• Tunnel and Underground Space
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• v.15 no.2 s.55
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• pp.119-128
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• 2005

Although the evaluation of the mechanical properties and behavior of jointed rock masses is very important for the design of tunnel and underground openings, it has always been considered the most difficult problem. One of the difficulties in describing the rock mass behavior is the selection of the appropriate constitutive model. This limitation may be overcome with the progress in discrete element software such as PFC, which does not need the user to prescribe a constitutive model for rock mass. In this paper, a 30\;m\;\times\;30\;m\;\times\;30\;m m jointed rock mass of road tunnel site was analyzed. h discrete fracture network was developed from the joint geometry obtained from core logging and surface survey. Using the discontinuities geometry from the DFN model, PFC simulations were carried out, starting with the intact rock and systematically adding the joints and the stress-strain response was recorded for each case. With the stress-strain response curves, the mechanical properties of jointed rock masses were determined. As expected, the presence of joints had a pronounced effect on mechanical properties of the rock mass. More importantly, getting the mechanical response of the PFC model doesn't require a user specified constitutive model.

• Tunnel and Underground Space
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• v.17 no.2 s.67
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• pp.109-118
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• 2007

The excavation damaged zone (EDZ) is an area around an excavation where in situ rock mass properties, stress condition. displacement. groundwater flow conditions have been altered due to the excavation. Various studies have been carried out on EDZ, but most studies have been focused on the mechanical bahavior of EDZ by in situ experiment. Even though the EDZ could potentially form a high permeable pathway of groundwater flow, only a few studies were performed on the analysis of groundwater flow in EDZ. In this study, the' hydraulic EDZ' was defined as the rock Lone adjacent to the excavation where the hydraulic aperture has been changed due to the excavation. And hydraulic EDZ (hydraulic aperture changed zone) estimated by two-dimensional DEM program was considered in three-dimensional DFN model. From this approach the groundwater flow characteristics corresponding to hydraulic aperture change were examined. Together. a parametric study was performed to examine the boundary conditions that frequently used in DFN analysis such as constant head or constant flux condition. According to the numerical analysis, hydraulic aperture change induced by the hydraulic-mechanical interaction becomes one of the most important factors Influencing the hydraulic behavior of jointed rock masses. And also from this study, we suggest the proper boundary condition in three-dimensional DFN model.

• Journal of Wetlands Research
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• v.15 no.3
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• pp.413-422
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• 2013

In recent, the rainfall is showing different properties in space and time but the ground rain gauge only can observe rainfall at a point. This means the ground rain gauge has the limitations in spatial and temporal resolutions to measure rainfall and so there is a need to utilize radar rainfall which can consider spatial distribution of rainfall This study tried to apply radar rainfall for runoff simulation on an urban drainage system. The study area is Guro-gu, Seoul and we divided study area into subbasins based on rain gauge network of AWS(Automatic Weather station). Then the radar rainfalls were adjusted using rainfall data of rain gauge stations the areal rainfalls were obtained. The runoffs were simulated by using XP-SWMM model in subbasins of an urban drainage system. As the results, the adjusted radar rainfalls were underestimated in the range of 60 to 95% of rain gauge rainfalls and so the simulated runoffs from the adjusted radar and gauge rainfalls also showed the differences. The runoff peak time from radar rainfall was occurred more fast than that from gauge rainfall.

• Journal of Veterinary Clinics
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• v.24 no.3
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• pp.406-409
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• 2007

A 12-year-old female mixed Chihuahua dog was referred because of acute blindness and progressive tetraparesis. Mutifocal lesions in the cerebrum were noted on brain magnetic resonance images and cerebrospinal fluid analysis showed monocytic pleocytosis. Based on these results, granulomatous meningoencephalitis (GME) was strongly suspected. Cerebral lesions were definitely diagnosed as GME based on histopathological findings and positive results of immunohistological stains of brain with T-cell marker (CD3). This report describes the clinical findings, diagnostic imaging characteristics, and immunohistopathologic features of GME in an old dog. In addition, this case demonstrates that clinical signs of GME were mediated by perivascular infiltration of T lymphocytes and identification of causes in T cell-mediated inflammation should be further studied.

• Journal of Oriental Neuropsychiatry
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• v.22 no.3
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• pp.101-113
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• 2011

Objectives : Trend of R&D of herbal medicine for dementia treatment was examined based on the quantitative information analysis for establishing the national strategy of research on dementia treatment with oriental medicine. Methods : Definition was made to clarify the technology for development of herbal medicine for dementia treatment. Based on the initial keyword provided by experts in the field, queries were compounded to conduct search in the search engines of WoS and DWPI. The raw data (papers or patents) extracted from the initial search were examined by expert-review before objects of analysis were determined. Then, the accumulated data was analyzed in terms of year, country and organization, which led to examination of the trend of R&D. And the research performance evaluation for dementia treatment technologies was also made in terms of country, organization and researcher based on the forward citation analysis. The international cooperation intensity was examined on the basis of analysis of network by researcher before analysis results were put together to select lead researchers. Results : According to the quantitative information analysis of 1,330 articles that were selected as analysis objects, the number of papers on natural products research for dementia treatment has increased by around 4.6 times in recent five years. This indicates that the intensive studies have been underway recently. It was found to be the US that had the highest level in research filed of herbal medicine for dementia treatment and the highest capacity of international cooperation for that purpose. On the contrary, Korea had the share of papers at 5.1%, the number of countries in cooperation research at 8, and the article quality index at 0.40, showing that the qualitative level was insufficient, compared to the quantitative outcome. In particular, Korea was found to have no intensity of international cooperation among researchers. In case of patent, the results of information analysis of 305 patents selected as analysis objects demonstrated that China had the highest share while Korea had the very low frequency of patent application quantitatively. Conclusions : In this study, the research to develop herbal medicine for dementia treatment has recently drawn much attention that has spread around the globe. Therefore, these results suggest establishing the strategy to develop technology for dementia treatment with oriental medicine in the future based on quantitative information analysis.

• Molecules and Cells
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• v.26 no.4
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• pp.338-343
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• 2008

An embryonic stem cell is a powerful tool for investigation of early development in vitro. The study of embryonic stem cell mediated neuronal differentiation allows for improved understanding of the mechanisms involved in embryonic neuronal development. We investigated expression profile changes using time course cDNA microarray to identify clues for the signaling network of neuronal differentiation. For the short time course microarray data, pattern analysis based on the quadratic regression method is an effective approach for identification and classification of a variety of expressed genes that have biological relevance. We studied the expression patterns, at each of 5 stages, after neuronal induction at the mRNA level of embryonic stem cells using the quadratic regression method for pattern analysis. As a result, a total of 316 genes (3.1%) including 166 (1.7%) informative genes in 8 possible expression patterns were identified by pattern analysis. Among the selected genes associated with neurological system, all three genes showing linearly increasing pattern over time, and one gene showing decreasing pattern over time, were verified by RT-PCR. Therefore, an increase in gene expression over time, in a linear pattern, may be associated with embryonic development. The genes: Tcfap2c, Ttr, Wnt3a, Btg2 and Foxk1 detected by pattern analysis, and verified by RT-PCR simultaneously, may be candidate markers associated with the development of the nervous system. Our study shows that pattern analysis, using the quadratic regression method, is very useful for investigation of time course cDNA microarray data. The pattern analysis used in this study has biological significance for the study of embryonic stem cells.

• Molecules and Cells
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• v.37 no.1
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• pp.74-80
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• 2014

The peroxisome is an intracellular organelle that responds dynamically to environmental changes. Various model organisms have been used to study the roles of peroxisomal proteins in maintaining cellular homeostasis. By taking advantage of the zebrafish model whose early stage of embryogenesis is dependent on yolk components, we examined the developmental roles of the D-bifunctional protein (Dbp), an essential enzyme in the peroxisomal ${\beta}$-oxidation. The knockdown of dbp in zebrafish phenocopied clinical manifestations of its deficiency in human, including defective craniofacial morphogenesis, growth retardation, and abnormal neuronal development. Overexpression of murine Dbp rescued the morphological phenotypes induced by dbp knockdown, indicative of conserved roles of Dbp during zebrafish and mammalian development. Knockdown of dbp impaired normal development of blood, blood vessels, and most strikingly, endoderm-derived organs including the liver and pancreas - a phenotype not reported elsewhere in connection with peroxisome dysfunction. Taken together, our results demonstrate for the first time that zebrafish might be a useful model animal to study the role of peroxisomes during vertebrate development.

• Information Systems Review
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• v.5 no.2
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• pp.241-256
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• 2003

This empirical study is to explain critical success factors for building effective regional IT cluster from the literature reviews which have some limitations, and is to suggest new key factors from the views of Regional Innovation System and Sectoral Systems of Innovation. For building successful cluster, the new key factors not only stress on regional networks, the spill-over of tacit knowledge through learning by interacting, institutions which contain regional custom, norms, established practices, culture, and characteristics from the Regional Innovation System, but also emphasize on heterogeneous agents who are interacting by each others from Sectoral Systems of Innovation. From these factors we suggest some strategies for building effective "Daegu IT Cluster" as following; making characterized IT brands which are selected and concentrated based on regional and IT sectoral characteristics, strengthening learning competence of tacit knowledge built in multiple heterogeneous agents network, establishing strong agent networks which are composed of universities, companies, institutes and government, and sharing the institution of mind-opening culture in order to correspond with environmental changes and link to other industrial clusters. By putting above strategies in force, the compatabilities of Daegu region are reinforced. Tacit knowledges spill over and the regional innovation competence are accumulated. Also IT cluster plays core role of employment in Daegu for long term. Especially, "Daegu IT Cluster" changes city's image from medium and small manufacturing city to new industrial city based on high technologies.

• Applied Chemistry for Engineering
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• v.16 no.6
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• pp.809-814
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• 2005

In this work, the thermal properties of epoxy coating system on the liner plate in the containment structure of nuclear power plants had been examined by irradiation and design basis accident (DBA) conditions. The effect of immersion in hot water on adhesion strength of the coating system had been also studied. The glass transition temperature ($T_g$) and thermal stability of ET-5290/carbon steel A 32 epoxy coating systems were measured by DSC and TGA analyses, respectively. Contact angle measurements were used to determine the effect of immersion on the surface energetics of epoxy coating system, with a viewpoint of surface free energy. Adhesion tests were also executed to evaluate the adhesion strength at interfaces between carbon steel plate and epoxy resins. As a result, it was found that the irradiation led to an improvement of internal crosslinked structure in cured epoxy systems, resulting in significantly increasing the thermal stability, as well as the $T_g$. Also, the immersion in hot water made a role in the post-curing of epoxy resins and increased the mechanical interlocking of the network system, resulting in increasing the adhesion strength of the epoxy coating system.

• Journal of Internet Computing and Services
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• v.10 no.2
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• pp.1-13
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• 2009

Intrusion detection is a process that identifies the attacks and responds to the malicious intrusion actions for the protection of the computer and the network resources. Due to the fast development of the Internet, the types of intrusions become more complex recently and need immediate and correct responses because the frequent occurrences of a new intrusion type rise rapidly. Therefore, to solve these problems of the intrusion detection systems, we propose a sequential pattern miner for analysis of the alert data in order to support intelligent and automatic detection of the intrusion. Sequential pattern mining is one of the methods to find the patterns among the extracted items that are frequent in the fixed sequences. We apply the prefixSpan algorithm to find out the alert sequences. This method can be used to predict the actions of the sequential patterns and to create the rules of the intrusions. In this paper, we propose an extended prefixSpan algorithm which is designed to consider the specific characteristics of the alert data. The extended sequential pattern miner will be used as a part of alert data analyzer of intrusion detection systems. By using the created rules from the sequential pattern miner, the HA(high-level alert analyzer) of PEP(policy enforcement point), usually called IDS, performs the prediction of the sequence behaviors and changing patterns that were not visibly checked.