• Korean Journal of Veterinary Service
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• v.36 no.4
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• pp.303-309
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• 2013

This study was conducted to determine the content of 7 mycotoxins (aflatoxin $B_1$, $B_2$, $G_1$, $G_2$, $M_1$, ochratoxin A and zearalenone) using LC-MS/MS in pork available on the Korean markets. The analysis was carried out using following conditions; C18 column ($2.1{\times}100mm$, $1.7{\mu}m$), mobile phase composed of $H_2O$ (0.1 mM $NH_4Ac$ 0.01% HCOOH) : Methanol (0.1 mM $NH_4Ac$ 0.01% HCOOH), binary pump at a flow rate of 0.5 mL/min and $2{\mu}L$ of injection volume, MS/MS detector with ESI positive and negative mode. The quantication of mycotoxins was based on matrix-matched calibration curves with a correlation coefficient in excess of 0.99 for the 7 mycotoxins. The dectection limits were ranged 0.74~2.13 ng/g, with mean recoveries between 73.10~97.46% except aflatoxin $B_1$ (61.31%). We also monitored mycotoxin residues in 208 pork samples. The test results, mycotoxins were not found except one sample. Ochratoxin A in one sample of the test samples was detected below the quantification limit.

• YAKHAK HOEJI
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• v.46 no.4
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• pp.290-294
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• 2002

Cephradine is an orally absorbed cephalosporin with a broad spectrum of activity against gram-positive and gram-negative bacteria and is highly resistant to beta-lactamase degradation. The purpose of the present study was to evaluate the bioequivalence of two cephradine capules, Cephradine capsule (Donggu Pharmaceutical Co., reference drug) and Cephradine capsule (Shinpoong Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration. Twenty-six normal volunteers, 24.6 $\pm$ 3.70 years in age and 62.4 $\pm$ 8.99 kg in body weight, were divided into two groups and a randomized 2 $\times$ 2 cross-over study was employed. After one capsule containing 250 mg of cephrdine was orally administered, blood was taken at predetermined time intervals and the concentrations of cephrdine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as AU $C_{t}$ to $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUCt, $C_{max}$ and $T_{max}$ between two products were 2.89％, 1.05％ and 1.06％, respectively, when calculated against the reference drug. The 90％ confidence intervals were within log0.8 $\leq$ $\delta$ $\leq$ log1.25 (e.g., log0.9803 $\leq$ $\delta$ $\leq$ log1.0734 and log0.9674 $\leq$ $\delta$ $\leq$ log1.220 for AU $C_{t}$, and $C_{max}$, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Cephradine capsules (Shinpoong Pharmaceutical Co.) is bioequivalent to Cephradine capsules (Donggu Pharmaceutical Co.).o.).o.).).o.).

• Atmosphere
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• v.31 no.2
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• pp.157-170
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• 2021

To investigate the effect of snowfall on the traffic of general roads in Gangwon-do, case analysis was performed in Gangneung, Pyeongchang, and Chuncheon using ASOS (Automated Synoptic Observing System) snowfall data and VDS (Vehicle Detector System) traffic data. First, we analyzed how much the traffic volume and speed decrease in snowfall cases on regional roads compared to non-snow cases, and the characteristics of monthly reduction due to snowfall were investigated. In addition, Pearson correlation analysis and regression analysis were performed to quantitatively grasp the effect of snowfall on traffic volume and speed, and sensitivity tests for snowfall intensity and cumulative snowfall were performed. The results showed that the amount of snowfall caused decrease both in the traffic volume and speed from usual (non-snowfall) condition. However, the trend was different by region: The decrease rate in traffic volume was in the order of Gangneung (17~22%), Chuncheon (14~17%), and Pyeongchang (11~14%). The decrease rate in traffic speed was in the order of Chuncheon (9~10%), Gangneung (8~9%), Pyeongchang (5~6%). No significant results were found in the monthly decrease rate analysis. In all regions, traffic volume and speed showed a negative correlation with snowfall. It was confirmed that the greater the amount of traffic entering the road, the greater the slope of the trend line indicating the change in snowfall due to the traffic volume. As a result of the sensitivity test for snowfall intensity and cumulative snowfall, the snowfall information at intervals of 6-hours was the most significant.

• Nuclear Engineering and Technology
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• v.55 no.2
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• pp.655-668
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• 2023

In radiography, an antiscatter grid is a well-known device for eliminating unexpected x-ray scatter. We investigate a new stationary grid artifact suppression method based on a nonsubsampled contourlet transform (NSCT) incorporated with Gaussian band-pass filtering. The proposed method has an advantage that extracts the Moiré components while minimizing the loss of image information and apply the prior information of Moiré component positions in multi-decomposition sub-band images. We implemented the proposed algorithm and performed a simulation and an experiment to demonstrate its viability. We did this experiment using an x-ray tube (M-113T, Varian, focal spot size: 0.1 mm), a flat-panel detector (ROSE-M Sensor, Aspenstate, pixel dimension: 3032 × 3800 pixels, pixel size: 0.076 mm), and carbon graphite-interspaced grids (JPI Healthcare, 18 cm × 24 cm, line density: 103 LP/inch and 150 LP/inch, ratio: 5:1, focal distance: 65 cm). Our results indicate that the proposed method successfully suppressed grid artifacts by reducing them without either reducing the spatial resolution or causing negative side effects. Consequently, we anticipate that the proposed method can improve image acquisition in a stationary grid x-ray system as well as in extended x-ray imaging.

• Journal of the Korean Institute of Gas
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• v.28 no.1
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• pp.53-58
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• 2024

Due to the development of industry and improvement of living standards, the amount of natural gas used in the world is constantly increasing, and related industrial facilities such as power plants, storage facilities, and supply pipelines are constantly increasing. Natural gas is a convenient and clean fuel that does not pollute the environment, but in the event of an accident due to leakage, it can cause human casualties, large-scale property damage, and negative effects on the global warming effect. In addition to the severe penalties under the Severe Disaster Punishment Act, it is necessary to ensure safety. Therefore, by applying the principle of laser-based absorption spectroscopy, we developed a long-range portable methane leakage gas detection system that can detect the concentration of methane leaking from a distance of up to 30 meters and verified its effectiveness.

• Journal of Forest and Environmental Science
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• v.40 no.3
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• pp.227-240
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• 2024

Trees improve air quality through the accumulation of air pollutants in their leaves; however, the responses of different tree species to air pollution varies. Hence, this study evaluated the responses to air pollution of selected tree species in the Swamp Forest Research Station, Onne. Ten tree species (Cola pachycarpa, Khaya grandifoliolia, Irvingia gabonensis, Garcinia kola, Chrysophyllum albidum, Treculia africana, Dacryodes edulis, Tectonia grandis, Gmelina aborea, and Nauclea diderrichii) were selected based on their abundance in the area. Leaves were collected from all sides in 3 replicates for each tree species. Laboratory analysis was carried out using standard procedures. Portable Multi Gas Detector was used to determine the concentrations of air pollutants. One-way analysis of variance was employed to test for significant difference (p≤0.05) in biochemical parameters among the tree species while Pearson's correlation was utilized to determine the level of association between different biochemical parameters and APTI; heavy metals and APTI. Results showed high concentration of PM₁₀, CO, moderate concentration of NO₂, PM_2.5, and VOC, and low concentration of ground O₃. Heavy metals - Cadmium, Mercury, Lead, Nickel and Copper were all present in the tree species at varying rates. There were significant differences in the biochemical parameters and APTI values. C. pachycarpa exhibited the highest APTI value (89.88), while D. edulis had the lowest APTI value (8.24). C. pachycarpa, K. grandifoliolia, C. albidum, G. kola, T. africana, and N. diderrichii were identified as tolerant tree species to air pollution. G. aborea, T. grandis, and I. gabonensis were considered intermediate tolerant species, while D. edulis was the only tree species sensitive to air pollution. Ascorbic Acid, Chlorophyll, Hg and Ni had positive correlations with APTI; Cd and Cu had negative association with APTI at the 0.05 significance level. C. pachycarpa, T. africana, K. grandifoliolia, C. albidum, N. diderrichii and G. kola, are recommended for planting in pollution-prone areas.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.4
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• pp.811-817
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• 2009

The rapid growth of network based IT systems has resulted in continuous research of security issues. Probe intrusion detection is an area of increasing concerns in the internet community. Recently, a number of probe intrusion detection schemes have been proposed based on various technologies. However, the techniques, which have been applied in many systems, are useful only for the existing patterns of probe intrusion. They can not detect new patterns of probe intrusion. Therefore, it is necessary to develop a new Probe Intrusion Detection technology that can find new patterns of probe intrusion. In this paper, we proposed a new network based probe intrusion detector(NePID) using anomaly traffic analysis and fuzzy cognitive maps that can detect intrusion by the denial of services attack detection method utilizing the packet analyses. The probe intrusion detection using fuzzy cognitive maps capture and analyze the packet information to detect syn flooding attack. Using the result of the analysis of decision module, which adopts the fuzzy cognitive maps, the decision module measures the degree of risk of denial of service attack and trains the response module to deal with attacks. For the performance evaluation, the "IDS Evaluation Data Set" created by MIT was used. From the simulation we obtained the max-average true positive rate of 97.094% and the max-average false negative rate of 2.936%. The true positive error rate of the NePID is similar to that of Bernhard's true positive error rate.

• Management & Information Systems Review
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• v.35 no.4
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• pp.169-184
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• 2016

Deferred tax assets (liability) in a company's financial statements are to reflect the temporary difference between taxable income and accounting income and therefore can provide useful information as a proxy for discretionary accruals. In addition, deferred tax assets allow a company to manage its earnings by reviewing the feasibility of the assets' recognition. As such, this study focused on deferred tax assets to examine their relationship with discretionary accruals, which were measured by a modified Jones model (Dechow et al. 1995), and investigated the impact of audit quality on this relationship. In order to control for the effects of tax rate change and measurement credibility, deferred tax assets of 2,670 non-financial firms from 2009 to 2010 were collected as samples for the study. The results of the empirical analysis are as follows. First, the samples as a whole indicated that deferred tax assets have a negative relationship with discretionary accruals in a general sense, but a high-quality audit did not reveal a significant relationship between them. Second, the 1,379 samples with negative discretionary accruals did not reveal a significant relationship between deferred tax assets and discretionary accruals; however, the result showed a significant negative relationship under a high-quality audit. These findings suggest that in the case of negative discretionary accruals, a high-quality audit restricts an earnings management technique that utilizes deferred tax assets and that the assets can be a useful tool for detecting discretionary accruals. The present study is meaningful in that, unlike previous research, it combined the two contrasting roles of deferred tax assets-that of an earnings management detector and an earnings management tool-to examine their general relationship. The study also suggested that audit quality could influence the usefulness of deferred tax assets in providing information on discretionary accruals.

• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.215-221
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• 2002

Cephradine is a first generation cephalosporin and has broad spectrum antibacterial activity against gram-positive and gram-negative microorganisms, through inhibition of bacterial cell wall synthesis. Cephradine is useful for treatment of infections of the urinary and respiratory tract, skin and soft tissues. The purpose of the present study was to evaluate the bioequivalence of two cephradine capsules, Cefradine Yuhan (YuHan Corporation) and Broadcef (Ilsung Pharmaceuticals Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cephradine release from the two cephradine capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, $23.10{\pm}2.90$ years in age and $67.69{\pm}8.04\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cephradine was orally administered, blood was taken at predetermined time intervals and the concentrations of cephradine in serum were determined using HPLC method with UV detector. The dissolution profiles of two cephradine capsules were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AVC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Cefradine Yuhan were -2.87%, -0.96% and -4.85%, respectively. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of 1og(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.02)\;and\;log(0.88){\sim}log(1.13)\;for \;AVC_t\;and\;C_{max},\;respectively)$. The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g., \;-17.54{\sim}7.78\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Broadcef capsule is bioequivalent to Cefradine Yuhan capsule.

• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.135-140
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• 2002

Cefadroxil is a semi-synthetic cephalosporin active against many Gram-positive and Gram-negative bacteria. The drug has been used for the treatment of the urinary and respiratory tract infections when caused by susceptible strains of the designated microorganism. The purpose of the present study was to evaluate the bioequivalence of two cefadroxil capsules, Duricef (Bo Ryung Pharmaceutical Co. Ltd.) and Hanacef (Korean Pharmaceutical Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cefadroxil release from the two cefadroxil capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $21.58{\pm}2.43$ years in age and $70.74{\pm}10.29$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cefadroxil was orally administered, blood was taken at predetermined time intervals and the concentrations of cefadroxil in serum were determined using HPLC with UV detector. The dissolution profiles of two cefadroxil capsules were very similar at all dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Duricef were 0.05%, -5.29% and 4.53%. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.95){\sim}log(1.05)\;and\;log(0.87){\sim}log(1.02)$ for $AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${pm}20%$ $(e.g.,\;-6.75{\sim}15.74\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Hanacef capsule is bioequivalent to Duricef capsule.