• 척추신경추나의학회지
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• 제8권2호
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• pp.21-29
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• 2013

Objectives : The purpose of this study is to investigate the relation between cervical spine lateroflexion and upper limb numbness after whiplash injury by traffic accident. Methods : Outpatients who visited Jaseng korean medicine hospital after traffic accident took cervical MRI. Patients who had Normal disc and bulging disc were reviewed to measure the cervical lateroflexion by C2-C7 Cobb's angle & scalenus muscle's length through neutrality AP X-ray views. For statistics, we used SPSS version 18.0 for windows. Results : Groups classified into difference of scalenus muscle's length were showen statistical significance than into cobb's angle. Means of numbness group's length difference are $4.18{\pm}2.26mm$ and that of non-numbness group is $1.59{\pm}1.17mm$. Unilateral numbness group had greater angle and longer of length's difference than non-numbness group. Conclusions : The more severe the lateroflexion of the upper extremity numbness occurs well. Group classifed into difference of scalenus muscle's length has more tendency of occurrence of upper limb numbness than that into cobb's angle. And upper limb numbness occurs more frequently at the same direction of lateroflexion.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제3권1호
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• pp.56-72
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• 1992

1986년 선행조사에서와 같은 학년 학생을 조사대상으로 하여 동일한 내용의 설문지를 동일한 조사방법을 통해 1991년에 재조사하여 아동구타 발생율의 변화를 살펴보고, 선행연구에서 얻어졌던 결과들과 후속연구결과를 비교해 보았다. 그 결과를 요약해 보면 다음과 같다. 1) 5년 전에 비해 매맞는 아동의 수가 상당히 증가된 것으로 나타났다($66.2%{\rightarrow}96.4%$), 2) 5년 전에 비해 심하게 구타당한 아동의 수, 즉 아동구타율은 거의 3배 정도 증가된 것으로 나왔다. 3) $가정{\cdot}사회{\cdot}$환경요인의 특징은 거의 대부분 5년 전의 결과와 동일하거나 유사하였다. 4) 구타양상이나 구타아동의 정신증상 및 신체증상 역시 5년 전의 결과와 동일했다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제14권1호
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• pp.103-111
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• 2003

목 적：본 연구에서는 미국에서 개발된 반 구조화된 진단적 인터뷰인 Berkeley Puppet Interview(BPI)의 유용성을 검증해 보고자 하였다. BPI는 만 4세에서 7세 사이의 아동들에 대한 진단적 도구로써 신뢰도와 타당도가 높다고 보고되고 있다. 따라서 이 연구에서는 BPI의 척도(symptomatology, marital relationship, parent-child relationship, academy & social scale) 중 임상 장면과 놀이 치료 장면에서 가장 유용하게 사용될 수 있을 것으로 생각되는 증상 척도(BPI-S)와 부모자녀 관계 척도(BPI-PC)가 아동의 문제를 진단하는 평가 도구로써 신뢰롭고 타당한지를 알아보고자 하였다. 방 법：수용 언어(Receptive language)가 부진한 아동을 제외한 만 4세에서 만 7세 아동을 대상으로 하였다. 수용 언어 능력을 평가하기 위하여 PTI의 어휘와 상식 및 이해 소검사를 실시하였으며, 토끼 손 인형을 사용하여 BPI 증상 척도와 부모 자녀 척도를 아동들에게 실시하였다. BPI-S에 대한 타당도를 평가하기 위하여, K-CBCL을 환아모에게 실시하였다. 결 과：BPI-S와 BPI-PC 모두에서 chronbach's alpha=0.74와 0.86 정도의 수준을 보여 통계적으로 신뢰로운 결과를 보였다. BPI-S의 타당도는 우울, 또래에 대한 공격성 및 ADHD 부주의형을 제외한 6개의 하위 유형에서 유의미한 결과를 보였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권1호
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• pp.64-71
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• 2016

Objectives: The objective of this study was to examine the effects of osmotic-controlled release oral delivery system methylphenidate on changes in regional cerebral blood flow (rCBF) in children with attention-deficit hyperactivity disorder (ADHD) using single photon emission computed tomography (SPECT). Methods: A total of 26 children with ADHD (21 boys, mean age: $9.2{\pm}2.05$ years old) were recruited. Each ADHD participant was examined for changes in rCBF using technetium-99m-hexamethylpropylene amine oxime brain SPECT before and after 8 weeks methylphenidate medication. Brain SPECT images of pediatric normal controls were selected retrospectively. SPECT images of ADHD children taken before medication were compared with those of pediatric normal controls and those taken after medication using statistical parametric mapping analysis on a voxel-wise basis. Results: Before methylphenidate medication, significantly decreased rCBF in the cerebellum and increased rCBF in the right precuneus, left anterior cingulate, right postcentral gyrus, right inferior parietal lobule and right precentral gyrus were observed in ADHD children compared to pediatric normal controls (p-value<.0005, uncorrected). After medication, we observed significant hypoperfusion in the left thalamus and left cerebellum compared to pediatric normal controls (p-value<.0005, uncorrected). In the comparison between before medication and after medication, there was significant hyperperfusion in the superior frontal gyrus and middle frontal gyrus and significant hypoperfusion in the right insula, right caudate, right middle frontal gyrus, left subcallosal gyrus, left claustrum, and left superior temporal gyrus after methylphenidate medication (p-value<.0005, uncorrected). Conclusion: This study supports dysfunctions of fronto-striatal structures and cerebellum in ADHD. We suggest that methylphenidate may have some effects on the frontal lobe, parietal lobe, and cerebellum in children with ADHD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.287-293
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• 2011

Objectives : The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population. Methods : Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software. Results : All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD. Conclusion : Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.253-261
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• 2011

Objectives : This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neuro-cognitive functions. Methods : Ninety-one subjects with ADHD (mean age 8.6${\pm}$2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug's effects. Results : After 0.92${\pm}$0.32mg/kg/day of MCD were administered for 57.4${\pm}$7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%). Conclusion : This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.

• 한방비만학회지
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• 제20권1호
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• pp.40-51
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• 2020

Objectives: We aimed to compare the quality of sleep, tongue diagnosis, oral microbiology differences in insomnia of Liver qi stagnation (LQS) and Non-Liver qi stagnation (NLQS). Methods: 56 patients were classified as LQS or NLSQ type insomnia through the insomnia differentiation questionnaire. The depression scores between the groups were compared through beck depression inventory (BDI), and the sleep quality was compared through Pittsburgh sleep quality index (PSQI) and Insomnia Severity Index (ISI). We analyzed the sleep efficiency, total sleep time, total awake frequency, total and average awake time through actigraph. For the tongue diagnosis, the distribution of tongue coating in six areas were measured through Winkel tongue coating index (WTCI). Linear discriminant analysis was performed to observe the differences in composition of microbial strains between the groups. Results: The scores of BDI, ISI and PSQI were significantly higher in LQS group. The total sleep time in LQS group was significantly less than that of NLQS group. Among the areas of tongue, according to the WTCI, the amount of tongue coating in zones A and C was significantly small. In oral microbial analysis, there was no significant difference between the groups at the phylum level. At the genus level, Prevotella, Veillonella, and Streptococcus were predominant in LQS group, whereas Prevotella, Neisseria, and Streptococcus in NLQS group. Conclusions: It was meaningful that insomnia was more likely in LQS group than in NLQS group, and the composition of oral microorganisms was significantly different, which could lead to the diseases caused by stress.

• 생명과학회지
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• 제16권7호
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• pp.1214-1218
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• 2006

페놀성 화합물들의 병용투여가 rat의 진정효과에 미치는 영향을 조사하였다. 천마성분으로서 positive GABAergic neuromodulation을 보이는 4-hydroxy-3-methoxybenzaldehyde와 강력한 항산화물질인 2,3-dihydroxlrbenzaldehyde를 동량 투여한 결과, pentyleneterazole에 의해 유발된 사망률이 유의하게 감소되었으며 pentobarbital에 의해 유도된 수면시간은 유의하게 연장되었으나 항불안효과와 근육이완효과는 나타나지 않았다. 이러한 결과로 보아 항경련효과를 가진 화합물과 항산화 효과를 가진 화합물을 병용투여 함으로서 경련이나 불면 등의 신경증상을 효과적으로 억제할 수 있을 것으로 사료된다.

• 보건교육건강증진학회지
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• 제26권3호
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• pp.85-96
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• 2009

Objectives: The purpose of this study was to assess input for health promoting schools (HPS), and to evaluate HPS based on WHO's guidelines through school characteristics, and to identify the schools' need among six areas of HPS. Methods: A stratified and random cluster sampling design was used to obtain a cross-sectional sample. A total of 59 elementary, middle and high schools in Seoul and Gyeonggi areas were included, and 333 teachers (males 40.6%, females 59.4%) participated in this survey. A self-reported questionnaire consisted of ten items for input for HPS, 50 items for the evaluation of HPS and three items for the schools' needs among six areas of HPS. Data was analyzed through a t-test, ANOVA, and a Duncan test. Results: The mean score of input for HPS was 48.5 ($\pm$15.3). Elementary schools had higher mean scores of input than middle schools. The mean score of schools with a management committee was higher than those schools without it. The schools which had meetings on health issues had higher mean scores. The mean score for HPS was 76.8 ($\pm$9.4): the area of "School Physical Environment" had the highest score (80.0$\pm$10.9), and the area of "Community Relationships" had the lowest score (67.1$\pm$13.9). Elementary schools had higher mean scores of HPS than middle and high schools. The schools which had less than nine classes and more than 31 classes had higher mean scores. The mean scores of schools with less than 340 students and more than 1201 students had higher. The schools which had meetings on health issues had higher mean scores. The same results were found on six areas of HPS. The teachers responded that the areas of "School Health Policy", "The School Physical Environment", and "Health Service" should be supported among the six areas of HPS. Conclusion: Based on these results, more concerns and support for school health are necessary. Middle schools should give more regard on the development of HPS. For comprehensive school health promotion, all six areas of HPS should be equally supported.

• 한방재활의학과학회지
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• 제28권4호
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• pp.51-57
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• 2018

Objectives Low back disability, along with low back pain, places a significant social burden in terms of work loss and medical expenses. Motion-Style-Acupuncture-Treatment using Traction (T-MSAT) is employed as one of the conservative treatments to such conditions. In the present study, effectiveness of Korean Medical treatments, including T-MSAT, was investigated in inpatients with low back disability and low back pain. Methods Among the patients who were admitted between January 2018 to June 2018 with disabled low back function, ones that were treated with T-MSAT were identified. Pain and function were compared at the point of admission and discharge, using Numerical Rating Scale (NRS) and Oswestry Disability Index (ODI), respectively. Results Over the hospitalization period of 34.55 days, pain intensity significantly decreased from NRS score of 6.14 to 3.26 and low back function also significantly improved from ODI score of 50.93 to 33.73 upon receiving Korean Medical treatments including T-MSAT. Conclusions Korean Medical treatments including T-MSAT were found to be effective in inpatients with low back disability with a statistical significance. To evaluate the sole effectiveness of T-MSAT, rigorous clinical trials are necessitated in future.