• Korean Journal of Social Welfare Studies
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• v.48 no.2
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• pp.121-141
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• 2017

The objective of this study was to investigate the influence age-friendly environment factors on different age groups' life satisfaction. Data were taken from "2014 Survey on the Aged Society", with total of 1,000 participants divided into three groups: 300 youth participants from age 20 to 44, 300 middle aged participants from age 45 to 64, and older adults participants from age 65 and more. Performing ANOVA and multiple regression analysis showed that age-friendly environment factors had positive correlations with life satisfaction, regardless of the participants'age. However, the sub-dimensions of age-friendly environment that affected each age group was different. Among three sub-dimensions of age-friendly environment, which were housing factor, social participation factor, and community and health service factor, only housing factor affected life satisfaction of the youth group, while both community and health service factor, and housing factor affected life satisfaction of the middle-aged and the elderly groups. The result clearly presents that age-friendly environment factors are not only beneficial for older people but for people at all ages. Therefore, various measures need to be taken in order to increase the age-friendliness of communities, and improve the quality of life.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.248-256
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• 2018

O-2-$^{18}F$-fluoroethyl-l-tyrosine ($[^{18}F]FET$) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to examine the value of $[^{18}F]FET$ for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic mouse model of GBM. Human U87MG cells were implanted into nude mice and then bevacizumab, a representative anti-angiogenic drug, was administered. We monitored the effect of anti-angiogenic agents using multiple imaging modalities, including bioluminescence imaging (BLI), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET/CT). Among these imaging methods analyzed, only $[^{18}F]FET$ uptake showed a statistically significant decrease in the treatment group compared to the control group (P=0.02 and P=0.03 at 5 and 20 mg/kg, respectively). This indicates that $[^{18}F]FET$ PET is a sensitive method to monitor the response of GBM bearing mice to anti-angiogenic drug. Moreover, $[^{18}F]FET$ uptake was confirmed to be a significant parameter for predicting the prognosis of anti-angiogenic drug (P=0.041 and P=0.007, on Days 7 and 12, respectively, on Pearson's correlation; P=0.048 and P=0.030, on Days 7 and 12, respectively, on Cox regression analysis). However, results of BLI or MRI were not significantly associated with survival time. In conclusion, this study suggests that $[^{18}F]FET$ PET imaging is a pertinent imaging modality for sensitive monitoring and accurate prediction of treatment response to anti-angiogenic agents in an orthotopic model of GBM.

• Korean Journal of Biological Psychiatry
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• v.26 no.1
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• pp.22-31
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• 2019

Objectives Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume changes in each amygdala nucleus might have not been fully reflected in the measure of the total amygdala volume, causing discrepant results. Thus, we aimed to investigate volume changes in each amygdala subregion and their association with subtypes of BD, lithium use and clinical status of BD. Methods Fifty-five BD patients and 55 HC underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of the whole amygdala and each amygdala subregion, including the anterior amygdaloid area, cortico-amygdaloid transition area, basal, lateral, accessory basal, central, cortical, medial and paralaminar nuclei using the atlas in the FreeSurfer. The volume difference was analyzed using a one-way analysis of covariance with individual volumes as dependent variables, and age, sex, and total intracranial volume as covariates. Results The volumes of whole right amygdala and subregions including basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area in the right amygdala of BD patients were significantly smaller for the HC group. No significant volume difference between bipolar I disorder and bipolar II disorder was found after the Bonferroni correction. The trend of larger volume in medial nucleus with lithium treatment was not significant after the Bonferroni correction. No significant correlation between illness duration and amygdala volume, and insignificant negative correlation were found between right central nucleus volume and depression severity. Conclusions Significant volume decrements of the whole amygdala, basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area were found in the right hemisphere in adult BD patients, compared to HC group. We postulate that such volume changes are associated with altered functional activity and connectivity of amygdala nuclei in BD.

• Korean Journal of Family Social Work
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• no.57
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• pp.99-124
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• 2017

The primary objective of this study is to examine differences between the persons with recent onset and chronic mental illness in their family function; and analyze factors influence on the family function. The independent variables are divided into four sets: socio-economic, clinical, familial, and social characteristics. The subjects of this study are the 628 with mental disorders, and the sample was selected in Pusan and Gyeong-nam area. The findings of this study can be summarized as followed: The family with chronic mental illness showed higher family function in comparison with recent onset. Result of hierarchical multiple regression analysis show that age of onset, difference between ideal and reality in family function variable only influenced family function for the recent onset group, and activities of daily living, difference between ideal and reality in family function, caregiver's health, community support variables influenced family function for the chronic group. The results suggest a need for using different treatment approaches for recent onset versus chronic mentally disabled families. Implications for mental health social work practice for family with disabled are suggested.

• 한국노년학
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• v.28 no.4
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• pp.1147-1164
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• 2008

There has been a sharp increase in the number of grandmothers raising grandchildren in contemporary Korean society. However, little is known about the complexity of the experiences of the custodial grandparenting. Most of the studies mainly examined burden/cost and have paid little attention to the positive aspects of custodial grandparenting. In order to overcome this limitation of previous research, this study aims 1) to examine not only the costs but also the rewards of custodial grandparenting and to explore related factors, 2) to develop the typology based on relative rewards-burden perception of grandmothers about custodial grandparenting and explore the group differences. The data were gathered from 449 grandmothers raising their grandchildren as a primary caregiver, using a structured questionnaire. The data were analyzed using descriptive statistics, correlation, hierarchical multiple regression and ANOVA, with SPSS WIN 12.0 program. Main findings are as follows: First, custodial grandmothers report not only care-giving burden such as physical burnout and economic burden but also various rewards such as joy of watching their grandchildren grow and feeling good about themselves to be a help with their adult children, i.e. grandchildren's father or mother. Second, factors related to the level of perceived cost of grandparenting are different from the factors affecting the positive aspects of grandparenting. Third, results of the two by two cross-tab analysis based on the level of rewards and burden show that about 32 percent of the grandparents belong to Type II group(high rewards-low cost). This result is quite contrary to the assumption of previous research focusing mostly on cost and burden of custodial grandparenting. Fourth, four groups were different in terms of grandmother & grandchildren's characteristics. Implications of these results are discussed.

• Journal of the Korean Applied Science and Technology
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• v.36 no.1
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• pp.84-89
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• 2019

To characterize the molecular structure of BzO-gal synthesized using Escherichia coli ${\beta}$-gal, NMR ($^1H$- and $^{13}C$-) spectroscopy and mass spectrometry of BzO-gal were conducted. $^1H$ NMR spectrum of BzO-gal showed multiple peaks corresponding to the galactosyl group, which is an evidence of galactosylation on BzOH. Five proton peaks around the aromatic region at ${\delta}_H$ 7.43 ~ 7.24 ppm and 2 peaks from ${\delta}_H$ 4.93 and 4.67 ppm were evidence of the presence of the benzyl group. Seven proton peaks at ${\delta}_H$ 4.32 ~ 3.46 ppm showed the presence of a monosaccharide and were indicative of galactosylation on BzOH. $^{13}C$ NMR spectrum also revealed the presence of 11 carbons suggestive of BzO-gal. The mass value (sodium adduct ion of BzO-gal, m/z = 293.0994) from mass spectrometry analysis of BzO-gal, and $^1H$ and $^{13}C$ NMR spectral data were in good agreement with the expecting structure of BzO-gal. We are expecting that through future study it will eventually be able to develop a new additive of low cytotoxicity.

• Journal of Internet Computing and Services
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• v.21 no.6
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• pp.57-69
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• 2020

As more people share their opinions in online communities, such as Internet portals and social networking services, more opinions are manipulated for the benefit of particular individuals and groups. In particular, when manipulations occur for political purposes, they influence election results as well as government policies and the quality of life. This type of manipulation has targeted the general public, and their analysis and detection has also focused on such manipulation. However, to more efficiently spread propaganda, recent manipulations have targeted common interest groups(e.g., a group of those interested in real estate) and propagated information whose content and style are customized to those groups. This work characterizes such manipulations on common interest groups and proposes method to detect manipulations. To this end, we collected and analyzed opinions posted on 10 common interest groups before and after an election. As a result, we found that manipulations on common interest groups indeed occurred and were gradually increasing toward the election date. We also proposed a detection system that examines individual opinions, their authors, and their collaborators. Using the collected opinions, we demonstrated that the proposed system can accurately classify more than 90% of manipulated opinions and that many of these opinions were posted by multiple collaborators. We believe that regular audits of opinions using the proposed system can quickly isolate manipulations and decrease their impact. Moreover, the proposed features can be used to identify manipulations in domains other than politics.

• 한국노년학
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• v.40 no.3
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• pp.511-530
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• 2020

The present study aimed to examine the moderating effects of marital satisfaction (MS) on the association between the number of chronic disease (CD) and depressive symptoms (DS) among ol der men and women. The 6th wave of the Korean Longitudinal Study of Ageing was utilized and the sample was married men (N=585) and women (N=460) aged 65 and over. Multiple regression analysis using SPSS WIN 25.0 and Process Macro was used to test moderating effects of MS. Control variables were age, education, household income, parent-child relationship satisfaction, self-rated health, cognitive function, current smoking status and CD of spouse. Resul ts from elderly men showed the moderating effect of MS was significant. Specifically, those with more CD were more likely to report higher level of DS in the low MS group. However, the effect of CD on DS was not significant in the high MS group. Results from elderly women showed the moderating effect of MS was not significant. This study showed the moderating effect of MS on the association between CD and DS differed by gender in later life. It suggests practical intervention to utilize the resources of spouses is in need to promote mentally healthy aging even though having chronically ill in later life.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.4
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• pp.122-134
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• 2009

Purpose: The purpose of this study is to know the blood stasis pattern for the patients who had hysterectomy. Methods: Among the patients who had hysterectomy in the department of obstetrics and gynecology, OO medical center from March 3rd 2009 to October 21st 2009, subjects who met inclusion criteria and submitted appropriate questionnaire. We compared blood stasis score and operational method, age, BMI, past operation history of abdominal and pelvic site, parity, whether adhesiolysis, oriental medicine intervention was done. For statistics, we used independent samples t-test, oneway analysis of variances(ANOVA) and SPSS version 13.0 for windows. Results: Blood stasis score of the subtotal hysterectomy group ($44.43{\pm}15.01$) is higher than that of the total hysterectomy group($39.04{\pm}12.46$). Blood stasis score under the age 40($51.88{\pm}12.68$) is higher than 40-49 age patients($40.34{\pm}14.24$) and over the age 50 patients($41.62{\pm}13.46$). There is no statistically significant difference between laparoscopic and abdominal trial, whether adhesiolysis, oriental medicine intervention was done, BMI, past operation history abdominal and pelvic site, parity, chief complaint before hysterectomy, oriental medicine intervention. Conclusion: Through the results showed, when traditional Korean medical doctors use static blood medication, history of hysterectomy and age should be considered as the history of subtotal hysterectomy and younger age tend to have a higher rate of a blood stasis pattern. We need a further study to develop blood stasis indicators with a validated questionnaire, and more subjects involved at multiple institutions.

• 한국노년학
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• v.31 no.4
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• pp.1119-1134
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• 2011

The purpose of this study is firstly to understand socio-demographic and health characteristics and economic characteristics of elderly single households aged over 60 and secondly to examine the relations between these factors and level of life satisfaction, especially differentiated relations by income level. We used the data drawn from third KREIS (Korean Retirement and Income Study) surveyed by National Pension Research Institute. The statistical methods used for the analyses were t-test, X², multiple regression analysis. For the whole sample, the results showed that the life satisfaction is positively related to higher income, better physical and emotional health status and having a religion. When we conducted the regression on two groups, the religion and income level were no longer significant factors. On the other hand, being a woman and enjoying good health contributed to life satisfaction for lower-income group while having a job and enjoying good health played a positive role in life satisfaction for higher-income group.