• Journal of Gynecologic Oncology
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• v.29 no.6
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• pp.95.1-95.17
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• 2018

Objective: Cervical cancer is one of the most common malignant tumors. Our previous results showed that long non-coding RNA (lncRNA) XLOC_006390 plays an important role in cervical cancer. In this study, we have explored the mechanism of action of lncRNA XLOC_006390. Methods: LncRNA XLOC_006390 was proposed to exercise its function as a competing endogenous RNA (ceRNA), and its potential targeted miRNAs was predicted through the database LncBase Predicted v.2. Two miRNAs, miR-331-3p, and miR-338-3p, were chosen for the study. Expression of miRNAs and lncRNA in cervical cancer cells and tissues was detected by reverse transcription polymerase chain reaction. To determine the correlation, silencing of XLOC_006390, over-expression of miR-331-3p, and miR-338-3p was performed in SiHa and Caski cell lines, respectively. Results: Based on the interactive effect between miRNA and lncRNA, miR-331-3p and miR-338-3p were significantly downregulated in cervical cancer cells and tissues, and their expression levels were negatively related to that of lncRNA. Our results also showed that the expression of miR-331-3p target gene NRP2, miR-338-3p target genes PKM2, EYA2 was significantly downregulated when the XLOC_006390 was knocked down. Further, XLOC_006390 was found to facilitate cervical cancer tumorigenesis and metastasis by downregulating miR-331-3p and miR-338-3p expression. Conclusion: Taken together, our study demonstrated that XLOC_006390 may serve as a ceRNA and reversely regulates the expression of miR-331-3p and miR-338-3p, thus facilitating cervical cancer tumorigenesis and metastasis.

• Journal of Engineering Education Research
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• v.24 no.1
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• pp.34-45
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• 2021

This research is a case study about "Critical Thinking and Debate Education" class which was done for freshmen at the engineering college of "S" Women's University. Real time remote classes through LMS and ZOOM were the most effective tools under on-line circumstances, considering the fact that video lectures only cannot cultivate students' capabilities of critical thinking and communication. Throughout the analysis on students' self-reflection journals and lecture evaluations, this paper examined considerable future points and the pros and cons of "Critical Thinking and Debate Education" under online presentation and discussion situation. As research outputs, students told they could feel less nervousness and anxiety when they exercise and have a presentation because they could choose familiar space for them. In addition, students also told that they feel comfortable about both self-feedback and peer evaluation, repeatedly seeing the recorded video clip. However, on the contrary, sometimes students felt uncomfortable due to unstable internet connection through the online classes, and they also were regretful about the missing chances of interaction between a teacher and students and of intimate exchanges among students. They also told they had felt a kind of limit of enhancing their presentation skills just in front of the monitor. Considering these outcomes, this research paper points out that online education needs to be proceeded by strengthening multi layered feedback to students with the build-up of a non-face-to-face stable educational infrastructure, application of online instructional strategy, and utilization of YouTube platform and video contents. Through this research paper, I hope the new system of encompassing on/off line "Critical Thinking and Debate Education" and effective teaching and learning method can be developed soon by strengthening the strength of online education.

• Physical Therapy Rehabilitation Science
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• v.10 no.1
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• pp.64-68
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• 2021

Objective: In clinical practice, there are a lot of exercise to reduce body weight or reduce the amount of body fat in order to solve back pain. However, many studies have contradicted the relationship between back pain and weight or body fat mass. The purpose of this study was to investigate the relationship between fat mass, body mass index and low back pain of office worker. Design: Crossed-sectional study Methods: Among the white-collar workers diagnosed with non-specific back pain by doctors, subjects who were not included in the exclusion criteria were selected to measure the subject's body fat mass, body mass index, pain intensity, and disability index due to back pain. The NPRS was used for the intensity of back pain of office workers, and the ODI was used for the degree of disability due to back pain. A body composition analyzer was used to measure the body fat mass and body mass index of white-collar workers. Results: There was no significant difference between the two groups in the comparison between the normal group and the excessive group according to the criteria of fat mass and body mass index. In the correlation analysis of fat mass, body mass index, pain intensity, and disability index, it was found that there was a significant correlation between fat mass and body mass index. However, neither fat mass nor body mass index had a significant correlation with pain intensity and disability index. Conclusions: The fat mass and body mass index of office worker do not affect low back pain.

• Journal of Digital Convergence
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• v.20 no.4
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• pp.759-768
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• 2022

The purpose of this study is to apply a chronic disease management non-face-to-face program for the prevention and management of chronic disease and to confirm the effect of a one-group pre-and post-design similar experimental study. The program consisted of nursing, nutrition, and exercise programs for 12 weeks. The subjects were 69 adult men and women using the chronic disease management center at public health centers, and the period was from May 3 to August 6, 2021. Systolic pressure, diastolic pressure, fasting blood sugar, BMI, depression, and quality of life were measured before and after the program. Data were analyzed with SPSS 20.0. As a result, systolic pressure, diastolic pressure, fasting blood glucose, and quality of life were found to be significant. Depression was not significant, but mild depression was reduced. Developing, applying, and managing various non-face-to-face programs for chronic disease management will contribute to the prevention of chronic diseases and the promotion of health maintenance.

• The Journal of Korean Society for School & Community Health Education
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• v.23 no.1
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• pp.29-40
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• 2022

Objectives: The purpose of this study is to identify the relationship between metabolic syndrome factor diseases and falls in the elderly aged 65 years or older and use them as basic data to reduce the risk of falls. Methods: The method of this study was to compare the injury-related characteristics of the fall and non-fall groups with a factor disease of metabolic syndrome in Korea over 65 years of age. Data from the 14th National Hospital Discharge In-depth Injury Survey in 2018 were used to conduct the study. A total of 7,991 data were analyzed using SPSS 23.0. Results: Among the total injuries, the fall group with metabolic syndrome factor disease accounted for 69.0% and the non-fall group 31.0%. Falls occurred in 86.3% of households. In the fall group with metabolic syndrome factor disease, the number of females was 1.9~2.1 times higher than that of males. Compared to 65~69 years of age, the incidence of falls was 1.4~1.5 times higher in 70~79 years, 1.7~2.2 times higher in 80~89 years, and 2.5~3.6 times higher in 90-year-olds and older. In NISS, the incidence of falls was 1.7 times higher in moderate compared to mild. In principle diagnosis, the incidence of falls was 2.2 times higher in S40-S99 compared to S00-S19. Conclusion: The elderly with metabolic syndrome factor disease should continue to promote health through light exercise that can strengthen muscle strength to prevent falls.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.1
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• pp.31-41
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• 2023

Purpose : This study was conducted to identify the common characteristics of older persons with sarcopenia and to explore the relationship between gait, balance, and stress using an integrated assessment tool. Methods : In this study, 95 people aged 65 years or older were screened using the sarcopenia diagnostic evaluation algorithm presented by the Asian Working Group for Sarcopenia in 2019. Skeletal muscle index, grip strength, and short physical performance battery were used as sarcopenia evaluation measurements. Based on the results of this evaluation, participants were grouped into the 'non-sarcopenia group' (41 participants) or the 'sarcopenia group' (54 participants). Participants underwent further assessment using an integrated evaluation tool capable of measuring gait, balance, and stress. Gait ability was evaluated using the timed up and go test, and balance ability was evaluated using the berg balance scale. And the stress of the last month was measured by modifying the stress index developed by a Korean researcher. Collected data were statistically analyzed using the independent t-test and Mann Whitney-U test. Results : The sarcopenia group and the non-sarcopenia group showed significant differences in all elements of the sarcopenia diagnostic evaluation. There were significant differences in all three integrated evaluation tools. For the evaluation of walking ability, the time measured in the timed up and go test was longer in the sarcopenia group, the berg balance scale score for the evaluation of balance ability was lower in the sarcopenia group, and the stress index was higher in the sarcopenia group. Conclusion : Through sarcopenia analysis using an integrated evaluation tool, it was confirmed that sarcopenia is closely related to decreased walking ability, poor balance, and increased stress. We recommend using this tool to reduce the risk of sarcopenia progression and stress exposure through the planning and implementation of an exercise program for sarcopenia prevention.

• Food Science of Animal Resources
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• v.43 no.3
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• pp.512-530
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• 2023

The present study evaluated the effects of fermented whey protein using kimchi lactic acid bacteria Lactobacillus casei DK211 on skeletal muscle mass, muscle strength, and physical performance in healthy middle-aged males performing regular resistance exercises. Effective protein supplementation and regular exercise are two important factors for improving muscle health. Therefore, in this study, the effects of consuming fermented whey protein twice a day were investigated and compared with that of non-fermented supplementation. Forty-eight males (average age 44.8) were randomly assigned to two groups: Fermented whey protein supplementation (FWPS) and non-fermented whey protein concentration supplementation (WPCS) groups. Each group ingested 37 g of FWPS or WPCS twice a day for eight weeks. Body composition, muscle strength, and physical performance were assessed pre- and post-intervention. Independent t-tests or chi-square tests for the categorical variables were performed for analyzing the observations. FWPS was effective in promoting the physical performance in dynamic balance measurement and muscle health, indicated through the increment in grip strength (left), upper arm circumference, and flat leg circumference from the baseline. However, similar improvements were not observed in the WPCS group. These results imply that whey protein fermented by L. casei DK211 is an effective protein supplement for enhancing muscle health in males performing regular resistance exercises.

• Physical Therapy Korea
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• v.29 no.2
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• pp.156-164
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• 2022

Background: Low back pain (LBP) is a representative disease, and LBP is characterized by muscle dysfunction that provides stability to the lumbar spine. This causes physical functional problems such as decreased posture control ability by reducing the muscular endurance and balance of the lumbar spine. Pelvic compression using instruments, which has been used during recent stabilization exercises, focuses on the anterior superior iliac spine of the pelvis and puts pressure on the sacroiliac joint during exercise, making the pelvis more symmetrical and stable. Currently, research has been actively conducted on the use of pelvic compression belts and non-elastic pelvic belts; however, few studies have conducted research on the application effect of pelvic compression using instruments. Objects: This study aimed to investigate whether there is a difference in trunk muscular endurance and dynamic and static balance ability levels by applying pelvic stabilization through a pelvic compression device between the LBP group and the non-LBP group. Methods: Thirty-nine subjects currently enrolled in Daejeon University were divided into 20 subjects with LBP group and 19 subjects without LBP (NLBP group), and the groups were compared with and without pelvic compression. The trunk muscular endurance test was performed with 4 movements, the dynamic balance test was performed using a Y-balance test, and the static balance test was performed using a Wii balance board. Results: There was a significant difference the LBP group and the NLBP group after pelvic compression was applied to all tests (p < 0.05). In the static and dynamic balance ability test after pelvic compression was applied, there was a significant difference in the LBP group than in the NLBP group (p < 0.05). Conclusion: These results show that pelvic compression using instruments has a positive effect on both those with and without LBP and that it has a greater impact on balance ability when applied to those with LBP.

• Journal of Positioning, Navigation, and Timing
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• v.12 no.3
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• pp.215-228
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• 2023

The State Space Representation (SSR) method provides individual corrections for each Global Navigation Satellite System (GNSS) error components. This method can lead to less bandwidth for transmission and allows selective use of each correction. Precise Point Positioning (PPP) - Real-Time Kinematic (RTK) is one of the carrier-based precise positioning techniques using SSR correction. This technique enables high-precision positioning with a fast convergence time by providing atmospheric correction as well as satellite orbit and clock correction. Currently, the positioning service that supports PPP-RTK technology is the Quazi-Zenith Satellite System Centimeter Level Augmentation System (QZSS CLAS) in Japan. A system that provides correction for each GNSS error component, such as QZSS CLAS, requires monitoring of each error component to provide reliable correction and integrity information to the user. In this study, we conducted an analysis of the performance of residual error bounding for each error component. To assess this performance, we utilized the correction and quality indicators provided by QZSS CLAS. Performance analyses included the range domain, dispersive part, non-dispersive part, and satellite orbit/clock part. The residual root mean square (RMS) of CLAS correction for the range domain approximated 0.0369 m, and the residual RMS for both dispersive and non-dispersive components is around 0.0363 m. It has also been confirmed that the residual errors are properly bounded by the integrity parameters. However, the satellite orbit and clock part have a larger residual of about 0.6508 m, and it was confirmed that this residual was not bounded by the integrity parameters. Users who rely solely on satellite orbit and clock correction, particularly maritime users, thus should exercise caution when utilizing QZSS CLAS.