• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2018년도 학술발표회
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• pp.145-145
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• 2018

Small islands rely heavily on groundwater resources in addition to rainwater as the source of freshwater since surface water bodies are often absent. The groundwater resources are vulnerable to sea level rise, coastal flooding, saltwater intrusion, irregular pattern of precipitation resulting in long droughts and flash floods. Increase in population increases the demand for the limited groundwater resources, thus aggravating the problem. In this study, the effects of climate change on Tongatapu Island, Kingdom of Tonga, a small island in Pacific Ocean, are investigated using a sharp interface transient groundwater flow model. Twenty nine downscaled General Circulation Model(GCM) predictions are input to a water balance model to estimate the groundwater recharge. The temporal variation in recharge is predicted over the period of 2010 to 2099. A set of GCM models are selected to represent the ensemble of 29 models based on cumulative recharge at the end of the century. This set of GCM model predictions are then used to simulate a total of six climate scenarios, three each (2010-2039, 2040-2069, and 2070-2099) under RCP 4.5 and RCP 8.5. The impacts of predicted climate change on groundwater resources is evaluated in terms of freshwater volume changes and saltwater ratios in pumping wells compared to present conditions. Though the cumulative recharge at the end of the century indicates a wetter climate compared to the present conditions the large variability in rainfall pattern results in frequent periods of groundwater drought leading to saltwater intrusion in pumping wells. Thus for sustaining the limited groundwater resources in small islands, implementation of timely assessment and management practices are of utmost importance.

• 대한치과교정학회지
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• 제53권5호
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• pp.289-297
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• 2023

Objective: To analyze the microimplant (MI) displacement pattern on treatment with a maxillary skeletal expander (MSE) using cone-beam computed tomography (CBCT). Methods: Thirty-nine participants (12 males and 27 females; mean age, 18.2 ± 4.2 years) were treated successfully with the MSE II appliance. Their pre- and post-expansion CBCT data were superimposed. The pre- and post-expansion anterior and posterior inter-MI angles, neck and apical inter-MI distance, plate angle, palatal bone thickness at the MI positions, and suture opening at the MI positions were measured and compared. Results: The jackscrew plate was slightly bent in both anterior and posterior areas. There was no significant difference in the extent of suture opening between the anterior and posterior MIs (P > 0.05). The posterior MI to hemiplate line was greater than that anteriorly (P < 0.05). The apical distance between the posterior MIs was greater than that anteriorly (P < 0.05). The palatal thickness at the anterior MIs was significantly greater than that posteriorly (P > 0.01). Conclusions: In the coronal plane, the angulation between the anterior MIs in relation to the jackscrew plate was greater than that between the posterior MIs owing to the differential palatal bone thickness.

• 한국임상수의학회지
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• 제39권6호
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• pp.311-318
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• 2022

Appropriate suture technique is crucial for successful tracheal anastomosis. However, standards for an ideal suture method have not yet been established. A previous study suggested tracheal anastomosis using barbed sutures that do not require knots; however, their use in small animals has not been reported. In this study, we aimed to compare knotless barbed sutures with conventional smooth sutures in terms of maximum tensile strength and suturing time in canine tracheal models to demonstrate the feasibility of using barbed sutures in tracheal anastomosis in dogs. Tracheal segments harvested from nine beagle dog cadavers were randomly assigned to three suture groups: barbed suture (B), smooth suture in simple interrupted pattern (SI), and smooth suture in simple continuous pattern (SC). The maximum tensile force and suturing time were compared according to the suturing method, and the mode of failure was evaluated. The average suturing time was 3.29 min in the B group; 4.41 min, SC group; and 8.99 min, SI group (p < 0.001). The average maximum tensile force in the SC group was 134.97 N, which was stronger than the SI (110.57 N) and B groups (103.10 N) (p < 0.05 and p < 0.01, respectively). The difference between the B and SI groups was not significant (p = 0.05). The B group demonstrated comparable mechanical strength and shorter suture time compared with the SI group. Therefore, tracheal anastomosis using barbed sutures could be an effective alternative to conventional smooth sutures in dogs.

• Clinical Pain
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• 제18권2호
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• pp.82-87
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• 2019

Objective: To evaluate which Korean pain descriptors are frequently used in the patients with neuromusculoskeletal diseases and compare the frequency of Korean pain descriptor according to age, gender, pain pattern and intensity, and clinical diagnosis. Method: Two hundreds sixty nine patients with neuromusculoskeletal diseases were enrolled in this study. The patients were asked to fill out a pain questionnaire using Korean. The Korean pain descriptors were collected and classified according to neurophysiological mechanism. The frequency of Korean pain descriptor was analyzed by age, gender, pain pattern and intensity, and clinical diagnosis. They were divided into axial spine and peripheral joint pain group depending on the location of causal disease and shoulder pain descriptors were divided into intra-articular and bursa group. Results: Among 24 Korean pain descriptors, 'arida' was the most common pain descriptor, followed by 'ssusida' and 'jjireunda'. When the pain descriptors were classified according to neurophysiological mechanism, superficial somatic pain was the most common, followed by deep somatic pain. There was a significant difference in the frequency of the pain descriptor between axial spine and peripheral joint pain group (p=0.007). The pain descriptor 'danggida' was used significantly more in the patients with axial spine pain than peripheral joint pain (p=0.024). However, there was no significant difference in other factors. Conclusion: The patients with neuromusculoskeletal diseases expressed their pain using various Korean pain descriptors with stabbing nature and superficial somatic pain. Our results may be helpful to assess and develop a new Korean pain quality measure in the patients with neuromusculoskeletal diseases.

• 한국조경학회지
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• 제17권2호
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• pp.27-39
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• 1989

The purpose of this study is to prove the factors affecting the fluctuation of daily visitors in five mountainous national park(Kayasan, kyeryongsan, Naejangsan, Soraksan, Songnisan), and to analyze the relationship between these factors and daily visitors in Korea. "Three Factors and Nine Categories"(Aoki, K. & Aoki, Y. : 1974, 1979) has been applied to this study, and statistical analysis method was carried out by computer program SAS and SPSS. The number of daily visitors is calculated based on the data of "Daily entrance ticket sale report" by administration office in each national park. The scope of time period is during the last 5years(1982∼1986: 1825days) and the results were as follows: 1) There were significant differences in the number of daily visitors of each national park among months, days of a week and weather-the same as the previous study of urban park case. But it wold be better for their category classification to be adjusted according to the fluctuation pattern of each national park. 2) The peak of monthly visitors comes in May(Kayasan, Soraksan, Songnisan) or October(Kyeryongsan, Naejangsan). These months are specified as group tour season. On the basis of monthly fluctuation pattern, Each national park were classified into seasonal type, that is, kayasan, Soraksan were proved to be three-season type(Spring, Summer, Autumn), Songnisan to be two-season type(Spring, Autumn), and Naejangsan to be one-season type(Autumn). 3) The weekly pattern differs from three category (weekday, weekend, holiday: Eom, Choi 1986) in the case of urban park study. And there is no significant difference in daily fluctuation pattern by weather (fine, cloudy and rainy day), but significant difference between snowy and the others. This result is due to the characteristics of visitors, which is, the major visits of national park are planned in a advance of the tour, therefore it is difficult to change the plan by the weather. 4) the result of correlation analysis showed that the most influential factor on national park use in Kayasan, Naejangsan, Soraksan and Songnisan is ′Monthly characters (M)′, on the contrary ′Day of week(D)′ in Kyeryongsan only. From the result, The more parks are resource-based, the more ′Monthly characters′-factor is supposed to affect the number of daily visitors rather than ′Day of the week′-factor. This means that kayasan, naejangsan, Sorakson and Songnisan are classified into resource-based type, but on the other hand Kyeryongsan should be classified into intermediate type.

• Genomics & Informatics
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• 제15권3호
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• pp.87-97
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• 2017

Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, ${\beta}$-2 microglobulin, and albumin. Recently, the term chromothripsis has emerged, which is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event. Many studies have shown an association of chromothripsis with the prognosis in several cancers; however, few studies have investigated it in MM. Here, we studied the association between chromothripsis-like patterns and treatment resistance or prognosis. First, we analyzed nine MM cell lines (U266, MM.1S, RPMI8226, KMS-11, KMS-12-BM, KMS-12-PE, KMS-28-BM, KMS-28-PE, and NCI-H929) and bone marrow samples of four patients who were diagnosed with MM by next-generation sequencing-based copy number variation analysis. The frequency of the chromothripsis-like pattern was observed in seven cell lines. We analyzed the treatment-induced chromothripsis-like patterns in KMS-12-BM and KMS-12-PE cells. As a result, breakpoints and chromothripsis-like patterns were increased after drug treatment in the relatively resistant KMS-12-BM. We further analyzed the patients' results according to the therapeutic response, which was divided into sensitive and resistant, as suggested by the International Myeloma Working Group. The chromothripsis-like pattern was more frequently observed in the resistant group. In the sensitive group, the frequency of the chromothripsis-like pattern decreased after treatment, whereas the resistant group showed increased chromothripsis-like patterns after the treatment. These results suggest that the chromothripsis-like pattern is associated with treatment response in MM.

• 대한통합의학회지
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• 제7권2호
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• pp.1-10
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• 2019

Purpose : To investigate the relationship between breathing pattern disorder and joint position error (JPE) in patients with chronic low back pain (CLBP). Methods : Thirty nine patients with CLBP participated. End-tidal $CO_2$ and respiration rate (RR) were measured using a capnography. Breathing-hold time (BHT) and Nijmegen Questionnaire (NQ) were investigated. Thoracic excursion was measured with a cloth tape measurement technique. Joint position error were measured using a small laser point mounted on a lightweight headband. they were asked to relocate the head, after the neck movement on the horizontal plane. Pearson 's test was used for correlation analysis between respiratory variables and JPE in patients with CLBP. Independent t-test was used to verify the difference between thoracic and diaphragm breathing pattern in patients with CLBP. The significance level was set at 0.05. Results : There was a significant correlation between JPE (LR) and JPE (RR, EX) (r=.639, r=.813) (p<.001) and a low negative correlation with end-tidal $CO_2$ (r=-.357) (p<.05). There was a significant correlation between RR and JPE (EX) (r=.750) (p<.001). There was a low correlation between JPE (EX) and NQ (r=.333) (p<.05). There was a somewhat high negative correlation between NQ and thoracic excursion (r=-.528) (p<.001). There was a somewhat high negative correlation between thoracic excursion and JPE (LR, RR, EX) (r=-.470, r=-.484, r=-.602) (p<.001). There were no significant differences in the RR, BHT, NQ, and thoracic excursion between the thoracic and diaphragmatic breathing (p>.05). There was a significant difference in the JPE (EX), end - tidal $CO_2$, and VAS values between the thoracic and diaphragm breathing (p<.05). Conclusion : There was a correlation between JPE (EX) and NQ in patients with CLBP, and correlation between thoracic excursion and JPE (LR, RR, EX) and NQ. There was a significant difference in the JPE (EX), end-tidal $CO_2$ level, and VAS value in the comparison of thoracic breathing and diaphragm breathing. The results showed that breathing patterns and JPE were related to each other.

• 한국철학논집
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• 제59호
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• pp.89-120
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• 2018

본 논문은 한주(이진상, 1818~1886)과 만구(이종기, 1837~1902)의 서신내용을 중심으로 19세기 심설논쟁의 발단양상을 고찰한 것이다. 본문에서는 정재(유치명)의 학문을 계승한 만구와 한주의 이론적 차이를 분석함으로써 심설논쟁의 발단을 제공한 한주와 정재의 논변에서 한주와 만구로 그 범위를 확장시켜 전개하고자 한다. 한주와 만구의 이론적 차이를 밝힘으로써 역으로 한주와 정재가 전개한 심설논쟁의 내용들이 좀 더 분명해질 수 있을 것이다. "한주집"에는 만구에게 보낸 9통의 서신이 실려 있으며, "만구집"에도 한주에게 보낸 3통의 서신이 실려 있다. 이들 서신에는 두 사람의 학문상에 일정한 차이가 있음을 보여준다. 따라서 본문에서는 이들의 서신내용을 중심으로 그 이론적 차이를 밝힘으로써 결국 이들의 이론적 차이가 심설논쟁의 하나의 발단양상으로 이어짐을 확인한다. 특히 이기에 대한 해석은 그대로 심에 대한 해석으로 이어진다. 심에 대한 해석은 주자의 '기의 정상'에 대한 해석을 중심으로 전개되는데, 한주가 '기의 정상'을 리로 볼 것을 강조한 반면, 만구는 '기의 정상'을 이기의 합으로 볼 것을 강조한다. '기의 정상'이란 주자의 심에 대한 해석이므로 결국 '기의 정상'에 대한 해석은 심에 대한 해석을 의미한다. 따라서 한주가 심을 리로 보려고 한 반면 만구는 심을 이기의 합으로 보려고 하였던 것이다. 이것이 바로 19세기 심설논쟁의 발단을 장식한 한주와 정재의 연장선상에서 전개된 한주와 만구의 심설논쟁이다. 이들의 논변을 통해 퇴계학파에서 전개된 심설논쟁의 발단양상에 관한 세부적 내용을 재차 확인하는 계기로 삼고자 한다.

• 대한본초학회지
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• 제27권6호
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• pp.37-42
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• 2012

Objectives : Angelica Gigantis Radix is prescribed as the root of different Angelica species on the pharmacopoeia in Korea, Japan and China. Chemical components and their biological activities were also different according to their species. A study for the development of simple method to compare Angelica roots was needed. In order to classify them, the methods such as DNA sequencing analysis and taste sensor were applied to three Angelica species like Angelica gigas, Angelica acutiloba and Angelica sinensis. Methods : PCR amplification of intergenic transcribed spacer (ITS) region was performed using ITS1 and ITS4 primer from nine Angelica roots, and then nucleotide sequence was determined. Taste pattern of samples were measured using the taste-sensing system SA402B equipped with a sensing unit, which consists of artificial lipid membrane sensor probes of anionic bitterness, astringency, saltiness, umami, and cationic bitterness (C00, AE1, CT0, AAE, and AN0, respectively). Results : As a result of comparing the similarity of the ITS region sequences, A. sinensis was discriminated from the others (A. gigas and A. acutiloba). Equally this genetic result, A. gigas and A. acutiloba showed similar taste pattern as compared to A. sinensis. Sourness, bitterness, aftertaste of bitterness, astringency, and aftertaste of astringency of A. sinensis were significantly high as compared with A. gigas and A. acutiloba. In contrast, richness was significantly low. Conclusions : These taste pattern can be used as a way of comparison of Angelica species and this technic could be applied to establish a taste pattern marker for standardization of herbs in various purposes.

• International Journal of Automotive Technology
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• 제6권1호
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• pp.53-63
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• 2005

We propose a fuzzy neural network (FNN) theory capable of deciding the quality of a road image prior to extracting lane-related information. The accuracy of lane-related information obtained by image processing depends on the quality of the raw images, which can be classified as good or bad according to how visible the lane marks on the images are. Enhancing the accuracy of the information by an image-processing algorithm is limited due to noise corruption which makes image processing difficult. The FNN, on the other hand, decides whether road images are good or bad with respect to the degree of noise corruption. A cumulative distribution function (CDF), a function of edge histogram, is utilized to extract input parameters from the FNN according to the fact that the shape of the CDF is deeply correlated to the road image quality. A suitability analysis shows that this deep correlation exists between the parameters and the image quality. The input pattern vector of the FNN consists of nine parameters in which eight parameters are from the CDF and one is from the intensity distribution of raw images. Experimental results showed that the proposed FNN system was quite successful. We carried out simulations with real images taken in various lighting and weather conditions, and obtained successful decision-making about $99\%$ of the time.