• 한국작물학회:학술대회논문집
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• 한국작물학회 2007년도 춘계학술발표회
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• pp.65-73
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• 2007

The objective of this study is to understand how regulatory mechanisms respond to sugar status for more efficient carbon utilization and source-sink regulation in plants. So, we need to identify and characterize many components of sugar-response pathways for a better understanding of sugar responses. For this end, genes responding change of sugar status were screened using Arabidpsis cDNA arrays, and confirmed thirty-six genes to be regulated by sucrose supply in detached leaves by RNA blot analysis. Eleven of them encoding proteins for amino acid metabolism and carbohydrate metabolism were repressed by sugars. The remaining genes induced by sugar supply were for protein synthesis including ribosomal proteins and elongation factors. Among them, I focused on three hydrolase genes encoding putative $\beta$-galactosidase, $\beta$-xylosidase, and $\beta$-glucosidase that were transcriptionally induced in sugar starvation. Homology search indicated that these enzymes were involved in hydrolysis of cell wall polysaccharides. In addition to my results, recent transcriptome analysis suggested multiple genes for cell wall degradation were induced by sugar starvation. Thus, I hypothesized that enzyme for cell wall degradation were synthesized and secreted to hydrolyze cell wall polysaccharides producing carbon source under sugar-starved conditions. In fact, the enzymatic activities of these three enzymes increased in culture medium of Arabidopsis suspension cells under sugar starvation. The $\beta$-galactosidase encoded by At5g56870 was identified as a secretory protein in culture medium of suspension cells by mass spectrometry analysis. This protein was specifically detected under sugar-starved condition with a specific antibody. Induction of these genes was repressed in suspension cells grown with galactose, xylose and glucose as well as with sucrose. In planta, expression of the genes and protein accumulation were detected when photosynthesis was inhibited. Glycosyl hydrolase activity against galactan also increased during sugar starvation. Further, contents of cell wall polysaccharides especially pectin and hemicellulose were markedly decreased associating with sugar starvation in detached leaves. The amount of monosaccharide in pectin and hemicellulose in detached leaves decreased in response to sugar starvation. These results supported my idea that cell wall has one of function to supply carbon source in addition to determination of cell shape and physical support of plant bodies.

• 한국도로학회논문집
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• 제19권5호
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• pp.49-58
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• 2017

PURPOSES : The objective of this study is to develop a simple regression model in designing the asphalt concrete (AC) overlay thickness using the Mechanistic-empirical pavement design guide (MEPDG) program. METHODS : To establish the AC overlay design equation, multiple regression analyses were performed based on the synthetic database for AC thickness design, which was generated using the MEPDG program. The climate in Seoul city, a modified Hirsh model for determining dynamic modulus of asphalt material, and a new damaged master curve approach were used in this study. Meanwhile, the proposed rutting model developed in Seoul city was then used to calibrate the rutting model in the MEPDG program. The AC overlay design equation is a function of the total AC thickness, the ratio of AC overlay thickness and existing AC thickness, the ratio of existing AC modulus and AC overlay modulus, the subgrade condition, and the annual average daily truck traffic (AADTT). RESULTS : The regression model was verified by comparing the predicted AC thickness, the AADTT from the model and the MEPDG. The regression model shows a correlation coefficient of 0.98 in determining the AC thickness and 0.97 in determining AADTT. In addition, the data in Seoul city was used to validate the regression model. The result shows that correlation coefficient between the predicted and measured AADTT is 0.64. This indicates that the current model is more accuracy than the previous study which showed a correlation coefficient of 0.427. CONCLUSIONS:The high correlation coefficient values indicate that the regression equations can predict the AC thickness accurately.

• Smart Structures and Systems
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• 제18권5호
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• pp.983-1004
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• 2016

Nowadays, there are two classes of methods for damage detection in structures consisting of static and dynamic. The dynamic methods are based on studying the changes in structure's dynamic characteristics. The theoretical basis of this method is that damage causes changes in dynamic characteristics of structures. The dynamic methods are divided into two categories: signal based and modal based. The modal based methods utilize the modal properties consisting of natural frequencies, modal damping and mode shapes. As the modal properties are sensitive to changes in the structure, these can be used for detecting the damages. In this study, using dynamic method and modal based approach (natural frequencies and mode shapes), the objective function is formulated. Then, detection of damages of truss structures is addressed by using Simplified Dolphin Echolocation algorithm and solving inverse optimization problem. Many scenarios are used to simulate the damages. To demonstrate the ability of the algorithm, different truss structures with several multiple elements scenarios are tested using a few runs. The influence of the two different levels of noise in the modal data for these scenarios is also considered. The last example of this article is investigated using a different mutation. This mutation obtains the exact answer with fewer loops and population by limited computational effort.

• Journal of Preventive Medicine and Public Health
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• 제25권1호
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• pp.64-72
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• 1992

To provide the information necessary for the insurance medicine management plan, price discount rates among the insurance medicines were studied. A total of 2,107 items of insurance medicine of which prices were discounted via governmental inspections of real transactional process of insurance medicine were analysed. The conclusions are as follows; 1. Among the variables relevant to the characteristics of manufacturers, price discount rates of insurance medicines were statistically significant with production rankings of manufacturers, incorporation year, existence of investments by foreign corporation, existence of a research institute, and enrollment in the exchange. And among the variables relevant to the properties of medicines, the number of enrolled items which have the same components, classification, the date of new enrollment, the sales of items, and the number of raw materials in the items were statistically significant. 2. Stepwise multiple regression was done to identify the factors which affect the price discount rates of insurance medicines. The number of enrolled items which have the same components, production rankings of manufactures, classification number (medicines for function of tissue cells), incorporation year(1940-1949), existence of investments by foreign corporations, classification number (anti-germ medicines), number of raw materials In the items, the sales of items, and medicines whose major objective is not treatment were significant variables and the $R^2$-value for these variables was 21.2%. Considering all of the above results, for management of insurance medicines, it seems important that the real transactional prices of insurance medicines should be identified systematically, focusing on the properties which affect the price discount rates of insurance medicines.

• 전자공학회논문지SC
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• 제49권1호
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• pp.20-28
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• 2012

보행을 관찰하고 객관적인 정보를 추출하여 그 기능을 평가하는 것을 보행 분석이라고 한다. 최근 사용되는 보행 측정 장비들은 다수의 카메라, 지면 반력 측정 장치로 구성되어 고가이며, 이를 설치할 넓은 장소를 필요로 한다는 단점이 있다. 본 연구에서는 이러한 문제점을 해결하기 위해 단일 카메라를 통해 얻은 영상에서 마커 없이 인체의 3차원 보행 동작을 측정하는 기법을 제안한다. 파티클 필터를 사용하여 훈련 데이터와 보행에 관한 사전 정보 없이 사람의 동작을 추적한다. 인체와 지면에 관한 동역학을 통해 물리적으로 합당한 인체의 동작들을 생성하였다. 보행 영상에서 계산한 모든 관절의 평균 에러는 제안한 방법에서 $12.4^{\circ}$로, 기존 파티클 필터의 에러 $34.6^{\circ}$보다 작았다. 이러한 결과를 바탕으로 단일 카메라만으로 보행을 정량적으로 측정하여 기존 복잡한 장비를 대체할 수 있는 가능성을 제시하였다.

• Clinical and Experimental Reproductive Medicine
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• 제27권2호
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• pp.133-144
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• 2000

Objective: Several water channels (aquaporins; AQP) that belong to the MIP (major intrinsic protein) family have identified. In the selected tissues including red blood cells or renal tubules, water movements are abundant and/or physiologically important. Unexpectedly, a high water permeability of human and ram sperm has been reported. Recent studies showed that AQP7 and AQP8 are present in testes, so that the high water permeability of human sperm suggested to be mediated by AQPs. Method: To identify the identity of aquaporins expressed in testes, RT-PCR was performed using degenerative primers, which were designed to correspond to highly conserved sequences surrounding the Asn-Pro-Ala (NPA) motifs in the aquaporins. New expressed AQP series were reconfirmed by immunohistochemical study using rabbit polyclonal antibodies. Results: DNA sequencing of PCR products revealed that AQP2 and AQP3 mRNA as well as AQP7 and AQP8 are expressed in human and rat testes. In human and rat testes, AQP2 are expressed in spermatozoa, interstitial cells and myofibroblasts and AQP3 are expressed in myofibroblasts of semineferous tubules on immunocytochemical stain. Conclusion: These results indicate that multiple aquaporins are expressed in testes, and that they may have important roles in the spermatogenesis and the germ cell function of testis.

• 한국사회복지학
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• 제65권1호
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• pp.5-31
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• 2013

본 연구는 WHO의 국제건강관련분류체계인 ICF를 적용하여, 한국의 근골격계질환 장애인(척수손상, 근육디스트로피, 왜소증, 류마티즘) 352명의 사회참여 관련요인을 분석하였다. 연구방법은 기술분석, 집단별 평균분석 및 분산분석과 사후검정, 단순상관분석, 다중회귀분석을 사용하였다. 연구결과 근골격계질환 장애인의 정신기능, 신경근육골격 및 운동과 연관된 기능, 비뇨생식기와 생식기능, 피부 및 관련구조, 학습과 지식 적용, 일반적 과제와 요구, 이동의 수준이 높을수록 사회참여의 수준도 높았다. 개인요인에서 소득이 근육디스트로피질환 장애인의 사회참여 관련요인으로 나타났고, 환경요인에서 서비스, 시스템 및 정책이 척수손상 장애인의 사회참여에 영향을 미치는 것으로 나타났다. 본 연구는 장애에 관한 보편주의적 접근을 의미하는 ICF 구성요소로 연구모형을 설정하고, ICF 코어셋을 검토하여 질환관련범주를 측정하였다는 점에 의의가 있다.

• 한국실내디자인학회논문집
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• 제15권6호
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• pp.205-212
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• 2006

The premise of this study is that an ultimate objective in planning an exhibition space is spectators' experiences shaped by a result of their first-hand experiences and responses within an exhibition space, and this result can be recognized in the spectators' movement. Thus, the sign system that can directly affects viewers' main line of flow and movement patterns was examined vis--vis a mutually complementary relation in a triangular composition with the structure of exhibition space and the exhibition contents. Based on the findings, predictive values before and after a complementary application of the sign system to the structure of exhibition space was analyzed and its validity was assessed. The results of this research analysis were drawn as follows. It was shown that an understanding of the locations of direction signs and the degree of recognition can function as an important factor to predict viewers' movement, along with an understanding of topological characteristics of an exhibition space. In terms of the connection and disconnection of space units that form the space structure, it suggests that the distribution of signs and the degree of recognition can adjust the degree of connection and disconnection. Even though exhibition spaces for research subjects were selected from a relatively large number of museums, but the research was limited with a focus on the structure of exhibition space and sign systems. Thus, it is proposed that future studies should be conducted by including varieties of exhibition and environmental factors.

• The Journal of Korean Physical Therapy
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• 제26권6호
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• pp.430-435
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• 2014

Purpose: The objective of this study was a virtual reality-based balance training program effective for improvement in physical function, examined the balance ability and fall efficacy of elderly women with experienced falls, intending to examine the program's usefulness as an exercise program to prevent the recurrence of a fall. Methods: The participants were 30 elderly women aged 65 or older who met the conditions. The participants were randomly assigned to either a balance training group (BT) or a virtual reality-based balance training group (VT) and received the training three times per week, 30 minutes per day, for six weeks. To measure static balance, the Tetrax Portable Multiple System (Tetrax Ltd, Israel) were used. To measure dynamic balance, the Berg Balance Scale (BBS) and functional reach test (FRT) was used, and regarding fall efficacy, the Korean Fall Efficacy Scale (K-FES) was used. Results: Tetrax significantly improved after the intervention in both the BT group and the VT group (p<0.05). The comparison between the two groups was not significantly. BBS and FRT result significantly improved after the intervention in both the BT and VT groups (p<0.001), while K-FES was significantly ameliorated in the VT group only (p<.05). Comparing the groups, there were more significant changes in the BBS (p<0.05) and FRT (p<0.01) result of the VT group than the BT group. Conclusion: A virtual reality-based balance training program is considered to be usable as an exercise program to prevent recurrence of falls in elderly women.

• 한국수자원학회논문집
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• 제32권6호
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• pp.711-720
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• 1999

서해안의 3개 실험유역을 선정, 강우-유출 현상 중 홍수수문곡선을 모의하기 위하여 선형저수지 모형을 적용하고 모형의 매개변수를 유역특성과 상관시켜 회귀분석을 실시하였다. 분석을 위하여 총 8개 모형이 이용되었으며 3개 유역, 5개 수위관측지점에서 시험·적용하였다. 선정된 모형의 매개변수 최적화는 선형계획기법의 일종인 Rosenbrock방법을 이용하였고 유도된 모형의 매개변수는 또 다른 강우-유출 사상에 모의하여 검정하였다. 그리고 검정된 모형 중 Nash모형은 저수지 수(N)와 저류상수(k), 그리고 선형저수지 모형의 경우 저류상수(k)를 유역특성치인 유역의 크기, 경사도 및 하천길이와 상관시켜 회귀분석을 실시하였으며 이 결과는 무계측 유역의 순간단위도(IUH)를 유도하는데 이용할 수 있을 것이다.