DOI QR코드

DOI QR Code

Advanced Imaging Applications for Locally Advanced Cervical Cancer

  • Petsuksiri, Janjira (Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital) ;
  • Jaishuen, Atthapon (Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital) ;
  • Pattaranutaporn, Pittayapoom (Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital) ;
  • Chansilpa, Yaowalak (Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital)
  • Published : 2012.05.30

Abstract

Advanced imaging approaches (computed tomography, CT; magnetic resonance imaging, MRI; $^{18}F$-fluorodeoxyglucose positron emission tomography, FDG PET) have increased roles in cervical cancer staging and management. The recent FIGO (International Federation of Gynecology and Obstetrics) recommendations encouraged applications to assess the clinical extension of tumors rather than relying on clinical examinations and traditional non-cross sectional investigations. MRI appears to be better than CT for primary tumors and adjacent soft tissue involvement in the pelvis. FDG-PET/CT has increased in usage with a particular benefit for whole body evaluation of tumor metabolic activity. The potential benefits of advanced imaging are assisting selection of treatment based upon actual disease extent, to adequately treat a tumor with minimal normal tissue complications, and to predict the treatment outcomes. Furthermore, sophisticated external radiation treatment and brachytherapy absolutely require advanced imaging for target localization and radiation dose calculation.

Keywords

References

  1. Amendola MA, Hricak H, Mitchell DG, et al (2005).Utilization of diagnostic studies in the pretreatment evaluation of invasive cervical cancer in the United States: results of intergroup protocol ACRIN 6651/GOG 183. J Clin Oncol. 23, 7454-9. https://doi.org/10.1200/JCO.2004.00.5397
  2. Amit A, Schink J, Reiss A, Lowenstein L (2011).PET/CT in gynecologic cancer: present applications and future prospects--a clinician's perspective. Obstet Gynecol Clin North Am, 38, 1-21. https://doi.org/10.1016/j.ogc.2011.02.001
  3. Balleyguier C, Sala E, Da Cunha T, et al (2011). Staging of uterine cervical cancer with MRI: guidelines of the european society of urogenital radiology. Eur Radiol, 21, 1102-10. https://doi.org/10.1007/s00330-010-1998-x
  4. Beadle BM, Jhingran A, Yom SS, Ramirez PT, Eifel PJ (2010). Patterns of regional recurrence after definitive radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys, 76, 1396-403. https://doi.org/10.1016/j.ijrobp.2009.04.009
  5. Belhocine T, Thille A, Fridman V, et al (2002). Contribution of whole-body 18FDG PET imaging in the management of cervical cancer. Gynecol Oncol, 87, 90-7. https://doi.org/10.1006/gyno.2002.6769
  6. Bell DJ, Pannu HK (2011). Radiological assessment of gynecologic malignancies. Obstet Gynecol Clin North Am, 38, 45-68. https://doi.org/10.1016/j.ogc.2011.02.003
  7. Bipat S, Glas AS, Van der Velden J, et al (2003). Computed tomography and magnetic resonance imaging in staging of uterine cervical carcinoma: a systematic review. Gynecol Oncol, 91, 59-66. https://doi.org/10.1016/S0090-8258(03)00409-8
  8. Chen CC, Lin JC, Jan JS, Ho SC, Wang L (2011). Definitive intensity-modulated radiation therapy with concurrent chemotherapy for patients with locally advanced cervical cancer. Gynecol Oncol, 122, 9-13. https://doi.org/10.1016/j.ygyno.2011.03.034
  9. Choi HJ, Ju W, Myung SK, Kim Y (2010). Diagnostic performance of computer tomography, magnetic resonance imaging, and positron emission tomography or positron emission tomography/computer tomography for detection of metastatic lymph nodes in patients with cervical cancer: meta-analysis. Cancer Sci, 101, 1471-9. https://doi.org/10.1111/j.1349-7006.2010.01532.x
  10. Downey K, DeSouza NM (2011).Imaging cervical cancer: recent advances and future directions. Curr Opin Oncol, 23, 519-25. https://doi.org/10.1097/CCO.0b013e328348329b
  11. Eifel PJ, Jhingran A, Levenback CF, Tucker S (2009). Predictive value of a proposed subclassification of stages I and II cervical cancer based on clinical tumor diameter. Int J Gynecol Cancer, 19, 2-7. https://doi.org/10.1111/IGC.0b013e318197f185
  12. Eifel PJ, Winter K, Morris M, et al (2004).Pelvic irradiation with concurrent chemotherapy versus pelvic and paraaortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol, 22, 872-80. https://doi.org/10.1200/JCO.2004.07.197
  13. Ferlay J, Shin HR, Bray F, et al (2010). "GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet].Lyon, France: International Agency for Research on Cancer; 2010." from http:// globocan.iarc.fr, accessed on day/month/year.
  14. Finlay MH, Ackerman I, Tirona RG, et al (2006). Use of CT simulation for treatment of cervical cancer to assess the adequacy of lymph node coverage of conventional pelvic fields based on bony landmarks. Int J Radiat Oncol Biol Phys, 64, 205-9. https://doi.org/10.1016/j.ijrobp.2005.06.025
  15. Follen M, Levenback CF, Iyer RB, et al (2003). Imaging in cervical cancer. Cancer, 98, 2028-38. https://doi.org/10.1002/cncr.11679
  16. Grigsby PW, Mutch DG, Rader J, et al (2005).Lack of benefit of concurrent chemotherapy in patients with cervical cancer and negative lymph nodes by FDG-PET. Int J Radiat Oncol Biol Phys, 61, 444-9. https://doi.org/10.1016/j.ijrobp.2004.05.046
  17. Grigsby PW, Singh AK, Siegel BA, et al (2004).Lymph node control in cervical cancer. Int J Radiat Oncol Biol Phys, 59, 706-12. https://doi.org/10.1016/j.ijrobp.2003.12.038
  18. Haie-Meder C, Mazeron R, Magne N (2010). Clinical evidence on PET-CT for radiation therapy planning in cervix and endometrial cancers. Radiother Oncol, 96, 351-5. https://doi.org/10.1016/j.radonc.2010.07.010
  19. Hancke K, Heilmann V, Straka P, Kreienberg R, Kurzeder C (2008). Pretreatment staging of cervical cancer: is imaging better than palpation?: Role of CT and MRI in preoperative staging of cervical cancer: single institution results for 255 patients. Ann Surg Oncol, 15, 2856-61. https://doi.org/10.1245/s10434-008-0088-7
  20. Hricak H, Gatsonis C, Chi DS, et al (2005). Role of imaging in pretreatment evaluation of early invasive cervical cancer: results of the intergroup study American college of radiology imaging network 6651-gynecologic oncology group 183. J Clin Oncol, 23, 9329-37. https://doi.org/10.1200/JCO.2005.02.0354
  21. Hricak H, Gatsonis C, Coakley FV, et al (2007). Early invasive cervical cancer: CT and MR imaging in preoperative evaluation - ACRIN/GOG comparative study of diagnostic performance and interobserver variability. Radiology, 245, 491-8. https://doi.org/10.1148/radiol.2452061983
  22. Kidd EA, Siegel BA, Dehdashti F, et al (2010).Clinical outcomes of definitive intensity-modulated radiation therapy with fluorodeoxyglucose-positron emission tomography simulation in patients with locally advanced cervical cancer. Int J Radiat Oncol Biol Phys, 77, 1085-91. https://doi.org/10.1016/j.ijrobp.2009.06.041
  23. Koyama T, Tamai K, Togashi K (2007). Staging of carcinoma of the uterine cervix and endometrium. Eur Radiol, 17, 2009-19. https://doi.org/10.1007/s00330-006-0555-0
  24. Leblanc E, Gauthier H, Querleu D, et al (2011).Accuracy of 18-fluoro-2-deoxy-D-glucose positron emission tomography in the pretherapeutic detection of occult para-aortic node involvement in patients with a locally advanced cervical carcinoma. Ann Surg Oncol, 18, 2302-9. https://doi.org/10.1245/s10434-011-1583-9
  25. Lee DW, Kim YT, Kim JH, et al (2010).Clinical significance of tumor volume and lymph node involvement assessed by MRI in stage IIB cervical cancer patients treated with concurrent chemoradiation therapy. J Gynecol Oncol, 21, 18-23. https://doi.org/10.3802/jgo.2010.21.1.18
  26. Lim K, Small W, Jr, Portelance L, et al (2011).Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer. Int J Radiat Oncol Biol Phys, 79, 348-55. https://doi.org/10.1016/j.ijrobp.2009.10.075
  27. Lin LL, Mutic S, Low DA, et al (2007). Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET. Int J Radiat Oncol Biol Phys, 67, 91-6. https://doi.org/10.1016/j.ijrobp.2006.08.017
  28. Ma DJ, Zhu JM, Grigsby PW (2011). Tumor volume discrepancies between FDG-PET and MRI for cervical cancer. Radiother Oncol, 98, 139-42. https://doi.org/10.1016/j.radonc.2010.10.004
  29. Magne N, Chargari C, Vicenzi L, et al (2008). New trends in the evaluation and treatment of cervix cancer: the role of FDG-PET. Cancer Treat Rev, 34, 671-81. https://doi.org/10.1016/j.ctrv.2008.08.003
  30. Mitchell DG, Snyder B, Coakley F, et al (2006).Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J Clin Oncol, 24, 5687-94. https://doi.org/10.1200/JCO.2006.07.4799
  31. Narayan K, Hicks RJ, Jobling T, Bernshaw D, McKenzie AF (2001). A comparison of MRI and PET scanning in surgically staged loco-regionally advanced cervical cancer: potential impact on treatment. Int J Gynecol Cancer, 11, 263-71. https://doi.org/10.1046/j.1525-1438.2001.011004263.x
  32. Nicolet V, Carignan L, Bourdon F, Prosmanne O (2000). MR imaging of cervical carcinoma: a practical staging approach. Radiographics, 20, 1539-49. https://doi.org/10.1148/radiographics.20.6.g00nv111539
  33. Ozsarlak O, Tjalma W, Schepens E, et al (2003).The correlation of preoperative CT, MR imaging, and clinical staging (FIGO) with histopathology findings in primary cervical carcinoma. Eur Radiol, 13, 2338-45. https://doi.org/10.1007/s00330-003-1928-2
  34. Park W, Park YJ, Huh SJ, et al (2005).The usefulness of MRI and PET imaging for the detection of parametrial involvement and lymph node metastasis in patients with cervical cancer. Jpn J Clin Oncol, 35, 260-4. https://doi.org/10.1093/jjco/hyi079
  35. Pecorelli S (2009). Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet, 105, 103-4. https://doi.org/10.1016/j.ijgo.2009.02.012
  36. Pecorelli S, Odicino F (2003). Cervical cancer staging. Cancer J, 9, 390-4. https://doi.org/10.1097/00130404-200309000-00009
  37. Pecorelli S, Zigliani L, Odicino F (2009). Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet, 105, 107-8. https://doi.org/10.1016/j.ijgo.2009.02.009
  38. Petsuksiri J, Chansilpa Y, Therasakvichya S, et al (2008). Treatment options in bulky stage IB cervical carcinoma. Int J Gynecol Cancer, 18, 1153-62. https://doi.org/10.1111/j.1525-1438.2008.01195.x
  39. Potter R, Georg P, Dimopoulos JC, et al (2011). Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer. Radiother Oncol, 100, 116-23. https://doi.org/10.1016/j.radonc.2011.07.012
  40. Potter R, Haie-Meder C, Van Limbergen E, et al (2006). Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D imagebased treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol, 78, 67-77. https://doi.org/10.1016/j.radonc.2005.11.014
  41. Rockall AG, Ghosh S, Alexander-Sefre F, et al (2006).Can MRI rule out bladder and rectal invasion in cervical cancer to help select patients for limited EUA? Gynecol Oncol, 101, 244-9. https://doi.org/10.1016/j.ygyno.2005.10.012
  42. Rose PG, Bundy BN, Watkins EB, et al (1999).Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med, 340, 1144-53. https://doi.org/10.1056/NEJM199904153401502
  43. Schwarz JK, Siegel BA, Dehdashti F, Grigsby PW (2011). Metabolic Response on Posttherapy FDG-PET Predicts Patterns of Failure After Radiotherapy for Cervical Cancer. Int J Radiat Oncol Biol Phys, ?, ?-?.
  44. Sharma DN, Thulkar S, Goyal S, et al (2010).Revisiting the role of computerized tomographic scan and cystoscopy for detecting bladder invasion in the revised FIGO staging system for carcinoma of the uterine cervix. Int J Gynecol Cancer, 20, 368-72. https://doi.org/10.1111/IGC.0b013e3181d02d2d
  45. Taylor A, Rockall AG, Reznek RH, Powell ME (2005). Mapping pelvic lymph nodes: guidelines for delineation in intensitymodulated radiotherapy. Int J Radiat Oncol Biol Phys, 63, 1604-12. https://doi.org/10.1016/j.ijrobp.2005.05.062
  46. Whitney CW, Sause W, Bundy BN, et al (1999). Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a gynecologic oncology group and southwest oncology group study. J Clin Oncol, 17, 1339-48. https://doi.org/10.1200/JCO.1999.17.5.1339
  47. Yoon MS, Nam TK, Chung WK, et al (2011).Metabolic response of pelvic and para-aortic lymph nodes during radiotherapy for carcinoma of the uterine cervix: using positron emission tomography/computed tomography. Int J Gynecol Cancer, 21, 699-705.
  48. Zhang X, Yu H (2009). Evaluation of pelvic lymph node coverage of conventional radiotherapy fields based on bony landmarks in Chinese cervical cancer patients using CT simulation. J Zhejiang Univ Sci B, 10, 683-8. https://doi.org/10.1631/jzus.B0920114

Cited by

  1. Palliative Treatment of Advanced Cervical Cancer with Radiotherapy and Thai Herbal Medicine as Supportive Remedy - Analysis of Survival vol.14, pp.3, 2013, https://doi.org/10.7314/APJCP.2013.14.3.1593
  2. Diagnostic Accuracy of Magnetic Resonance Imaging versus Clinical Staging in Cervical Cancer vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5729
  3. The Role of Magnetic Resonance Imaging in Pretreatment Evaluation of Early-Stage Cervical Cancer vol.24, pp.7, 2014, https://doi.org/10.1097/IGC.0000000000000169
  4. Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma vol.24, pp.9, 2014, https://doi.org/10.1097/IGC.0000000000000287
  5. Dosimetric Comparison between Three-Dimensional Magnetic Resonance Imaging-Guided and Conventional Two-Dimensional Point A-Based Intracavitary Brachytherapy Planning for Cervical Cancer vol.11, pp.9, 2016, https://doi.org/10.1371/journal.pone.0161932