• Progress in Medical Physics
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• v.9 no.3
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• pp.155-162
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• 1998

Ho-l66 was produced by neutron reaction in a reactor at the Korea Atomic Energy Institute (Taejon, Korea). Ho-l66 emits a high energy beta particles with a maximum energy of 1.85 MeV and small proportion of gamma rays (80 keV). Therefore, the radiation absorbed dose estimation could be based on the in-vivo quantification of the activity in tumors from the gamma camera images. Approximately 1 mCi of Ho-l66 in solution was mixed into the flood phantom and planar scintigraphic images were acquired with and without patient interposed between the phantom and scintillation camera. Transmission factor over an area of interest was calculated from the ratio of counts in selected regions of the two images described above. A dual-head gamma camera(Multispect2, Siemens, Hoffman Estates, IL, USA) equipped with medium energy collimators was utilized for imaging(80 keV${\pm}$10%). Fifty-nine year old female patient with hepatoma was enrolled into the therapeutic protocol after the informed consent obtained. Thirty millicuries(110MBq) of Ho-166-CHICO was injected into the right hepatic arterial branch supplying hepatoma. When the injection was completed, anterior and posterior scintigraphic views of the chest and pelvic regions were obtained for 3 successive days. Regions of interest (ROIs) were drawn over the organs in both the anterior and posterior views. The activity in those ROIs was estimated from geometric mean, calibration factor and transmission factors. Absorbed dose was calculated using the Marinelli formula and Medical Internal Radiation Dose (MIRD) schema. Tumor dose of the patient treated with 1110 MBq(30 mCi) Ho-l66 was calculated to be 179.7 Gy. Dose distribution to normal liver, spleen, lung and bone was 9.1, 10.3, 3.9, 5.0 % of the tumor dose respectively. In conclusion, tumor dose and absorbed dose to surrounding structures were calculated by daily external imaging after the Ho-l66 therapy for hepatoma. In order to limit the thresholding dose to each surrounding organ, absorbed dose calculation provides useful information.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.2
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• pp.140-151
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• 2003

Purpose: We tried to evaluate the long term efficacy and positive predictive factors of interferon-alpha treatment in children with chronic hepatitis B. Methods: The study population included 113 children who received interferon therapy between May 1982 and July 2002 (20 years) for chronic hepatitis B in Department of Pediatrics, Yonsei University College of Medicine. Male to female ratio was 2.3 : 1 and the mean age at diagnosis was $11.1{\pm}4.1$ years old. Response to treatment was defined as normalization of alanine aminotransferase (ALT), disappearance of HBeAg and HBV-DNA Eighty two children responded while 32 did not. Interferon-alpha was given intramuscularly for 6 months at a dosage of $3{\times}10^6$ unit, 3 times weekly. In relapsed cases, lamivudine or interferon retreatment was done. Results: Seroconversion rate was 77.0% in terms of HBeAg, 74.3% in terms of HBV-DNA, and 80.5% in terms of ALT normalization after treatment. Seroconversion rate of both HBeAg and HBV-DNA was 72.6%. Analyzed by life table method, the effect of the treatment had been maintained over 10 years after cessation of therapy. Pre-treatment ALT level was the only significant positive predictive factor of response. Eleven cases (13.4%) relapsed, and 2 out of 3 showed response when treated with lamivudine and 1 out of 3 with interferon retreatment. Conclusion: Interferon-alpha showed significant efficacy in the treatment of chronic hepatitis B in our study. Further studies about the effect of interferon therapy on complications of hepatitis such as hepatocarcinoma, cirrhosis are warranted.

• Journal of the Korean Geotechnical Society
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• v.19 no.5
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• pp.133-144
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• 2003

Horizontal consolidation characteristics of Busan marine clay were investigated by computing coefficient of horizontal consolidation from Piezocone data and comparing their results with those of standard consolidation test. It is well known that current prediction models of $c_h$ for high plastic soils have large uncertainties, and show a great difference between the predicted and the measured values. However, the spherical models and expanding cavity theory of Torstensson(1977), and Burns & Mayne(1998) based on modified Cam-Clay model with critical limit state concepts have relative reliability in estimating $c_h$ and good applicability in highly plasticity soils. In this paper, a normalization technique was used to evaluate $c_h$ using the Burns and Mayne's method based on the dissipation test, and their normalized consolidation curves give 0.015 of time factor($T_{50}$) when 50% degree of consolidation is completed. Comparison study using Piezocone data obtained at other similar ground site shows 1.5 times less systematicality than that of standard consolidation test, which indicates considerable approximation with the measured values because standard consolidation test gives the difference of three to few times compared with the measured values. In addition, design chart for estimating $c_h$ based on the chart from Robertson et al.(1992) and using the other method of the direct prediction from the of dissipation test was newly proposed. It is judged that new proposed chart is very applicable to Korean marine soils, especially in very high plastic soils.

• Journal of Korean Society for Geospatial Information Science
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• v.6 no.2 s.12
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• pp.105-117
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• 1998

The main object of this study was to prove the effectiveness of satellite Image data for extraction of the pine needle gall midge damaged area in the part of Kangwon-do area, and to present the detailed procedure of a digital image processing for extraction of those damaged area. The effectiveness of extraction of damaged area was improved by using the BRCT(Backwards Radiance Correction Transformation) with DEM for the normalization of topographic effects. The topographic surface analysis of the extracted damaged area revealed that the general damaged area was at south-west and south-east aspect with the slope of 31 to 38 degrees, the temperature of 21 to 25, and 23% to 39% of the highest altitude mountains. The new damaged area in which expanded area was at 27 to 30 degree of slope, the aspect of 46 to 180 degrees, the temperature of $11^{\circ}C\;to\;12^{\circ}C$ and 27% to 39% of the highest altitude mountains. The NDI(New Damaged Index) was developed using the environment factor and simple vegetation index.

• Journal of Wetlands Research
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• v.15 no.3
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• pp.367-380
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• 2013

In this study, sub-indicators, and thematic mid-indexes to evaluate the water use characteristics were selected through historical data analysis and factor analysis, and consisted of the subject approach framework. And the integrated index was developed to evaluate water use characteristics of the watershed. Using developed index, the water use characteristics were assessed for 812 standard basins with the exception for North Korea using data of 1990 to 2007 from the relevant agencies. A sensitivity analysis is conducted for this study to determine the proper way through various normalization and weighting methods. To increase the objectivity of developed index, the history of the damage indicators are excluded in the analysis. In addition, in order to ensure its reliability, results from index with and without consideration of the damage history were compared. Also, the index is also applied to real data for 2008 Gangwon region to verify its field applicability. Through the validation process this index confirmed the adequacy for the indicators selection and calculation method. The results of this study were analyzed based on the spatial and time vulnerability of the basin's water use, which can be applied to various parts such as priority decision-making for water business or policy, mitigations for the vulnerable components of the basin, and supporting measures to establishment by providing relevant information about it.

• The Journal of Engineering Geology
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• v.32 no.4
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• pp.585-596
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• 2022

This study determined major factors influencing landslide occurrence along a forest road near Sangsan village, Sancheok-myeon, Chungju-si, Chungcheongbuk-do, South Korea. Within a 2 km radius of the study area, landslides occur intensively during periods of heavy rainfall (August 2020). This makes study of the area advantageous, as it allows examination of the influence of only geological and tomographic factors while excluding the effects of rainfall and vegetation. Data for 82 locations (37 experiencing landslides and 45 not) were obtained from geological surveys, laboratory tests, and geo-spatial analysis. After some data preprocessing (e.g., error filtering, minimum-maximum normalization, and multicollinearity), structural equation model (SEM) and logistic regression (LR) analyses were conducted. These showed the regolith thickness, porosity, and saturated unit weight to be the factors most influential of landslide risk in the study area. The sums of the influence magnitudes of these factors are 71% in SEM and 83% in LR.

• Biomolecules & Therapeutics
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• v.32 no.6
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• pp.744-758
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• 2024

Asthma is a chronic inflammatory disorder of the lungs that results in airway inflammation and narrowing. BS012 is an herbal remedy containing Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts. To elucidate the anti-asthma effect of BS012, this study analyzed the immune response, respiratory protection, and changes in metabolic mechanisms in an ovalbumin-induced allergic asthma mouse model. Female BALB/c mice were exposed to ovalbumin to induce allergic asthma. Bronchoalveolar lavage fluid and plasma were analyzed for interleukin and immunoglobulin E levels. Histological analyses of the lungs were performed to measure morphological changes. Apoptosis-related mediators were assayed by western blotting. Plasma and lung tissue metabolomic analyses were performed to investigate the metabolic changes. A T-helper-2-like differentiated cell model was used to identify the active components of BS012. BS012 treatment improved inflammatory cell infiltration, mucus production, and goblet cell hyperplasia in lung tissues. BS012 also significantly downregulated ovalbumin-specific immunoglobulin E in plasma and T-helper-2-specific cytokines, interleukin-4 and -5, in bronchoalveolar lavage fluid. The lungs of ovalbumin-inhaled mice exhibited nerve growth factor-mediated apoptotic protein expression, which was significantly attenuated by BS012 treatment. Ovalbumin-induced abnormalities in amino acid and lipid metabolism were improved by BS012 in correlation with its anti-inflammatory properties and normalization of energy metabolism. Additionally, the differentiated cell model revealed that N-isobutyl-dodecatetraenamide is an active component that contributes to the anti-allergic properties of BS012. The current findings demonstrate the anti-allergic and respiratory protective functions of BS012 against allergic asthma, which can be considered a therapeutic candidate.

• Korean Journal of Cognitive Science
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• v.13 no.3
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• pp.1-10
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• 2002

This study was performed to analyze the physical attributes of the faces and affective words on the fares. For analyzing physical attributes inside of a face, 36 facial features were selected and almost of them were the lengths or distance values. For analyzing facial contour 14 points were selected and the lengths from nose-end to them were measured. The values of these features except ratio values normalized by facial vortical length or facial horizontal length because the face size of each person is different. The principal component analysis (PCA) was performed and four major factors were extracted: 'facial contour' component, 'vortical length of eye' component, 'facial width' component, 'eyebrow region' component. We supposed the five-dimensional imaginary space of faces using factor scores of PCA, and selected representative faces evenly in this space. On the other hand, the affective words on faces were collected from magazines and through surveys. The factor analysis and multidimensional scaling method were performed and two orthogonal dimensions for the affections on faces were suggested: babyish-mature and sharp-soft.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.2
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• pp.153-160
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• 2009

A PM10 (aerodynamic diameter${\leq}$10 ${\mu}m$) sampler is used to quantify the potential human exposure to suspended particulate matter (PM) and to comply with the governmental regulation. This study was conducted to compare and evaluate the same PM10 cutpoint and different slopes between United States Environmental Protection Agency (USEPA) PM10 sampling criterion and American Conference of Governmental Industrial Hygienists/$Comit\acute{e}$ $Europ\acute{e}en$ de Normalization/International Organization for Standardization thoracic PM10 sampling criterion through theory and experiment. Four PM10 samplers according to the USEPA criterion and one RespiCon sampler in accordance with the thoracic PM10 criterion were used in the present study. In addition, one DustTrak monitor was used to measure real time PM10 mass concentrations. All six aerosol samplers were tested in a PM generation chamber using polydisperse fly ash. Theoretical mass concentrations were calculated by applying the measured particle size distribution characteristics (geometric mean = 6.6 ${\mu}m$, geometric standard deviation = 1.9) of fly ash to each sampling criterion. The measured mass concentrations through a chamber experiment were consistent with theoretical mass concentrations in that a RespiCon sampler with the thoracic PM10 criterion collected less PM than a PM10 sampler with the USEPA criterion. The overall chamber experiment results indicated, when a PM10 sampler was used as a reference sampler, that (1) a RespiCon sampler had a normalizing factor of 1.6, meaning that this sampler underestimated an average 60% of PM10 mass sampled from a PM10 sampler, and (2) a DustTrak real-time monitor using a PM10 inlet had a calibration factor of 2.1.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.5
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• pp.705-715
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• 2010

The adoption of carbon foot print system is being activated mostly in the developed countries as one of the long-term response towards tightened up regulations and standards on carbon emission in the agricultural sector. The Korean Ministry of Environment excluded the primary agricultural products from the carbon foot print system due to lack of LCI (life cycle inventory) database in agriculture. Therefore, the research on and establishment of LCI database in the agriculture for adoption of carbon foot print system is urgent. Development of LCA (life cycle assessment) methodology for application of LCA to agricultural environment in Korea is also very important. Application of LCA methodology to agricultural environment in Korea is an early stage. Therefore, this study was carried out to find out the effect of lettuce cultivation on agricultural environment by establishing LCA methodology. Data collection of agricultural input and output for establishing LCI was carried out by collecting statistical data and documents on income from agro and livestock products prepared by RDA. LCA methodology for agriculture was reviewed by investigating LCA methodology and LCA applications of foreign countries. Results based on 1 kg of lettuce production showed that inputs including N, P, organic fertilizers, compound fertilizers and crop protectants were the main sources of major emission factor during lettuce cropping process. The amount of inputs considering the amount of active ingredients was required to estimate the actual quantity of the inputs used. Major emissions due to agricultural activities were $N_2O$ (emission to air) and ${NO_3}^-$/${PO_4}^-$ (emission to water) from fertilizers, organic compounds from pesticides and air pollutants from fossil fuel combustion in using agricultural machines. The softwares for LCIA (life cycle impact assessment) and LCA used in Korea are 'PASS' and 'TOTAL' which have been developed by the Ministry of Knowledge Economy and the Ministry of Environment. However, the models used for the softwares are the ones developed in foreign countries. In the future, development of models and optimization of factors for characterization, normalization and weighting suitable to Korean agricultural environment need to be done for more precise LCA analysis in the agricultural area.