• International Journal of Advanced Culture Technology
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• 제5권2호
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• pp.19-25
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• 2017

The research is to identify social networks of problems that have an influence on the quality of ageing people's lives by using social network analysis, based on the premise that there are differences in networks of ageing problems in urban and rural areas. From analyzing network of ageing people's problems using NodeXL, vertices in the networks of both urban and rural areas are well-connected. For urban areas, financial poverty is the core problem related to the quality of life. It has direct connections with illness and health, family responsibility, housing, role loss in community, and employment, which have positive or negative interactions with the quality of older people's lives. For rural areas, on the other hand, role loss in community is the major problem. It has direct connections with the elderly abuse, financial poverty, leisure activity, divorce, isolation and loneliness from society, education, and suicide. As a result, the research shows that the problems of ageing people have strong linkages and interactive effects with a structure of network, and the networks are different depending on types of places for living.

• 대한의생명과학회지
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• 제23권3호
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• pp.175-184
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• 2017

Cholera toxin (CT) is an ADP-ribosylating bacterial exotoxin that has been used as an adjuvant in animal studies of oral immunization. The mechanisms of mucosal immunogenicity and adjuvanticity of CT remain to be established. In this study, we investigated the role of indoleamine 2,3-dioxygenase (IDO), which participates in the induction of immune tolerance, in CT-mediated breakdown of oral tolerance. When IDO-deficient ($IDO^{-/-}$) mice and their littermates were given oral ovalbumin, significant changes in antibody responses, footpad swelling and $CD4^+$ T cell proliferation were not observed in $IDO^{-/-}$ mice. Feeding of CT decreased IDO expression in mesenteric lymph nodes (MLN) and Peyer's patch (PP). CT-induced downregulation of IDO expression was reversed by inhibitors of nuclear factor-kappa B (NF-${\kappa}B$), pyrrolidine dithiocarbamate and p50 small interfering RNA. IDO expression was downregulated by the NF-${\kappa}B$ inducers lipopolysaccharide and tumor necrosis factor-${\alpha}$. CT dampened IDO activity and mRNA expression in dendritic cells from MLN and PP. These data indicate that CT disrupts oral tolerance by activating NF-${\kappa}B$, which in turn downregulates IDO expression. This study betters the understanding of the molecular mechanism underlying CT-mediated abrogation of oral tolerance.

• Journal of Plant Biotechnology
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• 제6권2호
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• pp.69-75
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• 2004

Optimal protocol for efficient genetic transformation has been defined to aid future strategies of genetic engineering in pigeon pea with agronomically important genes. Transgenic pigeonpea plants were successfully produced through Agrobacterium tumefaciens-mediated genetic transformation method using cotyledonary node explants by employing defined culture media. The explants were co-cultivated with A. tumefaciens strain C-58 harboring the binary plasmid, pCAMBIA-1301 [con-ferring $\beta$-glucuronidase(GUS) activity and resistance to hygromycin] and cultured on selection medium (regeneration medium supplemented with hygromycin) to select putatively transformed shoots. The shoots were then rooted on root induction medium and transferred to pots containing sand and soil mixture in the ratio of 1:1. About 22 putative TO transgenic plants have been produced. Stable expression and integration of the transgenes in the putative transgenics were confirmed by GUS assay, PCR and Southern blot hybridization with a transformation efficiency of over 45%. Stable integration and expression of the marker gene has been confirmed in the TO and T1 transgenics through PCR, and Southern hybridization.

• The Journal of the Acoustical Society of Korea
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• 제25권4E호
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• pp.154-158
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• 2006

In this paper, we suggest a noise estimation method for speech enhancement in nonstationary noisy environments. The proposed method consists of the following two main processes. First, in order to receive fewer affect of variable signals, a best fitting regression line is used, which is obtained by applying a least squares method to coefficient magnitudes in a node with a uniform wavelet packet transform. Next, in order to update the noise estimation efficiently, a differential forgetting factor and a correlation coefficient per subband are used, where subband is employed for applying the weighted value according to the change of signals. In particular, this method has the ability to update the noise estimation by using the estimated noise at the previous frame only, without utilizing the statistical information of long past frames and explicit nonspeech frames by voice activity detector. In objective assessments, it was observed that the performance of the proposed method was better than that of the compared (minima controlled recursive averaging, weighted average) methods. Furthermore, the method showed a reliable result even at low SNR.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4147-4156
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• 2015

Lung cancer is a serious health problem and leading cause of death worldwide due to its high incidence and mortality. More than 80% of lung cancers feature a non-small cell histology. Over few decades, systemic chemotherapy and surgery are the only treatment options in this type of tumor but due to their limited efficacy and overall poor survival of patients, there is an urge to develop newer therapeutic strategies which circumvent the problems. Enhanced knowledge of translational science and molecular biology have revealed that lung tumors carry diverse driver gene mutations and adopt different intracellular pathways leading to carcinogenesis. Hence, the development of targeted agents against molecular subgroups harboring critical mutations is an attractive approach for therapeutic treatment. Targeted therapies are clearly more preferred nowadays over systemic therapies because they target tumor specific molecules resulting with enhanced activity and reduced toxicity to normal tissues. Thus, this review encompasses comprehensive updates on targeted therapies for the driver mutations in non-small cell lung cancer (NSCLC) and the potential challenges of acquired drug resistance faced i n the field of targeted therapy along with the imminent newer treatment modalities against lung cancer.

• 동의생리병리학회지
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• 제20권3호
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• pp.710-718
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• 2006

The present study was carried out to investigate the effect of Chihyo-san (CHS) administration on asthma induced by Alum/OVA treatment in the mice. In CHS-treated animal group, lung weight, which was increased after asthma induction, was significantly decreased, and total number of cells in the lung, peripheral lymph node (PLN) and spleen tissue was significantly decreased in CHS-treated group compared to the asthma control group. The number of immune cells including natural killer (NK) cells in asthmatic animals was largely regulated by CHS treatment, showing a similar pattern as that of CsA-treated positive control group. Levels of mRNAs encoding inflammatory cytokines IL-5, IL-13, $TNF-{\alpha}$, and eotaxin were determined by RT-PCR in the lung tissue and showed decreases in CHS-treated group to the similar levels of CsA-treated control group, Histamine level in the serum was significantly lower in CHS-treated group than asthma-induced control group. Both haematoxylin and eosin staining and Masson's trichrome staining results showed decreased number of inflammatory cells, reduced immune cell infiltration, and normalized epithelial cell layering in the bronchial tissue of CHS-treated mouse group. Thus, the present findings suggest that CHS may be useful for protecting bronchial tissues from consistent inflammatory damages that occur in asthma patients.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권11호
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• pp.5322-5342
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• 2016

In vehicle-to-vehicle (V2V) networks, where selfishness degrades node activity, countermeasures for collaboration enforcement must be provided to enable application of a sage and efficient network environment. Because vehicular networks feature both high mobility and various topologies, selfish behavior judgment and establishment of a stable routing protocol become intensely challenging. In this paper, a two-phase-based generous cooperative routing protocol (called GEC) is presented for V2V networks to provide resistance to selfishness. To detect selfish behaving vehicles, a packet forwarding watchdog and an average connection rate based on the multipath weight method are used, where evidence is gathered from different watchdogs. Then, multihop relay decisions are made using a generous cooperative algorithm based on game theory. Finally, through buffering of the multiple end-to-end paths and judicious choice of optimal cooperative routes, route maintenance phase is capable of dealing with congestion and rapidly exchanging traffic. Specifically, it is proved that the GEC is theoretically subgame perfect. Simulation results show that for V2V networks with inherently selfish nodes, the proposed method isolates uncooperative vehicles and is capable of accommodating both the mobility and congestion circumstances by facilitating information dissemination and reducing end-to-end delay.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2011년도 한국컴퓨터종합학술대회논문집 Vol.38 No.1(D)
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• pp.115-117
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• 2011

Intrusion detection systems (IDS) are supposed to be an efficient safety measure against inside attacks. In purely distributed IDS approach, IDS agent is installed in every node. It checks abnormal behavior of neighboring nodes locally. It collects the data that it receives from nodes in its radio range. Sensor nodes audit that data and generate alerts for abnormal activity. Here, there are two ways of taking decision. First, it can take decision individually and second, it can communicate with its neighbor to find the status of the claimed compromised nodes. In this paper, we propose a collaborative decision making scheme for purely distributed detection system. The proposed scheme is light weight compared to consensus based validation methodology. It provides a better scheme to find intrusions by interacting with other nodes.

• 한국컴퓨터정보학회논문지
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• 제1권1호
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• pp.147-158
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• 1996

본 논문에서는 작업 스케쥴러를 가진 통합된 실 시간 동시성제어 수행 과정을 분석하여 특수화된 데이타 흐름 그래프에 기초로한 동시성 제어구조를 제안하였다. 자료들은 토큰들의 이산 흐름에서 한 노드로부터 다른 노드까지의 연결 호 상에 나타내었다. 또 한 E-R모델에서 알려진 네트워크는 데이타 흐름 그래프로 나타내는 고정적인 문제점을 질의어 토큰을 이용하여 그래프상에 나타내게 하였다 그리고 모든 동시성 제어 기법들은 서로 다른 성능을 비교하여 실험으로 측정하였고, DBFG 스케줄링은 분산 환경에서 2PL보다 뛰어난 성능을 갖는다는 것을 비교 분석하였다.

• Transactions on Electrical and Electronic Materials
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• 제12권4호
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• pp.131-134
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• 2011

Back-end-of-line using ultra low-k (ULK; k < 2.5) has been required to reduce resistive capacitance beyond 45 nmtechnologies, because micro-processing units need higher speed and density. There are two strategies to manufacture ULK inter-layer dielectric (ILD) materials using an air-gap (k = 1). The former ULK and calcinations of ILD degrade the mechanical strength and induce a high cost due to the complication of following process, such as chemical mechanical polishing and deposition of the barrier metal. In contrast, the air-gap based low-k ILD with a relatively higher density has been researched on the trench-type with activity, but it has limited application to high density devices due to its high air-gap into the next metal layer. The height of air-gap into the next metal layer was reduced by changing to the via-typed air-gap, up to about 50% compared to that of the trench-typed air-gap. The controllable ULK was easily fabricated using the via-typed air-gap. It is thought that the via-type air-gap made the better design margin like via-patterning in the area with the dense and narrow lines.