• Journal of Periodontal and Implant Science
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• 제48권5호
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• pp.326-333
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• 2018

Purpose: The present study investigated the outcomes of a newly-developed, simple, and practical nonsurgical treatment modality suitable for most forms of intrabony defects around failing dental implants using intrasulcular delivery of chlorhexidine solution and minocycline hydrochloride (HCl). Methods: Forty-five dental implants in 20 patients diagnosed with peri-implantitis were included. At baseline and the study endpoint, the probing pocket depth (PPD), clinical attachment level (CAL), and the presence of bleeding on probing (BOP) at 6 sites around each implant were recorded. The radiographic osseous defect morphology at the mesial or distal proximal aspect of each implant was classified as 1) narrow or wide and 2) shallow or deep. For a comparative analysis of bone changes according to the defect morphology, the distance from the implant shoulder to the most coronal bone-to-implant contact point (DIB) at the mesial and distal aspects of each implant was measured at baseline and the endpoint. Patients were scheduled to visit the clinic every 2-4 weeks for intrasulcular irrigation of chlorhexidine and delivery of minocycline HCl. Results: We observed statistically significant decreases in PPD, CAL, and BOP after treatment. At the endpoint, bone levels increased in all defects, regardless of the osseous morphology of the intrabony defect. The mean DIB change in deep defects was significantly greater than that in shallow defects. Although the mean bone gain in narrow defects was greater than in wide defects, the difference was not statistically significant. Conclusions: We propose that significant and sustainable improvements in both clinical and radiographic parameters can be expected when intrabony defects around dental implants are managed through a simple nonsurgical approach involving combined intrasulcular chlorhexidine irrigation and local delivery of minocycline HCl.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5537-5540
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• 2015

Purpose: To research the association between pre-treatment elevated platelet count and clinicopathologic characteristics in breast cancer (BC), as well as explore the relationship between pre-treatment elevated platelet count and HER2 status and prognosis of BC patients. Materials and Methods: A retrospective cohort of BC patients who were newly diagnosed or treated by surgery only and had pathological detection results and platelet values in the Department of Oncology, the First Affiliated Hospital of Liaoning Medical College were enrolled from 1/1/2008 until 31/12/2009, and followed up until 31/12/2014. Age, thrombocyte parameters before chemotherapy and/or radiotherapy, immunohistochemical (IHM) indexes, and regional lymph node (LN) involvement and progression-free survival (PFS) were recorded. Results: A total of 447 eligible subjects were included in this research. As we analyzed, for HER2, positive and negative, the incidence rates of elevated platelet count were 25.8% and 14.7% (P<0.05). In the Cox proportional hazards model both variables were independent risk factors for BC (for HER2, OR, 0.592, 95% confidence interval, CI, 0.355 to 0.985, P=0.044;f or PLT, OR, 0.998, 95% CI, 0.996 to 1.000, P=0.042). For ER, PR, Ki67 and LN involvement, the differences were not statistically significant (P>0.05). Conclusions: In this research, pre-treatment elevated level of platelet count demostrated a significantrelationship with HER2 amplification/overexpression, and both variables significantly influenced the prognosis of BC. However, elevated platelet count did not exhibit any association with ER, PR, Ki67 and LN involvement.

• 복식
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• 제53권8호
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• pp.121-135
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• 2003

The purpose of this study is to suggest a theoretical basis to name Sa(紗) and Ra(羅) remains properly by comparing and analyzing the name, usage, value, length and width of Sa(紗) and Ra(羅) recorded on documents made at the end period of Joseon. The features of Sa(紗) and Ra(羅) at the end of the Joseon Period are as follows. 1. The kinds of Sa(紗) are about 80, those of Ra(羅) are about 12, and those of Sa(紗) are significantly more than those of Ra(羅). In regard to the aspect of patterns, there were about 20 types of patterns in the case of Sa(紗), but no specific pattern for Ra(羅). 2. Some newly revealed patterns in the case of Sa (紗) are as follows. Baek -bok-mun(백복문) was a pattern full of ‘bats(박쥐[복])’, and Baek-jeop-mun(백접문) was a pattern full of ‘butterflies(나비[蝶])’ Jeop-mun(접문) was classified into ‘butterfly patterns(나비문[접문])’ and ‘traditional window flame patterns(창살문[접문])‘. 3. When considering the usages of Sa(紗) and Ra(羅), Sa(紗) was used for various detailed purposes according to their kinds and patterns, but Ra(羅) was mostly used for underwear. The most commonly used Sa(紗) was the Gab-sa type(甲紗類). On the contrary, the Go-sa type(庫紗類) was significantly less used than the Gab-sa type(甲紗類). However, it must have been of relatively high quality Sa(紗), shown by the fact that it was used for outer garments. In addition, the Gung-sa type(宮紗類) was the best quality Sa(紗), shown by the fact that it was used for court dress and official uniforms in the royal court. 4. Sa(紗) and Ra(羅) whose features have been examined we Gapsa(甲紗), Sun-in (純仁), Gosa(庫紗), Gwansa(官紗), Jusa(走紗), Eunjosa(은조사), Gwangsa(廣紗), Waesa(倭紗), Dorisa(도리사), Gong-yangsa(공양사), Rasa(羅紗), Danghangra(唐亢羅), Yanghangra(洋亢羅), Yunjura(윤주라), Eunra(銀羅), Jeohangra(저항라), Chura(秋羅). 5. Regarding the values of Sa(紗) and Ra(羅), they were high quality textures and its length and width of 1 Pil(疋), a roll of cloth, were not subdivided in detail such as in the case of plain weaved silks(平絹).

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3351-3354
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• 2015

Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. All patients with RMS regardless of their initial stage or group receive combination chemotherapy as 'standard therapy' consisting of vincristine, actinomycin-D and cyclophosphamide. Actinomycin-D was not readily available in Turkey at one time. Carboplatin was used instead in order to prevent delays in treatment. The aim of this report is to present the results of patients with rhabdomyosarcoma receiving carboplatin or actinomycin-D therapy. Materials and Methods: Twenty four patients with rhabdomyosarcoma treated between December 2000 and June 2011 were included in this retrospective study. The patients were treated according to International Rhabdomyosarcoma Study Group guidelines. Eleven patients were treated with actinomycin-D and 13 with carboplatin ($250mg/m^2/dose$ for 2 days). The two groups were then compared in terms of 2- and 5-year overall survival (OS) and hematological and non-hematological toxicities. Results: Age, sex, stage and the mean duration of follow-up were similar in both groups (p>0.05). Two- and five-year OS levels were 68.2% in the carboplatin group and 78.0% and 40.0%, respectively, in the actinomycin-D group. There was no statistical difference in the number of febrile episodes (p=0.86) and no other hematological and non-hematological adverse effects were recorded in both groups. Conclusions: The findings show that carboplatin can be used as an alternative drug in the primary treatment of rhabdomyosarcoma in the event that actinomycin-D is unavailable or not tolerated.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3459-3463
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• 2016

Background: Breast cancer is the second most common cancer in women in Cambodia, a low income country in South-East Asia. The Sihanouk Hospital Centre of Hope (SHCH) is a charity hospital set up by an international non-governmental organisation, HOPE Worldwide. In 2008, SHCH partnered with AmeriCares, a global health organisation to set up and deliver a breast cancer programme to provide education, diagnosis and treatment for women with breast cancer. The objective of this study is to characterise the presentation, diagnosis, treatment and outcomes of women treated under this program. Materials and Methods: A total of 215 women newly diagnosed with breast cancer from 1 March 2008 until 31 March 2011 were studied. Age at diagnosis, tumour size, histological type, tumour grade, ER, lymph node involvement, treatment modalities (surgery, radiotherapy, chemotherapy, hormone therapy) were recorded. Data on mortality at 3 years were obtained whenever possible. Results: The median age was 47 years old. Some 77.8% were diagnosed with stage 3 and 4 lesions, and 78.5% underwent mastectomy, of which 28.4% the intent was palliative. Of those whose ER status were known, only 48.3% were ER positive. Only 6 patients could afford chemotherapy while only 1 patient had radiotherapy. Hormone therapy was provided free for those who were ER positive. The overall survival rate at 3 years was 39.1%. Conclusions: Breast cancer presents at a late stage, and because treatment is suboptimal, survival is poor in Cambodia. A more aggressive approach to early detection and treatment needs to be developed to improve outcome from this potentially curable disease.

• 대한한의학원전학회지
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• 제26권1호
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• pp.27-38
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• 2013

Objective : This article shows that while Seishu Hanaoka(華岡靑洲) is known to have developed an effective anesthetic formula composed of traditional herbs and performed the world first partial mastectomy under a general anesthesia in 1804, anesthetic formulas very similar to those developed by him were widely recorded and deemed used in Japan and Northeast Asia before his invention. The origin of the formulas will be tracked down to compare with the several formulas broadly administered in the region. Methods : Historical literature analysis was adopted to achieve the objective. 1. Mayaku-ku (麻藥考): this book is the main medical classic by Nakagawa Syutei(中川修亭) that introduces Seishu Hanaoka, his anesthetic formulas and mastectomy. 2. Northeast medical classics: Seuideukhyobang (世醫得效方) in 1337, Uibangryuchui (醫方類聚), Uihui(宜彙) and so on. Result : Herbs such as aconitum and datura were applied as a anesthetic agent early on before the Chinese Yuan dynasty. In Korea as well, some old medical books documented such use of those herbs and relevant formulas. Conclusion : Formulas that counted as invented and employed by Seishu Hanaoka as anesthetics, in fact, had been widely known and used in the region before his era. We should pay due attention to his creativity that combined a western surgical intervention and traditional anesthetic agents and successfully performed a newly introduced surgical practice in Japan. The point is that Hanaoka took note of anesthetic herbs or formulas traditionally inherited in North-east Asian medicine and successfully applied them to the surgical procedures for breast cancer, or mastectomy and mammotomy. This history alerts us to neglected or forgotten potentials of traditional medicine in anesthetic treatment and more.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2005년도 제30회 춘계학술대회
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• pp.71-74
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• 2005

To introduce the four-dimensional computed tomography (4DCT, Light Speed RT, General Electric, USA) scanner newly installed in our department and evaluate its feasibility for gated radiotherapy. Respiratory signal measured by real-time position management (RPM$^{\circledR}$, Varian Medical, USA) was recorded in synchronization with the 4DCT scanner. 4DCT data were acquired in axial cine mode and sorted retrospective image based on respiratory phase. PTVs delineated from helical CT and 4DCT images were compared. The PTV delineated from conventional helical CT images was 2 cc larger than that from 4DCT images. Dose in PTV of the plan from retrospective CT was 99.3% (minimum=72.0%, maximum=106.5%) and that of helical CT plan was 95.2% (minimum=24.1%, maximum=106.4%) of prescribed dose. Comparing with DVHs of both plan, the coverage for 4CDT plan was 3.7% improved. It is expected that 4DCT could improve tumor control and reduce radiation toxicity for liver cancer.

• 생태와환경
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• 제33권2호통권90호
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• pp.80-108
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• 2000

본 연구는 한국 담수산 Trachelomonas 속을 대상으로 분류학적 이해에 입각한 종속지를 마련하고자 함에 그 목적이 있다. 재료는 1994년 5월부터 1997년 6월 까지 한국 전역의 58 담수계에서 총231회 채집되었다. 총 47 분류군의 분류학적 기재, 그림 및 사진을 제시하였다. 이 중 19 분류군이 한국산 Trachelomonas 종속지에 미기록으로 보고되었고, T. curta var. reticulata, T. koreana, T. planctonica var. papillosa, T. spina는 신종 또는 신 변종으로 기재한다. 따라서 한국산 Trachelomonas 종속지는 기 보고된 23분류군과 더불어 총 70 분류군으로 정리되었다. Trachelomonas 종들은 방죽이나 자연늪 등과 같이 유기물질과 영양염류가 풍부한 오래된 정체수역에서 다양하게 출현하였다. T. bacillifera, T. hispida, T. volvocina는 춘계와 하계에 자연늪이나 양어장에서 대발생하는 경항을 보였다.

• Animal Systematics, Evolution and Diversity
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• 제7권1호
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• pp.127-150
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• 1991

한국산 산호충류 중 돌산호류의 계통분류학적 연구를 하기 위하여 1969년부터 1986년까지 우리나라의 삼면연안과 도시지방(35개지역)으로부터 채집된 표본들을 동정 분류하고 지리적 분포도 고찰하였다. 그 결과 5아목 7과 15속 24종이 밝혀졌으며 이 중에서 7종은 한국 미기록종이었다. 한국산 돌산호류를 분포형으로 보면 열대형(16종, 66.7%)과 온대형(8종, 33.3%)으로만 되어있고, 해역별로 보면 제주도 해역에 16종(4온대종,12열대종)으로 가장 많은 종이 분포하였으며 황해에 3종 (2온대종, 1열대종)으로 가장 적은 종이 분포하였다. 해역간 유사계수를 근거로 보면 대한해협과 동해 사이의 유사성(0.596)이 가장 크고, 황해와 제주도해역 사이의 유사성(0)은 전혀없었다.

• 한국물환경학회지
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• 제23권1호
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• pp.87-96
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• 2007

In this paper a methodology of identifying individual pipes according to the internal and external characteristics of pipe is developed, and the methodology is applied to a case study water distribution pipe break database. Using the newly defined individual pipes the hazard rates of the cast iron 6 inch pipes are modeled by implementing the proportional hazards modeling approach for consecutive pipe failures. The covariates to be considered in the modeling procedures are selected by considering the general availability of the data and the practical applicability of the modeling results. The individual cast iron 6 inch pipes are categorized into seven ordered survival time groups according to the total number of breaks recorded in a pipe to construct distinct proportional hazard model (PHM) for each survival time group (STG). The modeling results show that all of the PHMs have the hazard rate forms of the Weibull distribution. In addition, the estimated baseline survivor functions show that the survival probabilities of the STGs generally decrease as the number of break increases. It is found that STG I has an increasing hazard rate whereas the other STGs have decreasing hazard rates. Regarding the first failure the hazard ratio of spun-rigid and spun-flex cast iron pipes to pit cast iron pipes is estimated as 1.8 and 6.3, respectively. For the second or more failures the relative effects of pipe material/joint type on failure were not conclusive. The degree of land development affected pipe failure for STGs I, II, and V, and the average hazard ratio was estimated as 1.8. The effects of length on failure decreased as more breaks occur and the population in a GRID affected the hazard rate of the first pipe failure.