• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2713-2717
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• 2015

Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.

• Journal of Industrial Technology
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• v.31 no.B
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• pp.107-112
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• 2011

Recently, climate change around the world due to global warming has became an important issue and damages by climate change have a bad effect on human life. Changes of Sea Surface Temperature(SST) is associated with natural disaster such as Typhoon and El Nino. So we predicted daily future SST using Statistical Downscaling Method and CGCM 3.1 A1B scenario. 9 points of around Korea peninsular were selected to predict future SST and built up a regression model using Multiple Linear Regression. CGCM 3.1 was simulated with regression model, and that comparing Probability Density Function, Box-Plot, and statistical data to evaluate suitability of regression models, it was validated that regression models were built up properly.

• Journal of applied mathematics & informatics
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• v.42 no.2
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• pp.257-281
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• 2024

In real life, a decision-maker can assign multiple values for pairwise comparison with a certain confidence level. Studies incorporating multi-choice parameters in multi-criteria decision-making methods are lacking in the literature. So, In this work, an extension of the Best-Worst Method (BWM) with multi-choice pairwise comparisons and multi-choice confidence parameters has been proposed. This work incorporates an extension to the original BWM with multi-choice uncertainty and confidence level. The BWM presumes the Decision-Maker to be fully confident about preference criteria vectors best to others & others to worst. In the proposed work, we consider uncertainty by giving decision-makers freedom to have multiple choices for preference comparison and having a corresponding confidence degree for each choice. This adds one more parameter corresponding to the degree of confidence of each choice to the already existing MCDM, i.e. multi-choice BWM and yields acceptable results similar to other studies. Also, the consistency ratio remained low within the acceptable range. Two real-life case studies are presented to validate our study on proposed models.

• Journal of Korean Institute of Industrial Engineers
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• v.27 no.3
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• pp.297-304
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• 2001

Procurement decisions for inspection equipment are often made heavily based on the initial purchase price instead of the effects of inspection cost, equipment calibration and utilization over the lifetime. Cost of ownership(COO) models that take into account all of these cost factors together have been developed focusing on a single quality characteristic. In modern manufacturing environment, inspection equipment often can deal with more than one quality characteristic simultaneously. In this paper, we propose the revised COO model for the economic evaluation of the inspection equipment that can accommodate multiple quality characteristics. We also employ an engineering economy model to compare equipments with different life span. Software is developed for handy comparison of the COO of alternative equipments along with sensitivity analysis far the optimal procurement decision.

• Journal of Microbiology and Biotechnology
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• v.28 no.9
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• pp.1413-1425
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• 2018

Shiga toxins (Stxs) are the main virulence factors expressed by the pathogenic Stx-producing bacteria, namely, Shigella dysenteriae serotype 1 and certain Escherichia coli strains. These bacteria cause widespread outbreaks of bloody diarrhea (hemorrhagic colitis) that in severe cases can progress to life-threatening systemic complications, including hemolytic uremic syndrome (HUS) characterized by the acute onset of microangiopathic hemolytic anemia and kidney dysfunction. Shiga toxicosis has a distinct pathogenesis and animal models of Stx-associated HUS have allowed us to investigate this. Since these models will also be useful for developing effective countermeasures to Stx-associated HUS, it is important to have clinically relevant animal models of this disease. Multiple studies over the last few decades have shown that mice injected with purified Stxs develop some of the pathophysiological features seen in HUS patients infected with the Stx-producing bacteria. These features are also efficiently recapitulated in a non-human primate model (baboons). In addition, rats, calves, chicks, piglets, and rabbits have been used as models to study symptoms of HUS that are characteristic of each animal. These models have been very useful for testing hypotheses about how Stx induces HUS and its neurological sequelae. In this review, we describe in detail the current knowledge about the most well-studied in vivo models of Stx-induced HUS; namely, those in mice, piglets, non-human primates, and rabbits. The aim of this review is to show how each human clinical outcome-mimicking animal model can serve as an experimental tool to promote our understanding of Stx-induced pathogenesis.

• Journal of Elementary Mathematics Education in Korea
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• v.7 no.1
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• pp.45-64
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• 2003

This study analyzes divisor and multiple in elementary school mathematics textbooks published according to the first to the 7th curriculum, in a view point of the didactic transposition theory. In the first and second textbooks, the divisor and the multiple are taught in the chapter whose subject is on the calculations of the fractions. In the third and fourth textbooks, divisor and multiple became an independent chapter but instructed with the concept of set theory. In the fifth, the sixth, and the seventh textbooks, not only divisor multiple was educated as an independent chapter but also began to be instructed without any conjunction with set theory or a fractions. Especially, in the seventh textbook, the understanding through activities of students itself are strongly emphasized. The analysis on the each curriculum periods shows that the divisor and the multiple and the reduction of a fractions to the lowest terms and to a common denominator are treated at the same period. Learning activity elements are increase steadily as the textbooks and the mathematical systems are revised. The following conclusion can be deduced based on the textbook analysis and discussion for each curriculum periods. First, loaming instruction method also developed systematically with time. Second, teaching method of the divisor and multiple has been sophisticated during the 1st to 7th curriculum textbooks. And the variation of the teaching sequences of the divisor and multiple is identified. Third, we must present concrete models in real life and construct textbooks for students to abstract the concepts by themselves. Fourth, it is necessary to develop some didactics for students' contextualization and personalization of the greatest common divisor and least common multiple. Fifth, the 7th curriculum textbooks emphasize inquiries in real life which teaming activities by the student himself or herself.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.232-238
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• 2018

Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed to help overcome potential drawbacks related to animal experiments and avoid ethical issues, their use remains vital for the testing of new drug candidates and to identify the most effective strategies for therapeutic intervention. Particularly, the study of metabolic diseases requires the use of animal models to monitor whole-body physiology. In line with this, the National Institute of Food and Drug Safety Evaluation (NIFDS) in Korea has established their own animal strains to help evaluate both efficacy and safety during new drug development. The objective of this study was to characterize the response of C57BL/6NKorl mice from the NIFDS compared with that of other mice originating from the USA and Japan in a chemical-induced diabetic condition. Multiple low-dose treatments with streptozotocin were used to generate a type-1 diabetic animal model which is closely linked to the known clinical pathology of this disease. There were no significantly different responses observed between the varying streptozotocin-induced type-1 diabetic models tested in this study. When comparing control and diabetic mice, increases in liver weight and disturbances in serum amino acids levels of diabetic mice were most remarkable. Although the relationship between type-1 diabetes and BCAA has not been elucidated in this study, the results, which reveal a characteristic increase in diabetic mice of all origins are considered worthy of further study.

• Advances in aircraft and spacecraft science
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• v.4 no.1
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• pp.1-19
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• 2017

Fatigue life prediction of a multi-row countersunk riveted lap joint was performed numerically. The stress and strain conditions in a highly stressed substructure of the joint were analysed using a global/local finite element (FE) model coupling approach. After validation of the FE models using experimental strain measurements, the stress/strain condition in the local three-dimensional (3D) FE model was simulated under a fatigue loading condition. This local model involved multiple load cases with nonlinearity in material properties, geometric deformation, and contact boundary conditions. The resulting stresses and strains were used in the Smith-Watson-Topper (SWT) strain life equation to assess the fatigue "initiation life", defined as the life to a 0.5 mm deep crack. Effects of the rivet-hole clearance and rivet head deformation on the predicted fatigue life were identified, and good agreement in the fatigue life was obtained between the experimental and the numerical results. Further crack growth from a 0.5 mm crack to the first linkup of two adjacent cracks was evaluated using the NRC in-house tool, CanGROW. Good correlation in the fatigue life was also obtained between the experimental result and the crack growth analysis. The study shows that the selected methodology is promising for assessing the fatigue life for the lap joint, which is expected to improve research efficiency by reducing test quantity and cost.

• Journal of muscle and joint health
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• v.21 no.2
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• pp.125-134
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• 2014

Purpose: The purpose of this study was to identify factors associated with quality of life of nursing students during clinical practice. Methods: A convenience sample of 332 nursing students completed the questionnaire from July to September, 2013. A self-reported questionnaire was used to obtain data on quality of life, stress related to clinical practice, and health promotion behavior. Data was analyzed with independent t-test, one way ANOVA and Scheff${\acute{e}}$'s post hoc test, Pearson correlation coefficients, and hierarchical multiple regression by using SPSS version 20.0. Results: There were significant differences in quality of life scores by age, economic status, interpersonal relationships, daytime somnolence, number of visits in pharmacy and/or healthcare center, health status, and stress management. Quality of life had positive correlation with health promotion behavior but had negative correlation with the level of stress related to clinical practice. Models including these variables explained 34.3% (F=9.77, p<.001) of the variance for quality of life. Age, economic status, sleep amount, numbers of pharmacy/hospital visits, health status, stress during clinical practice, and health promotion behavior were significantly associated with quality of life in nursing students. Conclusion: There is a need to develop and implement new strategies that will result in improvement in nursing students' quality of life.

• Research in Community and Public Health Nursing
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• v.26 no.4
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• pp.342-354
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• 2015

Purpose: The purpose of this study was to examine social capital and health-related quality of life (HRQoL) of residents who were living in the three regions(Masan, Jinhae, and Changwon) of integrated Changwon and to analyze the effect of social capital on HRQoL. Methods: This study used the Masan, Jinhae and Changwon data of the 2013 Community Health Survey. The social capital questionnaire consisted of three subdomains (trust, participation, and network). HRQoL was measured with the Korean-version EQ-5D. The effect of social capital on HRQoL was analyzed using multiple regression with controlling for general characteristics and health behavior. Results: The trust level of Masan citizen was highest among the three regions. Jinhae citizen showed the highest level of participation and network out of the three regions. Trust was not a significant influencing factor in any of the three models. Participation was a significant influencing factor in all of the three models. Network was a significant influencing factor only in the Masan model. Conclusion: Participation was the most important factor for health among the three social capital subdomains. Strategies for encouraging social participation are needed for health promotion for the residents of integrated Changwon.