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Comparison of Human Blood Cadmium Concentrations using Graphite Furnace Atomic Absorption Spectrometry (GF-AAS) and Inductively Coupled Plasma-mass Spectrometry (ICP-MS) (흑연로 원자 흡광 광도기와 유도 결합 플라즈마 질량 분석기를 이용한 인체 혈중 카드뮴 농도 비교)

  • Kwon, Jung-Yeon;Kim, Byoung-Gwon;Lim, Hyoun-Ju;Seo, Jeong-Wook;Kang, Min-Kyung;Kim, Yu-Mi;Hong, Young-Seoub
    • Journal of Environmental Health Sciences
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    • v.44 no.5
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    • pp.491-501
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    • 2018
  • Objectives: The aims of this study were to compare concentrations and the correspondence of human blood cadmium by using graphite furnace atomic absorption spectrometry (GF-AAS) and inductively coupled plasma-mass spectrometry (ICP-MS), which are representative methods of heavy metal analysis. Methods: We randomly selected 79 people who agreed to participate in the research project. After confirming the linearity of the calibration curves for GF-AAS and ICP-MS, the concentrations of cadmium in a quality control standard material and blood samples were measured, and the correlation and the degree of agreement were compared. Results: The detection limit of ICP-MS (IDL: $0.000{\mu}g/L$, MDL: $0.06{\mu}g/L$) was lower than that of GF-AAS (IDL: $0.085{\mu}g/L$, MDL: $0.327{\mu}g/L$). The coefficient of variation of the quality control standard material showed stable values for both ICP-MS (clinchek-1: 5.35%, clinchek-2: 6.22%) and GF-AAS (clinchek-1: 7.92%, clinchek-2: 5.22%). Recovery was relatively high for both ICP-MS (clinchek-1: 95.1%, clinchek-2: 92.8%) and GF-AAS (clinchek-1: 91.4%, clinchek-2: 98.8%), with more than 90%. The geometric mean, median, and percentile of blood samples were all similar. The agreement of the two instruments compared with the bias of the analytical values found that about 81% of the analytical values were within ${\pm}30%$ of the deviation from the ideal reference line (y=0). As a result of the agreement limit, the value included in the confidence interval was about 94%, which shows high agreement. Conclusion: In this study, we confirmed there was no significant difference in concentrations of a quality control standard material and blood samples. Since ICP-MS showed lower concentrations than GF-AAS at concentrations below the method detection limit of GF-AAS, it is expected that more precise results will be obtained by analyzing blood cadmium with ICP-MS.

Characteristics of Trigeminal Evoked Potential and It's Pathway in the Rat (백서에서 삼차신경 유발전위의 특성과 경로 분석)

  • Kim, Se-Hyuk;Zhao, Chun-Zhi;Kwon, Oh-Kyoo;Lee, Bae-Hwan;Park, Yong-Gou;Chung, Sang-Sup
    • Journal of Korean Neurosurgical Society
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    • v.29 no.8
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    • pp.985-994
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    • 2000
  • Objective : There are some advantages of trigeminal evoked potential(TEP) recording compared to other somatosensory evoked potential(SSEP) recordings. The trigeminal sensory pathway has a pure sensory nerve branch, a broader receptive field in cerebral cortex, and a shorter pathway. Despite these advantages, there is little agreement as to what constitutes a normal response and what wave forms truly characterize the intraoperative TEP. This study presents the normative data of TEP recorded on the epidural surface of the rat with a platinum ball electrode. Materials & Methods : Under general anesthesia with urethane, the adult Sprague-Dawley male rats(300-350g) were given electrical stimulation with two stainless steel electrodes which were inserted into the subcutaneous layer of the area around whiskers. A reference electrode was positioned in the temporalis muscle ipsilateral to the recording site. Results : TEPs were recorded in the Par I area of somatosensory cortex and recorded most apparently on the point of 2mm posterior from the bregma and 6mm lateral from the midline. The typical wave form consisted of 5 peaks (N1-P1-N2-P2-N3 according to emerging order, upward negativity). Each latency to corresponding peaks was not influenced by the different intensities of stimulation, especially from 1 to 5mA. Average latencies of 5 peaks were in the following order ; 7.7, 11.1, 15, 22.3, 29.4ms. There was also no significant difference between latencies before and after administration of muscle relaxant(pancuronium). For the electrophysiological localization of recorded waves, the action potential of a single unit was recorded with glass microelectrode(filled with 2M NaCl, $3-5M{\Omega}$) in the thalamus of rat. A sharp wave was recorded in the VPM nucleus, in which the latency was shorter than that of N1. This suggests that all 5 peaks were generated by neural activities in the suprathalamic pathway. Conclusion : In terms of recording near-field potentials, our data also suggests that TEP in the rat may be superior to other SSEPs. In overall, these results may afford normative data for the studies of supratentorial lesions such as hydrocephalus or cerebral ischemia which can have an influence on near-field potentials.

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A Study on the Development of English Inflectional Morphemes Based on the CHILDES Corpus (CHILDES 코퍼스를 기반으로 한 아동의 영어 굴절형태소 발달 연구)

  • Min, Myung Sook;Jun, Jongsup;Lee, Sun-Young
    • Korean Journal of Cognitive Science
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    • v.24 no.3
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    • pp.203-235
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    • 2013
  • The goal of this paper is to test the findings about English-speaking children's acquisition of inflectional morphemes in the literature using a large-scale database. For this, we obtained a 4.7-million-word corpus from the CHILDES (Child Language Data Exchange System) database, and analyzed 1,630 British and American children's uses of English derivational morphemes up to age 7. We analyzed the type and token frequencies, type per token ratio (TTR), and the lexical diversity (D) for such inflectional morphemes as the present progressive -ing, the past tense -(e)d, the comparative and superlative -er/est with reference to children's nationality and age groups. To sum up our findings, the correlations between the D value and children's age varied from morpheme to morpheme; e.g. we found no correlation for -ing, a marginal correlation for -ed, and a strong correlation for -er/-est. Our findings are consistent with Brown's (1973) classical observation that children learn progressive forms earlier than the past tense marker. In addition, overgeneralization errors were frequently found for -ed, but rarely for -ing, showing a U-shaped developmental pattern at ages 2-3. Finally, American children showed higher D scores than British children, which showed that American children used inflectional morphemes for more word types compared with British children. The present study has its significance in testing the earlier findings in the literature by setting up well-defined methodology for analyzing the entire CHILDES database.

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A Study on the Classification Criteria of Landscape Type for Urban Landscape Planning (도시경관계획을 위한 경관유형 분류기준에 관한 고찰)

  • Bang, Jae-Sung;Yang, Byoung-E
    • Journal of the Korean Institute of Landscape Architecture
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    • v.37 no.2
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    • pp.78-89
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    • 2009
  • The purpose of this study is to build fundamental data for the classification of landscape type as a base for landscape planning and management practices. To do this, prior dissertations and landscape plan reports were analyzed, which presented the classification criteria for landscape type. Based on this, classification criteria for landscape type which could be usable in zoning ordinances has been suggested. The result is as follows: Firstly, in landscape analysis and assessment study based on ecological and formal aesthetic models, landscape type is classified by the character of the landscape element. Secondly, there is no logical classification of landscapetype in urban landscape planning according to mixed use of landscape type for analysis and planning. It is therefore difficult to identify the object of landscape planning, which is intimately linked with the shortage of concrete practice for landscape management. In connection with this issue, classification criteria for landscape type are suggested based on utility in landscape planning. This could be divided into internal criteria and external criteria. The former are land-use, topographical characteristics, characteristics of the view object, and landscape elements while the latter are viewpoint, distance to view object, and urban form. Applying the landscape type classified by the criteria suggested in this paper, it is possible to manage an entire urban area. In addition, landscape type could be reference data for operating a zoning system.

A Comparative Analysis of Body Composition, Physical Fitness, and Physical Self-Concept between Gifted Students in Math and Science and Non-Gifted Students (과학영재 학생들과 일반학생들의 신체조성, 체력 및 신체적 자아개념 비교 분석)

  • Song, Kang-Young;Ahn, Jeong-Deok
    • The Journal of the Korea Contents Association
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    • v.14 no.11
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    • pp.450-466
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    • 2014
  • This study compared and analyzed body composition, physical fitness, and physical self-concept between gifted students in mathematics and science attending Korea Science Academy (KSA) and non-gifted students attending traditional high schools. The KSA students were 117 males who entered the school in 2009. As a control group, a total of 117 non-gifted students were randomly selected from 5 cities. The results of covariate analysis taken 2 year interval, pretest (2009) and posttest (2010), indicated that gifted students were significantly taller (p<.05) than non-gifted students, and were lower in BMI (p<.05) and PBF (p<.001). There was no significant difference in physical fitness between gifted and non-gifted students. But non-gifted students have a significantly higher self-concept in physical appearance (p<.05) and physical strength (p<.05). The internal/external frame of reference model and the Big Fish Little Pond Effect (BFLPE) theory were supported. Especially, gifted students were significantly higher (p<.01) in endurance self-concept than non-gifted students. We have discussion this result as the future research subject whether it come from the characteristics of the gifted's tenacity at high level tasks.

Integrated Broiler Production System - As a Means of Stabilizing Whole Industry with Particular Reference to U.S. Experience - (브로일러계열화 생산조직에 관한 고찰 - 미국의 예를 중심으로 -)

  • 박영인
    • Korean Journal of Poultry Science
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    • v.6 no.2
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    • pp.91-102
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    • 1979
  • The basic problem of the broiler industry is that of fluctuating prices, mainly thanks to unstable supply of and inelastic demand for products as usually indicated as a peculiarity of agricultural commodities. This particularly brings the producer to a great economic risk, because he has to sell products under the condition of pure competition, whereas others from whom he has to buy deal under the condition of oligopoly or even monopoly. Therefore, producers economic position is generally placed in the worst comparing others dealing with, which results in unbalanced economic status of elements involved in broiler operation and further obstruction of industry development as a whole. A certain type of business coordination to overcome such a problem should be measured in order to improve the efficiency of entire operation and thus assure the balanced industry development. The concept of the economic integration developed in modern business system had been adapted to U.S. poultry industry which became common later around the world as a means of stabilizing producers price and whole industry as well. There are two main typos of integration; horizontal and vertical The former refers to the general grouping of similar business units, eg. a hatchery tying with other hatchery, while the latter refers to the knitting together of two or more stages of economic activities, eg. tying together among units of hatching, fled milling, production, processing and marketing. By having the industry integrated, risk and uncertainty involved in various stages of operation could be diversified. The typo of integrating contract between producers and integrators include the share of profits, flat fee payment, feed conversion payment and salary basis. In the U.S., extensive changes in production, processing, and marketing during the last few decades have changed the thicken broiler industry from one of small, widely scattered farms to one that is largo, concentrated and efficient. More than 99 percent of all broilers produced are grown under contract and by integrated firms which vary in size of operation and complexity. About 84 percent of all production is concentrated in 10 States. Some of the other factors ;hat contributed to these choses arc costs, energy use, prices, processing, marketing and demand. No integrated broiler production system has yet been applied in Korea's poultry industry, thus all stages all broiler operation run independently seeking for its own profit. Consequently, producers price fluctuate very widely around the year even more than 50 percent in a few months. This also leads to disadvantages of material supplies, processors and distributors and enforce the industry unstable. The current economic environment in Korea seems that the time for broiler integration comes and as an ideal integrator, feed millers, food processors and producers group may be considered.

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Amendment of the Inspection Standard for Diagnostic Radiation Equipment Applying IEC 60601-1-3: Medical Electrical Equipment - Part 1-3: General Requirements for Basic Safety and Essential Performance - Collateral Standard: Radiation Protection in Diagnostic X-ray Equipment (KS C IEC60601-1-3: 의료용 전기기기-제1-3부: 기본 안전 및 필수 성능에 관한 일반 요구사항-보조표준: 진단용 X선 장치의 방사선 방어를 적용한 진단용 방사선 발생장치의 검사기준 개선안)

  • Park, Hye-Min;Kim, Jung-Min;Kim, Jung-Su;Kim, Seong-Ok;Choi, Young-Min
    • Journal of radiological science and technology
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    • v.41 no.5
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    • pp.493-504
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    • 2018
  • The diagnostic radiation equipment is managed in accordance with the "Rules for Safety Management of Diagnostic Radiation Equipment" enacted in 1995. The equipments should be inspected before use and every three years after use in accordance with the [Appendix 1] of the same rule. The inspection standard has been maintained without particular revision since enacted. But, over the past two decades new types of equipments have been manufactured and used. So, it is necessary to revise [Appendix 1] by making inspection items and inspection standards. In this study, we revised the classification system of equipments and reviewed international standards of IEC 60601 series, IEC 61223 series and AAPM TG 18 On-line Report No.03. And identified the problem of current inspection standards. Through this, we revised, deleted and added the inspection items and inspection standard of each equipment to meet the domestic circumstances. As a result of the study, we reorganized the classification system of equipment which are current classified as 5 classes into 22 classes as X-ray system etc. (7 classes), CT system etc. (5 classes) and Dental X-ray system etc. (10 classes). And then, we developed 70 inspection items for 6 types of equipments according to the reorganized classification system of equipments. The inspection items and inspection standards derived from this study have been proposed to the KCDC and will be applied to the revision of the Rule's [Appendix 1]. Therefore, we expect to be used as reference materials for domestic medical center, inspection institutions, and equipment manufacturing import companies.

A Study on the Application of Finishing Materials According to the Locational Function of the Chapel in Church Space (교회공간 예배실의 위치적 기능에 따른 마감재 적용 연구)

  • Yeo, Mi;Lee, Chang No
    • Korean Institute of Interior Design Journal
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    • v.24 no.1
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    • pp.178-188
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    • 2015
  • This study has the main objective of being of help as a reference data for the application of the finishing materials when designing the interior of the chapel of the church space through analysis of the finishing materials against the chapels of church space which has complex function. As precedent studies for this, the composition of the function and concept of the church space was surveyed and the complex function of the church space was surveyed. The theoretical surveyed was performed according to the casual composition, behavior of the community and role and location of the duties of the church members. The case objects were 10 chapels constructed by 5 professional interior design companies. The content of the analysis was the finishing materials in the chapels and their application characteristics. The detailed considerations to be referred to when designing the interior of the chapels of church space in the future were proposed. The analysis result of the application of the finishing materials according to the locational function of the chapels of church space can be explained as follows. First, the platform area was the characteristic of applying finishing materials which induce visual immersion. As for the floor materials in the platform, in order to minimize the floor sound and vibration phenomenon occurring during movements, noise insulation and dust protection rubber sheet was place and on top of it the floor or the carpet was placed. Second, the Choir area had the difficult problem of having to consider the appropriate sound absorption occurring due to the proliferation of sound and performance of classical instruments at the same time. However, in the case, this problem was solved through the sculptures of convex shape. Third, since the scheelite is a space where many people move around, the finishing material which absorbs sound was mainly used. Fourth, the entrance area was composed of thick wall materials compared to other walls, and the sound absorption character was most significantly considered when applying the finishing material. Fifth, the broadcasting room was composed either in independent type or an open type and performed its function and the main finishing materials was transparent glass which was highest use frequency.

Diversity of vir Genes in Plasmodium vivax from Endemic Regions in the Republic of Korea: an Initial Evaluation

  • Son, Ui-han;Dinzouna-Boutamba, Sylvatrie-Danne;Lee, Sanghyun;Yun, Hae Soo;Kim, Jung-Yeon;Joo, So-Young;Jeong, Sookwan;Rhee, Man Hee;Hong, Yeonchul;Chung, Dong-Il;Kwak, Dongmi;Goo, Youn-Kyoung
    • Parasites, Hosts and Diseases
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    • v.55 no.2
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    • pp.149-158
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    • 2017
  • Variant surface antigens (VSAs) encoded by pir families are considered to be the key proteins used by many Plasmodium spp. to escape the host immune system by antigenic variation. This attribute of VSAs is a critical issue in the development of a novel vaccine. In this regard, a population genetic study of vir genes from Plasmodium vivax was performed in the Republic of Korea (ROK). Eighty-five venous blood samples and 4 of the vir genes, namely vir 27, vir 21, vir 12, and vir 4, were selected for study. The number of segregating sites (S), number of haplotypes (H), haplotype diversity (Hd), DNA diversity (${\pi}$ and ${\Theta}_w$), and Tajima's D test value were conducted. Phylogenetic trees of each gene were constructed. The vir 21 (S=143, H=22, Hd=0.827) was the most genetically diverse gene, and the vir 4 (S=6, H=4, Hd=0.556) was the opposite one. Tajima's D values for vir 27 (1.08530, P>0.1), vir 12 (2.89007, P<0.01), and vir 21 (0.40782, P>0.1) were positive, and that of vir 4 (-1.32162, P>0.1) was negative. All phylogenetic trees showed 2 clades with no particular branching according to the geographical differences and cluster. This study is the first survey on the vir genes in ROK, providing information on the genetic level. The sample sequences from vir 4 showed a clear difference to the Sal-1 reference gene sequence, whereas they were very similar to those from Indian isolates.

A Study on Establishment of Time Series Model for Deriving Financial Outlook of Basic Research Support Programs (기초연구지원사업의 재정소요 전망 도출을 위한 시계열 모형 수립 연구)

  • Yun, Sujin;Lee, Sangkyoung;Yeom, Kyunghwan;Shin, Aelee
    • Journal of Technology Innovation
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    • v.27 no.4
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    • pp.21-48
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    • 2019
  • In the basic research field, quantitative expansion is carried out with active support from the government, but there is no research and policy data suggesting systematic investment plans or data-based financial requirements yet. Therefore, this study predicted future financial requirements of basic research support programs by using time series prediction model. In order to consider various factors including the characteristics of the basic research field, we selected the ARIMAX model which can reflect the effect of multi valuable factors rather than the ARIMA model which predicts the value of single factor over time. We compared the predictions of ARIMAX and ARIMA models for model suitability and found that the ARIMAX model improves the prediction error rate. Based on the ARIMAX model, we predicted the fiscal spending of basic research support programs for five years from 2017 to 2021. This study has significance in that it considers the financial requirements of the basic research support programs as a pilot research conducted by applying a time series model, which is a statistical approach, and multi-variate rather than single-variate. In addition, considering the policy trends that emphasize the importance of basic research investment such as 'the expansion of basic research budget twice', which is the current government's national policy task, it can be used as reference data in establishing basic research investment strategy.