• Korean Journal of Pharmacognosy
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• 제34권2호통권133호
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• pp.156-160
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• 2003

$NF-{\kappa}B$ (nuclear factor-kappa B) plays a particularly central role in epidermal biology. It has been established that ultraviolet radiation (UVR) is one of the mechanisms to induce the activation of $NF-{\kappa}B$ in human skin. We previously demonstrated that melanogenic inhibitors may act through the inhibition of $NF-{\kappa}B$ activation in keratinocytes. In order to find another type of melanogenic inhibitors of $NF-{\kappa}B$ activation, various kinds of the extracts from crude drugs $(30\;{\mu}g/ml)$ were preincubated with transfectant HaCaT cells for 3 hrs and then UVR $(60\;mj/cm^2)$ was irradiated. UVR-exposed cells were incubated for another 6 hrs to measure the $NF-{\kappa}B$ activity. $NF-{\kappa}B$ activation was measured with the secreatory alkaline phosphates (SEAP) reporter gene assay using a fluorescence detection method. Among natural products, Lycium chinense, Acanthopanax senticosus, Angelica koreana, Kalopanax pictus and Asparagus cochinchinensis were the most potent inhibitors of $NF-{\kappa}B$ activation by UVR. These observations suggest that some crude drugs might act partially through the modulation of the synthesis of melanotrophic factors to decrease melanogenesis in keratinocytes.

• IMMUNE NETWORK
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• 제6권3호
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• pp.117-122
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• 2006

Background: Caveolin, a family of integral membrane proteins are a principal component of caveolae membranes. In this study, we investigated the effect of p38 kinase on differentiation and on inflammatory responses in sodium nitroprusside (SNP)-treated chondrocytes. Methods: Rabbit articular chondrocytes were prepared from cartilage slices of 2-week-old New Zealand white rabbits by enzymatic digestion. SNP was used as a nitric oxide (NO) donor. In this experiments measuring SNP dose response, primary chondrocytes were treated with various concentrations of SNP for 24h. The time course of the SNP response was determined by incubating cells with 1mM SNP for the indicated time period $(0{\sim}24h)$. The cyclooxygenase-2 (COX-2) and type II collagen expression levels were determined by immunoblot analysis, and prostaglandin $E_2\;(PGE_2)$ assay was used to measure the COX-2 activity. The tyrosine phosphorylation of caveolin-1 was determined by immunoblot analysis and immunostaining. Results: SNP treatment stimulated tyrosine phosphorylation of caveolin-1 and activation of p38 kinase. SNP additionally caused dedifferentiation and inflammatory response. We showed previously that SNP treatment stimulated activation of p38 kinase and ERK-1/-2. Inhibition of p38 kinase with SB203580 reduced caveolin-1 tyrosine phosphorylation and COX-2 expression but enhanced dedifferentiation, whereas inhibition of ERK with PD98059 did not affect caveolin-1 tyrosine phosphorylation levels, suggesting that ERK at least is not related to dedifferentiation and COX-2 expression through caveolin-1 tyrosine phosphorylation. Conclusion: Our results indicate that SNP in articular chondrocytes stimulates dedifferentiation and inflammatory response via p38 kinase signaling in association with caveolin-1 phosphorylation.

• Journal of the Korean Wood Science and Technology
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• 제23권2호
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• pp.47-54
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• 1995

This study was to measure the properties of logs and classify them by non-destructive methods. The purpose of this experiment was focused at mensurability of logs by non-destructive methods. The non-destructive instrument, Stress-Wave Timer 239A which was made by Metriguard in U.S.A., was used. The stress wave velocities of log's cross direction were measured and compared with three different methods; 1. with hammer, 2. with hammer and D.B.H. meter, 3. with manufactured instrument. Number of used logs were seven logs, which were classified by naked eye into six groups; very severe rot, severe rot, mild rot & knot, mild rot & check, mild rot, sound log, and in diameter were into three groups; large(57.4cm), medium(36~41.2cm), small(28.9cm) log. The results, which were classified by mensurability with non-destructive methods, were followed; 1. The stress wave velocities were very different between rot and sound log. So it meant the possibility of mensurability of logs by non-destructive method even if high standard error. 2. The stress wave velocities decreased with checks more than with rots, which meant the checks affected speeds more. 3. The stress wave velocities increased with knot. 4. The velocities with manufactured instrument showed lower standard error, so more accurate results than other methods. Especially the required labour decreased from 3~4 to 2 persons. 5. Finally, the mensurability showed more accurate results and made the classification of logs scientific.

• Journal of the Korean Institute of Gas
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• 제21권6호
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• pp.70-80
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• 2017

According with annual report by the OECD (Organization for Economic Co-operation and Development), South Korea is at the top of the list of countries with bad air pollution (fine dust particles) and the South Korean government announced the cause to be due to the particle emissions of large and old diesel vehicles. To solve this issue, the government (jointly with related ministries), promoted the "Special Measures for Comprehensive Fine Dust Management Program" as a way to improve environmental pollution by reducing the overall output of fine dust particles emitted by public vehicles. The measure implemented a gas subsidy system to convert eco-friendly vehicles of city and chartered buses throughout the country. In this study, we take a look at the economical evaluation, comparison and analysis of the conversion of diesel vehicles to natural gas (CNG) vehicles. This report represent the basis for the need to expand the funds of the subsidy program and reviews the feasibility of the policy by taking into consideration the social and economical benefits and the effect in the environment when converting diesel fuel to natural gas vehicles through the type-specific fuel conversion scenarios.

• Analytical Science and Technology
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• 제30권5호
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• pp.287-294
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• 2017

As the demand for natural gas increases with industrial development, the supply of natural gas is expected to become unstable with a shortage of imported natural gas. It is hence necessary to meet this demand by introducing and developing various types of natural gas, such as pipeline natural gas (PNG) and substituted natural gas (SNG), in addition to liquefied natural gas (LNG). The components included in PNG as well as their concentrations must be measured accurately, and a standard gas should be developed to accurately measure hydrocarbons ($C_6-C_{10}$), which are trace components included in natural gas. The components in the primary standard gas mixtures (PSMs) developed in the present study were hexane, heptane, octane, nonane, and decane with concentrations of $10-30{\mu}mol/mol$ with methane as the balance gas. Standard hydrocarbon ($C_6-C_{10}$) gas mixtures were prepared in aluminum cylinders by a gravimetric method with traceability following ISO 6142 with raw material gases, for which the purity of each component was analyzed completely. The prepared standard gas mixtures were analyzed by to evaluate the preparation consistency between the standard gas mixtures, the adsorbability of the cylinders, the variation of the stability, and the uncertainty. The results showed that aluminum cylinders have little adsorptive loss on their internal surfaces with excellent long-term stability. The developed standard gas mixture, containing hexane, heptane, octane, nonane, and decane with concentrations of $10-30{\mu}mol/mol$, showed an uncertainty in a range of 0.79 % - 1.63 %.

• Journal of Korean Society on Water Environment
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• 제20권2호
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• pp.120-125
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• 2004

Exposure to volatile disinfection by-products (DBPs) such as chloroform included in chlorinated tap water can occur during household activities via inhalation as well as ingestion and dermal absorption. This study was conducted to examine the significance of inhalation route of exposure since humans are unintentionally exposed to volatile DBPs while staying home. Two sets of experiments were carried out in an apartment to measure: 1) the variation of chloroform concentrations in the living room air following kitchen activities (cooking and dish-washing); and 2) the variation of chloroform concentrations in the bathroom and living room following showering. Cooking, dish-washing, and showering all contributed to the elevation of household chloroform levels. Even a few minutes of natural ventilation resulted in the reduction of the chloroform levels to the background. Estimates of daily chloroform doses and lifetime cancer risks suggested that inhalation of household air during staying home be a major route of exposure to chloroform and that ingestion be a minor one in Korean people. It is also suggested that ventilation be a simple and important measure of mitigating human exposure to volatile DBPs indoors.

• Journal of The Korean Society of Agricultural Engineers
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• 제48권6호
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• pp.3-13
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• 2006

Although the drought impacts are comparably not catastrophic, the results from the drought are fatal in various social and economical aspects. Different from other natural hazards including floods, drought advances slowly and spreads widely, so that the preparedness is quite important and effective to mitigate the impacts from drought. Soil moisture depletion directly resulted from rainfall shortage is highly related with drought, especially for crops and vegetations, therefore a drought can be evaluated using soil moisture conditions. In this study, SMI (Soil Moisture Index) was developed to measure a drought condition using soil moisture model and frequency analysis for return periods. Runs theory was applied to quantify the soil moisture depletions for the drought condition in terms of severity, magnitude and duration. In 1994, 1995, 2000, and 2001, Korea had experienced several severe droughts, so the SMI developed was applied to evaluate applicability in the mid-range hydrologic unit watershed scale. From the results, SMI demonstrated the drought conditions with a quite sensitive manner and can be used as an indicator to measure a drought condition.

• Journal of the Korean Society of Physical Medicine
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• 제6권4호
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• pp.397-406
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• 2011

Purpose : Recently ultrasound images has been used to measure the subacromial space with a linear measurement of the acromiohumeral distance. The purpose of this study was to comparison of distance of subacromial space using ultrasonographic measurement on arm positions of shoulder injured patients. Methods : The subjects were 30 shoulder injured patients (19 males and 11 females). Ultrasonography was performed to measure subacromial space during each shoulder resting position, $45^{\circ}$ abduction, internal rotation with $45^{\circ}$ abduction and external rotation with $45^{\circ}$ abduction. Results : Subacromial space was a significantly difference between injured arm and normal arm at shoulder resting position. At $45^{\circ}$ abduction, subacromial space was narrowing significantly between injured arm and normal arm. At external rotation with $45^{\circ}$ abduction, subacromial space were wider in normal arm than in injured arm but it was not significantly. Intra-observer reliability for ultrasonography measurement of subacromial distance was excellent (.96~.99). Conclusion : These results identified that positions of injured shoulder was related to subacromion space.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제10권5호
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• pp.992-999
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• 2009

The pulse transit time(PTT), which is determined by measuring the electrocardiogram(ECG) and pulse wave, gives comprehensive information about the cardiovascular system. However, a little movement of body and/or inaccurate pressure applied to skin during the measurement of pulse wave leads to acquire incorrect results. To overcome such problem, we developed an integrated sensor system which makes it possible to measure ECG, pressure pulse wave(PPW) and photoplethysmograph(PPG) at the same time. Futhermore, we implemented a new metal electrode which enables to continuously measure ECG. We verified that both integrated sensor system and new electrode provide useful effect.

• Proceedings of the KSRS Conference
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.555-558
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• 2006

In recent years, urban development has expanded rapidly in Nawabshah City of Pakistan. A major effect associated with this population trend is transformation of the landscape from natural cover types to increasingly impervious urban land. The core objective of this study are to provide time-series information to define and measure the urban land cover changes of Nawabshah, Pakistan between the years 1992 and 2002, and to examine related urbanization impacts on air quality of the study area. Two multi-temporal Landsat images acquired in 1992 and 2002 together with standard topographical maps to measure land cover changes were used in this study. The image processing and data manipulation were conducted using algorithms supplied with the ERDAS Imagine software. An unsupervised classification approach, which uses a minimum spectral distance to assign pixels to clusters, was used with the overall accuracy ranging from 84 percent to 92 percent. Land cover statistics demonstrate that during the study period (1992-2002) extensive transformation of barren and vegetated lands into urban land have taken place in Nawabshah City. Results revealed that land cover changes due to urbanization has not only contaminated the air quality of the study area but also raised the health concerns for the local residents.