• Journal of Korean Clinical Nursing Research
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• v.23 no.1
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• pp.40-53
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• 2017

Purpose: The purpose of this study was to identify core competencies for new nurses and valuate the appropriateness and capability of core competencies. Methods: Mixed method was applied for the study. Qualitative data were obtained from preceptor and nurse manager utilizing an open-ended survey question and qualitative data analysis was conducted. The quantitative data were collected from 238 nurses (79 new nurses, 78 preceptors, 81 nurse managers) and descriptive statistics, ANOVA, $x^2$ tests were applied. Results: Three themes (20 contents) were identified as core competencies: competency as an employee, competency to perform nursing care for patient, competency to maintain nursing expertise. New nurses recognized themselves as having higher competency as an employee and to perform nursing care for patient when compared to nurse managers. Conclusion: The findings identified core competencies for new nurses need to be reflected to developing human resource management strategies for hiring new nurses.

• Mycobiology
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• v.44 no.3
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• pp.146-154
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• 2016

The wood decay fungi are a diverse taxonomic group that plays a pivotal role in forest carbon cycling. Wood decay fungi use various enzymatic pathways to digest dead or living wood in order to obtain carbon and other nutrients and these enzymatic systems have been exploited for both industrial and medical applications. Over 600 wood decay fungi species have been described in Korea; however, the recent application of molecular markers has dramatically altered the taxonomy of many of these wood decay fungi at both the genus and species levels. By combining molecular methods, specifically sequences of the internal transcribed spacer region, with traditional morphological characters, this study identified five new species records for Korea in five genera: Aurantiporus, Favolus, Neofavolus, Loweomyces, and Hymenochaetopsis. Three of these genera (Aurantiporus, Favolus, and Loweomyces) were previously unknown in Korea. The relatively simple morphology of the wood decay fungi often leads to ambiguous taxonomic assignment. Therefore, molecular markers are a necessary component of any taxonomic or evolutionary study of wood decay fungi. Our study highlights the need for a more robust and multifaceted approach in investigating new wood decay fungi in Korea.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.722-723
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• 2006

A new method has been developed to fabricate microcomponents by a combination of photolithography and sintering of metallic powder mixtures, without the need for compression and the addition of Mg. This involves (1) the fabrication of a micromould, (2) mould filling of the powder/binder mixture, (3) debinding and (3) sintering. The starting powdered materials consisted of a mixture of aluminium powder(average size of 2.5 um) and alloying elemental powder of Cu and Sn(less than 70nm), at appropriate proportions to achieve nominal compositions of Al-6wt%Cu, Al-6wt%Cu-3wt%Sn. This paper presents detailed investigation of debinding behaviour and microstructural development.

• International Journal of Stem Cells
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• v.16 no.2
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• pp.156-167
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• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.

• The Journal of the Korean dental association
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• v.57 no.9
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• pp.504-513
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• 2019

Dental education is gradually transitioning to competency-based education system, which aims to help dentists achieve certain core competencies by means of various systems, such as curriculum accreditation. This study examined satisfaction with dental school education and the differences in the perceived importance and self-assessment of competencies among general dentists, in an attempt to propose a desirable direction for dental education. A questionnaire was administered to new general dentists who graduated from a dental school within the past 10 years. The results of the survey were analyzed using the Importance-Performance Analysis to understand differences in dentists' perceptions. Overall satisfaction with education was low in terms of the curriculum's relevance to actual practice and its capacity for cultivating required competencies. Furthermore, many of the respondents strongly perceived the need to improve dental education. Additional investigations into the satisfaction with education showed no difference. Among the seven key competency domains, dentists perceived Health Promotion to be important and also assessed themselves as having high competence. However, regarding the perceived importance of the remaining domains, self-assessment of competence was low for Professionalism, Communication & Interpersonal Skills, Knowledge Base, Information Handling & Critical Thinking, Clinical Information Gathering, Diagnosis & Treatment Planning, and Establishment & Maintenance of Oral Health. The results of this study suggest that a competency-based education model should be developed and incorporated into dental education to set performance standards and to promote systematic self-assessment in order to foster the development of competence in dental students.

• Journal of Microbiology and Biotechnology
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• v.28 no.11
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• pp.1771-1781
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• 2018

The emergence of multidrug-resistant microorganisms, as well as fungal infectious diseases that further threaten health, especially in immunodeficient populations, is a major global problem. The development of new antifungal agents in clinical trials is inferior to the incidence of drug resistance, and the available antifungal agents are restricted. Their mechanisms aim at certain characteristics of the fungus in order to avoid biological similarities with the host. Synthesis of the cell wall and ergosterol are mainly targeted in clinical use. The need for new approaches to antifungal therapeutic agents or development alternatives has increased. This review explores new perspectives on mechanisms to effectively combat fungal infections and effective antifungal activity. The clinical drug have a common feature that ultimately causes caspase-dependent cell death. The drugs-induced cell death pathway is associated with mitochondrial dysfunction, including mitochondrial membrane depolarization and cytochrome c release. This mechanism of action also reveals antimicrobial peptides, the primary effector molecules of innate systems, to highlight new alternatives. Furthermore, drug combination therapy is suggested as another strategy to combat fungal infection. The proposal for a new approach to antifungal agents is not only important from a basic scientific point of view, but will also assist in the selection of molecules for combination therapy.

• Asia Marketing Journal
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• v.14 no.1
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• pp.159-174
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• 2012

This study investigate the role of consumer's perception of quality in new technology adoption process in China which is given little attention in the field of Information System and Communication Technology. Here, we developed a simple model in the level of consumer perception by exploring the antecedent of perceived quality. Three factors are introduced as determinants of perceived quality: perceived usefulness, perceived risk and trialability. An empirical study is conducted with analysis of the adoption mechanism of a new innovative product. Data analysis results support some of our proposed hypotheses. It indicates that perceived quality is positively related to the adoption intention and fully mediates the relationship between triablility and purchase intention. And we conclude that a product's perceived quality plays an important role in adoption intention. And what makes Chinese customers perceive product's quality good is a trialability of a product. This suggests that when market managers plan to launch products in China, they need to craft an effective strategy based on the market system of the consumer especially understanding the consumers' critical factor for adopting a new product. Chinese are more interested to purchase a product with free trial and free experiential period, therefore, suggesting an advertisement highlighting the trialability of a product is possible in China.

• Oral Biology Research
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• v.42 no.4
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• pp.198-207
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• 2018

Guided tissue regeneration (GBR) has been used to promote new bone formation in alveolar bone reconstruction at defective bone sites following tooth loss. Bone grafts used in GBR can be categorized into autogenous, xenogenous, and synthetic bones, and human allografts depending on the origin. The purpose of this study was to compare the rates of bone regeneration using two different bone grafts in the cranial defects of rabbits. Ten New Zealand rabbits were used in this study. Four defects were created in each surgical site. Each defect was filled as follows: with nothing, using a 50% xenograft and 50% human freeze-dried bone allograft (FDBA) depending on the volume rate, human FDBA alone, and xenograft alone. After 4 to 8 weeks of healing, histological and histomorphometric analyses were carried out. At 4 weeks, new bone formation occurred as follows: 18.3% in the control group, 6.5% in group I, 8.8% in group II, and 4.2% in group III. At 8 weeks, the new bone formation was 14.9% in the control group, 36.7% in group I, 39.2% in group II, and 16.8% in group III. The results of this study suggest that the higher the proportion of human FDBA in GBR, the greater was the amount of clinically useful new bone generated. The results confirm the need for adequate healing period to ensure successful GBR with bone grafting.

• Transactions of the Korean hydrogen and new energy society
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• v.27 no.1
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• pp.36-41
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• 2016

The development need of new renewable energy is more and more important to resolve exhaustion of chemical fuels and environmental pollution. Polymer electrolyte membrane fuel cell has been widely studied to the extent that it can be used commercially. But there are many problems to be solved. One of them is to enhance the stability of fuel cell stacks. This paper proposes a new fault diagnosis method using Least Square Method (LSM) which is one of parameter estimation methods. The proposed method extracts equivalent circuit parameters from on-line measurements. Parameters of the circuit are estimated according to normal and abnormal states using simulation. The variation of parameters estimated in each states enables the estimation of state in fuel cells. Thus the LSM presented can be a suitable on-line parameter estimation method in PEMFC.

• Journal of Broadcast Engineering
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• v.11 no.1 s.30
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• pp.66-79
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• 2006

As constant development of digital broadcasting and data broadcasting system, new technology will be introduced to digital broadcasting and new broadcasting service will be appeared. These services need to be changed and processed to suit each services and the software of the receiver need to be upgraded. Though, generally the digital broadcasting receivers are not getting updated once it's delivered to home for long time and it need to be done by hand or collected each one of them with trouble. Therefore this paper suggests a way to overcome these difficulties via broadcasting stream. This research is to describe how three modules-namely (1) Downloader, downloads new software from data carrousel stream, (2) Update Loader, installs the software received by downloader; and (3) Recoverer, recovers the former version of the software if some serious problem has been occurred during downloading and installing the software. This paper tries to realize the accommodation of terrestrial STB based on the new technique and service following ATSC A-97 agreement.