• Genomics & Informatics
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• v.18 no.4
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• pp.39.1-39.8
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• 2020

Alzheimer's disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals' memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated the hub genes of AD. Proteins interact with other proteins and non-protein molecules, and these interactions play an important role in understanding protein function. Computational methods are useful for understanding biological problems, in particular, network analyses of protein-protein interactions. Through a protein network analysis, we identified the following top 10 hub genes associated with AD: PTGER3, C3AR1, NPY, ADCY2, CXCL12, CCR5, MTNR1A, CNR2, GRM2, and CXCL8. Through gene enrichment, it was identified that most gene functions could be classified as integral to the plasma membrane, G-protein coupled receptor activity, and cell communication under gene ontology, as well as involvement in signal transduction pathways. Based on the convergent functional genomics ranking, the prioritized genes were NPY, CXCL12, CCR5, and CNR2.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.2060-2077
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• 2019

Recently, mobile healthcare services have attracted significant attention because of the emerging development and supply of diverse wearable devices. Smartwatches and health bands are the most common type of mobile-based wearable devices and their market size is increasing considerably. However, simple value comparisons based on accumulated data have revealed certain problems, such as the standardized nature of health management and the lack of personalized health management service models. The convergence of information technology (IT) and biotechnology (BT) has shifted the medical paradigm from continuous health management and disease prevention to the development of a system that can be used to provide ground-based medical services regardless of the user's location. Moreover, the IT-BT convergence has necessitated the development of lifestyle improvement models and services that utilize big data analysis and machine learning to provide mobile healthcare-based personal health management and disease prevention information. Users' health data, which are specific as they change over time, are collected by different means according to the users' lifestyle and surrounding circumstances. In this paper, we propose a prediction model of user physical activity that uses data characteristics-based long short-term memory (DC-LSTM) recurrent neural networks (RNNs). To provide personalized services, the characteristics and surrounding circumstances of data collectable from mobile host devices were considered in the selection of variables for the model. The data characteristics considered were ease of collection, which represents whether or not variables are collectable, and frequency of occurrence, which represents whether or not changes made to input values constitute significant variables in terms of activity. The variables selected for providing personalized services were activity, weather, temperature, mean daily temperature, humidity, UV, fine dust, asthma and lung disease probability index, skin disease probability index, cadence, travel distance, mean heart rate, and sleep hours. The selected variables were classified according to the data characteristics. To predict activity, an LSTM RNN was built that uses the classified variables as input data and learns the dynamic characteristics of time series data. LSTM RNNs resolve the vanishing gradient problem that occurs in existing RNNs. They are classified into three different types according to data characteristics and constructed through connections among the LSTMs. The constructed neural network learns training data and predicts user activity. To evaluate the proposed model, the root mean square error (RMSE) was used in the performance evaluation of the user physical activity prediction method for which an autoregressive integrated moving average (ARIMA) model, a convolutional neural network (CNN), and an RNN were used. The results show that the proposed DC-LSTM RNN method yields an excellent mean RMSE value of 0.616. The proposed method is used for predicting significant activity considering the surrounding circumstances and user status utilizing the existing standardized activity prediction services. It can also be used to predict user physical activity and provide personalized healthcare based on the data collectable from mobile host devices.

• Journal of Korean Society of Transportation
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• v.6 no.2
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• pp.7-20
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• 1988

Recent developments in combining transportation planning models and input-output approaches, together with inclusion of intensity of land uses, have made it possible to construct realistic comprehensive urban and regional activity models. These modes form the basis for a rigorous approach to studying the interactions among urban activities. However, efficient computational solution methods for implementing such comprehensive models are still not available. In this paper an efficient solution method for the urban activity model is developed by combining Evans' partial linearization technique with Powell's hybrid method. The solution algorithm is applied to a small but realistic urban area with a detailed transportation network.

• International Journal of Computer Science & Network Security
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• v.24 no.5
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• pp.111-118
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• 2024

In general network-based intrusion detection system is designed to detect malicious behavior directed at a network or its resources. The key goal of this paper is to look at network data and identify whether it is normal traffic data or anomaly traffic data specifically for accounting information systems. In today's world, there are a variety of principles for detecting various forms of network-based intrusion. In this paper, we are using supervised machine learning techniques. Classification models are used to train and validate data. Using these algorithms we are training the system using a training dataset then we use this trained system to detect intrusion from the testing dataset. In our proposed method, we will detect whether the network data is normal or an anomaly. Using this method we can avoid unauthorized activity on the network and systems under that network. The Decision Tree and K-Nearest Neighbor are applied to the proposed model to classify abnormal to normal behaviors of network traffic data. In addition to that, Logistic Regression Classifier and Support Vector Classification algorithms are used in our model to support proposed concepts. Furthermore, a feature selection method is used to collect valuable information from the dataset to enhance the efficiency of the proposed approach. Random Forest machine learning algorithm is used, which assists the system to identify crucial aspects and focus on them rather than all the features them. The experimental findings revealed that the suggested method for network intrusion detection has a neglected false alarm rate, with the accuracy of the result expected to be between 95% and 100%. As a result of the high precision rate, this concept can be used to detect network data intrusion and prevent vulnerabilities on the network.

• Korean Institute of Interior Design Journal
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• v.15 no.1 s.54
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• pp.20-29
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• 2006

The concept of a 'place' in contemporary cities has been fundamentally challenged by the social, economical changes as well as the global digital network. The complex and multi-layered contemporary everyday life blur the boundaries of the existing architectural programs. In contemporary architecture, various proposals have attempted to overcome the physical limitations. 'Activity Diagram' is one of them. Activity diagram is a diagrammatized design process In which the given program is analyzed into individual activities, then it is re-organized and finally spatialized based on the analysis. In many projects by Manuel Gausa, Ben Van Berkel and Vicente Guallart, the activity diagram is applied in various forms and they are explained with theoretical backgrounds. Based on how the given program is re-organized into assembly of activities and how diagram is applied, five analytical elements were selected to critically analyze three chosen architects' case projects. In this study, it is found that architects attempt to construct an open networked world where diverse activities are freely interconnected in spite of some fundamental limitations of activity diagrams.

• IMMUNE NETWORK
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• v.14 no.4
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• pp.201-206
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• 2014

IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.

• Journal of Information Technology Services
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• v.10 no.4
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• pp.33-46
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• 2011

This research focus on the economic activity as consumer and producer traits of future customers in the convergence age. We assess level of convergence for digital devices and services respectively by questionnaire survey and interview for 14 professions. And then, for evaluating convergence level and usage of digital services of each respondents, we conducted the questionnaire survey for 343 samples. Findings of our research hold that the group who showed higher level of convergence tends to use the socialized digital services more. Convergence generation were heavy users in appstore on smart-phone and wireless game and more participating. In digital service area, facebook/cyworld, twitter, UCC, portal, internet community in digital service. Convergence generation are global network communication, buying decision making activity, actively opinion expression, prosumer attitude, dependency on digital device, experience based purchase behavior, enthusiastic information sharing.

• Journal of the Korean Chemical Society
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• v.59 no.6
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• pp.483-487
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• 2015

The different calculated quantum chemical descriptors by DFT method were used for prediction of some sulphanilamide Schiff bases inhibitor activity as a binding constant (log K). Multiple linear regression (MLR) and artificial neural network (ANN) were employed for developing the useful quantitative structure activity relationship (QSAR) model. The obtained results presented superiority of ANN model over the MLR one. The offering QSAR model is very easy to computation and Physico-Chemically interpretable. Sensitivity analysis was used to determine the relative importance of each descriptor in ANN model. The order of importance of each descriptor according to this analysis is: molecular volume, molecular weight and dipole moment, respectively. These descriptors appear good information related to different structure of sulphanilamide Schiff bases can participate in their inhibitor activity.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.05a
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• pp.542-544
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• 2019

Changes in a person's health affect one's lifestyle and work activities. According to the World Health Organization (WHO), abnormal activity is growing faster in people aged 60 or more than any other age group in almost every country. This trend steadily continues and expected to increase further in the near future. Abnormal activity put these people at high risk of expected incidents since most of these people live alone. Human abnormal activity analysis is a challenging, useful and interesting problem among the researchers and its particularly crucial task in life and health care areas. In this paper, we discuss the problem of abnormal activities of old people lives alone at home. We propose Convolutional Neural Network (CNN) based model to detect the abnormal behaviors of elderlies by utilizing six simulated action data from daily life actions.

• IMMUNE NETWORK
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• v.20 no.6
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• pp.47.1-47.13
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• 2020

Tetracyclines, which have long been used as broad-spectrum antibiotics, also exhibit a variety of nonantibiotic activities including anti-inflammatory and immunomodulatory properties. Tetracyclines bind to the 30S ribosome of the bacteria and inhibit protein synthesis. Unlike antimicrobial activity, the primary molecular target for the nonantibiotic activity of tetracycline remains to be clarified. Nonetheless, the therapeutic efficacies of tetracyclines, particularly minocycline and doxycycline, have been demonstrated in various animal models of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and asthma. In this study, we summarized the anti-inflammatory and immunomodulatory activities of tetracyclines, focusing on the mechanisms underlying these activities. In addition, we highlighted the on-going or completed clinical trials with reported outcomes.