• Title/Summary/Keyword: nRP

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Reduced Port Surgery for Prostate Cancer is Feasible: Comparative Study of 2-port Laparoendoscopic and Conventional 5-port Laparoscopic Radical Prostatectomy

  • Akita, Hidetoshi;Nakane, Akihiro;Ando, Ryosuke;Yamada, Kenji;Kobayashi, Takahiro;Okamura, Takehiko;Kohri, Kejiro
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6311-6314
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    • 2013
  • Background: While 5-port laparoendoscopic radical prostatectomy is standard practice, efforts have been focused in developing a single port surgery for cosmetic reasons. However, this is still in the pioneering stage considering the challenging nature of the surgical procedures. We have therefore focused on reduced port surgery, using only 2-ports. In this study, we compared 2-port laparoendoscopic radical prostatectomy (2-port RP) and conventional 5-port laparoscopic radical prostatectomy (LRP) for clinically localized prostate carcinoma and evaluated the potential advantages of each. Materials and Methods: From January 2010 to December 2010, all 23 patients with clinically localized prostate cancer underwent LRP. Starting November, 2010, when we introduced the reduced port approach, we performed this procedure for 22 consecutive patients diagnosed with early-stage prostate cancer (cT1c, cT2N0). The patients were matched 1:1 to 2-port RP or LRP for age, preoperative serum PSA level, clinical stage, biopsy and pathological Gleason grade, surgical margin status, pad-free rates and post-operative pain. Results: There was a significant difference in operative time between the 2-port RP and LRP groups ($286.5{\pm}63.3$ and $351.8{\pm}72.4$ min: p=0.0019, without any variation in blood loss (including urine) ($945.1{\pm}479.6$ vs $1271.1{\pm}871.8ml$: p=0.13). The Foley catheter indwelling period was shorter in the 2 port RP group, but without significance ($5.6{\pm}1.8$ vs $8.0{\pm}5.6$ days: p=0.057) and the total perioperative complication rates for 2 port RP and LRP were comparable at 4.5% and 8.7% (p=0.58). There was an improvement in pad-free rates up to 6 months follow-up (p=0.090), and significantly improvement at 1 year (p=0.040). PSA recurrence was 1 (4.5%) in 2-port RP and 2 (8.7%) in LRP. Continuous epidural anesthesia was used in most of LRP patients (95.7%) and in early 2-port RP patients (40.9%). In these patients, average total amount of Diclofenac sodium was 27.8mg/patient in 2-port RP and 50.0mg/patient in LRP. Conclusions: Thus the reduced port approach is as efficacious as LRP in terms of many outcome measures, with significant cosmetic advantages and reduction in post surgical pain. This method can be readily performed safely and therefore can be recommended as a standard laparoscopic surgery for prostate cancer in the future.

Comparison of postoperative pain intensity after using reciprocating and continuous rotary glide path systems: a randomized clinical trial

  • Adiguzel, Mehmet;Yilmaz, Koray;Tufenkci, Pelin
    • Restorative Dentistry and Endodontics
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    • v.44 no.1
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    • pp.9.1-9.9
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    • 2019
  • Objectives: The aim of this study was to compare postoperative pain intensity after root canal treatment with One G (OG) vs. R-Pilot (RP) files used for glide path preparation. Materials and Methods: Ninety-three single-canaled mandibular premolar teeth with asymptomatic non-vital pulp were randomly assigned into 3 groups (n = 31): OG, RP, or without glide path (WGP). After creating the glide path, the root canals were prepared using sequential Mtwo rotary files to size 30/0.05. One endodontic specialist carried out single-visit endodontic treatment. The patients were asked to rate the severity of postoperative pain on a visual analogue scale at 24, 48, and 72 hours after the visit. They were also asked to record their intake of prescribed analgesics taken. The data were analyzed using the ${\chi}^2$, Friedman, Kruskal-Wallis, and Mann-Whitney U tests. Results: In all 3 groups, postoperative pain decreased significantly at each time interval (p < 0.05). At 24 hours, the OG group had less postoperative pain than the WGP group (p < 0.05). However, no significant difference was found between the RP group and the others. No statistically significant difference was found among the WGP, OG, and RP groups in postoperative pain intensity at 48 or 72 hours or in analgesic tablet intake at the 3 assessed time intervals. Conclusions: The OG group had less postoperative pain than the WGP group in the first 24 hours. The OG and RP systems were similar regarding postoperative pain intensity and analgesic intake.

Homotopical triviality of entire rational maps to even dimensional spheres

  • Suh, Dong-Youp
    • Communications of the Korean Mathematical Society
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    • v.11 no.3
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    • pp.807-814
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    • 1996
  • Let $G = Z_2$. Let X be any compact connected orientable nonsingular real algebraic variety of dim X = k = odd with the trivial G action, and let Y be the unit sphere $S^{2n-k}$ with the antipodal action of G. Then we prove that any G invariant entire rational map $f : x \times Y \to S^{2n}$ is G homotopically trivial. We apply this result to prove that any entire rational map $g : X \times RP^{2n-k} \to S^{2n}$ is homotopically trivial.

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Levosulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-2-methoxybenzamide, enhances the transduction efficiency of PEP-1-ribosomal protein S3 in vitro and in vivo

  • Ahn, Eun-Hee;Kim, Dae-Won;Kim, Duk-Soo;Woo, Su-Jung;Kim, Hye-Ri;Kim, Joon;Lim, Soon-Sung;Kang, Tae-Cheon;Kim, Dong-Joon;Suk, Ki-Tae;Park, Jin-Seu;Luo, Qiuxiang;Eum, Won-Sik;Hwang, Hyun-Sook;Choi, Soo-Young
    • BMB Reports
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    • v.44 no.5
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    • pp.329-334
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    • 2011
  • Many proteins with poor transduction efficiency were reported to be delivered to cells by fusion with protein transduction domains (PTDs). In this study, we investigated the effect of levosulpiride on the transduction of PEP-1 ribosomal protein S3 (PEP-1-rpS3), and examined its influence on the stimulation of the therapeutic properties of PEP-1-rpS3. PEP-1-rpS3 transduction into HaCaT human keratinocytes and mouse skin was stimulated by levosulpiride in a manner that did not directly affect the cell viability. Following 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, levosulpiride alone was ineffective in reducing TPA-induced edema and in inhibiting the elevated productions of inflammatory mediators and cytokines, such as cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6 and -1${\beta}$, and tumor necrosis factor-${\alpha}$. Anti-inflammatory activity by PEP-1-rpS3 + levosulpiride was significantly more potent than by PEP-1-rpS3 alone. These results suggest that levosulpiride may be useful for enhancing the therapeutic effect of PEP-1-rpS3 against various inflammatory diseases.

Multicast Secure Architecture based on PIM-SM (소규모 멀티캐스트를 기반으로 한 멀티캐스트 보안구조)

  • 김성선;이상순;정영목
    • Journal of the Korea Society of Computer and Information
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    • v.6 no.2
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    • pp.116-122
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    • 2001
  • A conventional multicast secure protocol. MVMRP, CBT is designed for a large scaled r protocol so the PIM-SM (protect Independent Multicst-Sparse Mode) routing protocol which small number of clients, long distance path among the hosts and shortest path routing chara weak point of require it's own Core tree and re-keying when the traffic is pass through the ro In this study, proposes a architect for a licit information secure of join/leave to all the user or on-service user. With proposed architect, subgroups for multicast secure group mana will be divided by RP (Rendezvous-Point) unit and each RP has a subgroup manager. As a result, the transmitting time is shortened because there is no need to data translation by group key on data sending and the whole architecture size is samller than the other multicast secure architecture.

The deformation space of real projective structures on the $(^*n_1n_2n_3n_4)$-orbifold

  • Lee, Jungkeun
    • Bulletin of the Korean Mathematical Society
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    • v.34 no.4
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    • pp.549-560
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    • 1997
  • For positive integers $n_i \geq 2, i = 1, 2, 3, 4$, such that $\Sigma \frac{n_i}{1} < 2$, there exists a quadrilateral $P = P_1 P_2 P_3 P_4$ in the hyperbolic plane $H^2$ with the interior angle $\frac{n_i}{\pi}$ at $P_i$. Let $\Gamma \subset Isom(H^2)$ be the (discrete) group generated by reflections in each side of $P$. Then the quotient space $H^2/\gamma$ is a differentiable orbifold of type $(^* n_1 n_2 n_3 n_4)$. It will be shown that the deformation space of $Rp^2$-structures on this orbifold can be mapped continuously and bijectively onto the cell of dimension 4 - \left$\mid$ {i$\mid$n_i = 2} \right$\mid$$.

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Solubilization of Hardly Soluble Phosphates and Growth Promotion of Maize (Zea mays L.) by Penicillium oxalicum Isolated from Rhizosphere

  • SHIN WANSIK;RYU JEOUNGHYUN;CHOI SEUNGJU;KIM CHUNGWOO;GADAGI RAVI;MADHAIYAN MUNUSAMY;SESHADRI SUNDARAM;CHUNG JONGBAE;SA TONGMIN
    • Journal of Microbiology and Biotechnology
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    • v.15 no.6
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    • pp.1273-1279
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    • 2005
  • Penicillium oxalicum strain CBPS-3F-Tsa, an efficient phosphate solubilizing fungus, was evaluated for its production of organic acid in vitro and effect of inoculation on the growth promotion of Maize under greenhouse conditions. The fungus solubilized 129.1, 118.8, and 54.1 mg P/1 of tricalcium phosphate [$Ca_{3}(PO_{4})_{2}$], aluminum phosphate ($A1PO_{4}$),and ferric phosphate ($FePO_{4}$), respectively, after 72 h of incubation. Malic acid, gluconic acid, and oxalic acid were detected in the flasks supplemented with various phosphate sources [240, 146, 145 mM/1 $A1PO_{4},\;FePO_{4},\;and\;Ca_{3}(PO_{4})_{2}$, respectively] together with a large amount of malic acid followed by the other two. The effects of inoculation of P. oxalicum CBPS-3F-Tsa on maize plants were studied under pot culture conditions. P. oxalicum CBPS-3F-Tsa was inoculated to maize plants alone or together with inorganic phosphates in the form of fused phosphates (FP) and rock phosphates (RP). Inoculation of P. oxalicum CBPS-3F-Tsa increased the plant growth and N and P accumulation in plants, compared with control plants, and also had positive effects when applied with RP. The results of this study show that the fungus P. oxalicum strain CBPS-3F-Tsa could solubilize different insoluble phosphates by producing organic acids, particularly malic acid, and also improved the efficiency of RP applied to maize plants.

Characteristics of Immobilized Rhodopseudomonas sp. for Wastewater Treatment (폐수처리를 위한 고정화 Rhodopseudomonas sp.균의 특성)

  • 이범규;김상희;김중균
    • Journal of Life Science
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    • v.9 no.3
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    • pp.268-275
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    • 1999
  • Rhodopseudomonas sp. was immobilized in three supports(agar, k-carrageenan, and PVA) in order to remove nitrate in wastewater coming from fish farm. Among them 3% agar was the most suitable support when denitrification rate and bead durability were tested. Optimum bead size was 4mm-diameter when the substrate transfer into the bead and shear stress for bead were considered, and optimum cell loading was 25mg dry $cells/cm^2$gel gel. Ethanol was the best as a carbon source, and optimum C:N ratio, temperature and pH were 1.5:1, $31^{\circ}C$,, and 6, respectively. Under these conditions the maximum denitrification rate in synthetic wastewater was $$345{\MU}{\ell};N_2/Cm^3 gel{\cdot}hr;and that in modified MYC medium was 450{\MU}{\ell}};N_2/Cm^3 gel{\cdot}hr $$.

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Observation of Castability of Dental DLP 3D Printer Materials (치과용 DLP 3D Printer 가공체의 주조성 관찰)

  • Song, Joon-boo;Park, Yu-jin;Choi, Sung-min
    • Journal of Technologic Dentistry
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    • v.41 no.4
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    • pp.255-262
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    • 2019
  • Purpose: Recently, the production technology of dental prosthesis using 3D Printer workpeices has been developed. However, the lack of information on the work processes and casting techniques of materials for 3D printing casting is expected to require research. Therefore, in this study, we intend to cast a Dental DLP 3D Printer workpiece, which is being commercialized, to identify its appearance and internal clearance, and to observe its castability. Methods: Castability of the 3D Printer workpiece was evaluated. The specimen is prepared in a cylindrical shape and in a 1 mm thick coping shape. The control specimen is made of wax and the experimental specimen is made of resin using two types of 3D printers. After casting, the appearance of the casting body was observed and the internal clearance of the coping was measured. Results: RP1 and RP2, cylindrical specimens, were partially cast or fin. When coping-type specimens were measured before casting, the internal clearance of PE2 was more accurate than that of PC and PE1. When coping-type specimens were measured after casting, CE1 was the most accurate in occlusal clearance and CE2n was the most accurate in axial clearance. Conclusion: 1. Exterior observations of the casting body indicated casting defects and fins. 2. Internal clearance observations show that the occlusal clearance of the castings is larger after casting, and the axial clearance of the castings is smaller after casting. 3. It is judged that the RP2 specimen is more likely to be applied for casting than the RP1 specimen.