• KSBB Journal
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• 제13권4호
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• pp.391-398
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• 1998

The effect of culture medium copper availability on the specific growth rate(${\mu}$) and carbon conversion efficiency (CCE) was sutided for an obligatory methanotroph Methylosinus trichosporium OB3b under various combinations of carbon and nitrogen sources. Methane or methanol was used as a carbon source, and nitrate or ammonium was used as a nitrogen source. Medium copper availability determined the intracellular location or kind of methane monooxygenase (MMO), cell-membrane (particulate or pMMO) when copper was present and cytoplasm (soluble or sMMO) when copper was deficient. When methane was used as a carbon source, copper-containing medium exhibited higher ${\mu}$ and CCE than copper-free medium regardless of the kind of nitrogen source. When methanol was used as a carbon source, however, the effect of copper disappeared. Ammonium gave the higher ${\mu}$ and CCE than nitrate for both methane and methanol. Those observation suggest that there exist an important difference in energy utilization efficiency for methane assimilation between sMMO and pMMO.

• 지식경영연구
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• 제6권2호
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• pp.123-148
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• 2005

This study aims to extend the research areas of the organization behavior(OB) fields. The paper assumes that the main thrust of "Productivity through people" in the traditional OB has to be replaced by the "Creativity through people" paradigm. OB research issues and topics have not been expended or explored during the past 40 years, but been criticized such as a saturated field and even more "moribund or fallow" areas. Recently, new theoretical and research trends are identified in the area of creativity studies and in OB in general. Conceptual debates and different thoughts on the creativity studies (including creative behaviors) are reviewed selectively. Also, some theoretical issues and research implications are discussed and suggested.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2003년도 제45차 추계학술대회
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• pp.131-132
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• 2003

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.153.2-154
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• 2001

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.151.1-151.1
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• 2001

• 대한한방부인과학회지
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• 제19권4호
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• pp.1-16
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• 2006

Purpose : The purpose of this research was to investigate the effects of Kamibojoongikkitang (KBT) on the immune cells in C57BL/6 mice. Methods : KBT (500mg/kg) was administerd p.o. once a day for 7 days. Results : KBT decreased the cell viability of thymocytes in vivo and in vitro system and decreased the cell viability of splenocytes in vivo, but increased the viability of splenocytes in vitro system. In addition, KBT did not affect the population of helper T (Th) cells and cytotoxic T (Tc) cells in thymocytes and decreased the population of T- and B-lymphocytes and the population of Th and Tc cells in splenocytes. Furthermore, KBT did not affect the production of ${\gamma}%-interferon and interleukin-4 in splenocytes. KBT increased the production of nitric oxide in vivo but decreased the production of nitric oxide in vitro system. KBT enhanced the phagocytic activity of peritoneal macrophages in vivo, but decreased the phagocytic activity in vitro. Conclusion : KBT has an inhibitory action on the specific immune response via decrease of the cell viability of thymocytes and splenocytes and has a potent action on the non-specific immunity via increase of phagocytic activity of peritoneal macrophages.

• 대한한방부인과학회지
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• 제19권4호
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• pp.159-173
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• 2006

Purpose : The purpose of this study is to find out relation between DSOM scores and an attack of uterus myoma in oriental medicine. Methods : We analyze the medical records for 386 patients including 257 uterus myoma patients who visited Dongeui University Oriental Medical Center from May 2001 to June 2006. We investigate the DOSM symptom scores which effect uterus myoma patients using logistic regression model. Results : Logistic regression analysis indicate that 14 items of DSOM were associated with the myoma, and the results show that correct rate is equal to 79.79%, sensitivity is 83.66%, specificity is 72.09%. Conclusion : There is fair relation between DSOM scores(14 items of DSOM) and an attack of uterus myoma in oriental medicine.

• Biomolecules & Therapeutics
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• 제12권4호
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• pp.215-220
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• 2004

In an attempt to develop new anti-diabetic agents, a series of aryloxypropanolamine derivatives was synthesized to serve as ${\beta}_3$ adrenoceptor agonists. Among these derivatives, 1-{1-methyl-3-[4-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)phenyl]propylamino}-3-phenoxy-2-propanol (KR60886) possessed a high affinity for the ${\beta}_3$ adrenoceptor (Ki = 28 nM) and moderate affinities for ${\beta}_1$ and ${\beta}_2$ adrenoceptors (Ki = 95 nM and 100 nM, respectively). In addition, KR60886 stimulated cAMP production with an EC$_{50}$ of 0.4 ${\mu}M$, confirming its agonistic activity for the ${\beta}_3$ adrenoceptor. In vivo activities of KR60886 were examined by using a fat-fed/streptozotocin (STZ)-treated rat model and the ob/ob mouse model. Oral administration of KR60886 (10 mg/kg) for 3 days (b.i.d.) to fat-fed/STZ-treated rats significantly lowered plasma glucose levels and reduced plasma free fatty acid concentrations. Similarly, KR60886 treatment (10 mg/kg/day for 7 d) resulted in a reduction of plasma glucose concentrations in ob/ob mice. The present study suggests that KR60886 is a potent ${\beta}_3$ receptor agonist with in vivo anti-diabetic properties.

• 천문학논총
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• 제28권3호
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• pp.83-93
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• 2013

NGC 6871을 중심으로 한 Cyg OB3 성협 영역에 대한 변광성 탐사로부터 Paper I에 이어 27개의 식쌍성과 19개의 장주기형 불규칙 변광성을 찾았다. 이 중에서 5개를 제외한 나머지는 모두 새로 발견한 것이다. 27개의 식쌍성 중에서 20개는 주기와 변광진폭 등을 구하였으며, 나머지 7개는 모두 EA형 식쌍성으로 보이지만 관측자료의 부족으로 주기를 결정하지는 못하였다. 주기를 구한 20개의 식쌍성 중에서 주극소의 깊이를 확실하게 구하지 못한 V27를 제외한 V와 B등급의 변광진폭비 $A_V/A_B$가 0.88로서 Paper I의 ${\delta}$ Scuti형 변광성의 결과를 이용한 0.72와 뚜렷이 구분된다. EW형 식쌍성 만을 이용할 경우 변광진폭비는 0.92로 더 뚜렷이 구분되었다. 19개의 장주기형 불규칙 변광성은 주기가 너무 길고, 또한 비주기성 변광성으로 보이므로 주기를 얻지는 못하고, 밝기 변화만 알 수 있었다. 이 연구에서 찾은 변광성은 V등급이 9.05등급부터 16.47등급까지 분포하며, 변광진폭이 클 경우 16.5등급까지도 변광 여부를 확인할 수 있었다.

• 한국식품과학회지
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• 제39권2호
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• pp.189-193
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• 2007

This study investigated the effects of Gymnema sylvestre (GS) extract on body weight, adiposity, and lipid metabolism in leptin-deficient ob/ob mice. The experimental mice were divided into the following 4 groups: basal diet (AIN-93G diet) and 0.5%, 1%, and 1.5% GS supplemented groups. Each group was fed the experimental diet for 9 weeks. The final body weights, adipocyte sizes, and epididymal fat weights of the GS groups were significantly lower than those of the control group. There were no significant differences in food intake and food efficiency ratios among the treated groups. Serum triglyceride levels and the atherogenic index were significantly lower in the GS groups compared to the control group. Serum HDL cholesterol levels were significantly higher in the 1% and 1.5% GS groups compared to the control group. Serum glutamate oxaloacetate transaminase and glutamate pyruvate transaminase activities did not differ among the four experimental groups. The total hepatic lipid content was significantly lower in the GS groups, and hepatic cholesterol and triglyceride contents tended to be reduced in the GS groups compared to the control group. These results suggest that GS extract may be useful for ameliorating dyslipidemia and fatty liver.