• 한국의학물리학회지:의학물리
• /
• 제35권1호
• /
• pp.1-9
• /
• 2024

Margin inclusion or exclusion remains the most critical and controversial aspect of stereotactic radiosurgery (SRS) for metastatic brain tumors. This review aimed to examine the available literature on the impact of margins in SRS of brain metastasis and to assess the response of some medical physicists on the use of these margins. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method was used to review articles published in PubMed, Embase, and Science Direct databases from January 2012 to December 2022 using the following keywords: planning target volume, brain metastasis, margin, and stereotactic radiosurgery. A simple survey consisting of five questions was completed by ten medical physicists with experience in SRS treatment planning. The results were analyzed using IBM SPSS Statistics version 26.0. Of the 1,445 articles identified, only 38 articles were chosen. Of these, eight papers were deemed relevant to the focus of this review. These papers showed an increase in the risk of radionecrosis, whereas differences in local control were variable as the margin increased. In the survey, the response rate to whether or not to use margins in SRS, a critical question, was 50%. Margin addition increases the risk of radio necrosis. The local control rate varies among treatment modalities and cannot be generalized. From the survey, no consensus was reached regarding the use of these margins. This calls for further deliberations among professionals directly involved in SRS.

• 대한한의학방제학회지
• /
• 제12권2호
• /
• pp.175-202
• /
• 2004

Nitric oxide(NO) play an important role in normal and pathophysiological cells including as a messenger molecule, neurotransmitter, microbiocidal agent, or dilator of blood vessels and artheriosclerosis, hypertension, myocardial infarction, respectively. To investigate that Ondamtang in the potential contribution of the levels of nitric oxide generated by endothelial nitric oxide synthase (eNOS) and the mechanisms of protection against L-NAME, human ECV304 cells, which normally do not express eNOS, were expressed by L-NAME. L-NAME stimulated rat or cells were found to be resistant to injury and delayed death following the Ondam-tang. Inhibition of nitric oxide synthesis abolished the protective effect against L-NAME, thrombin and collagen exposure. Interestingly, such effects have bee observed during stimulation with agents such as KCl on L-NAME mediate rats, were damaged by the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME). Cardiovascular diseases is one of the blood vessels and renin-angiotensin system dynfunction. So we studied on herbal medicine that have a relation of vessels endothelium necrosis. In Oriental Medicine, Ondam-tang has been used for disease in relation to cardiovascular system. We studied on the protection and inhibitory effects of cardiovascular diseases in L-NAME induced rat or ECV304 cell lines through the Cell morphological pattern, Tunel assay, LDH activity, heart rate, blood pressure and immunohistochemistric analysis by Ondam-tang. As the result of this study, In group, the anti-apoptosis and necrosis in the cardiovascular system have a potential capacity for prevented, protected and treating the diseases of cardiovascular system, against the necrosis of rat and ECV304 cells with eNOS and calpain expression by L-NAME is promoted.

• 식물병연구
• /
• 제12권3호
• /
• pp.226-230
• /
• 2006

노지 포장에서 채집한 고추 잎에 바이러스 병징을 나타내는 총 62개 시료 중 32개(52%)시료가 CMV에 감염되었다. CMV에 감염된 32개체 중 22개(68.8%) 시료는 엽맥퇴록 및 엽맥괴저 병징을 나타냈으며 모두 CMV(CMV-VCH)에 단독감염되어 있었다. 생물검정결과 Nicotiana glutinosa에서 접종엽에 엽맥퇴록, 상엽에 엽맥녹대, 엽맥괴저, 순괴저에 이르는 심한 병징을 보였고, N. benthamiana와 N. tabacum cv. 'Ky-57'에서 접종엽에 무병징, 상엽에 엽맥녹대, 기형 및 물집 병징을 일으켰다. 고추 시판품종인 '부강', '마니따' 그리고 '꽈리풋고추' 모두 엽맥퇴록 병징이 나타났으며 후기에는 기형이 되었다. RT-PCR 유전자 진단결과 엽맥퇴록 병징의 시료는 모두 CMV에 감염되었으며, CMV-VCH 바이러스 입자는 약 30 nm의 구형 이었다. 자외선 흡광도는 260nm에서 최고, 242nm에서 최저였으며 핵산과 단백질 비율은 1.71이었다. CMV-VCH의 핵 단백질은 단일 단백질이며 분자량은 24.5kDa 이었다.

• 한국어병학회지
• /
• 제30권1호
• /
• pp.1-9
• /
• 2017

2016년 2월에서 9월까지 강원도 고성, 양양, 강릉에서 각각 양성 중인 명태를 샘플링하여 RT-PCR법으로 바이러스(viral hemorrhagic septicemia virus, VHSV; nervous necrosis virus, NNV; marine birnavirus, MABV)의 검출을 시도하였다. 비장시료를 대상으로 한 one-step PCR에서 VHSV, NNV, MABV 모두 검출되지 않았으며, 뇌시료에서 NNV가 1.8%(1/55)의 검출률을 나타내었다. Two-step PCR에서는 VHSV가 51.6%(32/62 set), NNV가 1.6%(1/62 set)의 비장시료에서 검출되었으며 MABV는 검출되지 않았다. 뇌시료에서는 NNV가 3.6%(2/55)의 검출률을 나타내었다. 본 연구결과를 통해 양식산 명태에서 처음으로 VHSV와 NNV가 검출되었다. 그러나 거의 모든 양성개체에서 two-step PCR법으로 해당 바이러스의 유전자가 검출되었으며, 모니터링 기간 동안 바이러스 감염이 의심되는 외관증상을 보이는 개체 및 폐사 개체는 발견되지 않아 바이러스의 역가는 매우 낮을 것으로 생각된다. 차후 지속적인 모니터링 및 세포주를 사용한 바이러스의 분리, 병원성의 확인, PCR 양성개체의 캐리어 가능성 확인 등이 필요할 것으로 생각된다.

• 생명과학회지
• /
• 제25권5호
• /
• pp.539-547
• /
• 2015

본 연구는 다슬기(Semisulcospira libertine) 열수 추출물이 D-galactosamine에 의해 급성 간독성이 유도된 흰쥐에 미치는 보호 효과를 조사하였다. 다슬기 열수 추출물은 D-galactosamine에 의해 유발된 간 조직 내 국소적 지방변성과 염증세포 침윤을 크게 완화하여 대조군과 유사하게 보호하는 경향을 보였다. 또한 다슬기 열수 추출물을 처리한 실험군은 간 손상 지표 효소인 AST와 ALT, LDH 및 ALP의 활성이 대조군 수준으로 유지되었으며 간조직 내 지질함량과 과산화지질함량이 감소되는 것으로 나타나 다슬기 열수 추출물이 D-galactosamine으로 인한 혈중 효소 활성과 조직 내 지질함량을 개선하는 것으로 조사되었다. 또한 다슬기 열수 추출물을 처리한 실험군은 염증반응을 촉진시켜 조직 상해 및 괴사를 유도하는 TNF-α의 발현을 억제하고 있어 염증 반응에서 세포 손상을 감소시키는 데 관여하는 것으로 나타났다. 따라서 다슬기 열수 추출물은 D-galactosamine에 의한 조직 괴사를 감소시키고 혈중 효소의 활성과 조직 내 지질함량을 개선하는 효과를 나타내고 있으며 염증 반응 인자의 발현과 항산화효소 활성을 조절하여 간독성에 대해 보호 효과가 높을 것으로 생각된다.

• 대한한의학회지
• /
• 제26권4호
• /
• pp.1-11
• /
• 2005

This study was to investigate the effect of Danchunwhangagam(DCWGG) extract on the production of proinflammatory cytokines in peripheral blood mononuclear cells (PBMCs) from Cerebral infarction(CI) patients. Methods: We examined how the inhibition rate of tumor necrosis factor (TNF)-$\alpha$, interleukin(IL)-1$\alpha$, IL-1$\beta$, IL-6, and IL-8 productions in DCWGG pretreatment PBMCs culture supernatant in the lipopolysaccaride(LPS)- or desferrioxamine(DFX)treated cells compared to unstimulated cells. Results: DCWGG inhibited the productions of TNF-$\alpha$, IL-1$\alpha$, IL-1$\beta$, IL-6, and IL-8 induced by LPS in a dose-dependent manner. Conclusions: DCWGG might have regulatory effects on LPS or DFX-induced cytokine production, which might explain its beneficial effect in the treatment of CI.

• Advances in pediatric surgery
• /
• 제3권2호
• /
• pp.126-132
• /
• 1997

Reduction of intussusception using air or oxygen has wide acceptance as an alternative to conventional hydrostatic reduction. This study was undertaken to evaluate the results and complications of air pressure enema in 948 pediatric intussusception. One hundred and twenty nine cases were operated on at the Department of Surgery, Masan Samsung Hospital from 1985 to 1996 because of air reduction failure. The success rate was 86.4 %. Twenty-one patients(2.2 %) showed perforation during air reduction. Risk prone factors of perforation were; age less than 3 months(42.9 % vs 11.1 %), duration of symptoms greater than 48 hours (66.7 % vs 33.3 %), and presence of pathologic leading point(28.6 % vs 3.7 %). Vomitting and spontaneous rectal bleeding revealed higher prediction to the complication. In nineteen cases, bowel infarction, coagulated necrosis and hemorrhage suggested that the cause of perforation was due to the preexisting strangulation. In conclusion, when doing an air pressure enema reduction, care must be taken if the patient is of a young age or the symptoms are of long duration.

• 한국수의병리학회:학술대회논문집
• /
• 한국수의병리학회 2003년도 추계학술대회초록집
• /
• pp.53-53
• /
• 2003

This benign canine histiocytoma was the most common single tumor type, followed lipoma, adenoma, soft tissue sarcoma, mast cell tumor and lymphosarcoma [2]. Canine cutaneous histiocytoma (CCH) most commonly occur as solitary lesions, head and pinnae are prefermential sites, that undergo spontaneous regression. The histologic appearance varies greatly, depending on the age of the lesion and the degree of necrosis and secondary inflammation. The age-specific incidence rate for CCH drops precipitously after 3 years, although histiocytomas occur in dogs of all ages [5]. Their etiology and pathogenesis are unknown. This case reports the gross and histopathological findings of canine cutaneous histiocytoma of observed in a young dog with localized calcification of lingual muscle. (omitted)

• Journal of Chest Surgery
• /
• 제25권8호
• /
• pp.877-884
• /
• 1992

From October, 1986, to June, 1992 16 patients, 13 male and 3 female patients ranging in age 28 to 70 years, were operated on for thoracic aortic aneurysm, The etiology of these patients was atherosclerotic in 10, cystic medial necrosis in 4, and trauma in 2 cases, All patients were treated by use of CPB and circulatory arrest was applicated in one patient, Ten patients had aneurysms involving ascending aorta and six patients had descending aortic aneurysm, Among ten patients with ascending aortic aneurysm, annuloaortic ectasia with aortic regurgitation were seven and all underwent surgery with composite technique [Bentall operation], The other six patients with descending thoracic aneurysm were performed graft replacement. There was no early mortality but two late deaths occurred due to cerebral hemorrhage and renal problems at POD 3mo and 39mo respectively, We obtained satisfactory long-term results and overall survival rate at 5 year was 74.7%.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제39권
• /
• pp.5.1-5.9
• /
• 2017

Many congenital and acquired defects occur in the maxillofacial area. The buccal fat pad flap (BFP) is a simple and reliable flap for the treatment of many of these defects because of its rich blood supply and location, which is close to the location of various intraoral defects. In this article, we have reviewed BFP and the associated anatomical background, surgical techniques, and clinical applications. The surgical procedure is simple and has shown a high success rate in various clinical applications (approximately 90%), including the closure of oroantral fistula, correction of congenital defect, treatment of jaw bone necrosis, and reconstruction of tumor defects. The control of etiologic factors, size of defect, anatomical location of defect, and general condition of patient could influence the prognosis after grafting. In conclusion, BFP is a reliable flap that can be applied to various clinical situations.