• 대한약리학회지
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• 제16권2호
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• pp.15-24
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• 1980

[${\alpha}$]-Amylase catalyses the hydrolysis of starch, glycogen, and related poly- and oligosac-charide by random cleavage of ${\alpha}$-D-(l-4) glucan linkage. In man large amounts of amylase are secreted into the digestive tract by the salivary and exocrine pancreatic gland, minimal amount being produced also in other tissues. It has been known that ${\alpha}$-amylase exists in multiple molecular forms, isoenzyme which can be separated from each other because of difference in their physicochemical properties. By using various methods, several groups of investigator have separated the many isoenzyme in serum, saliva and pancreatic juice. Furthermore, changes of the normal serum isoenzyme pattern is diagnostically useful even when the total serum enzyme activity is noninformative, such as the clinical use of isoenzyme of serum lactate dehydrogenase. Procarboxypeptidase-A which is one of the pancreatic enzymes is also present as isoenzymes. Four forms of procarboxypeptidase-A haye been found in the bovine enzyme and three forms of the porcine enzyme. In human pancreatic juice four forms of procarboxypeptidase-A isoenzyme were found by isoelectric focusing method. Recently, the so-called isoamylase analysis was developed for the diagnostic use of amylase in pancreatic diseases. In alcohotic patients, the serum concentration of pancreatic isoamylase is subnormal and this lowered activity provides strong evidence for pancreatic exocrine insufficiency. The purpose of this study was to elucidate the variations of the isoenzyme of amylase and procarboxypeptidase-A in serum, saliva and pancreatic juice of the experimental animals. The results are as follow. 1) Three main forms of isoenzyme of amylase by isoelectric focusing were found in pancreatic juice of normal rabbit. However, many new bands were appeared in the pancreatic juice of cholic acid administered animal intravenously while the infusion of cholic acid or elastase into pancreatic duct produced the decrease of number of the fractions on the isoelectric focusing. In the case of serum isoenzyme from normal animal, two major and a few minor isoamylases were observed. By injecting alcohol intravenousely the fractions of serum isoamylase were significantly decreased and in contrary to the pattern in the pancreatic juice the infusion of cholic acid or elastase into pancreatic duct exhitited a significant decrease of the isoenzyme of amylase fractions. In saliva from normal animal three main isoamylase were produced of the administration of alcohol. 2) In the case of procarboxypeptidase-A isoenzyme, two major fractions which have isoelectric point at 6.2 and 6.4 and other two minor bands were observed in the pancreatic juice of normal rabbit. By the treatment of the juice with trypsin, only one band was produced on the isoelectric focusing. No procarboxypeptidase was appeared on the electrofocusing by the infusion of cholic acid or phospholipase A into the pancreatic duct of rabbit. However, a single major fraction of procarboxypeptidase-A was appeared at 3 hr after simple ligation of the pancreatic duct. No significant changes were observed in the juice of the alcohol or cholic acid administered group.

• 한국해양학회지
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• 제25권2호
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• pp.106-116
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• 1990

본 연구는 마산만 일대의 와편모조류 군집의 구조와 동태 및 계절적 천이 그리고 환경요인과의 상호관계를 포괄하고자 1986년 4월부터 1987년 3월까지 일년 동안 제정 된 6개 정점에서 매월 실시하였다. 와편모조류에 현존량의 분포는 44-2,798,900 cella-/l, 저층에서 52-165,714 cells/l로서 층별, 월별, 정점별 차이가 매우 크게 나 타났으며 대발생(500,000 cells/l)의 양상은 표층의 4월부터 8월까지로써 춘·하계에 집중되어 있으며 정점별 외만보다 내만의 정점에서 더욱 두드러지게 나타났다. 출 현종의 세포크기에 의한 현존량의 분포를 조사한 결과 대부분의 우점종이 20-40 um 크 기로 대표할 수 있었으며, 이들 종류들은 내만에 더욱 우점하는 특이한 경향을 나타내 었다. 출현종 중 우점종은 육속 구종 이며, 우점종의 계절적인 천이는 Gyrodinium fissum이 년중 전 계절에 걸쳐 우점하였으며 5월에 Scrippsiellat trochoidea가 6월 에서 9월까지 Prorocentrum minimum, Protoperidinium bipes가 9월에서 12월까지 Ceratium fusus, Prorocentrum micans, Prorocentrum triestinum이 12월에 4월까지 Heterocapsa triquetra가 우점하는 천이의 양상을 나타내었다. 와편모조류의 현존량의 변화와 분석된 환경요인과의 상관관계를 단계식 중회귀식에 의해 분석한 결과 pH, 연 분 투명도, 실소등이 영향을 미치는 것으로 나타났다.

• Archives of Plastic Surgery
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• 제47권5호
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• pp.460-466
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• 2020

Background Sternoclavicular joint (SCJ) osteomyelitis is a rare pathology requiring urgent intervention. Several operative approaches have been described with conflicting reports. Here, we present a multi-institutional study utilizing multiple surgical pathways for SCJ reconstruction. Methods A multi-institutional retrospective cohort study was conducted to identify patients who underwent surgical repair for sternoclavicular osteomyelitis between 2008 and 2019. Patients were stratified according to reconstruction approach: single-stage reconstruction with advancement flap and delayed-reconstruction with flap following initial debridement. Demographics, operative approach, type of reconstruction, and postoperative outcomes were analyzed. Results Thirty-two patients were identified. Mean patient age was 56.2±13.8 years and 68.8% were male. The average body mass index (BMI) was 30.0±8.8 kg/㎡. The most common infection etiologies were intravenous drug use and bacteremia (both 25%). Fourteen patients (43.8%) underwent one-stage reconstruction and 18 (56.2%) underwent delayed two-staged reconstruction. Both single and delayed-stage groups had comparable rates of reinfection (7.1% vs. 11.1%, respectively), surgical site complications (21.4% vs. 27.8%), readmissions (7.1% vs. 16.6%), and reoperations (7.1% vs. 5.6%; all P>0.05). The single-stage reconstruction group had a significantly lower BMI (26.2±5.7 kg/㎡ vs. 32.9±9.1 kg/㎡; P<0.05) and trended towards shorter hospital length of stay (11.3 days vs. 17.9 days; P=0.01). Conclusions Both single and delayed-stage approaches are appropriate methods with comparable outcomes for reconstruction for SCJ osteomyelitis. When clinically indicated, a single-stage reconstruction approach may be preferable in order to avoid a second operation as associated with the delayed phase, and possibly shortening total hospital length of stay.

• 한국치위생학회지
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• 제9권1호
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• pp.125-139
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• 2009

Objective : This study was performed in order to provide basic data for halitosis prevention and establish a device to efficiently eliminate halitosis and to analyze the factors that affect the halitosis. Methods : Oral examination on the Gingival index, CPITN, Tongue Plaque index, and OHI-S as well as halitosis measurement among 293 rural residents. Results : Gingival index was high at mild on female and at moderate on male(p=0.025). Sorting the result by age, mild was 54.1% in the 40s, and moderate was 49.5%, 42.0% and 70.0% each in the 50s, 60s, and the 70s(p=0.005). The need for dental plaque management was 100%. The need for scaling was high with 78.3%, 93.0%, 89.9%, and 90.0% each for the 40s, 50s, 60s, and 70s. The need for complex periodontal treatment was also high with 32.4%, 47.5%, 48.7% and 60.0%, each for the 40s, 50s, 60s, and 70s(p=0.050). The highest bad condition for OHI-S was 69.5%, and good being 18.9%, and very bad being 11.6%. For moderate tongue plaque index was 74.4% as the highest. As the level of education increased, the slight tongue plague was increased, but in contrast, the moderate and higher tongue plague index was decreased(p=0.010). OG under 50ppm was 61.1% on male and OG over 50ppm was 50.9% on female(p=0.041). In OG over 50ppm, CPITN was 52.1% and 41.9% in scaling and complex periodontal treatment group(p=0.018). OHI-S, in bad and very bad condition with OG, over 50ppm, was 48.7% and 46.9%(p=0.019). The higher tongue plague index showed significant amount of increase at OG and EG above 50ppm(p=0.006). $NH_3$, as the tongue plaque index increased, the wider range of distribution was shown(p=0.000). As for the multiple regression analysis result, there have been selected females and tongue plaque index as factors affecting OG. There have been selected age and tongue plaque index as factors affecting EG and there have been selected females as factors affecting on $NH_3$. Conclusions : With the aforementioned results in mind, the status of halitosis among rural residents is considered to bare a close relation with oral environments. we have to focus on correct tooth brushing methods and tongue brushing, with using tongue cleaner to remove fur of tongue plaque. Also, in order to analyze exactly the factors of individual halitosis, we need continuous and systematic study.

• 보건행정학회지
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• 제3권2호
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• pp.100-129
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• 1993

This study is designed to find out some intra-clinic factors affecting the content of practice provided by primary care physicians in Korea, and proposed factors in this study are characteristcs of each private clinc --- physician-related variables(age, sex, specialty), bfed-related variables for inpatient care, laboratory-related variables for precise diagnosis. We have tried to estimate the difference of disease entities cared by each primary care physician according to above factors by analyzin gdisease data claimed during one month(April, 1992) to National Federation of Medical Insurance. The diagnosis codes by ICD-9 in the research disease data were reclassified to 'diagnosis clusters' by virtue of clinical similarities for effective analyses. We have converted frequent-tsing ICD-9 codes to 86 diagnosis clusters, which incorporated 97.4 percents of all ambulatory visits to private clinics. This result means proposed diagnosis-cluster method is effective tool for analysis of the content of ambulatory medical care carried out by primary care physicians. Comparisons and analyses of multiple diagnosis-clusters made on the basis of presented factors were done and the results were as follows; - Major factors affecting the difference between diagnosis-cluster pattern by each variables were phyusician's age, sex, specialty and bed counts of each private clinic for inpatient care and the size of laboratories of each clinic. - Middle aged(30th to 40th) group physicians are providing more comprehensive care than 20th or above 50th aged groups. Male physicians are more adequate for comprehensive care than female physicians, because woman-doctors are providing narrow-spectrum care. The content of practice of obstetricians and gynecologists shows much difference from primary medical practice, and they cannot be included in primary care physician, this study suggested. Pediatricians are also providing short-spectum acre, and nearly all visits to pediatricians were incorporated only 2-3 diagnosis-clusters. General surgeons' practices are very similar to general practioners' or family physicians' practices, the means they are providing primary care rather than special surgical care. And small number of beds(under 5 beds) and only basic(2-3 sorts of)diagnostic apparatuses are sufficient for primary physicians' clinic to carry out primary care. In conclusion, to reinforce primary care department in Korea, there must be support with health policy to expand office-based primary care practice-- with small number of beds for inpatient care and only basic laboratories-- provided by general practitioner of family physician.

• 한국산학기술학회논문지
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• 제19권10호
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• pp.549-558
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• 2018

본 연구는 119구급대원들의 직무스트레스 수준을 파악하고, 이들의 인구사회학적 특성, 건강관련행위 특성 및 직업관련 특성과의 관련성을 규명하고자 시도하였다. 조사대상은 전국 14개 소방서에 근무하고 있는 119구급대원 1,240명으로 하였으며, 조사는 2016년 3월 1일부터 4월 30일까지의 기간 동안에 구조화된 무기명 자기기입식 설문지를 이용한 설문조사에 의하였다. 연구결과, 조사대상자의 직무스트레스는 기혼군보다 미혼군에서, 커피를 마신다는 군보다 마시지 않는 군에서, 주관적인 수면의 질이 좋다는 군보다 좋지 않다는 군에서, 주관적인 건강상태가 좋다는 군보다 좋지 않다는 군에서, 직급이 낮을수록, 근무 경력이 낮을수록, 업무에 대한 신체적 부담이 적당하다는 군보다 힘들다는 군에서, 업무에 만족한다는 군보다 만족하지 못한다는 군에서, 업무가 적성에 맞는다는 군보다 맞지 않는다는 군에서, 직업을 전환할 의사가 없다는 군보다 있다는 군에서 유의하게 높았다. 다중회귀분석결과, 조사대상자의 직무스트레스에 영향을 미치는 요인으로는 커피음용여부, 주관적인 수면의 질, 근무경력, 업무에 대한 신체적 부담, 업무에 대한 만족도, 업무에 대한 적성여부 및 직업전환의사가 유의한 변수로 선정되었다. 따라서 조사대상자의 직무스트레스는 인구사회학적 특성, 건강관련행위 특성 및 직업관련 특성의 여러변수들과 유의한 관련성이 있음을 시사한다.

• 대한한의학회지
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• 제27권2호
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• pp.145-154
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• 2006

Objectives : Methods to evaluate obesity are growing to be important in studying links between health and disease. Physicians are using BMI (body mass index) to evaluate obesity, but they can't know how much fat the body has by using that method. Even though there are several assessments, there are different scales, so patients are diagnosed as obese, by some but not by others. These studies are limited in evaluating obesity; it is necessary to study based on new knowledge. According to Oriental Medical Theory, obese people are categorized into 3 types, Fei, Kao and Liu Ren. They have different pathology and body shapes than non-obese people. The relationship between Oriental Medical Theory and BMI and assessment of body fat is a fundamental need to easily approach and treat obesity. Methods : At 00 Oriental Medical Center, 145 female subjects who intended to lose weight were given physical tests and grouped into 5 types of obesity. The physical tests were height measurement, BMI, body composition (body fat mass and lean body mass), skin elasticity and physical strength tests. One-way analysis of variance was done to compare the means of physical tests between the five types of obese women. There was some relationship between characteristics of the five types based on physical tests and Fei, Kao and Liu Ren based on Oriental Medical Theory. Least significant difference (LSD) was used in multiple comparisons. Results : 1. According to the skin elasticity test, obesity type 5 placed between obesity types 3 and 4 and obesity types 1 and 2. Obesity types 3 and 4 were in the low skin elasticity result group; obesity types 1 and 2 were in the high ones (p<0.1).Based on Oriental Medical Theory, Fei Ren and Kao Ren can be distinguished by skin elasticity degree. This result should form the basis of obesity diagnosis. 2. According to Oriental Medical Theory, Fei Ren is smaller than others. Based on height measurement, obesity types 3 and 4 were significantly lower than other obesity types (p<0.1), so there is a relationship between Fei Ren and obesity types 3 & 4. 3. There were significant differences between obesity type 2 and obesity type 4 in the body fat mass result (p<0.1). This study did not have large enough a sample size to distinguish Liu Ren. Conclusions : Further clinical research is necessary to study measurement methods of body shape type and skin elasticity for distinguishing Fei Ren from Kao Ren. The diagnosis and treatment based on the relationship of these types should be studied further.

• 해양환경안전학회지
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• 제26권6호
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• pp.644-655
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• 2020

본 연구는 항해사가 근접상황에서 심리적 충돌의 두려움으로 당황하여 규정된 충돌 회피조치를 수행하지 못하는 인적오류 상황을 연구하였다. 연구 목적은 선박 간 근접상황에서 항해사의 인적특성 요인인 승선경력, 면허등급, 연령요인이 충돌위험도에 미치는 영향을 규명하는 것이다. 본선과 상대선박 간 네 가지 대표적인 근접상황의 충돌침로에서 항해사가 지각한 충돌위험도 값을 측정, 정량화된 데이터를 얻기 위하여 시뮬레이터를 이용하여 충돌위험도 측정실험을 설계하고 두 척의 선박이 거리 2.5해리에서 충돌상황까지 상호 10노트의 속도로 접근할 때 본선의 30명의 항해사의 심장박동변이를 측정하여 항해사가 지각한 충돌위험도 측정데이터를 확보하였다. 측정값에 대한 다중회귀분석 결과 항해사의 승선경력과 면허등급 요인은 충돌위험도에 부(-)의 영향을 미쳤고, 연령은 영향을 미치지 않았다. t-검정 결과 승선경력≤4년인 항해사는 승선경력≥5년인 항해사 보다 충돌위험도 값이 유의미하게 높았고 면허등급 요인은 4 ~ 6급 그룹이 2 ~ 3급 그룹보다 충돌위험도 값이 유의미하게 높게 나타났다. 본 연구결과는 충돌위험경보시스템 개발에 적용될 수 있을 것이다.

• 정신신체의학
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• 제2권1호
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• pp.59-68
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• 1994

본 연구는 정신신체장애, 불안장애 및 우울장애 환자들 간에 alexithymia의 정도를 비교하기 위해서 실시되었다. 연구대상은 정신과 외래에 내원 하였거나 타과에서 정신과에 자문의뢰된 정신신체장애 환자 100명(긴장성 두통환자 47명 포함), 불안장애환자 52명, 우울장애환자 50명으로 하였다. 조사방법은 반체계적 면담용 평가도구인 Alexithymia provoked Response Questionnaire(APRQ)를 사용하였다. 정신신체장애환자들은 불안장애 및 우울장애환자들보다 alexithymia의 정도가 더 낮았으나 세 군간에 유의한 차이는 없었다. 반면 긴장성 두통환자들은 불안장애 및 우울장애환자들에 비해 alexithymia의 정도가 각각 유의하게 더 높았다. 우울장애환자들이 불안장애환자들보다 aluithymia의 정도가 더 높았으나 양군간에 유의한 차이는 없었다. 성별, 연령, 교육수준, 종교 및 직업유무와 같은 인구학적 특징들은 조사대상 모든 군에서 alexithymia와 유의한 관계가 없었다. 이 결과들은 일반적으로 정신신체장애환자들이 alexithymia를 보인다는 기존 보고와 다르게 정신신체장애 중 긴장성 두통과 같은 특정 정신신체장애환자들에서 alexithymia가 현저함을 시사한다. 따라서 긴장성 두통환자들에서의 치료전략으로 감정표현을 유도하는 특수한 형태의 면담방법이 개발될 필요가 있다.

• 한국산학기술학회논문지
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• 제10권4호
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• pp.707-716
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• 2009

본 연구는 일부 소방직공무원들의 스트레스 및 피로 수준을 파악하고, 스트레스와 피로에 관련된 요인을 구명하고자 청주시의 소방공무원 262명을 대상으로 구조화된 무기명 자기기입식 설문지(self-administrated questionnaire)를 이용한 설문조사를 실시하였다. 연구결과 전체 조사대상 소방공무원들의 사회심리적 스트레스 수준은 잠재적 스트레스군이 12.2%, 고위험스트레스군이 87.5%이었으며, 건강군은 한 명도 없었다 피로수준은 중앙값을 기준으로 구분하였을 경우, 낮은 군이 51.1%, 높은 군이 48.9%를 차지하였다. 단계별 다변량 회귀분석 결과 사회심리적 스트레스에 영향을 미치는 요인으로는 주관적인 건강상태, 직장생활만족도, 직무요구도, 음주상태 등이 선정되었으며, 피로수준에 영향을 미치는 요인으로는 주관적 건강상태, 규칙적인 운동여부 등이 선정되었다. 이상의 연구결과는 소방공무원의 사회심리학적 스트레스나 피로수준이 대단히 높은 것을 시사하며 여러 요인들이 관여하고 있음을 알 수 있다. 따라서 소방공무원들의 스트레스나 피로를 감소시키기기 위한 건강증진프로그램의 개발 및 시행이 필요할 것으로 생각된다.