• Asian Pacific Journal of Cancer Prevention
• /
• 제14권8호
• /
• pp.4621-4625
• /
• 2013

The purpose of this study was to construct a protein-protein interaction (PPI) network related to oral squamous cell carcinoma (OSCC). Each protein was ranked and those most associated with OSCC were mined within the network. First, OSCC-related genes were retrieved from the Online Mendelian Inheritance in Man (OMIM) database. Then they were mapped to their protein identifiers and a seed set of proteins was built. The seed proteins were expanded using the nearest neighbor expansion method to construct a PPI network through the Online Predicated Human Interaction Database (OPHID). The network was verified to be statistically significant, the score of each protein was evaluated by algorithm, then the OSCC-related proteins were ranked. 38 OSCC related seed proteins were expanded to 750 protein pairs. A protein-protein interaction nerwork was then constructed and the 30 top-ranked proteins listed. The four highest-scoring seed proteins were SMAD4, CTNNB1, HRAS, NOTCH1, and four non-seed proteins P53, EP300, SMAD3, SRC were mined using the nearest neighbor expansion method. The methods shown here may facilitate the discovery of important OSCC proteins and guide medical researchers in further pertinent studies.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2007년도 Proceedings of ISRS 2007
• /
• pp.616-619
• /
• 2007

Nowadays, urbanized area expands its boundary, and distribution of urbanized area is gradually transformed into more complicated pattern. In Korea, SMA(Seoul Metropolitan Area) has outstanding urbanized area since 1950s. But it is ambiguous whether urban distribution is clustered or dispersed. This study aims to show the way in which expansion of urbanized area impacts on spatial distribution pattern of urbanized area. We use quadrat analysis, nearest-neighbor analysis and fractal analysis to know distribution pattern of urbanized area in time-series urban growth. The quadrat analysis indicates that distribution pattern of urbanized area is clustered but the cohesion is gradually weakened. And the nearest-neighbor analysis shows that point patterns are changed that urbanized area distribution pattern is progressively changed from clustered pattern into dispersed pattern. The fractal dimension analysis shows that 1972's distribution dimension is 1.428 and 2000's dimension is 1.777. Therefore, as time goes by, the complexity of urbanized area is more increased through the years. As a result, we can show that the cohesion of the urbanized area is weakened and complicated.

• 지능정보연구
• /
• 제14권2호
• /
• pp.193-206
• /
• 2008

의료 진단 문제는 기정의된 특성치들로 표현되는 환자의 상태 데이터로부터 병의 유무를 판단하는 일종의 분류 문제로 간주할 수 있다. 본 연구는 혼용 유전자 알고리즘 기반의 분류방법을 도입함으로써 의료 진단 문제와 같은 다차원의 패턴 분류 문제를 해결할 수 있는 방안을 제안하고 있다. 일반적으로 분류 문제는 데이터 패턴에 존재하는 여러 클래스 간 구분경계를 생성하는 접근방법을 사용하는데, 이를 위해 본 연구에서는 일단의 영역 에이전트들을 도입하여 이들을 유전자 알고리즘 및 국소 적응조작을 혼용함으로써 데이터 패턴에 적응하도록 유도하고 있다. 일반적인 유전자 알고리즘의 진화단계를 거친 에이전트들에 적용되는 국소 적응조작은 영역 에이전트의 확장, 회피 및 재배치로 이루어지며, 각 에이전트의 적합도에 따라 이들 중 하나가 선택되어 해당 에이전트에 적용된다. 제안된 의료 진단용 분류 방법은 UCI 데이터베이스에 있는 잘 알려진 의료 데이터, 즉 간, 당뇨, 유방암 관련 진단 문제에 적용하여 검증하였다. 그 결과, 기존의 대표적인 분류기법인 최단거리이웃방법(the nearest neighbor), C4.5 알고리즘에 의한 의사 결정트리(decision tree) 및 신경망보다 우수한 진단 수행도를 나타내었다.

• International Journal of Computer Science & Network Security
• /
• 제23권8호
• /
• pp.95-100
• /
• 2023

Due to Traffic accidents people faces health and economical casualties around the world. As the population increases vehicles on road increase which leads to congestion in cities. Congestion can lead to increasing accident risks due to the expansion in transportation systems. Modern cities are adopting various technologies to minimize traffic accidents by predicting mathematically. Traffic accidents cause economical casualties and potential death. Therefore, to ensure people's safety, the concept of the smart city makes sense. In a smart city, traffic accident factors like road condition, light condition, weather condition etcetera are important to consider to predict traffic accident severity. Several machine learning models can significantly be employed to determine and predict traffic accident severity. This research paper illustrated the performance of a hybridized neural network and compared it with other machine learning models in order to measure the accuracy of predicting traffic accident severity. Dataset of city Leeds, UK is being used to train and test the model. Then the results are being compared with each other. Particle Swarm optimization with artificial neural network (PSO-ANN) gave promising results compared to other machine learning models like Random Forest, Naïve Bayes, Nearest Centroid, K Nearest Neighbor Classification. PSO- ANN model can be adopted in the transportation system to counter traffic accident issues. The nearest centroid model gave the lowest accuracy score whereas PSO-ANN gave the highest accuracy score. All the test results and findings obtained in our study can provide valuable information on reducing traffic accidents.

• 치과방사선
• /
• 제28권2호
• /
• pp.387-413
• /
• 1998

Image resampling is of particular interest in digital radiology. When resampling an image to a new set of coordinate, there appears blocking artifacts and image changes. To enhance image quality, interpolation algorithms have been used. Resampling is used to increase the number of points in an image to improve its appearance for display. The process of interpolation is fitting a continuous function to the discrete points in the digital image. The purpose of this study was to determine the effects of the seven interpolation functions when image resampling in digital periapical images. The images were obtained by Digora, CDR and scanning of Ektaspeed plus periapical radiograms on the dry skull and human subject. The subjects were exposed to intraoral X-ray machine at 60kVp and 70 kVp with exposure time varying between 0.01 and 0.50 second. To determine which interpolation method would provide the better image, seven functions were compared; (1) nearest neighbor (2) linear (3) non-linear (4) facet model (5) cubic convolution (6) cubic spline (7) gray segment expansion. And resampled images were compared in terms of SNR(Signal to Noise Ratio) and MTF(Modulation Transfer Function) coefficient value. The obtained results were as follows ; 1. The highest SNR value(75.96dB) was obtained with cubic convolution method and the lowest SNR value(72.44dB) was obtained with facet model method among seven interpolation methods. 2. There were significant differences of SNR values among CDR, Digora and film scan(P<0.05). 3. There were significant differences of SNR values between 60kVp and 70kVp in seven interpolation methods. There were significant differences of SNR values between facet model method and those of the other methods at 60kVp(P<0.05), but there were not significant differences of SNR values among seven interpolation methods at 70kVp(P>0.05). 4. There were significant differences of MTF coefficient values between linear interpolation method and the other six interpolation methods (P< 0.05). 5. The speed of computation time was the fastest with nearest -neighbor method and the slowest with non-linear method. 6. The better image was obtained with cubic convolution, cubic spline and gray segment method in ROC analysis. 7. The better sharpness of edge was obtained with gray segment expansion method among seven interpolation methods.

• International journal of advanced smart convergence
• /
• 제2권2호
• /
• pp.40-42
• /
• 2013

Recent medical industry is an aging society and the application of national health insurance, with state-of-the-art research and development, including the pharmaceutical market is greatly increased. The nation's health care industry through new support expansion and improve the quality of life for the research and development will be needed. In addition, systemic administration of basic medical supplies, or drugs are needed, the drug at the same time managing how systematic analysis of pharmaceutical ingredients, based on data through the purchase of new medicines and pharmaceutical ingredients automatically classified by analyzing the statistics of drug purchases and the future a system that can predict a patient is needed. In this study, the drugs to the patient according to the component analysis and predictions for future research techniques, k-means clustering and k-NN (Nearest Neighbor) Comparative studies through experiments using the techniques employ a more efficient method to study how to proceed. In this study, the effects of the drugs according to the respective components in time according to the number of pieces in accordance with the patient by analyzing the statistics by predicting future patient better medical industry can be built.

• 물과 미래
• /
• 제28권2호
• /
• pp.169-180
• /
• 1995

관망상배관(Looped networks)시스템에서 관수로시스템의 전체비용은 폐회로유량(Loop flows)에 따라 영향을 받는다. 따라서 관망상배관의 최적설계를 위한 수학적모형을 추계학적 최적화방법에 적용하기 위하여 폐회로유량의 섭동(Perturbations)으로 전체비용이 변하게 하였다. 관망상 배관문제의 분석가능영역은 수많은 국지해(Local optimum)를 갖는 비볼록(Nonconvex)이므로 분석가능영역의 효율적인 심사를 위하여 수정추계학적 심사방법을 제안하였으며 이 방법은 국부심사단계(Global search phase)와 국지심사단계(Local search phase)로 구성되어 있다. 국부탐사에서는 점차적으로 국지해를 증진시키며 국지탐사에서는 국부탐사단계에서 교착상태에 있는 국지해로 부터 벗어나게 하거나 최종국지해를 증진시킨다. 제안한 방법의 효율성을 검정하기 위하여 참고문헌에 있는 기존관수로시스템의 병열관로(Parallel pipe line) 확장문제를 표본으로 채택하여 제안한 방법을 적용한 결과 먼저 발표된 연구자들의 비용보다 적은 비용으로 설계할 수 있었다.

• 유통과학연구
• /
• 제16권1호
• /
• pp.87-99
• /
• 2018

Purpose - The Export Infrastructure Strengthening Program(EISP) is a project to expand exports of agri-food products through providing customized export information to food distribution companies and supporting overseas information activities. A total of 39.6 billion won was provided by 2016. So, the purpose of this study is to analyze whether EISP is effective for expanding exports of agri-food products. Research design, data, and methodology - A simple average difference between the export performance of the policy beneficiaries and the non-policy beneficiaries can be biased if the export capacity or inherent characteristics of the enterprise are not taken into consideration. In order to solve the problem of such a bias, the propensity score matching(PSM) method has been employed in this study. PSM is a method of converting the characteristics of an export company into an index through logit analysis and then reducing the matching to one dimension to improve the accuracy of the performance measurement. Results - The balancing test was conducted to determine how the characteristics of the policy beneficiary group and the matched policy non-beneficiary group corresponded to each other. As a result of the test, we could not reject the null hypothesis that there was no difference between the two groups, so that after the matching, the two groups were similar and the explanatory variables were well controlled. Using the nearest neighbor matching with propensity score estimating through logit analysis, we estimated average treatment effect on the treated(ATT). The food companies participating the EISP had the effect of increasing the exports of $ 5.88 million. As a result, the number of export contracts increased by 11.77, the number of exporting countries by 7.52, the number of export items by 47.51, and the number of buyers' consultation by 3.50. And overseas marketing expenses increased by 35.92 million won. Except for the number of export contracts, other export performance results showed statistically significant results. Conclusions - As the EISP has a positive effect on the expansion of agro-food exports, efforts should be made to find out the limitations or problems of the policy in the future and to make a greater contribution to the increase of exports.