DOI QR코드

DOI QR Code

A Case Study of Metastatic Cholangiocarcinoma with Sepsis who Showed Symptomatic Improvement after Treated with Handayeolso-tang, Fel Tauri, and Antibiotics

전이된 담도암 환자의 패혈증을 한다열소탕 및 우담과 항생제를 병행하여 치료한 환자 1례

  • Lee, Soo-Min (Graduate school of Clinical Korean Medicine, Kyung Hee University) ;
  • Choi, Seong-Heon (Graduate school of Clinical Korean Medicine, Kyung Hee University) ;
  • Song, An-Na (Graduate school of Clinical Korean Medicine, Kyung Hee University) ;
  • Lee, Ji-Young (Cancer Center, Kyung-Hee University hospital at Gangdong, College of Korean medicine, Kyung Hee University) ;
  • Chae, Jin (Cancer Center, Kyung-Hee University hospital at Gangdong, College of Korean medicine, Kyung Hee University) ;
  • Jung, Eu-Hong (Cancer Center, Kyung-Hee University hospital at Gangdong, College of Korean medicine, Kyung Hee University) ;
  • Lee, Soo-Kyung (Cancer Center, Kyung-Hee University hospital at Gangdong, College of Korean medicine, Kyung Hee University)
  • 이수민 (경희대학교 대학원 임상한의학과) ;
  • 최성헌 (경희대학교 대학원 임상한의학과) ;
  • 송안나 (경희대학교 대학원 임상한의학과) ;
  • 이지영 (경희대학교 한의과대학 강동경희대학교병원 한방암센터) ;
  • 채진 (경희대학교 한의과대학 강동경희대학교병원 한방암센터) ;
  • 정의홍 (경희대학교 한의과대학 강동경희대학교병원 한방암센터) ;
  • 이수경 (경희대학교 한의과대학 강동경희대학교병원 한방암센터)
  • Received : 2013.10.25
  • Accepted : 2013.11.21
  • Published : 2013.12.31

Abstract

Objectives Despite the treatment with antibiotics, patients with sepsis has a high mortality (80%) in the underlying disease group. The aim of this study was to report the improvement of septic condition of the cholangiocarcinoma patient after the treatment with Handayeolso-tang, Fel Tauri, and antibiotics. Methods We retrospectively reviewed the medical records. The patient's subjective symptoms such as chilling and abdominal pain were evaluated by NRS and the performance status was evaluated by ECOG. This case was literally compared with relevant published studies on prognosis of sepsis. Results Despite poor prognostic factor(MEDS score 18), the patient's symptoms such as fever, chilling, abdominal pain, and diarrhea and ECOG(Eastern Cooperative Oncology Group) improved. The patient was hemodynamically stabilized on 3rd day from the treatment, and her laboratory test results were normalized on 7th day. Conclusions A female patient of metastatic cholangiocarcinoma came to the hospital for cholangitis, later causing septic shock. Both her symptoms and laboratory tests showed significant improvement after the treatment of antibiotics, Handayeolso-tang and Fel Tauri. To our knowledge, this is the first case reporting the synergistic combination of Korean oriental medicine and Western medicine approaching to sepsis.

Keywords

References

  1. Farley DR, Weaver AL, Nagorney DM. "Natural history" of unresected cholangiocarcinoma: patient outcome after noncurative intervention. Mayo Clin Proc 1995;70:425-429. https://doi.org/10.4065/70.5.425
  2. Um JW, Kim KH, Kim YC, Koo BW. Analysis of Survival Rate of the Gall Bladder and Extrahepatic Bile Duct Cancer. J Kor Sur Soc. 1995;48(4):531-541. (Korean)
  3. Mark DW, Lee AB, Liesl MC, Joseph J, Richard VW, Rebecca LQ, et al. Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care. Crit care. 2004;8(5):R291-R298 https://doi.org/10.1186/cc2893
  4. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Eng J Med. 2003;348:1546-1554. https://doi.org/10.1056/NEJMoa022139
  5. Miura F, Takada T, Kawarada Y, Nimura Y, Wada K, Hirota M, et al. Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg. 2007;14:27-34. https://doi.org/10.1007/s00534-006-1153-x
  6. Huang J, Chang CH, Wang JL, Kuo HK, Lin JW, Shau WY, et al. Nationwide epidemiological study of severe gallstone disease in Taiwan. BMC Gastroenterol. 2009;9:63. https://doi.org/10.1186/1471-230X-9-63
  7. Kim JY, Lee JY, Wang DJ, Ahn DJ. A Case of a Yolgwol Headache with Bacteremia. J of Oriental Neuropsychiatry. 2007;18(3):321-30. (Korean)
  8. Scott AJ. Bacteria and disease of biliary tract. Gut. 1971;12:487-92. https://doi.org/10.1136/gut.12.6.487
  9. Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M, et al. Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg 2007;14:15-26. https://doi.org/10.1007/s00534-006-1152-y
  10. Kinney TP. Management of ascending cholangitis. Gastrointest Endosc Clin N Am 2007;17:289-306. https://doi.org/10.1016/j.giec.2007.03.006
  11. Kim SG, Kwon OY, Lee JS, Choi HS, Hong HP, Ko YG. Computed Tomography Findings for Acute Cholangitis in an Emergency Department: Comparison of Sepsis and Non-sepsis Patient Groups. Kor Cirt Care Med. 2010;21(4):459-64. (Korean)
  12. Shapiro NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003;31:670-675. https://doi.org/10.1097/01.CCM.0000054867.01688.D1
  13. Go CY, Kim YS, Shin TY, Ha YR. Comparing the Usefulness of the Initial Acute Physiologic and Chronic Health Evaluation (APACHE) 2 Score in the Emergency Department (ED) and the Mortality in Emergency Department Sepsis (MEDS) Score for Predicting the Prognosis of Sepsis. Korean J of Crit Care Med. 2008;23(2):90-95. (Korean) https://doi.org/10.4266/kjccm.2008.23.2.90
  14. Bae YS, Park HS, Jung YS, Min YK. Prognostic Factors and Adequacy of Empirical Antibiotic Therapy for Patients with Bloodstream Infection in the Emergency Department. J of the Korean society of Emerg Med. 2005;16(1):18-24
  15. Hwang JI, Lee KJ, Park KN, Lee WJ, Oh DR, Park SH, et al. Bactremia in elderly emergency patients. Korean J of Crit Care Med. 1994;5(2):299-305. (Korean)
  16. Kim OY, Cho JS, Lee HM, Park SJ, Park HS. A Case of Taeeum-ia Hangwol Symptomatology Patient who Showed Improvement with the Handayeolso-tang. J Sasang Constitut Med. 2009;21(3):202-208. (Korean)
  17. Choi EJ, Song HS, Yoon WY, Yoo JS. A Tae-Eumin Exterior-Cold-Disease by the Cold in the Esophagus's Case Study of Diagnosed as Acute Hepatitis A. J Sasang Constitut Med. 2009;21(3):216-222. (Korean)
  18. Cho HS. Principles and Prescriptionology of Sasang Constitutional medicine. rev. ed. Seoul:Jipmoondang. 2011:276-280. (Korean)
  19. Park SS. A clinical study about Tae-eumin Handayeolsotang. J Sasang Constitut Med. 1992;4(1):231-240. (Korean)
  20. Choi JR, Bae HS, Han KS, Park EK, Choi JY, Park SS. A clinical study about Treatment of a chill without fever. J Sasang Constitut Med. 2002;5(1):118-122. (Korean)

Cited by

  1. An Analysis of Case Reports and Case Series on Taeeum Person in Journal of Sasang Constitutional Medicine from 2006 to 2015 vol.28, pp.2, 2016, https://doi.org/10.7730/JSCM.2016.28.2.83