• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.117-123
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• 2005

본 연구의 목적은 청소년들을 대상으로 문제행동증후군과 사회능력에 있어서의 성차에 대하여 조사하는 것이다. 12세에서 17세 사이의 청소년 6570명(남 2549명, 여 4021명)의 K-YSR자료와 부모 2373명(남자 청소년 1173명, 여자 청소년 1200명)의 K-CBCL자료를 분석하였다. K-YSR분석 결과, 남자 청소년은 사회적 미성숙 척도와 비행척도에서 높은 평균 점수를 보고했고, 여자 청소년은 내재화 문제와 총행동문제증후군 척도에서 뿐만 아니라 위축, 신체 증상, 우울/불안, 공격성 척도에서도 높은 평균 점수를 보고하였다. 또한 여자 청소년들은 사회성과 총 사회능력 척도에서도 높은 점수를 보고하였다. K-CBCL에서는 부모가 남자 청소년에 대해 주의집중 문제와 비행 척도에서 높은 평균 점수를 보고하고 있는 반면, 여자 청소년에 대해서는 내재화 문제 뿐 아니라 위축, 신체 증상, 우울/불안, 공격성 척도에서 높은 평균 점수를 보고하였다. 부모의 보고인 K-CBCL의 사회능력 척도에서는 성차가 발견되지 않았다. 요약하면, K-YSR과 K-CBCL 모두에서 여자 청소년들은 내재화 문제에서 일관적으로 높은 점수를 보이고 있으며, 외현화 문제에 있어서는 유의미한 성차가 발견되지 않았다. 그러나 여자 청소년의 경우 외현화문제에 해당하는 소척도 중 공격성 척도에서 높은 평균 점수를 보였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.72-78
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• 2005

목 적 : 종합병원에서의 소아청소년을 대상으로 한 정신과 자문의 임상적 특징을 알아보고자 하였다. 방 법 : 4년 동안 한 종합병원에서 소아정신과에 의뢰된 302명의 환자의 병원기록을 조사 분석하였다. 결 과 : 학령기 아동과 청소년의 소아정신과 자문비율은 $2.15\%$였다. 중, 고등학생에서는 여자에서 더 많이 자문이 의뢰되었으나 학령전기 아동에서는 남자에서 더 많이 의뢰되었다. 자문의 $50\%$가 내과와 소아과로부터 의뢰되었다. 자문의뢰의 주된 이유는 정신과적 평가$(31.1\%)$, 우울$(11.6\%)$, 그리고 불안$(11.3\%)$이었다. 가장 자주 행해진 치료 목적의 정신과적 처치는 정신과적 교육과 지지적 정신치료였다$(21.2\%)$. 결 론 : 정신과 자문 의뢰의 임상적 양상은 성인과 소아청소년 사이에 차이가 있다. 소아 및 청소년을 위한 자문서비스를 강화시키기 위하여 더 많은 연구가 필요하다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제7권1호
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• pp.61-67
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• 1996

본 연구에서는 청소년의 자아상과 우울, 불안, 그리고 사회적 민감성간의 구조적 관계를 실증적으로 규명해보고자 하였다. 우선, 자아상이 부정적인 청소년들이 자아상이 긍정적인 청소년보다 더 우울하고 불안하며 대인 관계나 사회적 상황에서 더 예민한 반응을 보이는 지를 알아보고자 하였고, 두번째로는 낮은 자아상이 사회적 민감성에 직접적으로 영향을 미치는지 , 아니면 낮은 자아상을 가진 청소년들이 우울이나 불안감을 더욱 느끼게 되고, 그 결과 사회적 민감성이 증가되는지 그 인과적인 관계를 알아보고자 하였다. 이를 위해 중, 고등학교에 재학중인 남, 여 학생 총 1,602명 (남자 697명, 여자 905명)에게 Offer의 자아상 척도와 간이 정신진단 검사의 하위 척도중 우울, 불안, 사회적 민감성 척도를 실시한 후, 자아상이 낮은 집단과 높은 집단간의 차이를 알아본 결과, 자아상이 낮은 집단이 자아상이 높은 진단에 비해 우울.불안, 사회적 민감성 척도점수상에서 통계적으로 유의미하게 높은 점수를 보이는 것으로 나타났다. 또한 자아상과 우울, 불안, 사회적 민감성간의 구조적 관계를 LISREL로 분석한 결과, 자아상이 사회적 민감성에 직접적으로 영향을 준다기 보다는, 자아상이 낮은 청소년들은 자기 자신에 대해 우울이나 불안감을 느끼게 되고, 그로 인해 사회적 민감성이 증가되는 것으로 나타났다. 이러한 결과는 청소년들이 사회적 불안과 대인 공포를 발전시키지 않도록 하기 위해서는 무엇보다도 긍정적 자아상을 형성할 수 있도록 도움을 주는 것이 중요하다는 점을 시사해주었고. 사회 공포증 청소년 환자에 대한 치료및 예방에 있어 임상적 시사점을 가지는 것으로 논의되었다.

• 대한한의학회지
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• 제30권2호
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• pp.30-45
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• 2009

Background: The safety of herbal products is an important issue in Korea. It is more complicated because of the concomitant use of conventional western drugs and herbal medicine, including prescribed medicine, folk herbs and food supplements. Although both western and traditional Korean medical doctors have studied on the safety of HMP, their results did not show relevant or consistent conclusions because of the poor quality of studies, including bias. Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials. Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature. Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting. Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.

• 생물정신의학
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• 제12권2호
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• pp.123-135
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• 2005

Objectives:EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods:EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifact-free 2-seconds epochs and the differences were compared among three groups by two different statistical methods;F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe's multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results:In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- cantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion:These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.

• 생물정신의학
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• 제3권2호
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• pp.170-180
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• 1996

Lowered immune function in the senile dementia patients may be related to the abnormal metabolism of amyloid precursor protein(APP). To investigate the passibility of an abnormal metabolism of APP in lymphocytes and the possible role of APP in the activation of lymphocytes in senile dementia patients, immunohistochemical study of rat spleen and fluorescence activated cell sorter analysis(FACS) of human lymphocytes with the specific antigen far each lymphocyte and double fluorescent marker with antibody to APP were performed. After stimulating lymphocyte with phytohemagglutinin(PHA), APP mRNA and protein were extracted and quantitfied and the influence of ${\beta}$-amyloid protein($A{\beta}$) specific antibody on lymphocyte division was investigated. In spleen, the majority of cells showing $A{\beta}$ immunoreactivity was found in the T-sell dependent zone. FACS indicated that around 90% $CD_4(+)$ T-cells and 60% of $CD_8(+)$ T-sell were immunoreactive to $A{\beta}$ specific antibody(mAb 4G8). Northern blot analysis shows that lymphocyte APP mRNA was gradually increased to reach a maximum at 3 days after activation with lectin mitogen PHA. However, the $A{\beta}$ immunoreactivity an cell surface remained constant during stimulation with PHA, indicating that the release of APP(secreted farm of APP) might be increased. A very large increase in soluble APP secretion was observed in T-lymphocyte upon activation, but only law levels in the resting stale. Immunoblot was carried out an the protein obtained from cell lysate after stimulating lymphocyte by applying PHA to the cultured lymphocyte, and the result was that $A{\beta}$ band of immature farm under 116 KDa marker decreased as the duration of culture was increased after PHA stimulation. The monoclonal $A{\beta}$ specific(4G8) and polyclonal APP antibodies did not inhibit the [$^3H$]-thymidine uptake of mitogen-treated lymphocytes significantly, suggesting that mitogenesis can not be inhibited by specific $A{\beta}$ and polyclonal APP antibody. These results suggest that APP is expressed in T-cell and might be closely associated with the function of T-cells.

• 생물정신의학
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• 제2권1호
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• pp.3-19
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• 1995

Numerous investigators have conducted extensive investigation in the search for biological markers in psychiatric illness. There are, as a test of q biological approach to the diagnosis of the psychiatric illness, tests for the neurotransmitters, their metabolites, and related enzymes, the neurotransmitter receptors, the neuroendocrine output and response, the membrane transport, peptides and eletrolytes. They are called the biological markers, and they are helpful for the diagnosis or differential diagnosis, choice of treatment or drugs, symptom improvement, predictor of recurrence and anticipation of suicidal attempt. These studies are among the main purposes that are pursued in the neuroscience and based on the potential utility of the biological markers mentioned above. Since 1970's, lots 01 biological markers' studies for the diagnosis, differential diagnosis or subtypes differentiation have been done but varieties of different opinions have been drawn since then through they could explain the charaters of main psychiatric illness(especially schizophrenia and mood disorder). But, the search for biological markers, including displines of neuroendoclinology and neurochemistry(neurotransmitter and thair metabolite), has yielded a number of putative trait merkers and state markers for psychayric illness. This paper aims to anticipate or evaluate the good response to the therapy(Therpeutic response) with lots of markers. Acoording to the diagnosis of lots of diseases or subtypes, we are going to review the papers, mainly concern with 'Is there any Marker' or 'Is any test possible to detect the improvement clinically?' 'Is it possible to predict the recurrence or good prognsis?' or 'Is it possible to select any drug or therapy to bring the good response?' The biological tests to review are mainly the metabolites of catecholamine neurotransmitter, and especially neuroendocrine test based on the knowledge that hormons of the adenohypophysis are influenced by activity of the cerebral or limbic neurons as well as the hypothalamus ones. Among them, author introduced some clinically available tests that are DST, TRH stimulation test(TRHST), GH stimulation test, and the urine MHPG test that can give us the evaluation of the treatment response, the predictor for recurrence or choice of drug that can bring a good response. So author discussed thair potential utility in clarifying, therapeutic, and prognostic issues in psychatric illness. We hope they'll be used and look forward to more active study on the different opinion.

• 대한한방내과학회지
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• 제27권1호
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• pp.288-293
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• 2006

Background : Monoplegia is the paralysis of a limb. It is commonly caused by an injury to the cerebral cortex, and rarely caused by injury to the internal capsule, brain stem, or spinal cord. Most problems with cerebral cortex is derived from the occlusion of a brain cortex blood vessel due to thrombus or embolus. Objectives : This study is to see if there is a significance in thermal differences of acupoints in diagnosis and treatment of monoplegia on an upper extremity to test the validity of acupuncture and herbal treatment for it. Methods : By using Digital Infrared Thermographic Imaging(DITI), thermal differences$({\Delta}T)$ of acupoints on the upper extremity in a patient with monoplegia on the right upper extremity were measured after an attack of the disease. By giving Mangeum-tang(萬金湯) and treating the patient with acupuncture. the temperature changes of the upper extremity were examined through DITI and improvement was observed. Results : Compared with the left arm which suffered no such injury, the right recovered about 80% of sensation, and the grade of monoplegia improved from Grade O to Grade V. Also, the temperatures of right palmar-dorsal hand and the region of Weiguan(外關, Waiguan, TE5) were $1^{\circ}C$ and $1.45^{\circ}C$ higher than the same left region on admission day, but the thermal differences$({\Delta}T)$ narrowed to $0.5^{\circ}C$ by the last day. Conclusions : Results suggest that DITI screening is a reliable method of prognosis and that the time required for treatment can be estimated through this method in cases of monoplegia to an upper extremity. Also, progress in treatment is reflected in thermal differences of acupoints of the monoplegic upper extremity in accordance with the theory of meridian. This supports a role for acupuncture and herbal treatment for monoplegia.

• 대한한방내과학회지
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• 제41권5호
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• pp.705-716
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• 2020

Objective: Tension Type Headache is the most common primary headache, and the prevalence is highest among people in their thirties. The 2009 domestic headache epidemiological survey indicated a prevalence rate of 30.8% per year. The patients often complain of feeling "as if they are tightening their head or wearing a band." No other symptoms, such as nausea and vomiting, accompany the headache, and the physical and neurological findings are normal. Korean medicine treatment of tension type headache is mainly with acupuncture, not herbal medicine. In the present study, a patient with tension type headache was admitted to the Korean medicine hospital for treatment. We report on the patient's progress and the effects of the herbal treatment. Methods: The patient was treated with Gaegyeolseogyeong-tang, acupuncture, herbal acupuncture therapy, and physical therapy. We used the Korean Headache Impact Test-6 and Numeric Rating Scale to assess changes in tension type headache symptoms. Results: The patient was diagnosed with Qi-stagnation syndrome (氣滯證) and Ganyangsanghang-headache (肝陽上亢頭痛). The patient was hospitalized for 42 days and showed recovery from the tension type headache without any adverse events. Conclusion: Patients with tension type headache could be treated with Korean medicine.

• Molecular & Cellular Toxicology
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• 제4권2호
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• pp.106-112
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• 2008

Parkinson's disease (PD) progresses severely by a gradual loss of dopaminergic neurons in the substantia nigra (SN). Epidemiological studies showed that the incidences of PD were reduced by smoking of which the major component, nicotine might be neuroprotective. But the function of nicotine, which might suppress the incidences of PD, is still unknown. Fortunately, recently it was reported that a glial reaction and inflammatory processes might participate in a selective loss of dopaminergic neurons in the SN. The levels of tumour necrosis factor (TNF)-${\alpha}$ synthesised by astrocytes and microglia are elevated in striatum and cerebrospinal fluid (CSF) in PD. TNF-${\alpha}$ kills the cultured dopaminergic neurons through the apoptosis mechanism. TNF-${\alpha}$ release from glial cells may mediate progression of nigral degeneration in PD. Nicotine pretreatment considerably decreases microglial activation with significant reduction of TNF-${\alpha}$ mRNA expression and TNF-${\alpha}$ release induced by lipopholysaccharide (LPS) stimulation. Thus, this study was intended to explore the role of nicotine pretreatment to inhibit the expressions of TNF-${\alpha}$ mRNA in human fetal astrocytes (HFA) stimulated with IL-$1{\beta}$. The results are as follows: HFA were pretreated with 0.1, 1, and $10{\mu}g/mL$ of nicotine and then stimulated with IL-$1{\beta}$ (100 pg/mL) for 2h. The inhibitory effect of nicotine on expressions of TNF-${\alpha}$ mRNA in HFA with pretreated $0.1{\mu}g/mL$ of nicotine was first noted at 8hr, and the inhibitory effect was maximal at 12 h. The inhibitory effect at $1{\mu}g/mL$ of nicotine was inhibited maximal at 24 h. Cytotoxic effects of nicotine were noted above $10{\mu}g/mL$ of nicotine. Moreover, Nicotine at 0.1, 1 and $10{\mu}g/mL$concentrations significantly inhibited IL-$1{\beta}$-induced TF-${\kappa}B$ activation. Collectively, these results indicate that in activated HFA, nicotine may inhibit the expression of TNF-${\alpha}$ mRNA through the pathway which suppresses the NF-${\kappa}B$ activation. This study suggests that nicotine might be neuroprotective to dopaminergic neurons in the SN and reduce the incidences of PD.