• BMB Reports
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• v.39 no.4
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• pp.339-345
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• 2006

The blood-neural barrier (BNB), including blood-brain barrier (BBB) and blood-retinal barrier (BRB), is an endothelial barrier constructed by an extensive network of endothelial cells, astrocytes and neurons to form functional 'neurovascular units', which has an important role in maintaining a precisely regulated microenvironment for reliable neuronal activity. Although failure of the BNB may be a precipitating event or a consequence, the breakdown of BNB is closely related with the development and progression of CNS diseases. Therefore, BNB is most essential in the regulation of microenvironment of the CNS. The BNB is a selective diffusion barrier characterized by tight junctions between endothelial cells, lack of fenestrations, and specific BNB transporters. The BNB have been shown to be astrocyte dependent, for it is formed by the CNS capillary endothelial cells, surrounded by astrocytic end-foot processes. Given the anatomical associations with endothelial cells, it could be supposed that astrocytes play a role in the development, maintenance, and breakdown of the BNB. Therefore, astrocytes-endothelial cells interaction influences the BNB in both physiological and pathological conditions. If we better understand mutual interactions between astrocytes and endothelial cells, in the near future, we could provide a critical solution to the BNB problems and create new opportunities for future success of treating CNS diseases. Here, we focused astrocyte-endothelial cell interaction in the formation and function of the BNB.

• The Journal of the Korea Contents Association
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• v.20 no.8
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• pp.513-521
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• 2020

Launched in August, 2016, the online public benefit project ANT FOREST has planted more than one hundred million trees in desertification areas and is currently continuing on with its activities. It is a fruit of online communications network development, and the public benefit project based on this puts more emphasis on the spirits of public interest rather than the investments of public services, unlike traditional public benefit activities. Hence the purpose of this study is to figure out the interaction between the users supporting the online public benefit and the public benefit progress online. The study was divided into 4 stages in order to find out the interaction, key factors for users to continue to support online public interest. First, preceeding studies on online public benefit will be reviewed to understand the characteristics of online public benefit. Second, determine the public benefit nature of ANT FOREST and investigate the project progress. Third, review the usage rate of ANT FOREST and categorize the properties of users. Fourth, interview was conducted to direct the interaction between the online public benefit project and the user. In conclusion, the online public benefit project completes the public benefit process through the user, the operator, and the supporter, the important factor connecting the energy connecting the process in cyber space and the public benefit activity in reality is the sense of participation, and the user continues the public benefit project through this sense of participation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.627-635
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• 2017

Modern warfare is gradually changing into a network war, and information electronic warfare is also progressing. In modern war, electronic warfare is all military activity concerned with electromagnetic field use, such as signal collecting, communication monitoring, information analysis, and electronic attack. The one key function of signal collecting for enemy signal analysis, direction finding, collects the signal radiated from enemy area and then calculates the enemy direction. This paper examined the Watson-Watt algorithm for an amplitude direction finding system and CVDF algorithm for phase direction finding system and analyzed the difference in the direction finding accuracy between in the clean electromagnetic field environment and in the real operating field environment of electronic warfare system. In the real field, the direction finding accuracy was affected by the reflected field from the surrounding obstacles. Therefore, this paper proposesan enhanced direction finding process for reducing the effect. The result of direction finding by applying the proposed process was enhanced above $1.24^{\circ}$ compared to the result for the existing process.

• Journal of Korean Traditional Oncology
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• v.11 no.1
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• pp.41-54
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• 2006

Ekongsan (EKS) was expected to have inhibitory effects on angiogenesis, considering the fact that its constituents such as Ginseng Radix, Glycyrrhizae Radix and Citri Pericarpium were reported to inhibit angiogenesis. Moreover, recently several metabolites transformed by the human intestinal microflora were reported to enhance effectiveness compared to their crude drugs. Based on these data, this study was designed to confirm whether the EKS metabolites (EKS-M) can significantly exert the anti-angiogenic and anti-metastatic activites. Hence, with EKS and EKS-M, viability assay, proliferation assay, in vitro tube formation assay, gelatin zymogram assay, in vitro invasion assay were carried out. EKS showed less toxicity in ECV304 and HT1080 cells than EKS-M. EKS-M inhibited the proliferation of HT1080 cells by 30% at 200 ${\mu}g/m{\ell}$ and 42% at 400 ${\mu}g/m{\ell}$ respectively. Also, EKS-M degraded the tube network at 200 ${\mu}g/m{\ell}$. EKS and EKS-M inhibited the expression of MMP-9 at 200 and 400 ${\mu}g/m{\ell}$in HT1080 cells. EKS reduced the invasive activity of HT1080 cells through matrigel coated transfilter at the concentration of 200 ${\mu}g/m{\ell}$ more effectively than EKS-M. These data suggest that EKS and EKS-M has anti-angiogenic and anti-metastatic activities.

• The Journal of the Korea Contents Association
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• v.14 no.8
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• pp.74-83
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• 2014

This study was conducted for the overall analysis for the interests, generally and uses of SNS (Social Network Service) of the overseas dance arts company. The subjects of this study were total 3,614 of countries, public, private and personal dance arts company in 100 countries on six continents. The selected 627 company which operate at least one SNS, and included them in this study. Then analyzed the SNS utilization six continental areas as per dance gener, types, and dance gener analyzed as per types. Also analyzed the SNS utilization six continental areas, dance gener as per types and obtained the following result First, It appeared that Ballet company of North America continent took advantage of SNS the most. Second, It appeared that Facebook, Twitter of North America was the most frequently used. Third, It appeared that Facebook wsa the most frequently used by traditional dance company. Fourth. Facebook, Twitter, Youtube were the most activity used by Ballet company of North America continent. In conclusion, this study recommends the policy alternatives related to the awareness of digital media, the establishment of the SNS marketing information system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.312-317
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• 2011

Vanilloid receptor TRPV1 (known as capsaicin channel, transient receptor potential vanilloid 1) is known to be a key protein in the pain signal transduction. However, the proteins controlling the activity of the channel are not much known yet. Recently mouse Rab11-FIP3 (Rab11-family interaction protein 3) was found and reported to interact with rat TRPV1. Rab11 has been shown to play a key role in a variety of cellular processes including plasma membrane recycling, phagocytosis, and transport of secretory proteins from the trans-Golgi network. Therefore, Rab11-FIP3 was proposed to be involved in the membrane trafficking of TRPV1. In this study, the unreported rat Rab11-FIP3 was yet cloned in order to show the specific interaction of the TRPV1 and Rab11-FIP3 in the same species of rat and to examine the membrane trafficking of TRPV1. The result showed that rat Rab11-FIP3 is expected to have 489 amino acids and showed 80% identity with that of human and over 90% identity with that of mouse. Rab11-FIP3 was found to be expressed in heart, brain, kidney, testis using northern and western blot analyses. We also found that rat Rab11-FIP3 was colocalized with rat TRPV1 but not with TRPV2 of same family in the rat brain by using immunohistochemistry showing that two proteins interact specifically, suggesting the role of Rab11-FIP3 in the membrane trafficking.

• The Journal of the Korea Contents Association
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• v.16 no.11
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• pp.253-263
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• 2016

We analyzed the social issue 'image of the elderly' using Big Data and Social Network Analysis. First, we analyzed the words extracted by the text mining technique by inputting the keyword 'elderly'. As a result of analysis, the image of the elderly viewed through media such as cafes, blogs, etc. Representing the trend of the public was using the word 'Senior' the most. The image of the elderly is expressed using the word having the highest frequency in the top 10, "The elderly are 'Senior' people who are respected by society, they are organized to earn money, to earn their qualifications, to health, and to 'Seniors' who desire to work healthy up to 100 years old". The purpose of this study is to differentiate from the existing analysis method by analyzing the macro-level image of the elderly including the social discourse by collecting vast amount of data and analyzing it with the social networking technique. When the image of the elderly that the public perceives is positively expressed as 'Senior', it can be said that the direction of the current elderly policy is evaluated as a desirable direction. On the other hand, it was able to feel the 'desire' of the public who wanted to be evaluated. Therefore, the policy direction of the elderly to be applied in the future should be the policy that enables the elderly to be perceived as 'Necessary existence' in society by taking on social roles. In addition, we proposed to implement the policy of the elderly that reflects priorities such as job creation, welfare, and alienation that can activity and maintain health.

• Journal of Intelligence and Information Systems
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• v.24 no.3
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• pp.119-134
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• 2018

A knowledge map as the taxonomy used in a knowledge repository should be structured to support and supplement knowledge activities of users who sequentially inquire and select knowledge for problem solving. The conventional knowledge map with a hierarchical structure has the advantage of systematically sorting out types and status of the knowledge to be managed, however it is not only irrelevant to knowledge user's process of cognition and utilization, but also incapable of supporting user's activity of querying and extracting knowledge. This study suggests a methodology for constructing a networked knowledge map that can support and reinforce the referential navigation, searching and selecting related and chained knowledge in term of contents, between knowledge. Regarding a keyword as the semantic information between knowledge, this research's networked knowledge map can be constructed by aggregating each set of knowledge links in an automated manner. Since a keyword has the meaning of representing contents of a document, documents with common keywords have a similarity in content, and therefore the keyword-based document networks plays the role of a map expressing interactions between related knowledge. In order to examine the feasibility of the proposed methodology, 50 research papers were randomly selected, and an exemplified networked knowledge map between them with content relevance was implemented using common keywords.

• Journal of Microbiology and Biotechnology
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• v.24 no.12
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• pp.1654-1663
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• 2014

To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2-methoxyestradiol (2-MeO-$E_2$), 2-MeO-$E_2$-induced cell cycle changes and apoptotic events were compared between the human colon carcinoma cell lines HCT116 ($p53^{+/+}$) and HCT116 ($p53^{-/-}$). When both cell types were exposed to 2-MeO-$E_2$, a reduction in the cell viability and an enhancement in the proportions of $G_2/M$ cells and apoptotic sub-$G_1$ cells commonly occurred dose-dependently. These 2-MeO-$E_2$-induced cellular changes, except for $G_2/M$ arrest, appeared to be more apparent in the presence of p53. Immunofluorescence microscopic analysis using anti-${\alpha}$-tubulin and anti-lamin B2 antibodies revealed that after 2-MeO-$E_2$ treatment, impaired mitotic spindle network and prometaphase arrest occurred similarly in both cell types. Following 2-MeO-$E_2$ treatment, only HCT116 ($p53^{+/+}$) cells exhibited an enhancement in the levels of p53, p-p53 (Ser-15), $p21^{WAF1/CIP1}$, and Bax; however, the Bak level remained relatively constant in both cell types, and the Bcl-2 level decreased only in HCT116 ($p53^{+/+}$) cells. Additionally, mitochondrial apoptotic events, including the activation of Bak and Bax, loss of ${\Delta}{\psi}m$, activation of caspase-9 and -3, and cleavage of lamin A/C, were more dominantly induced in the presence of p53. The Bak-specific and Bax-specific siRNA approaches confirmed the necessity of both Bak and Bax activations for the 2-MeO-$E_2$-induced apoptosis in HCT116 cells. These results show that among 2-MeO-$E_2$-induced apoptotic events, including prometaphase arrest, up-regulation of Bax level, down-regulation of Bcl-2 level, activation of both Bak and Bax, and mitochondria-dependent caspase activation, the modulation of Bax and Bcl-2 levels is the target of the pro-apoptotic action of p53.

• Korean Security Journal
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• no.49
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• pp.217-246
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• 2016

Most of the North Korean defectors are the socially disadvantaged, and formed the lowest class in South Korean society. Their main objectives are to achieve economic wealth. In this process, North Korean defectors have often committed the crime or have been criminal victims. The purpose of this study was to propose the effective preventive measures after analyzing the actual situation of North Korean defectors in criminal behaviors and criminal damages. This research has studied of the literature on the criminal behavior and the criminal damage by North Korean defectors, utilized the relevant statistical data, cited the news for the relevant cases, and proposed the effective preventive measures of criminal behaviors and criminal damages of North Korean defectors by doing in-depth interviews with personal protection officer First, in order to prevent criminal activity by North Korean defectors, we should uplift the identity as the members of Korean society, systemize the initial adapt education, enlarge the employment protection and the resettlement helper system, manage North Korean defectors according to adaptive type, develop the network, establish the management department for the defectors, strengthen the training of prison inmates, and strengthen the management of unprotected people. Next, in order to prevent the criminal damages of North Korean refugees, we should manage vulnerable North Korean defectors effectively, maintain the liaison between the personal protection officer and North Korean defector, arrange the personal safety measures in advance when traveling abroad, enhance the legal education for usual living in Korean society, and perform the re-education for the female socialization.