• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1713-1718
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• 2012

Advanced imaging approaches (computed tomography, CT; magnetic resonance imaging, MRI; $^{18}F$-fluorodeoxyglucose positron emission tomography, FDG PET) have increased roles in cervical cancer staging and management. The recent FIGO (International Federation of Gynecology and Obstetrics) recommendations encouraged applications to assess the clinical extension of tumors rather than relying on clinical examinations and traditional non-cross sectional investigations. MRI appears to be better than CT for primary tumors and adjacent soft tissue involvement in the pelvis. FDG-PET/CT has increased in usage with a particular benefit for whole body evaluation of tumor metabolic activity. The potential benefits of advanced imaging are assisting selection of treatment based upon actual disease extent, to adequately treat a tumor with minimal normal tissue complications, and to predict the treatment outcomes. Furthermore, sophisticated external radiation treatment and brachytherapy absolutely require advanced imaging for target localization and radiation dose calculation.

• Journal of Korean Neurosurgical Society
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• v.44 no.1
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• pp.47-51
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• 2008

Ligamentum flavum hematoma is a rare condition. Twenty cases including present case have been reported in English-language literature. Among them, only one case reported in pure thoracic spine. A 72-year-old man presented with thoracic myelopathy without precedent cause. Magnetic resonance images revealed a posterior semicircular mass which was located in T7 and T8 level compressing the spinal cord dorsally. T7-8 total laminectomy and extirpation of the mass was performed. One month later following surgery, the patient fully recovered to normal state. Pathologic result was confirmed as ligamentum flavum hematoma. Ligamentum flavum hematoma of rigid thoracic spine is a very rare disease entity. Most reported cases were confined to mobile cervical and lumbar spine. Surgeons should be aware that there seems to be another different pathogenesis other than previously reported cases of mobile cervical and lumbar spine.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.733-738
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• 2020

Glucose deprivation and hypoxia frequently occur in solid tumor cells, including pancreatic cancer cells. Glucose deprivation activates the unfolded protein response (UPR) and causes the up-regulation of glucose-regulated protein 78 (GRP78). Induction of GRP78 has been shown to protect cancer cells. Therefore, shutting down of GRP78 expression may be a novel strategy in anticancer drug development. Based on this understanding, a screening system established for anticancer agents that exhibit selective cytotoxicity on pancreatic cancer cells under glucose-deprived conditions. To test this hypothesis, the new compounds isolated, pancastatin A (PST-A) and B (PST-B), from Ponciri Fructus. PST-A and B were identified as glabretal triterpenoid moieties by electrospray ionization mass spectrometry and nuclear magnetic resonance spectroscopic methods. PST-A and B suppressed the accumulation of the UPR hallmark gene, GRP78, during glucose deprivation. Furthermore, PST-A and B showed selective cytotoxicity on PANC-1 pancreatic cancer cells under glucose deprivation. Interestingly, PST-A and B had no effect on these cells under normal growth conditions. Our results suggest that PST-A and B act as novel therapeutic agents to induce selective cell death in glucose-deprived pancreatic cancer cells.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.9 no.1
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• pp.32-37
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• 1998

Tonsillectomy is the one of operation that is performed the most commonly in otolaryngology field. Many changes that include range of voice, tone, voice quality and resonance were made by tonsillectomy. Sometimes, any patients taken tonsillectomy has suffer from these voice problem after tonsillectomy. However there are less study for these problems until now. Then, we studied to find the anatomical findings that affected the voice quality when tonsillectomy was performed. We evaluated the voice in 2 groups, one is the group showed the normal pharyngeal space by using the transnasal fiberscopy, the other is group showed medially bulging tonsil at pharyngeal cavity by using same method, with perceptual evaluation, nasalance score, nasality, oral formant and nasal formant. We used the computerized speech analysis system, the nasometer and the spectrogram in the CSL program. We could not find any differences in perceptual evaluation between two groups. But objective measures were provided. Nasalance score and nasality on the nasometric analysis were increased significantly and oral formant on the spectrogram was changed singnificantly after tonsillectomy in Group 2. Authors thought medially bulging tonsil in the pharynx is able to affect the voice quality after tonsillectomy when we evaluted through the nasal cavity by the using of fiberscopy and this evaluation would be important especially in singers.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.4 no.1
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• pp.24-32
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• 1991

Cleft palate or velopharyngeal incompetence shows many disorders and disabilities affecting speech transmission. including distortion. substitution. and the nasalization of the vowels. The nasalized vowels are produced primarily by lowering of the velum. resulting in opening a side passage for the air flow through the nasal cavity. These abnormal movements give rise to complex modification of the physical property of the sound or in the sound spectrum. The authors employed Sonagraph$^{\circledR}$ as a sound analyzer in order to ascertain the features which characterize the nasalization of vowels. Twenty healthy Korean male adult voluteers were analyzed in artificial conditions of anterior and posterior nasal obstruction. and velo-pharyngeal incompetence. The results were as follows : 1) Fundamental frequency was not changed by nasal obstruction or velopharyngeal incompetence. 2) There was no significant difference of the formant intensity between normal and nasal vowels. 3) In VPI, a decrease of the frequency of $F_2$ was observed in /e/ and /i/ vowels(p<0.001). 4) In VPI, the $F_2$ was frequently missed in /o/ and /u/ vowels. 5) In the consonant spectra of VPI, the 'release burst' was usually not observed.

• Annals of Clinical Neurophysiology
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• v.8 no.1
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• pp.53-57
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• 2006

Background: Vstibular evoked myogenic potentials(VEMP) have been known to be useful documenting abnormality in patients with various vestibular disorders and brainstem lesions but the studies of VEMP in patients with hemispheric lesions are rare. Methods: We recorded VEMP in 21 consecutive patients with acute ischemic stroke in the supratentorial lesions without evidence of brainstem or vestibular end organ lesions. All patients underwent magnetic resonance imaging and the main outcome measures of VEMP were recorded in all subjects. We interpreted each parameters of VEMP using our normal laboratory data. Results: VEMP abnormalities(prolonged latency or asymmetry of amplitude) were found in 57%(12/21) of acute infarction patients with supratentorial lesions. Bilateral VEMP abnormalities were found in six patients and unilateral abnormalities were found in another six patients with ipsilateral abnormalities in the three and controlateral abnormalities in the three patients. Conclusions: VEMP abnormalities were found in supratentorial stroke patients in our studies and this findings suggest supranuclear control may affect the generation of VEMP potentials.

• International Journal of Automotive Technology
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• v.5 no.1
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• pp.9-16
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• 2004

An experimental study was carried out to characterize the spray atomization process of micro-machined port fuel injectors with a piezoelectric atomization device, which can generate pressure pulsations through vibration of a piezoelectric transducer. In this study, several types of micro-machined arrays such as 30∼200-microns of hole arrays were tested. Both a dual-stream and a central-port injectors with micro-machined arrays were tested and compared with normal port fuel injectors. The spray visualization was conducted to characterize overall spray structure and phase Doppler particle analyzer (PDPA) system was used to quantify the droplet size and velocity. In addition, the pressure history was recorded by using digitized signal from pressure transducer. The results showed that modulation is effective to the spray atomization for tested injectors and atomization performance depends on injector design factors, orifice sizes, and frequency and power of the modulator. A number of resonance frequencies of the modulator was modified by injector parameters and temperature. In addition, our results suggested that design of sufficient space among holes is critical to avoid droplet coalescence in the multi-hole micro-machined injectors.

• Speech Sciences
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• v.4 no.2
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• pp.69-89
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• 1998

The aim of this study is to develop an objectively method of speech evaluation for children with cleft palates. To assess velopharyngeal function, Visi-Pitch, Computerized Speech Lab. (CSL), Nasometer and Palatometer were used for this study. Acoustic parameters were measured depending on the diagnostic instruments: Pitch (Hz), sound pressure level (dB), jitter (%) and diadochokinetic rate by Visi-Pitch, VOT and vowels formant ($F_1\;&\;F_2$) by a Spectrography and the degree of hypernasality by Nasometer. In addition, Palatometer was used to find the lingual-palatal patterns of cleft palate. Ten children with cleft palates and fifty normal children participated in the experiment. The results are as follows: (1) Higher nasalance of children with cleft palates showed the resonance disorder. (2) The cleft palate showed palatal misarticulation and lateral misarticulation on the palatogram. (3) Children with cleft palates showed the phonatory and respiratory problems. The duration of sustained vowels in children with cleft palates was shorter than in the control groups. The pitch of children with cleft palates was higher than in the control groups. However, intensity, jitter and diadochokinetic rate of children with cleft palates were lower than in the control group. (4) On the Spectrogram, the VOT of children with cleft palates was longer than control group. $F_1\;&\;F_2$ were lower than in the control group.

• Proceedings of the KIEE Conference
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• 2001.04a
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• pp.297-300
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• 2001

The SMZ half-bridge converter uses the resonance between the inductance of transformer and the resonant capacitances to transfer the input power to the load. In addition to this kind of characteristic of the converter, there are some features such as the capability of soft switching operation, a lower switching loss, and a higher power density in the converter. However in the low-voltage and high-output current applications of the converter, the extremely increased output ripple voltage prevents the converter from normal operation. In order to overcome the drawback of the converter, adding the output filter inductor to the converter, the converter shows the completely different resonant characteristics. In this paper, We analyzed the resonant characteristics of the SMZ converter with the output filter inductor and investigated what the analyzed results affect the converter operation. The experiment of a I50W prototype SMZ converter with 5V output and 310V input is carried out to verity the validity of the analyzed results.

• Journal of Ginseng Research
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• v.22 no.2
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• pp.96-101
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• 1998

This paper describes the determination of bulk density and the discrimination of internal structure of red ginseng by nuclear magnetic resonance (NMR). The 102 red ginseng roots were tested for bulk density. The NMR properties measured by NMR parameters such as spin-lattice relaxation time ($T_1$) and spin-spin relaxation time ($T_2$) were determined using the low field proton NMR analyzer. Bulk density of red ginseng root showed a highly negative significant correlation (r=-0.8934) with the value of $T_1$, but a highly positive significant correlation (r=0.7672 and 0.5909) with the value of T21 (short T2) and T22 (long T2), respectively. Multiple regression equation, Y=-0.0069.$T_1$+0.3044.$T_{21}$-0.0156.$T_{22}$-0.6368, using the MNR parameter values of 80 red ginseng roots can effectively predict the bulk density of 22 red ginseng roots with the correlation coefficient of 0.9396 and the standard error of 0.086. The differences in the internal structure of normal and inside white part of red ginseng were easily found by the signal intensity of NMR image based on magnetic properties of proton nucleus.