• Structural Engineering and Mechanics
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• 제14권6호
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• pp.679-698
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• 2002

In this paper some techniques for the dynamic analysis of non-classically damped linear systems are reviewed and compared. All these methods are based on a transformation of the governing equations using a basis of complex or real vectors. Complex and real vector bases are presented and compared. The complex vector basis is represented by the eigenvectors of the complex eigenproblem obtained considering the non-classical damping matrix of the system. The real vector basis is a set of Ritz vectors derived either as the undamped normal modes of vibration of the system, or by the load dependent vector algorithm (Lanczos vectors). In this latter case the vector basis includes the static correction concept. The rate of convergence of these bases, with reference to a parametric structural system subjected to a fixed spatial distribution of forces, is evaluated. To this aim two error norms are considered, the first based on the spatial distribution of the load and the second on the shear force at the base due to impulsive loading. It is shown that both error norms point out that the rate of convergence is strongly influenced by the spatial distribution of the applied forces.

• Korea-Australia Rheology Journal
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• 제15권2호
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• pp.55-61
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• 2003

The steady shear flow properties of vaseline generally used as a base of the pharmaceutical dosage forms were studied in the consideration of wall slip phenomenon. The purpose of this study was to show that how slip may affect the experimental steady-state flow curves of semisolid ointment bases and to discuss the ways to eliminate (or minimize) wall slip effect in a rotational rheometer. Using both a strain-controlled ARES rheometer and a stress-controlled AR1000 rheometer, the steady shear flow behavior was investigated with various experimental conditions ; the surface roughness, sample preparation, plate diameter, gap size, shearing time, and loading methods were varied. A stress-controlled rheometer was suitable for investigating the flow behavior of semisolid ointment bases which show severe wall slip effects. In the conditions of parallel plates attached with sand paper, treated sample, smaller diameter fixture, larger gap size, shorter shearing time, and normal force control loading method, the wall slip effects could be minimized. A critical shear stress for the onset of slip was extended to above 10,000 dyne/$\textrm{cm}^2$. The wall slip effects could not be perfectly eliminated by any experimental conditions. However, the slip was delayed to higher value of shear stress by selecting proper fixture properties and experimental conditions.

• 정보보호학회논문지
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• 제24권1호
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• pp.41-50
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• 2014

본 논문에서는 가우시안 정규기저를 갖는 유한체 $GF(2^n)$의 곱셈기 오류 탐지 방법을 제시한다. 제안하는 오류 탐지 방법은 하드웨어로 단순하게 구성된다. 즉 n-bit 출력 직렬 곱셈기에서는 1 개의 AND gate, n+1 개의 XOR gate, 그리고 1 개의 1-bit register로 구성되며, 병렬 곱셈기의 경우 n 개의 AND gate와 2n-1 개의 XOR gate로 구성된다. 제안하는 방법은 C=AB 연산에 홀수개의 오류가 발생하는 경우 탐지가 된다.

• Geomechanics and Engineering
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• 제7권4호
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• pp.355-374
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• 2014

An analytical solution of the fully coupled system of equations governing the plane strain deformation of a poroelastic medium with anisotropic permeability and compressible fluid and solid constituents is obtained. This solution is used to study the consolidation of a poroelastic clay layer with free permeable surface resting on a rough-rigid permeable or impermeable base. The stresses and the pore pressure are taken as the basic state variables. Displacements are obtained by integrating the coupled constitutive relations. The case of normal surface loading is discussed in detail. The solution is obtained in the Laplace-Fourier domain. Two integrations are required to obtain the solution in the space-time domain which are evaluated numerically for normal strip loading. Consolidation of the clay layer and diffusion of pore pressure is studied for both the bases. It is found that the time settlement is accelerated by the permeability of the base. Initially, the pore pressure is not affected by the permeability of the base, but has a significant effect, as we move towards the bottom of the layer. Also, anisotropy in permeability and compressibilities of constituents of the poroelastic medium have a significant effect on the consolidation of the clay layer.

• Archives of Plastic Surgery
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• 제33권1호
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• pp.87-94
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• 2006

This study is to investigate the patients who had blepharoplasty for cosmetic purposes or facial nerve disorders. 21 patients were examined with an age from 17 to 63 years. Sixteen cases were classified as a normal group for investigation of the histopathologic change according to the age. The rest were patients of Bell's palsy(2), $Botox^{(R)}$ injection(2) and blepharospasm (1). We measured a mean diameter of myofiber and dimension's proportion of muscluar tissue per regular visual field. First, we measured a statistical significance according to the age in normal cases by grouping them into younger than 30-year-old, 30's, 40's, 50's and 60's. Second, we divided normal cases(16) into Group A and B by two bases for statistical analysis. In conclusion, although there were several differences as vacuolation, internalization of sarcolemnic nuclei between 35-year-old and 62-year-old patients in simple comparison, there was no uniform decrease according to the age. There were also no significant statistical changes in the value of a diameter of myofibers and dimension's proportion of muscular tissue according to the age in any of the two normal groups. But in $Botox^{(R)}$ injection and Bell's palsy, blepharospasm patients, two values showed remarkable difference compared to the normal group of same age.

• Toxicological Research
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• 제11권1호
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• pp.1-8
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• 1995

Fumonisins are a family of mycotoxins produced by the fungus Fusarium moniliforme which is a common contaminant in corn. Fumonisins are potent inhibitors of sphingosine and sphinganine N-acyltransferase (ceramide synthase), key enzymes in sphingolipid metabolism. The purpose of this study was to provide the evidence that the elevated levels of free sphingoid bases (primarily sphinganine) and depletion of complex sphingolipids were closely related to the inhibition of cell growth in LLC-$PK_1$ cells exposed to fumonisin $B_1$$(\leq 35 {\mu}M)$. Concentrations of fumonisin $B_1$ between 10 and $35 {\mu}M$ were known to inhibit cell growth without cytotoxicity in $LLC-PK_1$ cells (Yoo et al. Toxicol. Appl. Pharmacol. 114, 9-15, 1992). Cells exposed to 35$\mu M$ fumonisin B$_1$ for 48 and 72 hr developed a fibroblast-like (elongated and spindle-shaped) appearance and were less confluent than normal cells. At between 24 and 48 hr after exposure to fumonisin $B_1$ cells were beginning to show the inhibition of cell growth and at 72 hr the number of viable cells in fumonisin-treated cultures was about 50% of concurrent control cultures. During the 24 hr lag period preceding inhibition of cell growth, the free sphinganine levels in cells exposed to $35 {\mu}M$ fumonisin $B_1$ were highly elevated (approximately 230 fold higher than normal cells). The elevated levels of free sphinganine were $435\pm14$$pmoles/{10^6}$ cells at 48 hr and approximately TEX>$333\pm11$$pmoles/{10^6}$ cells in cells exposed to $35{\mu}M$ fumonisin$B_1$ at 72 hr, while the levels of free sphinganine in normal cells were less than 2$pmoles/{10^6}$ cells. Under the same condition, depletion of intracellular complex sphingolipids as a consequence of fumonisin inhibition of de novo sphingolipid biosynthesis and turnover pathway was appeared. Content of free sphingold bases in dividing cells was more elevated than in confluent cells at 24-48 hr after cells were exposed to $20{\mu}M$ fumonisin $B_1$. The dividing cells were showing the inhibition of cell growth at 48-72 hr and $20{\mu}M$ fumonisin $B_1$. The results of this study support the hypothesis that the inhibition of cell growth is very well related to the disruption of sphingolipid metabolism in $LLC-PK_1$ cells.

• BMB Reports
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• 제44권2호
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• pp.123-128
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• 2011

Leucine-rich repeat containing protein 10 (LRRC10) is characterized as a cardiac-specific gene, suggesting a role in heart development and disease. A severe cardiac morphogenic defect in zebrafish morphants was recently reported but a contradictory result was found in mice, suggesting a more complicated molecular mechanism exists during mouse embryonic development. To elucidate how LRRC10 is regulated, we analyzed the 5'enhancer region approximately 3 kilo bases (kb) upstream of the Lrrc10 start site using luciferase reporter gene assays. Our characterization of the Lrrc10 promoter indicates it possesses complicated cis-and trans-acting elements. We show that GATA4 and MEF2C could both increase transcriptional activity of Lrrc10 promoter individually but that they do not act synergistically, suggesting that there exists a more complex regulation pattern. Surprisingly, knockout of Gata4 and Mef2c binding sites in the 5’enhancer region (-2,894/-2,889) didn't change the transcriptional activity of the Lrrc10 promoter and the likely GATA4 binding site identified was located in a region only 100 base pair (bp) upstream of the promoter. Our data provides insight into the molecular regulation of Lrrc10 expression, which probably also contributes to its tissue-specific expression.

• 한국발생생물학회지:발생과생식
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• 제16권3호
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• pp.155-168
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• 2012

Therapeutic cancer is a long lasting and turbulent history accompany with the milestones in surgical intervention, chemotherapy and radiotherapy. In the past decade, however, metastatic cancer still obstinately exists challenging the professional scientist. Beside the major forms of cancer treatment, Diphtheria toxin (DT) which is produced by a pathogenic strain of bacterium Corynebacterium diphtheria to shield themselves against the other dangerous organism, have been researched as a potential candidate to overcome the drawback such as non-specific, non-effect to drug resistant cancer cell and side effects when using chemotherapy and radiotherapy. In the context of suicide gene therapy, the DT expression under controlling of tissue-specific promoter will be targeted in cancer cell but defect in normal cell. The molecular mechanism, characteristic of DT-bases therapy and prominent achievements of preclinical and clinical studies for the past decade are summarized and discussed in this review.

• 전산구조공학
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• 제5권4호
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• pp.113-124
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• 1992

토목구조물 설계에 있어서 가장 보편적으로 사용되고 있는 도로교에 대한 하중계수에 기초한 최적신뢰성해석모델을 제안하고, 또 총기대비용 최소화원칙에 기인한 최적하중-저항계수 및 최적 공칭안전율에 대한 이론적 근거를 제시하는 것이 본 연구의 주요내용이다. MFOSM과 AFOSM을 포함하는 주요 2차 모멘트신뢰성 이론을 비교분석함으로써 AFOSM의 근사식과 대수정규포근사식을 본 연구에서 제안하는 최적신뢰성 및 설계규준의 유도에 사용함이 적절하다는 것을 알 수 있었다.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제4권1호
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• pp.40-44
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• 2004

In this paper we study the existence and uniqueness of fuzzy solutions for the nonlinear fuzzy integro-differential equations on $E^{n}_{N}$ by using the concept of fuzzy number of dimension n whose values are normal, convex, upper semicontinuous and compactly supported surface in $E^{n}_{N}$. $E^{n}_{N}$ be the set of all fuzzy numbers in $R^{n}$ with edges having bases parallel to axis $x_1$, $x_2$, …, $x_n$.