• 한국노년학
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• v.36 no.3
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• pp.541-562
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• 2016

The current study investigates the relationship and the mechanisms between bridge employment and change in marital satisfaction during midlife, using a three-wave panel dataset obtained from the Korean Baby Boomer Panel Study. A multivariate latent growth analysis reveals that the transition from career employment to bridge employment, compared to maintaining career employment, has an indirect negative effect on increase rate of marital satisfaction through the wage decrease. A steep decrease in wage following transition to bridge employment causes a lower increase in marital satisfaction. On the other hand, continuously engaging in bridge employment rather than career employment is associated with a higher increase in marital satisfaction via a higher increase in job commitment. This result implies that Baby Boomers adapt to bridge employment over time. Overall, the present study finds that the effect of bridge employment on the change in marital satisfaction during midlife varies with the duration of bridge employment. A future research needs to explore which factors can buffer the negative effect of decrease in wage during transition to the bridge employment on the change in marital satisfaction.

• Korean Journal of Veterinary Service
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• v.42 no.1
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• pp.31-37
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• 2019

There have been a total tenth FMD outbreaks in Korea and for the first time, type O and A were detected simultaneously in 2017, which led to difficulties in FMD control. For the effective prevention of FMD, the importance of discrimination of serotypes became greater. Therefore, the most urgent requirement in case of FMD outbreak is differential diagnosis of serotypes. In this study, we developed a PNA probe-mediated multiplex real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay using the peptide nucleic acid (PNA) probe, which is known to be stable to nucleotide mutation and that could specifically detect the all FMDV serotype A, FMDVA Yeoncheon strain which was occurred in Korea in 2017, and FMDV A viruses shown 96% similarity with FMDVA/Yeoncheon strain, at the same time. Therefore, It is believed that the newly introduced FMDVA will be effectively diagnosed using the PNA probe multiplex RT-PCR developed in this study, and ultimately contribute to the prevention of FMD.

• Elastomers and Composites
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• v.55 no.4
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• pp.306-313
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• 2020

To investigate the reinforcing effects of functional fillers in nitrile rubber (NBR) materials, high-structure carbon black (HS45), coated calcium carbonate (C-CaCO3), silica (200MP), and multi-walled carbon nanotubes (MWCNTs) were used as functional filler, and carbon black (SRF) as a common filler were used for oil-resistant rubber. The curing and mechanical properties of HS45-, 200MP-, and MWCNT-filled NBR compounds were improved compared to those of the SRF-filled NBR compound. The reinforcing effect also increased with a decrease in the particle size of the fillers. The C-CaCO3-filled NBR compound exhibited no reinforcing effect with increasing filler concentration because of their large primary particle size (2 ㎛). The reinforcing behavior based on 100% modulus of the functional filler based NBR compounds was compared by using several predictive equation models. The reinforcing behavior of the C-CaCO3-filled NBR compound was in accordance with the Smallwood-Einstein equation whereas the 200MP- and MWCNT-filled NBR compounds fitted well with the modified Guth-Gold (m-Guth-Gold) equation. The SRF- and HS45-filled NBR compounds exhibited reinforcing behavior in accordance with the Guth-Gold and m-Guth-Gold equations, respectively, at a low filler content. However, the values of reinforcement parameter (100Mf/100Mu) of the SRF- and HS45-filled NBR compounds were higher than those determined by the predictive equation model at a high filler content. Because the chains of SRF composed of spherical filler particles are similarly changed to rod-like filler particles embedded in a rubber matrix and the reinforcement parameter rapidly increased with a high content of HS45, the higher-structured filler. The reinforcing effectiveness of the functional fillers was numerically evaluated on the basis of the effectiveness index (��SRF/��f) determined by the ratio of the volume fraction of the functional filler (��f) to that of the SRF filler (��SRF) at three unit of reinforcing parameter (100Mf/100Mu). On the basis of their effectiveness index, MWCNT-, 200MP-, and HS45-filled compounds showed higher reinforcing effectiveness of 420%, 70%, and 20% than that of SRF-filled compound, respectively whereas C-CaCO3-filled compound exhibited lower reinforcing effectiveness of -50% than that of SRF-filled compound.

• Biomolecules & Therapeutics
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• v.24 no.4
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• pp.410-417
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• 2016

Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin-3-(2(G)-rhamnosylrutinoside (Rham2) are mono-, di-, and tri-glycosylated forms of quercetin, respectively. In a previous study, we showed that quercetin can enhance ${\alpha}7$ nicotinic acetylcholine receptor (${\alpha}7$ nAChR)-mediated ion currents. However, the role of the carbohydrates attached to quercetin in the regulation of ${\alpha}7$ nAChR channel activity has not been determined. In the present study, we investigated the effects of quercetin glycosides on the acetylcholine induced peak inward current ($I_{ACh}$) in Xenopus oocytes expressing the ${\alpha}7$ nAChR. $I_{ACh}$ was measured with a two-electrode voltage clamp technique. In oocytes injected with ${\alpha}7$ nAChR copy RNA, quercetin enhanced $I_{ACh}$, whereas quercetin glycosides inhibited $I_{ACh}$. Quercetin glycosides mediated an inhibition of $I_{ACh}$, which increased when they were pre-applied and the inhibitory effects were concentration dependent. The order of $I_{ACh}$ inhibition by quercetin glycosides was Rutin${\geq}$Rham1>Rham2. Quercetin glycosides-mediated $I_{ACh}$ enhancement was not affected by ACh concentration and appeared voltage-independent. Furthermore, quercetin-mediated $I_{ACh}$ inhibition can be attenuated when quercetin is co-applied with Rham1 and Rutin, indicating that quercetin glycosides could interfere with quercetin-mediated ${\alpha}7$ nAChR regulation and that the number of carbohydrates in the quercetin glycoside plays a key role in the interruption of quercetin action. These results show that quercetin and quercetin glycosides regulate the ${\alpha}7$ nAChR in a differential manner.

• Journal of Yeungnam Medical Science
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• v.33 no.1
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• pp.8-12
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• 2016

Background: The decision to administer oral anticoagulation therapy depends on accurate assessment of stroke risk in patients with atrial fibrillation (AF). Various stroke risk stratification schemes have been developed to help inform clinical decision making. The CHADS2 and CHA2DS2-VASc scores have been used in estimating the risk of stroke in patients with AF. Recently R2CHA2DS2-VASc score was developed. The objective of the current study is to validate the usefulness of the R2CHA2DS2-VASc score and to compare the accuracy of the CHADS2, CHA2DS2-VASc, and R2CHA2DS2-VASc scores in predicting a patient's risk of stroke. Methods: Based on medical records, we conducted a retrospective study of patients hospitalized with AF from March 2011 to July 2013. A total of 448 AF patients were included in this study. The receiver operating characteristic (ROC) curve analysis in MedCalc was used for comparison with respective diagnostic values. Results: The patient characteristics showed male predominance (60.9%). Among the 448 AF patients, 131 (29.2%) patients had strokes during the study. A R2CHA2DS2-VASc score of more than 5 is the optimal cut-off value for prediction of stroke. A risk score of three, the area under the ROC curve (AUC) of R2CHA2DS2-VASc score (AUC 0.631; 95% confidence interval, 0.585-0.679) was the highest. A significant difference was observed between AUC for R2CHA2DS2-VASc, CHADS2, and CHA2DS2-VASc scores, but no meaningful difference between CHADS2 and CHA2DS2-VASc scores. Conclusion: We determined the usefulness of the R2CHA2DS2-VASc score, which showed better association with stroke than the CHADS2 and CHA2DS2-VASc scores.

• Progress in Superconductivity
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• v.6 no.1
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• pp.79-83
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• 2004

We fabricated Bi-2223/Ag superconductor tape with 55 filaments and estimated the magnetic field dependence of critical current (I$_{c}$) and index n (n) up to 30 T at 4.2 K. The I$_{c}$ and n were characterized as a function of external magnetic field parallel to the tape surface on increasing and decreasing field, using a 35 T hybrid magnet. The $I_{c}$ was estimated to be 325 A, and n was 32, 22, and 26 in the electric field range of $0.1 ∼1\mu$V/cm, 1∼10 $\mu$V/cm, and 0.1∼10 $\mu$V/cm, respectively, under self-field at 4.2 K. It was observed that $I_{c}$ was dependent on magnitude of magnetic field and it decreased exponentially as the field increased; in a parallel and increasing field, It was 128 A at 30 T which is approximately 40% of critical current in self-field. In addition, the $I_{c}$ was higher on decreasing field than that on increasing one. On the other hand, n did not significantly depend on field strength up to 30 T, nor varied on whether increasing or decreasing field; n value in 0.1∼1 $\mu$V/cm was 23.0$\pm$5.2 and 27.8$\pm$8.0 on increasing and decreasing field, respectively. The n value on decreasing magnetic field was slightly higher than that on increasing field. This hysteretic behavior of n was similar to that of$ I_{c}$, which is related to the trapped flux at the grain boundary.ary.

• Cartoon and Animation Studies
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• s.45
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• pp.417-434
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• 2016

The wall painting of Altamira cave "eight-legged wild boar" is often presented as a typical example of long-held desire of humanity for expressing movement. However, the eight legs are the product of so-called "double layer", of two paintings painted in different periods. Nonetheless, the explanation of Altamira cave paintings linking with the origin of animation is constantly reproduced without any particular doubt, verification or citation of sources. The fact of associating eight legs with movement is irrelevant to visual perception transcending time. This should be considered a movement expression code invented in a particular period of time. Sequential photography tried in the late 19th century, in particular, chronography of $\acute{E}tienne$-Jules Marey plays a crucial role in this. Marey's photography of which a series of sequence movements are overlapped in one frame and printed was reflected in painting works of artists including Duchamp and Balla in the early 20th century and formed as movement expression code. Animation manuals started to emerge from that period of time introduced the images of Marey's chronophotography as a way of analyzing and embodying the movement. In sum, the act of considering Altamira cave paintings of eight-legged wild boar as an expression of movement is an error intending to look at the past through today's visual code.

• Polymer(Korea)
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• v.31 no.5
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• pp.422-427
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• 2007

Semiconducting layers are thin rubber film between electrical cable wire and insulating polymer layers having a volume resistivity of ${\sim}10^2{\Omega}cm$. Commercial semiconducting layers ire composed of polymer composites reinforced with more than 30 wt% of carbon blacks. A new semiconducting material was suggested in this study based on the carbon nanotube(CNT)-reinforced polymer nanocomposites. CNT-reinforced polymer nanocomposites were prepared by solution mixing and precipitation with various polymer type and dual filler system. The mechanical, thermal and electrical properties were investigated as a function of polymer type and dual filler system based on CNT and carbon black. The volume resistivity of composites was strongly related with the crystallinity of polymer matrix. With the decreased crystallinity, the volume resistivity decreased linearly until a critical point, and it remained constant with further decreasing the crystallinity. Dual filler system also affected the volume resistivity. The CNT-reinforced nanocomposite showed the lowest volume resistivity. When a small amount of carbon black(CB) was replaced the CNT, the crystallinity increased considerably leading to a higher volume resistivity.

• Journal of Ginseng Research
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• v.35 no.1
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• pp.92-103
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• 2011

Ginseng has been used as a general tonic agent to invigorate human body. In the present study, we isolated novel glycolipoproteins from ginseng that activate $Ca^{2+}$-activated $Cl^-$ channel (CaCC) in Xenopus oocytes and transiently increase intracellular free $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) in mouse Ehrlich ascites tumor cells. We named the active ingredients as gintonin. Gintonin exists in at least six different forms. The native molecular weight of gintonin is about 67 kDa but its apparent molecular weight is about 13 kDa, indicating that gintonin might be a pentamer. Gintonin is rich in hydrophobic amino acids. Its main carbohydrates are glucose and glucosamine. Its lipid components are linoleic, palmitic, oleic, and stearic acids. Gintonin actions were blocked by U73122, a phospholipase C inhibitor, 2-aminoethxydiphenyl borate, an inositol 1,4,5-trisphosphate receptor antagonist, or bis (o-aminophenoxy) ethane-N,N,N0,N0-tetracetic acid acetoxymethyl ester, a membrane permeable $Ca^{2+}$ chelator. In the present study, we for the first time isolated novel gintonin and showed the signaling pathways on gintonin-mediated CaCC activations and transient increase of $[Ca^{2+}]_i$. Since $[Ca^{2+}]_i$ as a second messenger plays a pivotal role in the regulation of diverse $Ca^{2+}$-dependent intracellular signal pathways, gintonin-mediated regulations of $[Ca^{2+}]_i$ might contribute to biological actions of ginseng.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.4
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• pp.405-411
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• 2015

Recently, according to the low-carbon green growth policy, the Stirling Engine has been increasing the interest of some sort of external combustion engines Stirling Engine is largely divided into three types ${\alpha}$, ${\beta}$ and ${\gamma}$. Among them, a ${\gamma}$-type engine is easy to design and can be applied variously. However, owing to the connection distance between the cylinder and the crank, there was a problem that ${\gamma}$-type occupies a larger volume than the ${\alpha}$ and ${\beta}$-types. As one of the methods to solve this problem, we have to consider about the Yoke crank which have been applied mainly to the ${\alpha}$-type. Because there are two advantages in not only reduction of engine volume but also parallelizing the cylinder. In this study, leading on from the existing design techniques for the Ross Yoke crank, this paper presents a simple method that can apply the yoke crank design of the ${\gamma}$-type stirling engine.