• 한국인터넷방송통신학회논문지
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• 제20권4호
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• pp.195-200
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• 2020

화석연료 고갈과 환경오염에 관한 관심이 고조되면서 국내에서 운행되고 있는 철도차량이 디젤 차량에서 전기 차량으로 전환이 확대되면서 진행되고 있다. 전기 차량의 전환의 한 예로 적용되고 있는 태양광발전 시스템은 무한정하고 무공해 하며 대기오염, 소음, 발열, 진동 등과 같은 위해요소들을 발생시키지 않고 에너지 생산이 가능하며, 연료 수송, 발전설비에 대한 유지보수가 거의 필요하지 않은 장점이 있다. 그러나 전력생산량이 지역별 일사량에 의존하고, 약 25㎡/kWp 발전량으로 에너지밀도가 낮아 큰 설치 면적이 필요하며, 설치장소가 제한적인 문제점을 가지고 있다. 이러한 문제점을 고려하여 철도 분야에서도 연료전지를 적용한 연구들이 많이 증가하고 있다. 특히 연료전지 발전시스템 철도 급전계통 연계방안은 태양광 및 풍력과는 다르게 철도차량에 전력을 공급해주는 급전계통에 연계해야 한다. 따라서 철도차량과 밀접한 관계를 가지는 시스템 토폴로지 (topology)에 따라 연계방식은 크게 달라질 수 있으므로 본 논문에서는 시스템 토폴로지에 따른 연계분석과 관련된 시뮬레이션 모델링을 통한 타당성을 연구하고자 한다.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 1999년도 학술발표회 진행표 및 논문초록
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• pp.61-62
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• 1999

;The mechanisms inducing hypertension are actively investigated and are still challenging topics. Basically hypertension must be caused by the disorder of $Ca^{2+}$ metabolism in vascular smooth muscle, such as the increase of $Ca^{2+}$ influx, the decrease of ci+ efflux, or the change of sensitivity of contractile protein etc. The one of cause of the increase of ci+ influx may be the change of ci+ channel activity. Even though the relationships of ci+ channel activity and hypertension were studied using various hypertension models, still it is not clear how much change of $Ca^{2+}$ channel activity in diabetes mellitus (DM) induced hypertension is occurred. We induced DM hypertension in SD rat and compared the $Ca^{2+}$ channel activity with age-matched normotensive SD rat. For inducing DM hypertension, left kidney was removed with 200 gm rat and, after 1 month, 60 mg/kg of streptozotocin was injected into peritoneal space to induce diabetes mellitus. Usually after 4-6 weeks, hypertension was fully induced. For isolating vascular smooth muscle cells (VSMC), we used mesenteric arteriole (3rd - 4th branch of mesenteric artery) of which diameter is below 150 urn. VSMCs were isolated enzymatically. $Ca^{2+}$ current was measured using whole cell patch clamp technique. All experiments were performed at $37^{\circ}C$. The cell membrane area of VSMC of DM hypertensive rat is larger than that of control VSMC($36.6{\pm}3.64{\;}pF{\;}vs{\;}22.4{\pm}1.29{\;}pF, {\;}mean{\pm}S.E.$) When we compared the current amplitude, the $Ca^{2+}$ current amplitude in VSMC of DM hypertensive rat is much larger than that in VSMC of normotensive age-matched rat. After $Ca^{2+}$ current amplitude was normalized by cell membrane area, the current amplitude in DM hypertension is increased to $249.1{\pm}15.9{\;}%{\;}(mean{\pm}S.E.M)$, which means the ;absolute current amplitude is about 4 times larger in DM hypertension. When we compared the steady state activation and inactivation. there were no noticeable differences. From these results. one of cause of the DM hypertension is due to the increase of $Ca^{2+}$ current amplitude. But it need further study why the $Ca^{2+}$ current is so large in VSMC of DM hypertension and how much $Ca^{2+}$ influx through $Ca^{2+}$ channel contribute to the increase of intracellular $Ca^{2+}$ and eventually contribute to development of hypertension.ypertension.

• 멤브레인
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• 제4권4호
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• pp.221-231
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• 1994

Dextran(Mw.:500,000)용액의 한외여과에 있어서, 현재 나권형 모듈의 유로형성체로 사용되는 난류촉진물체를 적용하여 실험한 결과, 난류촉진물체의 mesh가 증가할수록 막투과 flux가 향상되었으며, 난류영역에서는 층류영역에 비해 순환유속과 난류촉진물체의 사용에 따른 막투과 flux에 대한 영향이 상대적으로 적었다. 난류촉진물체의 사용에 따른 막투과 flux 향상율은 사용한 membrane의 종류에 따라 층류영역의 경우 최대 112%, 난류영역의 경우 50%에 달하였다. 또한 난류촉진물체를 사용함으로써 한외여과막의 고분자 용질에 대한 배제 성능을 높일 수 있었으며, 이러한 flux 및 배제 성능 증가 등의 효과들은 높은 조작압력차와 낮은 순환유속(농도분극이 상대적으로 심한 영역)에서 더욱 두드러졌다. 그러나, 난류촉진물체의 mesh 수와 순환유속이 증가함에 따라 한외여과 cell 내에서의 압력손실도 증가하였으며, 특히 난류영역에서는 그 영향이 매우 심하였으므로 실제 공정 설계시 순환유속과 압력차 및 난류촉진물체 형태에 따른 압력손실을 반드시 고려해 주어야 함을 알 수 있었다. 물질전달계수 예측을 위한 기존의 물질전달 상관관계식을 농도분극층에서의 고분자 물질의 물성변화를 고려하고 경계층 저항 모델에 근거하여 보정하였는 바, 기존의 관계식에 비해 오차를 줄일 수 있었으며, 이때의 관계식은 다음과 같았다.$N_{sh}=0.151(N_{Re})^{0.199}(N_{Sc})^{0.22}(N_{Scm})^{0.197}\;(625 $N_{sh}=0.0165(N_{Re})^{0.428}(N_{Sc})^{0.33}(N_{Scm})^{0.223}\;(5015

• 한국통신학회논문지
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• 제31권11A호
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• pp.1076-1084
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• 2006

본 논문에서는 차세대 이동통신 시스템에서 고려할 수 있는 새로운 형태의 채널 이중화를 위한 Hybrid Division Duplex (HDD) 방식의 개념과 구현 이슈를 살펴보고, 이에 따른 통합 무선 자원관리 기법을 제안한다. HDD는 TDD와 FDD의 장점을 동시에 수용하며, 멀티미디어 서비스의 상하향 비대칭적 트래픽 특성에 따라 나타나는 인접 셀 간 상호 간섭을 효과적으로 제어할 수 있는 구조를 갖는다. HDD는 각각 TDD와 FDD로 동작하는 2개의 대역을 이용하며, 이때 하향링크는 TDD 모드로만 동작을 하고, 상향링크는 단말의 위치에 따라 TDD모드 또는 FDD 모드로 동작할 수 있다. 따라서 HDD 방식에서는 상향링크의 이중화 모드와 비대칭적 멀티미디어 서비스에 따른 상 하향 링크의 비율을 결정하고, 이에 따른 상호 간섭을 완화하기 위한 통합적 무선 자원관리 기법이 요구되다. 본 논문은 HDD 시스템의 효율적인 운용을 위한 통합 자원관리 기법으로서 인접 셀 간 간섭을 최소화하면서, TDD 대역 자원을 효율적으로 사용함으로써 시스템의 효율성을 극대화할 수 있는 분산적 적응 제어기법을 제시한다.

• 정보처리학회논문지C
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• 제10C권4호
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• pp.471-478
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• 2003

오래 전부터 이동통신 서비스를 위한 통신 프로토콜이나 기능 요소들의 성능을 평가하기 위해서는 분석적 방법, 시뮬레이션 및 평가적 방법이 이용되어 왔다. 이중 시뮬레이션을 통한 평가 방법은 시스템 내부 구성 요소들의 연관 관계가 매우 복잡한 시스템을 테스트하는데 유용하게 사용되고 있으며, 이를 위해서는 이동통신 통화 특성을 반영하는 텔레트래픽 모델을 제시하고 있어야 한다. 텔레트래픽 모델은 일반적으로 트래픽 소스 모델과 네트워크 트랙픽 모델로 구성되어 있으며, 본 네트워크 트래픽 모델을 정의하기 위해 요구되는 실제 기지국 통화량 자료를 수집하고 분석한 결과를 제공하기 위한 것이다. 본 논문에서는 서울시를 상업, 주거, 준공업, 그리고 녹지 지역으로 되어 있는 도시계획 용도지역으로 구분하고, 여기에 설치되어 있는 기지국으로부터 실제 데이터를 시간대별로 수집하였다. 수집된 자료를 이용하여 각 지역별 기지국의 시간대별 통화량 분포와 최대 및 최소 발생 호 수 등을 제시하였다. 분석 결과는 보다 더 정확한 이동통신 네트워크 트래픽 모델을 정의하거나, 기존 이동통신 시뮬레이션 과정에서의 입력 자료로 사용할 수 있다.

• Journal of Trauma and Injury
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• 제20권1호
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• pp.52-56
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• 2007

Marjolin's ulcer is a rare and often-aggressive cutaneous malignancy that arises in previously traumatized or chronically inflamed skin, particularly after burns. We experienced two cases after burns. Case I involved a forty eight year-old man who had suffered from a flame burn at the parietal scalp area, where had been initially described three years earlier as a full-thickness wound including the pericranium. The man consulted us for a persistent ulcerative and infected wound on the burned lesion during the last 24 months, which turned out on the contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) to be the squamous cell carcinoma with involving the skull and the dura mater. Although the posterior auricular lymph node was enlarged on the ipsilateral side, recent positron emission tomography (PET) CT did not show any metastatic lesion. It was impossible for us to resect the intracranial involvement of the tumor radically, and the postoperative PET CT still showed a focal fluorodeoxyglucose (FDG) uptake around the wall of the superior sagittal sinus. We think that an aggressive combined approach is essential for treatment in early stages for a high success rate, before the intracranial structures are involved because there is no consensus on the treatment for advanced disease, and the results are generally poor. Case 1 also did not involve a radical resection because of the intracranial invasion to the wall of superior sagittal sinus and the possibility of damage to the major cortical veins. He received adjuvant radiotherapy and must be followed periodically. Case 2 involved an eighty six year-old women who suffered from a painful scalp ulcer lesion after flame burns three years earlier. Unlike case 1, neither tumor infiltration into the dura nor lymph node enlargement was observed on the contrast-enhanced computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET) CT. We did a radical resection of the tumor, including the involved bone, and a cranioplasty with bone cement.

• Journal of Plant Biology
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• 제3권2호
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• pp.6-18
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• 1960

The present experiments were designed in order to clarify the differences between the long and short styled plants and the transgressive gradition in the degree of dimorphism among the three heterostylous species of the Polygonus, P. japonica, F. esculentum, and P. senticosa, based on investigations regarding the floral structure, ecological and physiological traits, the results of which are summarized as follows: (1) P. japonica, although it exhibits typical dimorphism, has undergone so high a differentiation between long and short styled that its long styled individuals behave as if they were female; and short styled individuals as if male. In long-styled individuals, filament, anther, and pollen grains show signs of degeneration, most of the pollen being abortive. On the other hand, in short styled individuals, the filament, anther, and pollen grains have attained remarkable development; the pollen grians are large and fertile. In short-plant the fertilized flowers readily drop off in every stage of their embryo development. This species has completely lost the self-fertile property, which is characteristic of the non-dimorphic Polygonum genus. Although this specsei typically exhibits the physiological characteristics of the non-dimorphic Polygonum genus. Although this specisei typically exhibits the physiological characteristics of dimorphism in controlled pollination, the short-styled individuals bear no seed in nature, thus misleading taxonomists to idenfity the short-styled plant as male. 2) The morphological feature of the flower organ of P. senticosa obviously indicates definite dimorphism. Physiologically, however, no differentiation towards dimorphism was observed, the species still retaining, both in long and short-individuals, the self-fertile property common to the Polygonum genus. Elaborate examinations revealed that regardless of the modes of pollination, both fertiization and seed setting flourish, no differentiation betwen legitimate and illegitimate unions being recognizable. This sort of physiological property has not been observed in the investigations of other heterostylous plants. It is assumed that this species is differentiated structurally into dimorphism, but not yet physiologically. In nature, however, this plant would have more opportunities to be cross-pollinated, i.e., legitimately combined, than self-pollinated because of the development of two forms of flowers. 3) In terms of heterostylism, the F. esculentum just occupies the intermediate position between P. japonica and P. senticosa structurally, ecologically, and physiologically. Doescription of some of the physiological behavior of the plant will suffice to demonstrate the above facts. While P. japonica has completely lost its self-fertile property, P. senticosa still retains it wolly. In F. esculentum 2-6% of self-fertility is the result in illegitimate combination. There occur occasionally hereditary self fertile individuals among some of the F. or 20 min. irradiation plot, when they reach any stage of the same bacterial population. In addition to this increase of total population in the plots with the more dose of UV light irradiation, it seems that the more dose of UV light irradiation is the more shortened the generation time of Azotobacter. Therefore, it is clear that variation of reproductive rate must be, mere or less, due to the genetic effects induced by UV light irradiation. On the other hand, the lag phase or logarithmic growth phase in nonirradiated culture is shortened prominently, and this must be due to the difference in bacterial number of the original inoculm. The generation time of Azotobacter is shortened by exogeneous treatment of nuclei acid derivatives, and the degree is greater in case of DNA derivatives than RNA dervatives. W.H. Price reported that the rate of ribose nucleic acid to protein in Staphylococcus muscae is proportional to the generation time: that is the faster the cell can form ribose nucleic acid, the more rapid its growth. This explains the shortening of generation time by exogeneous RNA derivatives in this work reasonably. On the other hand, it is well known that the desoxyribose nuclic acid content per cell is constant and independent of the generation time. A.D. Laren and W.N. Takahashi reported that the infectious RNA from TMV is 6 times as sensitive to inactivation by UV as it is in the form of intact virus, and that inactivation of infectious TMV involves onlu a local change on RNA chain. But, the effect of exogeneous DNA in this work suggests that irradiated living cell which cotain DNA bring about some change on DNA moleculs as well as RNA molecules. And if the mutagenic effects of UV take into consideration, it is very reasonable. Therefore, it is clear that the variation of the generation time by UV irradiation is, more or less, due to the genetic effects. Therefore, it seems that the shortness of the average lifewpan of Azotobacter by UV irradiation is resulted not only from the influence of the environmental conditions, but also from the variation of genetic factor of the individual.

• 동의생리병리학회지
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• 제17권1호
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• pp.1-24
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• 2003

This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.

• 한국도로학회논문집
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• 제10권1호
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• pp.87-95
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• 2008

형상이 일정하지 않은 구조에 충돌하는 차량의 탑승자 안전을 확보하기 위해서 그 구조물의 앞에 공간이 허용하는 한도의 깊이만큼 충격을 흡수하는 재료로 만든 모듈을 쌓아두는 방법을 생각할 수 있다. 충격흡수모듈로 사용되기 위해서는 재료가 충분한 에너지 흡수능력을 가져야 하고 동시에 탑승자의 안전을 확보할 수 있어야 한다. 본 논문에서는 에너지 흡수능력과 더불어 탑승자의 안전을 보장하기 위하여 충격흡수재료가 가져야 할 조건을 설명하고 auard-Guard 시스템 모듈, 샌드백, 재활용 타이어, 지오컨테이너, 지오셀 그리고 EPS 블록에 대한 정적압축실험을 실시하여 그 결과를 분석하였다. 이로부터 $30kg/m^{3}$의 밀도를 갖는 EPS 블록이 쿠션모듈로 사용되기 적합한 재료임을 보였다. 한편 시속 35.6km/h까지의 충돌조건으로 Drop Test를 실시하여 EPS블록의 정적특성과 동적특성간 큰 차이가 없음을 보여 주었으며 쿠션모듈로서의 성질을 개선시키기 위한 방안으로 EPS 블록에 공극을 두는 방안을 제안하고 공극이 있는 EPS블록에 대하여 Drop Test를 실시하여 EPS 블록을 이용한 충격흡수시설의 설계에 필요한 재료적 특성치를 제시하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권1호
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• pp.57-61
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• 2010

Objective: Second primary malignancy (SPM) that occur in various period and region are important factors that deteriorate long-term survival rate in patients who recovered from oral cancer. Researches such as chemoprevention are being tried to reduce occurrence of SPMs. Only if analysis of clinical features of patients who develop SPM such as period, region and factors precedes, adequate prevention and treatment of SPM is possible. But, there are few researches about clinical features of SPMs that have primary lesion in oral cavity. In this study, we analysis that occurrence rates, regions that happen, risk factors and effect to survival rates of 2nd primary malignancies in oral cancer patients. From this survey, we willing to collect basic data for prevention and early diagnosis of SPMs. Methods: The medical records of 139 patients of oral oncology clinic of National Cancer Center who had up to 2-years follow up records after surgical or radiological treatment due to squamus cell carcinoma of oral cavity were reviewed. In these patients, survey of occurrence rate of SPMs, duration, survival rate and risk factors about occurrence of SPMs such as history of smoking, body mass index, age, sex, stage of primary lesion and history of radiologic treatment were achieved. Results: There are 15 patients who developed SPM in 139 cases. The actual occurrence rate of SPM was 10.79% and SPM were more likely to occur in male patients with 11 male Vs 4 female patients. Median age of these patient is 61.47 within 32 to 74 range. The regions that develop SPM are oral cavities (2 cases), stomach (4 cases), esophagus (2 cases), lung (2 cases) and others (1 case each breast, larynx, cervix, liver and kidney). In addition, metachronous cancers were 11 cases which happened more common than 4cases of synchronous cancers. Surveys of risk factors that relate to development of SPMs, such as sex, age, history of radiologic treatment, body mass index, history of smoking and stage of primary disease were done. Among them, factor of sex is only appear statistically significant (P=0.001), but rest are not significant in statistically. Conclusion: Occurrence rates of SPMs were reported from 10% to 20% by precede study. In this study, occurrence rate of SPMs is 10.79% that is similar to results of precede research. In comparison of 5-yr survival rates of groups that develop SPMs or not, there is statistically significance between two groups. Present treatment modalities of SPMs are surgical operation, radiotherapy, chemotherapy and combination of these modalities. In choosing the treatment modality, we must consider the first treatment modality, region of primary disease, region of SPMs and general conditions of patient. Because development of SPMs have big effect on prognosis, prevention of SPMs must regard to important objective of treatments in patients of SCCa in oral cavity.