• Journal of Wetlands Research
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• v.13 no.3
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• pp.411-426
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• 2011

The construction of composite indicators should be normalized and weighted to render them comparable and evaluable variables in the field, which undergoes absence of a distinct methodology and where the application of universally popular method is common. Constructing of indices does not compare and analyze applying various normalizing and weighting, but constructer generally use chosen method and develops indicators and indices in most research. In this study, indices are applied various normalization and weighting methods, thereby analyzing how much impact the index and identifying individual characteristics derive a more reasonable way to help other research in the future. 5 different methods of normalization and 4 different types of weights were compared and analyzed. There are different results depending applied normalized methods and Z-score method best reflects the characteristics of the variables. According to weighting methods, the calculated results show little difference, but the ranking results of indices did not changed significantly. It might be better to provide constructors with a set of normalization and weighting methods to reflect their characteristics in order to build flood indices through the result of this study.

• Economic and Environmental Geology
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• v.47 no.3
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• pp.227-235
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• 2014

For technology level assessment of KIGAM World Class Laboratories (WCL) candidates, bibliometric and qualitative analysis was conducted on their research papers listed on the SCIE database during 2009-2012. For the six research areas of geoscience and mineral resources, a research excellence indicator was applied using a Modified Rank Normalized Impact Factor (mrnIF), which was introduced by Heo et al. (2008) and Cho (2013). The KIGAM research department in rare metals utilization had the highest score for Impact Factor (IF) per paper in 2012 but the groundwater department or the exploration geophysics department came first based on the position and the mrnIF. Applying the mrnIF, the KIGAM research department in groundwater achieved excellent results in 2009 and 2011 and the urban mine department or exploration geophysics department came first place in other years. In the groundwater area, the percentage of research papers over 80 or 90 mrnIF, using Cho (2013)'s research excellence index, was the highest in 2011. The Cho (2013)'s excellent research indicator, 20%, the ratio of over 90 mrnIF was matched in the urban mining area for the whole research period, 2009-2012, and in the groundwater area for several years except 2010. Qualitative analysis of research papers can show the technology level of research departments. KIGAM World Class Laboratories (WCL) candidates should focus on increasing the quality and the quantity of their research papers.

• Journal of Korean Library and Information Science Society
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• v.52 no.1
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• pp.79-108
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• 2021

Information retrieval in the health field has several challenges. Health information terminology is difficult for consumers (laypeople) to understand. Formulating a query with professional terms is not easy for consumers because health-related terms are more familiar to health professionals. If health terms related to a query are automatically added, it would help consumers to find relevant information. The proposed query expansion (QE) models show how to expand a query using MeSH terms. The documents were represented by MeSH terms (i.e. Bag-of-MeSH), found in the full-text articles. And then the MeSH terms were used to generate LDA (Latent Dirichlet Analysis) topic models. A query and the top k retrieved documents were used to find MeSH terms as topic words related to the query. LDA topic words were filtered by threshold values of topic probability (TP) and word probability (WP). Threshold values were effective in an LDA model with a specific number of topics to increase IR performance in terms of infAP (inferred Average Precision) and infNDCG (inferred Normalized Discounted Cumulative Gain), which are common IR metrics for large data collections with incomplete judgments. The top k words were chosen by the word score based on (TP *WP) and retrieved document ranking in an LDA model with specific thresholds. The QE model with specific thresholds for TP and WP showed improved mean infAP and infNDCG scores in an LDA model, comparing with the baseline result.

• Journal of Sasang Constitutional Medicine
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• v.25 no.4
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• pp.432-441
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• 2013

Objectives Despite the treatment with antibiotics, patients with sepsis has a high mortality (80%) in the underlying disease group. The aim of this study was to report the improvement of septic condition of the cholangiocarcinoma patient after the treatment with Handayeolso-tang, Fel Tauri, and antibiotics. Methods We retrospectively reviewed the medical records. The patient's subjective symptoms such as chilling and abdominal pain were evaluated by NRS and the performance status was evaluated by ECOG. This case was literally compared with relevant published studies on prognosis of sepsis. Results Despite poor prognostic factor(MEDS score 18), the patient's symptoms such as fever, chilling, abdominal pain, and diarrhea and ECOG(Eastern Cooperative Oncology Group) improved. The patient was hemodynamically stabilized on 3rd day from the treatment, and her laboratory test results were normalized on 7th day. Conclusions A female patient of metastatic cholangiocarcinoma came to the hospital for cholangitis, later causing septic shock. Both her symptoms and laboratory tests showed significant improvement after the treatment of antibiotics, Handayeolso-tang and Fel Tauri. To our knowledge, this is the first case reporting the synergistic combination of Korean oriental medicine and Western medicine approaching to sepsis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.17 no.4
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• pp.248-256
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• 2014

Purpose: Non-alcoholic fatty liver disease (NAFLD) in children has become an important public health issue because of its high prevalence and severity. Several noninvasive methods for estimating NAFLD are under investigation. We aimed to evaluate the usefulness of serum ferritin as a biomarker of severity of pediatric NAFLD patients. Methods: A total of 64 NAFLD patient were enrolled from Severance Children's Hospital from March 2010 to February 2013. Serum ferritin levels, liver related laboratory tests, liver magnetic resonance imaging (MRI) (2-dimensional [2D] proton density-fat fraction) and NAFLD severity markers were compared between obese group and overweight group. Correlation analyses were performed between serum ferritin and laboratory values including NAFLD severity markers. Results: In obese group, serum ferritin, alanine aminotransferase (ALT), total bilirubin, international normalized ratio (INR), MRI 2D proton density-fat fraction, aspartate aminotransferase (AST) to platelet ratio index (APRI) and fibrosis- 4 (FIB-4) (an index score calculated from platelet count, ALT, AST and age) were significantly higher than those of overweight group. NAFLD severity markers, APRI and FIB-4, and liver specific important laboratory values, AST, ALT, INR, cholesterol, triglyceride and low density lipoprotein show significant correlation with serum ferritin in NAFLD patients. Conclusion: Serum ferritin concentrations could be a candidate of useful severity marker in the pediatric NAFLD patients.

• Journal of Korean Society for Atmospheric Environment
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• v.34 no.2
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• pp.223-232
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• 2018

As the Seoul metropolitan city has the largest numbers of population and vehicles, the citizens can be exposed to hazardous air pollutants(HAPs) mainly from the vehicular exhaust and human activities. In this study, we proposed a systematic method for the selection of priority monitoring areas for HAPs using Geographic Information System (GIS). First, emission parameters(emission data, vehicle registration, monitoring data, and so on) and population parameters (population and population density) were plotted using the inverse distance weighted (IDW) interpolation. Then, the interpolation data for individual parameters, which were normalized between 1 and 5 points, were compiled for 270 grids with a resolution of $2km{\times}2km$. The total score of each grid was calculated using weights(1~5) for the individual parameters. The final ranking of each grid was assigned by four scenarios with varying fractions of the emission and population parameters from 50 : 50 to 80 : 20. Consequently, nine grids were suggested as priority monitoring areas, and all of them are located in the southwestern part of Seoul.

• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.195-200
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• 2016

Background: Venous thromboembolism (VTE) is a common and life-threating condition in cancer patients. Low molecular weight heparins (LMWH), such as dalteparin, are recommended in the treatment of VTE. Also, rivaroxaban, an orally administered direct factor Xa inhibitor, was approved for the treatment of VTE. It showed similar efficacy to standard therapy (LMWH or warfarin) and was associated with significantly lower rates of major bleedings. However, in the real world, bleeding has been reported to occur frequently in cancer patient receiving rivaroxaban. The goal of this research was to analyze bleeding risks between rivaroxaban and dalteparin for treatment of VTE in cancer patients. Methods: Medical records of oncology patients who were treated with rivaroxaban or dalteparin for VTE from July 2012 to June 2014 were retrospectively reviewed. Data collected were as follows: age, sex, weight, height, cancer types and stages, ECOG (eastern cooperative oncology group) PS (performance score), VTE types, concurrently used medications, study drug information (dose and duration of therapy), INR (international normalized ratio), PT (prothrombin time), and platelet counts. Bleeding was classified into major bleedings, clinically relevant non-major bleedings, and minor bleedings. Results: A total of 399 patients were included in the study. Of these patients, 246 were treated with rivaroxaban and 153 with dalteparin. Bleeding rates were significantly higher in the rivaroxaban group than in the dalteparin group (adjusted odds ratio (AOR) 2.09, 95% CI 1.22-3.60) after adjusting for confounders. In addition, rivaroxaban remained independently associated with 1.78-fold (95% CI 1.14-2.76) shorter time to bleeding compared to dalteparin after adjusting other factors known to be associated with poor outcomes. Conclusion: This study suggested that rivaroxaban was associated with an increased risk of bleedings in cancer patients.

• The Journal of the Korea Contents Association
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• v.10 no.5
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• pp.268-284
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• 2010

The purpose of this study was to evaluate the effects of horseback riding simulation training(HRST) on gross motor function of children with cerebral palsy. Twenty-four children with cerebral palsy participated were divided into two groups randomly. Control group and experimental group both received 30 minutes of regular neuro-rehab exercises for three times a week per twelve weeks, but experimental group received additional 15 minutes of the HRST. Gross Motor Function Measure(GMFM) was used to evaluate the changes before and after HRST. Normalized GMFM scores were compared using Mann-Whitney U test, statistical significance was set at a=.05. The results were as followings: First, in each compared before and after the experiment, the control group showed significantly increased GMFM score in dimensions A and B. The experimental group showed significant increasing in all dimensions of GMFM test. Second, the experimental group showed significant differences comparing to control group in dimensions C, D and E of GMFM test. Consequently, HRST should be considered as a therapeutic method for physical therapy for the children with cerebral palsy to improve the functional movements.

• Journal of Korean Society of Forest Science
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• v.96 no.3
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• pp.300-306
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• 2007

This study was carried out to analyze the characteristics of forest environmental and stream morphological factors by using the quantification theory (I) for prediction of the suitable dam site. The results obtained from this study were summarized as follows; The selection of suitable site for erosion control dam was estimated by normalized score of each category. And the prediction method of suitable site for erosion control dam divided into class I (Very suitable site), II (Suitable site), and III (Poor suitable site) for the convenience of use. In conclusion, if we select the suitable site for construction of erosion control dam for disaster prevention, we could save the loss of tremendous budget, avoid the poor suitable site due to subjective judgment, and it would promote the functions of erosion control dam.

• Clinical and Experimental Pediatrics
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• v.60 no.6
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• pp.189-195
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• 2017

Purpose: The purpose of this study was to investigate the effects of lamotrigine for the treatment of attention-deficit hyperactivity disorder (ADHD) symptoms in children with epilepsy. Methods: Pediatric patients newly diagnosed with epilepsy (n=90 [61 boys and 29 girls]; mean age, $9.1{\pm}3.4years$) were enrolled. All patients were evaluated with the Korean ADHD rating scale (K-ARS)-IV before treatment with lamotrigine and after doses had been administered. The mean interval of ADHD testing was approximately 12.3 months. The initial dosage of lamotrigine was 1 mg/kg/day (maximum 25 mg/day for the first 2 weeks), and increased by 1 mg/kg every 2 weeks until titrated up to 7 mg/kg/day (or maximum 200 mg/day). Results: The mean ADHD test score of the 90 subjects was $17.0{\pm}1.8$ at baseline. It was slightly reduced to $15.6{\pm}1.7$ after lamotrigine monotherapy (P>0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy ($28.0{\pm}1.6$ reduced to $18.1{\pm}2.6$, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy. Conclusion: The results from our study show that lamotrigine had a positive effect in pediatric epilepsy patients by reducing ADHD symptoms, preventing seizures, and normalizing EEG. However, further research is required to determine whether lamotrigine is efficacious against ADHD symptoms independent of its effects on epileptic seizures.