• 한국보건간호학회지
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• 제27권1호
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• pp.27-39
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• 2013

Purpose: The purpose of this study was to identify the prevalence of osteoarthritis and its affecting factors among a community dwelling population aged 50 and over in Korea. Methods: A total of 2,640 subjects from the 2010 Korean National Health and Nutrition Examination Survey (KNHANES) were selected. Results: The prevalence of osteoarthritis was found to be 14.3%. Multivariate logistic regression analysis shows that osteoarthritis was more prevalent as people became older; in females; in people who graduated elementary school and had never educated as compared to those who graduated college; people without home ownership as compared to those with home ownership; in people with higher waist circumferences compared to those with normal waist circumference; in people who performed moderate intensity physical activity as compared to those who did not perform those physical activity. Conclusion: Our findings highlight the prevalence of osteoarthritis and its affecting factors, promoting the screening and prevention strategies for the aged 50 and over population in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1599-1603
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• 2012

Objectives: Since methylenetetrahydrofolate reductase (MTHFR) maintains the balance of circulating folate and methionine and blocks the formation of homocysteine, its regulation in relation to different cancers has extensively been studied in different populations. However, information on Pakistani breast cancer patients is lacking. The MTHFR gene has two most common mutations that are single nucleotide additions which result in change of amino acids C677T to Ala222val and A1298C to Glu429Ala. Methodology: 110 sporadic breast patients with no prior family history of cancer or any other type of genetic disorders along with 110 normal individuals were screened for mutations in exons 1 to exon 9 using single strand conformational polymorphism, RFLP and sequencing analyzer. Results: The p values for the 677CC, 677CT, and 677TT genotypes were 0.223, 0.006, and 0.077, respectively. Those for the 1298AA, 1298AC, and 1298CC genotypes were 0.555, 0.009, and 0.003, respectively. Conclusions: We found an overall a significant, weak inverse association between breast cancer risk and the 677TT genotype and an inverse association with the 1298C variant. These results for MTHFR polymorphism might be population specific in sporadic breast cancer affected patients but many other factors need to be excluded before making final conclusions including folate intake, population and disease heterogeneity.

• The Plant Pathology Journal
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• 제24권3호
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• pp.352-356
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• 2008

Root discs of 4-year-old ginseng, Panax ginseng C. A. Meyer, were inoculated with the higher($10^8$ colonyforming units(CFU)/ml) and lower($10^6\;or\;10^5$ CFU/ml) initial inoculum levels of a plant-growth promoting rhizobacterium(PGPR), Paenibacillus polymyxa GBR-1 to examine rot symptom development and bacterial population changes on the root discs. At the higher inoculum level, brown rot symptoms developed and expanded on the whole root discs in which the bacterial population increased continuously up to 4 days after inoculation. In light and electron microscopy, ginseng root cells on the inoculation sites were extensively decayed, which were characterized by dissolved cell walls and destructed cytoplasmic contents. However, no rot symptoms were developed and the bacterial population increased only during the initial two days of inoculation at the lower inoculum level($10^6$ CFU/ml) of P. polymyxa GBR-1. At the lower inoculum level($10^5$ CFU/ml), boundary layers with parallel periclinal cell divisions, structurally similar to wound periderm, were formed internal to the inoculation sites, beneath which the cells were intact containing numerous normal-looking starch granules and no disorganized cell organelles, suggesting that these structural features may be related to the suppression of symptom development, a histological defense mechanism.

• BMB Reports
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• 제35권3호
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• pp.251-254
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• 2002

The genetic factors that contribute to the development of coronary artery disease (CAD) are poorly understood. It is likely that multiple genes that act independently or synergistically contribute to the development of CAD and the outcome. Recently, an insertion/deletion (I/D) polymorphism of the human angiotensin I-converting enzyme (ACE) gene, a major component of the renin-angiotensin system (RAS), was identified. The association of the ACE gene D allele with essential hypertension and CAD has been reported in the African-American, Chinese, and Japanese populations. However, other studies have failed to detect such an association. It has been suggested that these inconsistencies may be due to the difference in backgrounds of the population characteristics. In the present study, we investigated the I/D polymorphism of the ACE gene in 103 subjects of both sexes, consisting of 59 normal controls and 44 patients with hypertension. The allele and genotype frequency were significantly different between the hypertensive and control groups (p < 0.01). Among the three ACE I/D variants, the DD genotype was associated with the highest value of the mean systolic blood pressure [SBP] and mean diastolic blood pressure [DBP] (p = < 0.05) in men, but not in women. In the overall population, the mean SBP and DBP was highest in DD subjects, intermediate in I/D subjects, and the least in II subjects.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제23권2호
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• pp.49-56
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• 2012

Methylphenidate is a widely used stimulant for treatment of attention-deficit hyperactivity disorder (ADHD). In addition to core symptoms of attention and behavioral symptoms, methylphenidate is even effective for executive functions. However, abuse and misuse of stimulants, including methylphenidate, for the purpose of cognitive enhancement is an issue of concern worldwide. Some prejudices and misunderstandings against methylphenidate are popular ; however, little attention has been given to the neuropsychiatric evidence of methylphenidate for enhancement of cognitive function among healthy populations. In this article, our aim was to conduct a review of previous studies investigating the effect of methylphenidate in healthy populations. Findings from several recent studies have demonstrated the effectiveness of methylphenidate for enhancement of cognitive function in healthy populations. The mechanisms of cognitive enhancement are thought to be associated with motivation and the reward circuit in the brain. However, when considering the risk to benefit, an official discussion of the use of methylphenidate among healthy members of the population would be premature. Instead, investigation of epidemiological studies of the prevalence of misuse of stimulants among healthy members of the population, particularly adolescents and college students, is needed. In addition, based on achievements reported in previous studies, investigation of the effect of an approach using non-pharmacological enhancing motivation, which will in turn result in increased cognitive function would be helpful.

• 한국농촌건축학회논문집
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• 제21권3호
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• pp.61-68
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• 2019

Dramatic increase of population migrating from suburban area to metropolitan area which started in 1990s resulted in the increase of aging population among this area. Centralized population also causes decreased number of students in suburban areas which in turn affects environmental facilities such as school and brings social issue. Additionally, compared to the alternative analysis and data regarding internal spatial arrangement of high school, there are not enough data or information on external spatial arrangement and how to construct such space. Therefore, the main purpose of this thesis is to provide fundamental data which can be used as a reference in improving educational environment of suburban high school by analyzing and investigating various factors including location, accessibility, facility status, and external spatial arrangement based on arrangement type of 8 normal high schools located across Jeju Island where the trend of decreasing number of students is prominent. Following is the result of such investigation. Despite the fact that high schools from suburban areas in Jeju Island possess diversity based on local characteristic, construction of external space is rather inconsistent as the plans regarding external space is not organized. Therefore, there is a need for preparing external spaces appropriate for each school based on the number of students and the characteristic of gymnasium.

• Journal of the Korean Statistical Society
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• 제5권2호
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• pp.91-100
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• 1976

The use of the statistic $t = \sqrt{n} (x-\mu)/S$, where $\bar{X) = \sum X_i/n, \mu = E(X_i), S^2 = \sum(X_i-\bar{X})^2/(n-1)$ in statistical inference is usually done under the assumption of normality of the population. If the population is not normally distributed the tabulated values of student t are no longer valid. The moments of t are obtained as a power series in $1/\sqar{n}$ whose coefficients are functions of the cumulants of X. The cumulants are obtained from the moments in the usual manner. The first eight cumulants of t are given up to terms of order $1/n^3$. The first eight cumulants of t are given up to terms of order $1/n^3$. These results extend those of Geary who gave the first six cumulants of t to order $1/n^2$.

• 아동학회지
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• 제38권2호
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• pp.17-35
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• 2017

Objective: The purpose of this study was to explore research trends in childhood executive function in Korean academic journal articles. This study showed which population groups were studied, which factors of executive function were measured, and which domains were studied in the selected articels. Methods: A systematic review of empirical studies of childhood executive function published in Korean academic journals from 2006 to 2016 was conducted. Through searching the KERIS database, 60 empirical studies were selected for review. Results: The results of the analyses showed that the population group the most studied was normal young children and that factors of executive function most studied were inhibition, cognitive flexibility, and working memory. Conclusion: Based on this systematic review of empirical studies of childhood executive function, several suggestions for future research are addressed.

• 천문학회지
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• 제29권spc1호
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• pp.123-124
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• 1996

Snapshots of eight SA and standard fields from low to high galactic latitudes were made using the KPNO 0.9m 2K $\times$ 2K CCD with a limiting magnitude from 19 to 22.5. The purpose of this study is to determine the vertical distribution of stars with respect to Galactic latitude and z-distance in comparison with the model simulation between intermediate population to the 'thick disk' component of scale height of a few kpc. Comparison of the preliminary results between observed and model simulation for 3 of the S fields shows good agreement both in V-mag and B- V color distributions. A bimodal distribution in B- V at high galactic latitude seems to be represented by a halo and 'thick disk' dwarf in the blue and by a normal disk dwarf population in the red.

• 품질경영학회지
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• 제23권3호
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• pp.126-139
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• 1995

We describe a formal approach to the construction of optimal classification rule for the two-group normal classification with equal population mean problem. Based on the utility function of Bernardo, we suggest a balanced design for the classification and construct the optimal rule under the balanced design condition. The rule is characterized by a constrained minimization of total risk of misclassification, the constraint of which is constructed by the process of equation between expected utilities of the two group conditional densities. The efficacy of the suggested rule is examined through numerical studies. This indicates that, in case little is known about the relative population sizes, dramatic gains in accuracy of classification result can be achieved.