients are diagnosed as identification of phlegm type there is good chance of abdominal visceral obesity.

• 한방비만학회지
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• 제1권1호
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• pp.47-56
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• 2001

Objectives: We want to understand body composition and states of obese patients and the clinical studies of obesity attribute to Dept. of Oriental Rehabilitation Medicine. Methods : The clinical studies were done on 42 cases of obese patients who were treated by obesity clinic in Dept. of Oriental Rehabilitation Medicine Dae-Jeon Oriental medical hospital in Dae-Jeon University from May 2000 to September 2000. We checked body composition using Inbody3.0. Results : Sexual ratio on this report is 1:4.98(male: female). Abnormal eating is Major cause of obesity that has caused orthopedic disease. Increasing of BMI, fluid, protein and mineral mass decrease.

• 약학회지
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• 제53권1호
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• pp.25-33
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• 2009

Metabolic syndrome is increasing nowadays and one of causes is obesity. Therefore prevention and treatment of obesity is very important to decrease of Metabolic syndrome. However currently many pharmacotherapy for obesity are popular in Korea and it may be dangerous. The aim of this study is to evaluate the purpose and relevance of obese treatment in two areas (capital & local) of Korea and suggest to guide for the right directions of pharmacotherapy in obesity treatment. We selected and surveyed 90 patients (88 females, 2 males, age of $23{\sim}60$) at random who received a prescription after consulting with a doctor at several clinics of Cheongju-area and Seoul-area, from May thru June, 2007. And we evaluated their prescriptions. In results, only 26.7% were obese (13.3%, 2325), most 73.3% patients were normal (65.6%, 18.5$m^2$). The purpose of treatment was for appearance (38.9%), health (41.1%) or both (18.9%, p<0.01). 94% patients had the past history of obese treatment. Prescriptions were consisted of CNS stimulant, anticonvulsants, antidepressant, laxatives, diuretics, or antianxietics. Obese treatment is very important for health to prevent disease such as Metabolic Syndrome. However it should not be abused. In conclusion, some patients of obese treatment is not relevant to obesity and pharmacist role is important to guide them for the right directions in obesity treatment.

• 정신신체의학
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• 제3권2호
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• pp.207-213
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• 1995

비만환자들의 정신역동과 정신분석치료의 기법을 문헌 고찰하였다. 비만의 원인은 구강기 고착과 충동조절을 못하는, 자아와 초자아의 결함에 있었다. 비만환자들은 사랑의 상실에 의한 고통을 해결하는 방법으로 음식을 사용한다. 먹음으로 자신을 달래주고(self-soothing), 대리만족을 취한다. 부모의 양육태도가 문제인데, 비만아의 부모는 아이를 통하여 자신의 욕망을 이루려는 분들이어서 지배적이고 음식을 강요하며 어린이의 성취에 대한 기재가 높다. 어린이에게 따뜻한 보살핌이 필요할 때에도 부모의 목표가 더 우선되기 때문에 어린이는 늘 욕구불만에 빠지게 된다. 가정에서 어린이에게 사랑이 필요할 때마다 사랑 대신에 음식을 먹이는 부모였다. 그래서 성장후에 사회적 좌절을 당하면 음식에서 위로를 받고, 음식을 씹음으로 공격욕구도 발산한다(Stunkard, 1985). 또한 비만환자의 부모는 정상적인 부모역할을 전반적으로 소홀히 하는 편이었다. 절제를 가르치지 못하는 부모였다. 그것은 부모 자신의 초자아에 문제가 있어서 요구할 것을 요구하지 못하기 때문이기도 했고, 특별히 어떤 자식을 유난히 무관심 속에 방치해 두어서 비만을 만들기도 한다(Wilson, 1992). 이처럼 비만환자들은 전에디푸스기에 병의 원인(preoedipal pathology)을 가지고 있기 때문에 이런 갈등을 가지고 있는 환자들을 치료할 때는 언제나 그렇듯이 분석가는 좀더 적극적인 해석을 해주어야 한다. 또한 전이대상만으로는 안되고, 이에 추가하여 아이를 잘 키우는 새로운 대상(new and different object)이 되어 줘야한다(Wilson 1989). 비만환자들의 거구를 대하면서 치료자들은 위축되는 역전이에 빠질 수가 있다는 것도 염두에 두어야 한다.