• 복식
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• 제53권4호
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• pp.31-47
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• 2003

The purpose of this study was to investigate the Digital Paradigm cords depicted on the Digital Clothing by borrowing nearby fields. Therefore, it will offer not only theoretical data but also databases for product development on functional and aesthetic views even though it is not systematically set up the idea vet. The Digital Paradigm cords of Interactivity. Nonlinearity and Combination in the Digital Clothing were determined. This study found that Interactivity Paradigm cord was expressed by the interaction of clothing and computer, the techniques of built in·attach·detach·fragment of the Digital Clothing at the external indicators, and maintained this personalizing that was pursued comprehension and the shape and silhouette of the existed clothing, that Nonlinearity Paradigm cord was able to overcome the limitation of a successively approach, in other words the discontinuous moving possibilities of time and space, that Combination Paradigm cord was contained creative concept without fixed ideas through coordination of Digital Clothing that was combination. continuous creation, changes and process between heterogeneous factors. In conclusion, introduction of the new Digital Paradigm is going to accelerate on lasting development and research.

• 대한한의학방제학회지
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• 제19권2호
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• pp.1-10
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• 2011

Objectives : Since its enactment in 1987, the 56 standard prescriptions covered by insurance have remained unchanged from its original version. In this study, we tried to discover most frequently used herbal combinations by analyzing prescriptions used in actual clinical settings. Methods : We have built Structured Query Language to analyze herbal combination and progressed this analysis through analyzing the frequencies of medicinal herb combinations in medical prescription slips. Results : We have found out that traditional Korean medical doctors use about 13 herbs in a prescriptions and usually use 253 kinds of herb. And We have found out the most frequently used herbal combination. Conclusions : In this study, We can suggest new method to decide what do we need on insurance prescriptions.

• International Journal of Reliability and Applications
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• 제3권3호
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• pp.113-124
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• 2002

This paper suggests the optimal periodic preventive maintenance policies after the combination warranty is expired. After the combination warranty is expired, a repairable system undergoes PM periodically and is minimally repaired at each failure. And also the system is replaced by a new system at the N th PM. In this case, we derive the mathematical formula for the expected cost rate per unit time. The optimal number and period for the periodic PM that minimize the expected cost rate per unit time are obtained. Some numerical examples are presented for illustrate purpose.

• KIEAE Journal
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• 제16권3호
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• pp.5-12
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• 2016

Purpose: In case of existing building, A lot of attempts are being made like changing thermal system or using high efficiency products to decrease energy load and increase energy efficiency. However, (1) Absence of systemed database of green-remodeling technology and products. (2) Absence of comparative analysis system and qualitative/quantitative evaluation method of energy performance and energy reduction cost. (3) Existing remodeling was very hard to access for non-experts. So, in this paper, the authors developed data base for green-remodeling(Impact Table A, Impact Table B) and optimum combination dedication tool for user convenience. Accordingly, purpose of this paper validate usefulness of Impact Table and optimum alternative dedication tool. Method: For validate the usefulness of Impact Table and optimum combination dedication tool, the authors selected five test model office buildings. Next, through research investigation, the authors diagnosed the present state of buildings. In base of diagnosis results, select technologies for remodeling by qualitative comparison (Impact Table A). Next, evaluate quantitative price and performance technologies that selected in Impact Table A (Impact Table B). Lastly, through final evaluation of Impact Taba A and Impact Table B, determine the direction of the green-remodeling. Result: Impact Table and optimum combination dedication tool can use relative indicator for green-remodeling, especially through ROI by detail field.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6463-6468
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• 2012

Purpose: To evaluated the effect of the gambogic acid (GA), one of the effective components of Garcinia, in combination with a new multi-targeted oral medication, sunitinib (SU) on renal cancer cell proliferation in vitro and on tumor growth in vivo. Methods: After treatment with GA or SU, either alone or in combination, MTT and FACS analysis were used to examine cell viability and cycle distribution of the renal carcinoma cell lines 786-0 and Caki-1. Western blotting was employed to examine the expression of proteins related to the cell cycle and vascular formation. Furthermore, a xenograft model was applied to study the antitumor efficacy of SU or GA alone or in combination, with immunohistochemistry to detect expression of proteins related to xenograft growth and angiogenesis. Western blotting was used to examine NF-${\kappa}B$ signaling pathway elements in xenografts. Results: Treatment of 786-0 and Caki-1 cells with GA or SU resulted in decreased tumor cell proliferation, especially with joint use. Cells accumulated more strongly in the sub-G1 phase after joint treatment with GA and SU than treatment of GA and SU alone. Western blotting arrays showed 1 protein significantly upregulated, 2 proteins downregulated, and 2 proteins unchanged. Moreover, combined use of GA and SU inhibited the growth and angiogenesis of xenografts generated from Caki-1 significantly. Immunohistochemistry arrays showed downregulation of the expression of proteins promoting xenograft growth and angiogenesis, and Western blotting showed inhibition of the NF-${\kappa}B$ signaling pathway after treatment by GA alone and in combination with SU in xenografts. Conclusions: Our results show that the joint use of GA and SU can provide greater antitumor efficacy compared to either drug alone and thus may offer a new treatment strategy for renal cell carcinoma.

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 1998년도 가을 학술발표대회 논문집 디자인 학 연구
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• pp.36-37
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• 1998

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.136-142
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• 2002

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.473-481
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• 2020

Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl, including R428, may be promising therapeutic agents for several human cancers, such as breast, lung, and pancreatic cancers. Here, we examined the cell growth inhibition mediated by R428 and auranofin individually as well as in combination in the human breast cancer cell lines MCF-7 and MDA-MB-231 to identify new advanced combination treatments for human breast cancer. Our data showed that combination therapy with R428 and auranofin markedly inhibited cancer cell proliferation. Isobologram analyses of these cells indicated a clear synergism between R428 and auranofin with a combination index value of 0.73. The combination treatment promoted apoptosis as indicated by caspase 3 activation and poly (ADP-ribose) polymerase cleavage. Cancer cell migration was also significantly inhibited by this combination treatment. Moreover, we found that combination therapy significantly increased the expression level of Bax, a mitochondrial proapoptotic factor, but decreased that of the X-linked inhibitor of apoptosis protein. Furthermore, the suppression of cell viability and induction of Bax expression by the combination treatment were recovered by treatment with N-acetylcysteine. In conclusion, our data demonstrated that combined treatment with R428 and auranofin synergistically induced apoptosis in human breast cancer cells and may thus serve as a novel and valuable approach for cancer therapy.

• Communications for Statistical Applications and Methods
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• 제4권1호
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• pp.49-63
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• 1997

We consider the problem of classifying a p x 1 observation into one of two multivariate normal populations when the training smaples contain a block of missing observation. A new classification procedure is proposed which is a linear combination of two discriminant functions, one based on the complete samples and the other on the incomplete samples. The new discriminant function is easy to use.

• Animal Systematics, Evolution and Diversity
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• 제25권1호
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• pp.95-98
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• 2009

Nemoura phasianusa n. sp. is similar to Nemoura jezoensis in general morphology especially lateral view, but can be distinguished by the combination of the characters of the epiproctal shape whose apex is depressed medially, and sclerites of epiproct, which look like question marks without dots.