• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.36-43
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• 2009

urpose : The renin-angiotensin system (RAS) has been demonstrated to play a major role in regulating blood pressure. Therefore, components of the RAS are likely candidate genes that may predispose an individual to essential hypertension and cardiovascular complications. Among them, the M235T polymorphism of the angiotensinogen gene has been speculated to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. This study aimed to analyze the angiotensinogen M235T polymorphism in hypertensive adolescents and investigate its relationship with cardiovascular risks. Methods : Forty Korean hypertensive adolescents (aged 16-17, systolic $BP{\geq}140 mmHg$ and/or diastolic $BP{\geq}90 mmHg$) and fifty seven normal adolescents were included. Obesity index (OI), body mass index (BMI) were calculated. BP was measured by oscillometric methods in resting state. Polymerase chain reaction (PCR) technique was performed on DNA from the hypertensives subjects to analyze the M235T polymorphism. Serum homocysteine, insulin, renin, aldosterone and angiotensin converting enzyme (ACE) were tested according to each genotype. The carotid intima-media thickness (IMT) and carotid artery diameter, Pulse wave velocity (PWV) and ankle-brachial index (ABI) were measured according to each genotype. Results : Genotype frequencies of T/T, M/T and M/M were 62.5%, 35.0%, 2.5%, respectively in hypertensive adolescents. The results were not significantly different compared to control group. Serum insulin, renin levels, BMI and OI were significantly higher in thoses with the M/M genotype as compared to those with the T/T of M/T genotype. Conclusion : This study showed that the M235T polymorphism was not associated with essential hypertension or any cardiovascular risks. Further clinical research is required to ascertain the relationship between this polymorphism and cardiovascular complications in Korean hypertensive adolescents.

• Pediatric Infection and Vaccine
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• v.4 no.1
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• pp.167-173
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• 1997

Acute infectious mononucleosis, caused by Epstein-Barr virus(EBV), is a self limited lymphoproliferative illness that is common in adolescents and young adults. It shows many complications in multiple organ systems, but the hepatobiliary and the respiratory complication is uncommon. We report a case with thickened gallbladder wall and pneumonia as complications of acute infectious mononucleosis in a child. Also the related literature were reviewed. A 4 year old boy presented with a history of high fever, cough, and abdominal distension for 20days. Physical Examination revealed audible crackles in whole lung field and gross hepatomegaly. Chest X-ray showed pneumonia and liver function tests were abnormal. Ultrasonography and computed tomography revealed a thickened gallbladder wall and hepatosplenomegaly. The diagnosis of primary Epstein-Barr viral infection was eventually made by specific serologic tests. The patients's fever subsided 6 weeks later and pneumonia was recovered around this time. Liver function tests returned near normal 2 months later and ultrasonography of gallbladder was normal at this time.

• International Journal of Contents
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• v.13 no.2
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• pp.6-13
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• 2017

It is a well-known fact that Internet addiction adversely affects mental health of adolescents. This study was conducted to determine whether there is a difference in the experience of depression according to the level of Internet addiction. Participants included 73,238 middle and high school students from the Korean Youth Risk Behavior Web-based Survey (KYRBWS) conducted in 2010. The level of Internet addiction and the experience of depression were assessed using self-diagnosis questionnaires. Multiple logistic regression analysis was used to identify the association between Internet addiction and depression. High-risk and potential-risk Internet users were 1.61 times and 1.21 times more likely to experience depression, respectively, than normal Internet users. The increase in depression was more significant in girls students. Acknowledging the connection between Internet addiction and depression, the problem should be tackled from the perspective of school health by providing systematic Internet addiction prevention and treatment programs.

• Clinical and Experimental Pediatrics
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• v.57 no.6
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• pp.257-263
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• 2014

The incidence of people living with congenital heart disease (CHD) has been increasing every year owing to remarkable advances in surgical and catheter intervention techniques and devices, and improved knowledge of critical care for patients with CHD. However, these patients continue to face physical, psychosocial, and environmental challenges, and a number of studies have shown higher rates of depression and anxiety disorders than the general population. To improve psychosocial functioning and quality of life for adults with CHD, health care providers are recommended to inform CHD patients of an accurate diagnosis, and overall treatment process, beginning in adolescence to facilitate a smooth transition from adolescence to adulthood. Active cooperation with psychiatrists, psychologists, social workers, chaplains, and family members is highly recommended to help CHD patients feel normal and optimistic and to promote good social interactions, close family relationships, and a strong sense of coherence.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.1
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• pp.77-92
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• 2010

Objectives The relationship between depression, obesity, life style of adolescents has been reported, but the results were not consistent. Thus this study was designed to find out the relationship. Methods The participants were the first and second grade middle school students. The participants were asked to measure their height and weight etc, and were asked to survey questionnaires. To diagnose the students' degree of depression, Children's Depression Inventory(CDI) by Kovas and Beck. Results The average depression score in the obese group was significantly higher than that of the normal body weight group. In addition, male obese group scored higher on CDI than the female obese group, and the obese group of participants who don't exercise, but like to play computer games and watch TV scored higher on CDI than the group who exercise and don't play computer games. Conclusions This study proved that depression in adolescent was closely related with obesity and obesity-related lifestyles. "The research was supported by the Kyung Hee University Research Fund in 2007"(KHU-20071638).

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.4
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• pp.150-168
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• 2013

Purpose: The purpose of this study is to find out the patterns of teenage girls who is easy to suffer from dysmenorrhea with the Inbody test results by Sasang constitutions. Methods: The data from the 1681 participants were collected using a structured menstrual history questionnaire. Based on the survey responses, we had 97 adolescents with menstrual disorder as the test group and 97 adolescents without menstrual disorder as the control group. The clinical trials subjects were asked to respond to another questionnaire for identifying their constitutional types and undergo Inbody test. Results: The result of a comparison of the test and control groups showed that there' no relevance to the body fat mass and body fat percentage with menstrual irregularities. The lesser yang person with menstrual irregularities was no relevance to the body fat percentage. The greater yin person with menstrual irregularities was especially lacking in body fat mass and body fat percentage. The lesser yin person with menstrual irregularities was poor in body fat mass. Conclusions: As for study, female high school students with menstrual disorders have nothing to do with muscle mass. Body fats shortage could pose problems. According to the study, Taeumin female high school students usually needed to higher body fat than a general standard. It seems to be needed more body fat and weight than modern standards in period of poor sexuality for having a normal menorrhea especially Taeumin. It will take some continuing study that BMI standards should be changed or not on the Sasang constitutions.

• Journal of the Korean Society of Food Culture
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• v.13 no.4
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• pp.383-391
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• 1998

This study was conducted to find the effect of in-class nutrition education and exercise program for obese adolescent boys in Taegu with the nutrition knowledge test before and after education program and anthropometric measurement. The subjects were consisted of a normal group (NG; n= 13) and an obese group (n=30). The obese group is divided into two groups; obese group A (OG-A; n=12), participated in a ten-week nutrition education only; and obese group B (OG-B; n=28), participated in a ten-week nutrition education and exercise program. The anthropometric data of the three groups were increased after the nutrition education program. However the obesity index(BMI, R hrer, WHR, Skinfold thickness) of OG-B were significantly decreased after the programs. The nutrition intake data were also changed after the nutrition education program. Especially the intake of carbohydrate was significantly decreased in OG-B from $421.5{\pm}155.9g$ to $349.0{\pm}41.0g$ (p<0.05) after the nutrition education program. It was noted that the intake of Ca was significantly decreased in all three groups after the nutrition education program. The mean score of the nutrition knowledge test also significantly increased from $13.7{\pm}3.1$ to $17.8{\pm}3.0$ after the nutrition education program. The result strongly suggested that nutrition education program should be successful if the obese adolescents and their parents especially mothers participated in the same class. In summary, nutrition education and exercise programs were effective on reducing obesity of obese adolescents. Nutrition knowledge of obese adolescent was significantly increased after nutrition education program.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.1
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• pp.59-67
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• 2018

Purpose: to compare cut off points corrected for age and gender (COOP) with fixed cut off points (FCOP) for fasting plasma insulin and Homeostatic model assessment-insulin resistance (HOMA-IR) for the diagnosis of IR in obese children and adolescents and their correlation with dyslipidemia. Methods: A multicenter, cross-sectional study including 383 subjects aged 7 to 18 years, evaluating fasting blood glucose, plasma insulin, and lipid profile. Subjects with high insulin levels and/or HOMA-IR were considered as having IR, based on two defining criteria: FCOP or CCOP. The frequency of metabolic abnormalities, the presence of IR, and the presence of dyslipidemia in relation to FCOP or CCOP were analyzed using Fisher and Mann-Whitney exact tests. Results: Using HOMA-IR, IR was diagnosed in 155 (40.5%) and 215 (56.1%) patients and, using fasting insulin, 150 (39.2%) and 221 (57.7%), respectively applying FCOP and CCOP. The use of CCOP resulted in lower insulin and HOMA-IR values than FCOP. Dyslipidemia was not related to FCOP or CCOP. Blood glucose remained within normal limits in all patients with IR. There was no difference in the frequency of IR identified by plasma insulin or HOMA-IR, both for FCOP and CCOP. Conclusion: The CCOP of plasma insulin or of HOMA-IR detected more cases of IR as compared to the FCOP, but were not associated with the frequency of dyslipidemia. As blood glucose has almost no fluctuation in this age group, even in the presence of IR, fasting plasma insulin detected the same cases of IR that would be detected by HOMA-IR.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.22 no.2
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• pp.95-102
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• 2011

Objectives : This present study examined the power of the Korean Child Behavior Checklist (K-CBCL) subscales to predict a DSM-IV diagnosis of oppositional defiant disorder (ODD). Methods : The sample included 37 children and adolescents with ODD and 46 normal controls. The participants and their parents were interviewed for clinical diagnosis using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL) and the parents completed the K-CBCL. Logistic regression analysis was used to predict the diagnosis of ODD. Results : Among the CBCL subscales, Delinquent and Aggressive Behavior scales significantly predicted ODD diagnosis. The means of these CBCL subscales were significantly higher in the ODD group when compared to the controls. Conclusion:Two CBCL subscales (Deliquent and Aggressive Behavior) displayed good diagnostic efficiency for assessing ODD in children and adolescents. Through combining information from the CBCL, an empirical-quantitative approach to psychopathology in children and the DSM-IV diagnostic criteria, the results demonstrated that a clinical diagnostic approach is an effective diagnostic paradigm for children with ODD.

• Journal of the Korean Society of Food Culture
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• v.14 no.5
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• pp.535-554
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• 1999

The present study was conducted to investigate the relation of eating behavior and food intake to 534 adolescents' obesity indices. Group means of relative body weight (RBW) were 93.66 for males and 97.12 for females. Body mass index(BMI) were 20.39 for males and 20.41 for females. Respondents were divided into 3 groups on the basis of RBW as an obesity index. Astonishingly, 44.76% of total respondents were underweight and 12.92% overweight and obese. 64.54% of respondents usually skipped their breakfasts and 24.23% their dinners. More males did not have their breakfasts than females. In contrast, more females skipped their dinners than males. A significant difference was found between males and females in their eating habits(p<.001) that should be changed. As their undesirable eating habits, males pointed out 'skipping meals', while females stressed 'overeating'. There were more overeating respondents in the overweight group, while more respondents skipping their meals were found in the underweight group. Many females(72.79%) and males(52.78%) tended to alternate consistently overeating and fasting to lose weight. The most important reason for losing weight was to improve their appearance(61.12%). In addition, nutrient score indices of respondents were very low with a mean of 33.39. Only 42.13% of total respondents showed good nutrient score indices. More males ate meat, bean, white vegetables, potato and fat than females(p<.05), whereas more females ate bread, rice cake and fruit than males(p<.01). Among the 3 groups -overweight, normal weight and underweight groups, overweight group was the most eaters of meat, fish, egg and milk; underweight group was the least eaters of them.