• 한국작물학회지
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• 제42권2호
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• pp.196-201
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• 1997

참당귀 묘크기와 저온처리가 추대에 미치는 영향을 알아보고자 수행한 시험결과를 요약하며 다음과 같다. 1. 저온처리 기간에 따른 추대율은 30일, 60일과 90일 처리에서는 각각 69.4％, 69.3％과 75.2％로 처리기간이 길어짐에 따라 추대율이 높았으며, 무처리에서는 29.6％로 낮았다. 2. 묘크기별 저온처리에 따른 추대율은 소묘일수록 낮고, 대묘일수록 높아지는 경향이었다. 정식후 추대까지의 기간은 저온처리 기간이 길수록, 대묘일수록 추대가 빨라지는 경향이었다. 3. 추대시 생육은 저온처리 기간이 길어지고 대묘일수록 초장이 짧고 추대엽위가 낮으며 진전엽수가 적어지는 경향이었다. 추대율은 추대시 생육과는 부의 상관을 보이고, 후기생육과는 정의 상관을 보였다.

• 한방안이비인후피부과학회지
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• 제27권1호
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• pp.37-44
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• 2014

Objective : This study aimed to survey the pattern of the treatment choice for atopic dermatitis. Methods : The questionnaire-based survey was conducted from the parents of 310 patients (median age 9 years, range 2 to 21 year, 158 male and 152 female) with atopic dermatitis. The questionnaire was consisted of 11 questions for the demographic information including treatment choice for atopic dermatitis. Results : The most agonizing factor of atopic dermatitis was pruritus, while the most frequent regions were arms and legs. Conventional therapy (60.3%), folk-remedy (23.9%) and treatment of Korean medicine (15.8%) were the preference of treatment by patients. Over half answers (58.4%) were negative for the current treatments, and the main complains was the absence of radical therapy (26.5%), insufficient information (20.6%), and expensive cost of treatments (19.0%), respectively. Conclusion : This study may provide the important information for the general prospective of parents of patients with atopic dermatitis, which is helpful to develop the Korean medicine-derived therapeutics for atopic dermatitis.

• 대한수의학회지
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• 제61권1호
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• pp.10.1-10.11
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• 2021

The purpose of this retrospective study was to provide additional data on the use of toceranib in a wide variety of tumor types in small breed dogs, especially < 8 kg (except 5 dogs). This was a retrospective study of 31 dogs with malignant tumors treated with a 2.5 mg/kg median dose of toceranib (Palladia; Zoetis, USA) on a Monday-Wednesday-Friday schedule. Clinical benefit was observed in 13 of 15 dogs (86.7%, 3 with complete response, 4 with partial response, 6 with stable disease) with gross disease. Distant metastasis, response to treatment, and treatment setting were significantly associated with survival time. Negative prognostic factors were multiple chemotherapy and distant metastasis (affecting progression-free survival [PFS]), surgery, regional enlarged lymph nodes, underlying disease, and toxicity (affecting median survival time [MST]). Positive prognostic factors were epithelial and round cell tumor (affecting PFS), epithelial tumor, microscopic disease, no evidence of disease response, and stable disease (MST). In conclusion, a clinical benefit from toceranib treatment was noted in most of the dogs with gross disease in our study. This study suggested that the toceranib is probably selective treatment to various tumor types in small breed dogs.

• 대한수의학회지
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• 제61권4호
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• pp.37.1-37.6
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• 2021

This study evaluated the efficacy of a new, single-dose otic solution combining florfenicol, terbinafine, and mometasone furoate for the treatment of canine otitis externa (OE) in vitro and in vivo. Forty-one client-owned dogs with OE were included in the study and divided into a treatment group that received the test solution and a negative control group that received a normal saline solution. On day 0, the dogs were treated either with the test or the control solution and evaluated over 30 days. Clinical efficacy was evaluated by clinical signs and cytological organism counts. In vitro antimicrobial susceptibility was evaluated by the minimum inhibitory concentration (MIC). After treatment with the test solution, clinical signs continuously decreased and cytological scores were significantly reduced. The results of MIC testing showed that the test solution was potent against the common pathogenic causes of canine OE. In this study, the most common causative pathogens were Staphylococcus pseudintermedius, Pseudomonas spp. and Malassezia pachydermatis. No issues related to safety were identified. Based on these results, this new ototopical drug can be used as first line treatment for canine OE.

• Medical Lasers
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• 제8권1호
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• pp.28-31
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• 2019

Superficial fungal infections with dermatophytes, nondermatophyte molds, or yeasts are treated primarily with topical and/or systemic antifungal agents. Additional or alternative treatment modalities, particularly energy-delivering modalities, however, are used widely to induce fungicidal effects via selective photothermal reactions. In addition to light- or laser-based devices, plasma therapy also has antifungal properties. This report describes a Korean male patient with mycologically confirmed tinea pedis that was treated effectively with two sessions of nitrogen plasma treatment at one-week intervals using a plasma delivering system. Nitrogen plasma was prepared by loading a 0.28-ml inert nitrogen gas/pulse that was activated by a microwave generator. The other treatment settings were a nozzle diameter of 5 mm, pulse energy of 0.75 J, pulse duration of 7 msec, and two passes. One week after the first session of nitrogen plasma treatment, the patient exhibited marked reductions in scale and inflammation. One month after the final treatment, no clinical features of recurrence were found, and successive potassium hydroxide testing revealed negative results.

• 대한한방소아과학회지
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• 제37권4호
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• pp.15-24
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• 2023

Objectives This study aimed to identify the current status and satisfaction with Korean medicine treatment and analyze the perceptions of parents about Korean medicine treatment in children. Methods A Web survey (Moaform) was conducted with 52 parents whose children used Korean medicine and 53 parents who did not. We investigated the reasons why the user group chose treatment and satisfaction with each treatment and why the non-user group did not choose the treatment. Results Children in the user group were frequently prescribed herbal medicines (decoctions) and acupuncture. However, they showed low satisfaction in terms of fear of acupuncture and dissatisfaction with the unique taste of herbal medicine. Non-user parents had a favorable opinion of Korean medicine, but had relatively negative perceptions about whether their children were willing to visit in the future. Conclusions Parents who used Korean medicine for their children had positive perceptions and trust in Korean medicine. However, those who did not use Korean medicine were concerned about the safety and potential harm of its application to their children.

• Journal of Hospice and Palliative Care
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• 제23권3호
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• pp.114-125
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• 2020

Purpose: This descriptive study investigated the effects of nurses' knowledge of withdrawal of life-sustaining treatment, death anxiety, and perceptions of hospice care on their attitudes toward withdrawal of life-sustaining treatment. Methods: Data were collected from 262 nurses at tertiary hospitals, general hospitals, or primary hospitals in Busan, Korea, and statistically analyzed using the t-test, analysis of variance, the Scheffé test, Pearson correlation coefficients, and hierarchical regression analysis. Results: The participants' scores were 3.68±0.45 (out of 5) for attitudes toward withdrawal of life-sustaining treatment, 0.65±0.15 (out of 1) for knowledge of withdrawal of life-sustaining treatment, 2.61±0.26 (out of 4) for death anxiety, and 4.06±0.43 (out of 5) for perceptions of hospice care. Furthermore, knowledge of withdrawal of life-sustaining treatment and perceptions of hospice care showed positive correlations with attitudes toward withdrawal of life-sustaining treatment, while death anxiety showed a negative correlation. The most significant factors influencing attitudes toward withdrawal of life-sustaining treatment were perceptions of hospice care, followed by having experienced caring for patients who withdrew life-sustaining treatment, death anxiety, having a spouse, and ethical values, and the overall explanatory power was 43.0%. Conclusion: This study showed that perceptions of hospice were an important factor influencing nurses' attitudes toward withdrawal of life-sustaining treatment. Therefore, it is necessary to develop and validate educational intervention programs that can improve perceptions of hospice care.

• 대한소아치과학회지
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• 제23권2호
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• pp.461-476
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• 1996

The purpose of this study was to investigate the effect of dental experience on the attitude of children toward the dentist and the dental treatment. The subjects of the study were 1,090 children from second grade to forth grade of three elementary schools of the Iksan city. The children were investigated by the questionnaire which consisted of seven items about the attitude toward the dentist, the attitude toward the dental treatment, the dental reatment experience, the number of times of dental treatment, the last time of the dental visit, pain of dental treatment, and fear of dental treatment. There were significant differences among the grades in the attitude toward the dental treatment and in the attitude toward the dentist (P<0.01). Second grade children had the most negative attitudes. But, there were no differences between boys and girls. Girls felt more pain and fear than boys (P<0.01). There were significant relationships between the pain and the attitude toward the dentist, between the pain and the attitude toward the dental treatment, between the fear and the attitude toward the dentist, and between the fear and the attitude toward the dental treatment (P<0.01, all). The number of dental visit had significant relationship with the attitude toward the dental treatment (P<0.05). There were significant relationships between the pain and the fear and between the attitude toward the dentist and the attitude toward the dental treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4647-4653
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• 2016

Background: The discovery of somatic acquired mutations of JAK2 (V617F) in Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) has not only improved rational disease classification and prognostication but also brings new understanding insight into the pathogenesis of diseases. Dosage effects of the JAK2 (V617F) allelic burden in Ph-negative MPNs may partially influence clinical presentation, disease progression, and treatment outcome. Material and Methods: Pyrosequencing was performed to detect JAK2 (V617F) and MPL (W515K/L) and capillary electrophoresis to identify CALR exon 9 mutations in 100 samples of Ph-negative MPNs (38.0 PV, 55 ET, 4 PMF, and 3 MPN-U). Results: The results showed somatic mutations of JAK2 (V617F) in 94.7% of PV, 74.5% of ET, 25.0% of PMF, and all MPN-U. A high proportion of JAK2 (V617F) mutant allele burden (mutational load > 50.0%) was predominantly observed in PV when compared with ET. Although a high level of JAK2 (V617F) allele burden was strongly associated with high WBC counts in both PV and ET, several hematological parameters (hemoglobin, hematocrit, and platelet count) were independent of JAK2 (V617F) mutational load. MPL (W515K/L) mutations could not be detected whereas CALR exon 9 mutations were identified in 35.7% of patients with JAK2 negative ET and 33.3% with JAK2 negative PMF. Conclusions: The JAK2 (V617F) allele burden may be involved in progression of MPNs. Furthermore, a high level of JAK2 (V617F) mutant allele appears strongly associated with leukocytosis in both PV and ET.

• 생약학회지
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• 제23권4호
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• pp.240-247
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• 1992

Impatiens balsamina Linne(Balsaminaceae) known as 'BONG SUN HWA' in Korea and has been used for the treatment of scrofulosis, carbunculus and dysenteria etc. Bioassay-guided fractionation of MeOH extract from the whole plants of Impatiens balsamina has afforded a simple naphthoquinone derivative, 2-methoxy-1,4-naphthoquinone. The structure of this compound was established by spectroscopic methods. This compound possessed strong antifungal activity against Candida albicans, AspergiIlus niger, Crytococcus neoformans and Epidermophyton floccusum. The activity of 2-methoxy-1,4-naphthoquinone on E. floccusum $(MIC{\;}:{\;}5.0{\;}{\mu}g/ml)$ was the same potency as that of nystatin. It showed also strong antibacterial activity against gram-positive bacteria Bacillus subtilis as well as gram-negative bacteria Salmonella typhimurium. Although the activity of this compound on gram-negative bacteria was lower than that of gram-positive bacteria.