• 정신신체의학
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• 제7권2호
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• pp.247-251
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• 1999

연구배경 : 철분결핍성빈혈은 매우 흔하며 그 원인이 다양하므로 근본 원인을 찾으려는 노력을 하여야만 한다. 저자는 소화기관 출혈, 임신, 과다월경 등의 원인 외에 우리 나라의 의료 특성상 빈번하게 이뤄지고 있는 부항에 의해 발생한 증례를 경험하였으므로 부항으로 인해 발생한 철분결핍성빈혈 2예를 보고하고자 한다. 이들의 행위는 설명모델로 이해될 수 있다. 증례 1 : 27세 여자 환자가 호흡곤란을 주소로 내원하였다. 환자는 10년 전부터 있었던 건선을 치료하기 위해 부항요법을 빈번하게 실시하였고 이로 인한 실혈로 철분결핍성빈혈이 발생하였다. 증례 2 : 70세 남자 환자가 식욕부진과 어지러움을 주소로 내원하였다. 환자는 내원 9개월 전에도 같은 증상이 있어 철분결핍성빈혈로 진단을 받고 치료 받았으나 5년 전부터 족부 무좀에 대해 실시한 부항요법을 지난 번 빈혈치료 후에도 반복해 실시한 결과 철분결핍성빈혈이 발생하였다. 결론 : 철분결핍성빈혈의 원인으로 우리나라 의료의 특성상 부항요법도 고려하여야 한다.

• Parasites, Hosts and Diseases
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• 제37권4호
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• pp.289-292
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• 1999

BALB/c mice infected with a high virulent strain of Trypanosoma brucei gambiense IL3707 were treated intraperitoneally (ip) with either Melarsoprol （Mel-B) or PSG(+) buffer as controls. The mice were subsequently monitored regularly for parasites by direct microscopic examination of their tail blood or buffy coat and by polymerase chain reaction (PCR). Mel-B was found to be an effective drug for treatment against T.b. gambiense because at the end of the first treatment schedule, all treated mice were negative for parasites even by PCR, while all the control animals were positive. Three of the five Mel-B treated mice, while parasitologically negative, were PCR positive between 53 and 80 days post infection (DPI), indicating that they still harbored an infection. All treated mice were subsequently negative for parasites even by PCR at 88 DPI. A combination of conventional microscopic examination and PCR offers a good prediction of cure following treatment of trypanosomosis.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제28권4호
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• pp.51-60
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• 2022

Purpose: This study aims to analyze and supplement the standards related to healthcare facilities, negative pressure isolation wards, and emergency treatment facilities. In addition, through environmental investigations, analysis of emergency remodeling cases centered on the structural and HVAC characteristics of healthcare facilities is conducted. Methods: Domestic and foreign standards related to healthcare facilities were analyzed. Field investigations and architectural drawing analysis of general and emergency treatment facilities were conducted. Results: Healthcare facilities have different space classifications and air conditioning methods depending on the site situation. Emergency treatment facilities are classified into cases where the HVAC system is remodeled and portable negative pressure unit is installed, and some facilities did not meet the standards for differential pressure and air change rate. Implications: When developing emergency remodeling technology, remodeling and safety evaluation guidelines, it is considered possible to propose clearer guidelines for emergency remodeling treatment facilities for infectious diseases in Korea by referring to the results of this study.

• 생물정신의학
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• 제16권3호
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• pp.170-180
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• 2009

Objectives : To assess clinical improvement and change in plasma brain-derived neurotrophic factor(BDNF) level after repetitive transcranial magnetic stimulation(rTMS) in patients with treatment-resistant schizophrenia. Methods : Seven patients with DSM-IV schizophrenia, who were proven to be treatment-resistant, were treated with 15 sessions of rTMS for three weeks as an adjuvant therapy to antipsychotic treatment. Clinical improvement and change in plasma BDNF level were measured after the treatment period. The symptom severity was assessed with the Positive and Negative Syndrome Scale(PANSS) and the Korean Version of Calgary Depression Scale for Schizophrenia(K-CDSS) at baseline and 7 days after the treatment. Plasma BDNF level was measured by enzyme-linked immunosorbent assay(ELISA) at baseline and 7 days after the treatment. Results : After the rTMS treatment, there was no significant improvement in PANSS total score(Z=-1.693, p=0.090) and no significant change in plasma BDNF was found(Z=-1.183, p=0.237). Negative correlations were found between percentage change in PANSS positive subscale score and duration of illness(rho=-0.991, N=7, p<0.0005, two-tailed), and PANSS negative subscale score at baseline and percentage change in plasma BDNF level(rho=-0.821, N=7, p=0.023, two-tailed). Conclusion : This preliminary study suggests that rTMS didn't make a significant change in clinical symptoms nor in plasma BDNF level in treatment-resistant schizophrenia. Percentage change in plasma BDNF, however, might be correlated with treatment resistance in schizophrenic patients. This is a pilot study with a small sample size, therefore, a further study with a larger sample size is needed.

• Journal of Chest Surgery
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• 제53권4호
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• pp.205-210
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• 2020

Esophageal anastomotic leak is the most common and serious complication following esophagectomy. However, the standard treatment for anastomotic leaks remains unclear. Recently, endoscopic vacuum therapy has become an important non-surgical alternative treatment method for patients with esophageal anastomotic leak. This treatment involves the endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. Subsequently, continuous negative pressure is delivered to the cavity through the tube. Several studies have reported a treatment success rate of 80% to 100%. In this study, we review the mechanism of action, the method of performing the procedure, its safety and efficacy, and prognostic factors for failure of endoscopic vacuum therapy in the management of patients with anastomotic leak, and on this basis attempted to confirm the possibility of establishing a standardized treatment protocol using endoscopic vacuum therapy.

• Tuberculosis and Respiratory Diseases
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• 제63권5호
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• pp.417-422
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• 2007

연구배경: 일차 항결핵제 치료 5개월 이후 배양 음전되었으나 도말 양성을 보이는 폐결핵 환자들의 임상적 특성과 치료 후 경과에 대하여 알아보고자 하였다. 방 법: 2002년 1월 1일부터 2003년 12월 31일까지 일개 결핵 전문 병원에 입원한 환자 중 일차 항결핵제로 치료를 종결하였고 약제감수성 검사상 일차 항결핵제에 모두 감성이거나 리팜핀을 제외한 단일 약제 내성이면서 추적관찰이 되었던 환자를 대상으로 임상적 특성과 재발여부와 이에 관련한 위험인자를 후향적으로 분석하였다. 결 과: 대상 환자는 60명이었고 모두 치료에 성공하였다. 객담 도말 검사상 음전은 평균 $8.3{\pm}2.3$개월이었고, 객담 배양 검사상 음전은 평균 $2.0{\pm}0.8$개월이었다. 당뇨는 14명(23%), 초치료는 46명(77%), 약제감수성 검사상 일차 항결핵제에 모두 감성인 경우가 37명(62%), 흉부방사선사진상 중증인 경우가 49명(81%)이었다. 재발률은 치료 1년 후 3.8%, 2년 후 10%, 5년 후 25.8%이었고 나이, 성별, 당뇨, 치료 2개월째의 배양검사 결과, 과거 치료력, 흉부방사선 사진 소견, 치료기간에 따라 재발률의 차이는 통계적으로 유의하지 않았다. 결 론: 일차 항결핵제로 치료시작 후 5개월에 객담 배양검사는 음전되었으나 도말검사는 양성인 환자들에서 치료약제의 변경 없이 모든 환자에서 치료가 성공되었다. 그러나 높은 재발률에 대한 추가적인 연구가 필요할 것으로 사료된다.

• 한국산림과학회지
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• 제97권4호
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• pp.423-430
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• 2008

산림의 건강 기능은 여러 인자에 의하여 수행된다. 본 연구는 산림의 건강물질 중의 하나라고 알려진 음이온의 건강 효과를 알아보기 위하여 수행되었다. 본 연구는 12명의 대학생집단을 피험자로 하여 실험군과 비교군으로 무작위 할당한 후 실험을 진행하였다. 실험군에 속한 피험자들에게는 음이온 (2,001,000 ion/cc)에 노출시키고 인지능력 테스트와 생리적인 변화의 측정을 위하여 채혈을 실시하였다. 자료의 분석결과 음이온에 노출된 실험군에서는 비교군에 비하여 긍정적인 생리적 변화가 발견되었다.

• 생물정신의학
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• 제3권1호
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• pp.75-82
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• 1996

Object : The aim of this study was to evaluate the changes of positive stmtoms. negative symptoms, and depressive symptoms after fluoxetine trial in haloperidol-stabilized schizophrenic in-patients. Method : Fluoxetine(20mg/day) was added for 6weeks to stable doses of haloperidol given to 32 schizophrenic in-patients. The subjects was divided into positive and negative schizophrenics by PANSS. The authors checked PANSS. HRSD at baseline, the 2nd week. the 4th week, the 6th week of treatment. Result were as follows : 1) In all subjects, positive and depressive symptoms were significantly improved. 2) As time went on, positive and negative symptoms were not significantly improved in positive and negative schizophrenics. 3) As time went on, depressive symptoms were not significantly improved in positive and negative schizophrenics. Conclusion : We suggested that fluoxetine may be useful in the treatment of positive symptoms in schizophrenia and, It may be due to the effect on the serotonin system and the interaction between serotonin and dopamine system.

• Journal of Korean Biological Nursing Science
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• 제17권2호
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• pp.159-168
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• 2015

Purpose: The purpose of this study was to determine the effects of auricular acupressure on menstrual pain, difficulties in daily life, negative feelings and autonomic nervous responses among college students. Methods: A Randomized Controlled Trial design was used. The treatment group A (n=12) receivedauricular acupressure therapy on the first or second day of their menstrual period. Treatment group B (n=18) regularly received an auricular acupressure therapy once a week for a month. The control group (n=19) received no auricular acupressure therapy. An independent t-test was used to examine pre-post test differences in the group. The ANOVA and Scheffe test were used to examine pre-post test differences among the group. Results: Subjects in treatment group A showed significantly less menstrual pain, difficulties in daily life, and negative feelings than the control group did. The participants in treatment group B also showed significantly less difficulties in daily life and negative feelings than the control group. Conclusion: The findings support that auricular acupressure therapy on menstrual periods is effective in controlling menstrual pain, difficulties in daily life, and negative feelings. As the method is simple, it would be useful for female students to learn to use this method to alleviate the symptoms related to menstruation through self care.

• 대한약리학회지
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• 제12권1호
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• pp.69-73
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• 1976

A combined syrup preparation of pyrantel pamoate and oxantel pamoate containing 50mg/ml of respective anthelminthics was evaluated on the efficacy to treat the human intestinal nematodes. Total 24 cases were treated with oral administration of above preparation 10 mg/kg body weight by single dose. The results were summarized as follows: 1. Out of 21 cases of Ascaris lumbricoides infection, 19 (90.5%) turned to be egg negative on 21 days after treatment and egg-reduction rate was 99.7%. 2. 17 cases out of 19 cases infected with Trichocephalus trichiurus were egg negative after treatment (84.2%) and egg reduction rate was 60.6%. 3. As for Ancylostoma duodenale infection, egg negative conversion rate was 88.9% and egg reduction rate was 98.1% by single oral administration among 9 infected cases. 4. In Enterobius vermicularis infection, all of 17 cases gave negative anal swab on 21th day after the treatment. From the above results, it was assumed that the anthelminthic activities of pyrantel pamoate and oxantel pamoate were not potentiated by the mixture of two kinds of drugs but showed simple additive effect.