• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.21-21
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• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.4 no.1
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• pp.41-51
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• 2001

'The Ecological Forest' in Youido Park was intended to be an artificial forest in urban center, following the form of natural forests in central Korea. This study was to investigate the planting plan and the vegetation change of 'the Ecological Forest' and to compare it with natural forests of similar plant composition. The natural forests had slopes between $12^{\circ}$ and $21^{\circ}$, whereas 'the Ecological Forest' had slopes between $2^{\circ}$ and $6^{\circ}$. It was unlikely that the slope condition was adequate to show 'toposequence succession' at 'the Ecological Forest'. The soil bulk density and soil hardness of 'the Ecological Forest' were higher than those of the natural forests. The soil pH of 'the Ecological Forest' was 7.45, which was greater than that of the natural forests. There were some changes in plant composition and amounts 2 years after the construction : the number of conifers was reduced from 383 to 338 ; the number of deciduous trees was reduced from 4717 to 1158. It was because of the young trees dead in the sub-tree layer. The herbaceous species planted were 14 families, 31 species, which increased to 37 families, 93 species after 2 years. In case of horizontal structure of vegetation, trees and shrubs were distributed evenly in the natural forests, whereas 'the Ecological Forest' showed uneven distribution with higher total density. In case of vertical structure of vegetation, the natural forests had distinctive layers with dominant species distributed in each layers. In 'the Ecological Forest', however, dominant species were only in tree layer. The natural forests had greater average tree height, tree density, however, and basal area than 'the Ecological Forest'. The results showed that there were some differences in the structure between 'the Ecological Forest' and natural forests. The management plan should be applied in order that the natural condition be restored in 'the Ecological Forest' by competition between plant species and natural processes.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2003.04a
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• pp.157-157
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• 2003

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2003.04a
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• pp.149-149
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• 2003

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2003.04a
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• pp.158-158
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• 2003

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2003.10a
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• pp.118-118
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• 2003

• Journal of the Korean Professional Engineers Association
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• v.42 no.4
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• pp.55-61
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• 2009

Retaining wall is a structure to stabilize the land slope as vertical retaining wall have constructed to make efficiency use of downtown area. Recently to commune with nature and refine a apartment and structure, natural friendly relations for retaining walls are tried to construct. The surface of the concrete walls are weave in various figures and colours, and in some places plant a shrub. Laying a landscape stone which have disclose a plane nature one means keeping up the natural slope, constructively safely set a anchor in front side and rear side wall between the natural stone, plant shrub or ground coverings to give shape into a rock. Natural stone is exposed of surface and planting the gardening, to be a type of natural friendly relations however that will be recycled. The size of blasted nature stone which is irregular become more natural type of one.

• Natural Product Sciences
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• v.9 no.1
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• pp.34-37
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• 2003

We examined methanol extracts prepared from the Korean plants for their inhibitory effects on rat lens aldose reductase (RLAR) activity in vitro. Among 41 plant extracts, the extracts of Lagerstroemia indica, Punica granatum, Eurya japonica, Liquidambar styraciflua, and Vitis coignetiae exhibited highest inhibitory potency, even more potent than tetramethylene glutaric acid (TMG), known as one of typical aldose reductase inhibitors $(IC_{50}\;value,\;0.51\;{\mu}g/ml)$. Especially, the extract of Lagerstroemia indica (Lythraceae), exhibited the most inhibitory potency $(IC_{50}\;value,\;0.069\;{\mu}/ml)$ on RLAR.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2000.10a
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• pp.38.2-38
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• 2000

• Korean Journal of Plant Resources
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• v.22 no.6
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• pp.498-505
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• 2009

The plant Agastache rugosa Kuntze has various physiological and pharmacological activities. Especially, it has been regarded as a valuable source for the treatment of anti-inflammatory and oxidative stress-induced disorders. However, little has been known about the functional role of it on oxidative damage in mammalian cells by ROS. In this study, we investigated the DPPH radical, hydroxyl radical, hydrogen peroxide and intracellular ROS scavenging capacity, and $Fe^{2+}$ chelating activity of the extracts from Agastache rugosa. In addition, we evaluated whether the extract can be capable of reducing $H_2O_2$-induced DNA and cell damage in NIH 3T3 cells. These extracts showed a dose-dependent free radical scavenging capacity and a protective effect on DNA damage and the lipid peroxidation causing the cell damage by $H_2O_2$. Therefore, these results suggest that Agastache rugosa is useful as a herbal medicine for the chemoprevention against oxidative carcinogenesis.