• 제목/요약/키워드: neurological impairment

검색결과 126건 처리시간 0.024초

가미귀비탕을 포함한 한방치료로 회상기억이 향상된 뇌졸중 후 인지저하 환자 2례 (Two Cases of Gami-Guibitang on Cognitive Impairment after Stroke with Improved Recall Memory including Korean Medicine)

  • 김정화;이형민;신희연;김하리;양승보;조승연;박성욱;고창남;박정미
    • 대한중풍순환신경학회지
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    • 제19권1호
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    • pp.21-30
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    • 2018
  • ■ Objectives This case study is to report the two cases of Gami-Guibitang on cognitive impairment after stroke with improved recall memory. ■ Methods We used Korean medicine treatments including Gami-guibitang, acupuncture and moxibustion to treat patients who had cognitive impairment after stroke for at least two months. We observed the changes of symptoms by measuring Korean version of Mini-mental status examination (MMSE-K), Clinical Dementia Rating (CDR) and Global Detration Scale (GDS). ■ Results After treatment, the patient's symptoms were improved including MMSE-K, CDR and GDS. Improvement appeared to be prominent in recall memory. The general condition were also improved after treatment. ■ Conclusion This clinical case study suggests that Korean medicine including Gami-guibitang could be used to treat patients who had cognitive impairment after stroke especially suffering from degraded recall memory.

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급성혈전성 뇌경색환자에서 당뇨군과 비당뇨군의 기능회복도에 관한 연구 - MBI, PULSES profile을 이용하여 - (Study on the relation between Diabetes Mellitus during 4 Weeks after the Onset and the Score of ADL(Activity Daily Living) of Patients with Acute Cerebral Thrombosis)

  • 고경덕;이동원;신길조;이원철
    • 대한한의학회지
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    • 제19권2호
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    • pp.296-312
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    • 1998
  • BACKGROUND The purpose of this study was to find out predictors influencing on the clinical course of stroke during the first 4 weeks after the onset through statistical research, especially whether the blood glucose level after stroke and the stroke with Diabetes Mellitus correlate with functional impairments and neurological outcome or not. METHOD During 7 months period(from 1-1-1997 to 7-31-1997), 32 selected patients prognosed as acute cerebral thrombosis were studied by using Modified Barthel Index, PULSES profile in an attempt to correlate Diabetes Mellitus and hyperglycemia(more than $120mg/d{\ell}$, $150mg/d{\ell}$) with functional impairment and neurological outcome and to evaluate the influence of sex, the side of hemiparesis and age at admission, 1 week and 4 weeks after admision(admitted within 2 days after the onset). RESULT 1. The sex, side of hemiparesis and age had no significant effect upon functional impairment during first 4 weeks after the onset, but recurrent-stroke resulted in significantly higher degree of functional impairment than first-stroke during first 4 weeks after the onset. 2. The patients with Diabetes Mellitusin in acute cerebral thrombosis resulted in significantly higher degree of functional impairment than the patients without Diabetes Mellitus in acute cerebral thrombosis during first 4 weeks after the onset. 3. The patients with hyperglycemia in acute cerebral thrombosis resulted in significantly more severe neurological outcome than the patients without hyperglycemia in acute cerebral thrombosis within 2 days after the onset. CONCLUSION The study suggested that recurrent-stroke and Diabetes Mellitus were the poorer prognosis factors of functional impairment in acute cerebral thrombosis patients during first 4 weeks after the onset. and the poorer prognosis factor of neurological outcome in acute cerebral thrombosis patients was hyperglycemia within 2 days after the onset.

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소아 위식도 역류 질환의 외과적 치료 (Surgical Management of Gastroesophageal Reflux Disease)

  • 김성철;김대연;김경모;김인구
    • Advances in pediatric surgery
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    • 제6권2호
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    • pp.100-105
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    • 2000
  • Eleven children with gastroesophageal reflux disease underwent fundoplication. Eight had neurological impairment, two had hiatal hernias and one had a history of esophageal repair for esophageal atresia. The most common and significant symptom was vomiting(81.8 %), followed by recurrent respiratory infections(72.7 %) and failure to thrive(72.7 %). The most common diagnostic tool was 24 hour esophageal pH study, which showed pH less than 4 for more than 10 % of the total recorded time in 6 of 9 patients. Nissen fundoplication was performed in 10 patients. Thal fundoplication was carried out in one patient with esophageal atresia. Stamm gastrostomy was added for nutritional and/or swallowing problem in all 8 patients with neurological impairment. The median follow up period was 13 months. There was one late death of unrelated cause and one recurrence. The quality of life after antireflux surgery was greatly improved. Antireflux surgery should be done if indicated, and a simultaneous gastrostomy considered in a patient with neurological impairment.

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대뇌반구의 병변과 동측에 반신마비 발생한 중풍 환자의 1례 (A Case Report of a patient with hemiplegia ipsilateral to affected cerebral hemisphere)

  • 조승연;곽자영;홍진우;나병조;박성욱;정우상;문상관;박정미;고창남
    • 대한중풍순환신경학회지
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    • 제8권1호
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    • pp.48-57
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    • 2007
  • Stroke is a disease which results in impairment of body functions and affects everyday life. The ability of cerebral neurons to become reorganized and restore function after damage is called plasticity. Motor impairment typically appears contralateral to the affected cerebral hemisphere in patients with cerebral lesions. The authors report a case of a patient with hemiplegia ipsilateral to affected cerebral hemisphere, along with its conjectured mechanism.

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신경독성물질에 의한 신경계장애 조기발견을 위한 색각검사의 활용가능성 (Usefulness of Color Vision Test for Early Detection of Neurological Damages by Neurotoxic Substances)

  • 이은희;최경호;채홍재;백도명
    • Journal of Preventive Medicine and Public Health
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    • 제41권6호
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    • pp.397-406
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    • 2008
  • This paper reviews the published literature that is concerned with color vision impairment from industrial and environmental exposure to neurotoxic substances, and we evaluated whether testing for color vision impairment could be an affordable procedure for assessing these neurotoxic effects. In general, most cases of congenital color vision impairment are red-green, and blue-yellow impairment is extremely rare. However, most of the acquired color vision impairment that is related to age, alcohol or environmental factors is blue-yellow impairment. Therefore, many studies have been performed to identify this relationship between exposure to neurotoxic substances, such as organic solvents and heavy metals, and the prevalence of blue-yellow color vision impairment. The test for color vision impairment is known to be very sensitive to the early signs of nervous system dysfunction and this can be useful for making the early diagnosis of neurotoxic effects from exposure to very low concentrations of toxic substances.

Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation

  • Kim, Buyun;Yun, Jangmi;Park, Byoungduck
    • Biomolecules & Therapeutics
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    • 제28권5호
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    • pp.381-388
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    • 2020
  • Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to drug addiction and causes serious health complications, including attention deficit, memory loss and cognitive decline. These neurological complications are strongly associated with METH-induced neurotoxicity and neuroinflammation, which leads to neuronal cell death. The current review investigates the molecular mechanisms underlying METH-mediated neuronal damages. Our analysis demonstrates that the process of neuronal impairment by METH is closely related to oxidative stress, transcription factor activation, DNA damage, excitatory toxicity and various apoptosis pathways. Thus, we reach the conclusion here that METH-induced neuronal damages are attributed to the neurotoxic and neuroinflammatory effect of the drug. This review provides an insight into the mechanisms of METH addiction and contributes to the discovery of therapeutic targets on neurological impairment by METH abuse.

뇌동맥류 파열 환자의 수술후 인지기능과 기억력장애에 관한 연구 (Cognition and Memory Impairment after Operation in Ruptured Cerebral Aneurysm Patients)

  • 김병주;최창화;김대진
    • Journal of Korean Neurosurgical Society
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    • 제30권7호
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    • pp.842-848
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    • 2001
  • Objectives : The mortality rate of subarachnoid hemorrhage(SAH) has been reduced recently due to refinement of microsurgical technique and improved perioperative management. Also, many survivors of SAH show excellent neurological recoveries. However, we found that a high proportion of the survivors do not fully regain their premorbid status in cognitive and memory function. Object of this study is to evaluate which factors might influence on cognitive and memory impairment in ruptured aneurysmal SAH patients. Methods : In this prospective study, a series of 66 patients with aneurysmal subarachnoid hemorrhage(SAH) from 1996 to 1998, most of whom had a "good" or "fair" neurological outcome, were assessed with various tests of cognition and memory function. All patients underwent clipping operation by pterional approach. Right side approach was performed in 16 case and left 21 cases. K-WAIS(Korean-Wechsler Adult Intelligence Scale) was used as method of cognition and memory function test. The time interval between SAH and assessment varied between 4 months and 8 months, averaging 6.2 months. Statistical analyses were carried out for each test score to see whether aneurysm site(A-com : non A-com), route of approach, age and sex, vasospasm, Hunt-Hess grade and Fisher CT group at admission, Glasgow Outcome Scale(GOS) at discharge affect cognitive and memory function. Results : Aneurysm site was not shown to be associated with performance on any test, and the initial grade (Hunt-Hess grade, Fisher CT group) of SAH and vasospasm had only minimal predictive values. The grade at discharge( GOS) was proved to be the best predictor of impairment of cognition and memory function within 1 year after operation. Conclusion : The authors conclude that the diffuse effects of SAH are more important than focal neuropathology in relation to cognitive impairment in this group of patients.

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신경학적 손상에 의한 언어장애인 음성 인식률 개선(H/W, S/W)에 관한 연구 (A Study on Improving Speech Recognition Rate (H/W, S/W) of Speech Impairment by Neurological Injury)

  • 이형근;김순협;양기웅
    • 한국정보통신학회논문지
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    • 제23권11호
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    • pp.1397-1406
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    • 2019
  • 신경학적 손상에 의한 언어장애인/비장애인 간의 일상적인 휴대폰 통화시 신경학적 손상으로 인한 발음의 정확도와 언어장애인의 발음 특징이 결합되어 원활한 의사소통을 저해하는 경우가 많다. 이러한 문제점을 개선하기 위하여 제한하는 방법은 언어장애인 특성에 맞춘 단어의 모호성(out of vocabulary) 개선과, 언어 장애인 구강 특성에 따른 어려운 발성 부분을 인위적으로 보정해주는 유도선이 포함된 MEMS(Micro Electro-mechanical System) Microphone 장치 개선이다. S/W적 개선은 도치기능이 포함된 결정트리이며, 연속어 특성을 감안하여 개선된 matrix-vector rnn 방법을 제시하였다. H/W와 S/W 특성을 감안하여 유사 사전을 만들어 원활한 의사소통을 위한 말명료도 향상에 기여하였다.

Does a cognitive-exercise combined dual-task training have better clinical outcomes for the elderly people with mild cognitive impairment than a single-task training?

  • 박진혁
    • 재활치료과학
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    • 제6권2호
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    • pp.71-83
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    • 2017
  • Objective: This study was to develop and verify the effects of the exercise-cognitive combined dual-task training program on cognitive function and depression of the elderly with mild cognitive impairment(MCI). Methods: The subjects were randomly assigned to the exercise-cognitive combined dual-task training group(n=32) or single-task training group(n=31). To identify the effects on cognitive function, general cognitive function, frontal lobe function, and attention/working memory were measured. Depression was evaluated using Korean version of Geriatric Depression Scale. The outcome measurements were performed before and after the 8 weeks of intervention(2 days per week). Results: After 8 weeks, general cognitive function, frontal cognitive function, attention/working memory function, depression of the dual-task training group were significantly increased than those of the single-task training group(p<0.05). Conclusion: The results indicated that an exercise-cognitive combined dual-task training for MCI was effective in improving general cognitive function, frontal /executive function, attention/working memory function and reducing depression.

경도인지장애 환자의 수단적 일상생활활동에 대한 고찰 (Review of the instrumental ADL for the Patients With Mild Cognitive Impairment)

  • 안시내
    • 재활치료과학
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    • 제2권2호
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    • pp.37-45
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    • 2013
  • 본 연구는 최근 많은 관심이 되고 있는 경도인지장애 환자의 특징과 수단적 일상생활활동에 대해 알아봄으로써 임상가들에게 작업치료에서 경도인지장애환자를 평가 및 치료하는데 도움이 되고자 하였다. 현재 치매환자를 위한 작업치료는 매우 활발하게 이루어지고 있으나 치매로 전환될 위험이 높은 경도인지장애 환자에 대하여 작업치료적 접근은 아직 이루어지지 않고 있다. 본 고찰에서는 정상노인과 감별하기 어려운 경도인지장애 환자의 작업영역 중 수단적 일상생활활동에 대해 초점을 맞추어야 한다는 근거들을 다루었으며, 경도인지장애 환자가 치매로 발전하는 것을 예방하기 위해서는 수단적 일상생활활동에 대한 고려가 필수적으로 이루어져야 함을 고찰하였다. 결론적으로, 치매로 발전 될 가능성이 높은 위험 집단인 경도인지장애 환자군의 작업영역을 고려한 수단적 일상생활활동에 대한 주기적인 평가와 그에 따른 작업치료적 개입이 필요할 것으로 보인다.