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Self-Organization of Dendron-Poly(ethylene glycol) Conjugates in an Aqueous Phase

  • Kim, Kyoung-Taek;Lee, Im-Hae;Park, Chiyoung;Song, Yu-Mi;Kim, Chul-Hee
    • Macromolecular Research
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    • v.12 no.5
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    • pp.528-533
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    • 2004
  • We have prepared amide dendrons having alkyl peripheral units and various focal moieties through a convergent synthetic approach. The amphiphilic properties, due to hydrophilic amide branches and the hydrophobic peripheral units, provide an opportunity for the amide dendrons to self-organize in water. The dendritic architecture itself is also one of the critical factors in the self-organization of the amide dendrons in water. In particular, function-alization was performed at the focal point to elucidate the relationship between the focal functionality and the self-organized structures of the dendritic building blocks in the aqueous phase. The dendron having a short poly(ethylene glycol) monomethyl ether (MeO-PEG) unit (M$\_$n/ =750) as the focal moiety formed a vesicular organization in water. As the size of the hydrophilic focal MeO-PEG increased to M$\_$n/ =2,000 and 5,000, the self-organized structures became rod-type and spherical micelles, respectively. Our observation of multiple morphologies for amide dendrons is in good agreement with previous reports that indicated that the micellar structures changed from vesicles to rod-types and then to spheres upon increasing the size of the hydrophilic moiety of the amphiphiles.

Global Sequence Homology Detection Using Word Conservation Probability

  • Yang, Jae-Seong;Kim, Dae-Kyum;Kim, Jin-Ho;Kim, Sang-Uk
    • Interdisciplinary Bio Central
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    • v.3 no.4
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    • pp.14.1-14.9
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    • 2011
  • Protein homology detection is an important issue in comparative genomics. Because of the exponential growth of sequence databases, fast and efficient homology detection tools are urgently needed. Currently, for homology detection, sequence comparison methods using local alignment such as BLAST are generally used as they give a reasonable measure for sequence similarity. However, these methods have drawbacks in offering overall sequence similarity, especially in dealing with eukaryotic genomes that often contain many insertions and duplications on sequences. Also these methods do not provide the explicit models for speciation, thus it is difficult to interpret their similarity measure into homology detection. Here, we present a novel method based on Word Conservation Score (WCS) to address the current limitations of homology detection. Instead of counting each amino acid, we adopted the concept of 'Word' to compare sequences. WCS measures overall sequence similarity by comparing word contents, which is much faster than BLAST comparisons. Furthermore, evolutionary distance between homologous sequences could be measured by WCS. Therefore, we expect that sequence comparison with WCS is useful for the multiple-species-comparisons of large genomes. In the performance comparisons on protein structural classifications, our method showed a considerable improvement over BLAST. Our method found bigger micro-syntenic blocks which consist of orthologs with conserved gene order. By testing on various datasets, we showed that WCS gives faster and better overall similarity measure compared to BLAST.

Static Performance Test for New Wave Dissipating Block Reinforced with FRP (FRP로 보강된 신형 소파블록의 정적 성능 실험)

  • Paik, In-Yeol;Oh, Young-Min
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.23 no.4
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    • pp.285-291
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    • 2011
  • In this study the mechanical performance of the new wave dissipating block is evaluated through experiment and numerical analysis. Also, by selecting adequate reinforcement, the improvement of the structural performance is examined. The reinforcement is designed by predicting the amount of tensile force and the location where the tensile stress develops in the new wave dissipating block through numerical analysis. The new wave dissipating block is reinforced with the ordinary steel bars and the fiber reinforced plastic(FRP) bars which have advantages in ocean environment in terms of corrosion and fatigue. The test result shows that the fracture resistance of the un-reinforced concrete block is 350 kN which is about 6.2 times that of the weight of the block. All the test blocks which are reinforced by either steel of FRP bars show strength capacity of over 900 kN which is the maximum load of the test equipment. Although the single reinforcement with larger-diameter bars has advantage in terms of construction convenience, it is recommended to use multiple number of smaller-diameter bars in order to reduce the crack width.

A Micro-observation on the Wing and Secondary Cracks Developed in Gypsum Blocks Subjected to Uniaxial Compression (일축압축상태의 석고 실험체에서 발생하는 날개크랙과 이차크랙에 대한 미시적 관측)

  • 사공명
    • Journal of the Korean Geotechnical Society
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    • v.19 no.2
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    • pp.171-178
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    • 2003
  • Wing and secondary cracks are unique types of cracks observed in rock masses subjected to uniaxial and biaxial compressive loading conditions. In this study, morphological features of wing and secondary cracks developed in gypsum specimens are investigated in the macro and micro scales. Along the path of wing crack, microtensile cracks are observed. Microtensile cracks coalesce with pores and show branch phenomenon. From the onset of the wing crack, multiple initiations of microtensile cracks are observed. Microtensile cracks show tortuous propagation paths and relatively constant aperture of the cracks during the propagation. It is shown that microtensile cracks propagate by splitting failure. At the micro scale, microfsults are observed in the path of the secondary cracks. Along the path of the secondary cracks, separation of grains and conglomerate grains, oblique microfaults, and irregular aperture of microfault are observed. These features show that the secondary cracks are produced in shear mode. The measured sizes of fracture process zone across the propagation direction near the tip of wing and secondary cracks range from 10$\mu{m}$ to 20$\mu{m}$ far wing cracks and from 100$\mu{m}$ to 200$\mu{m}$ for secondary cracks, respectively.

Link Scheduling Method Based on CAZAC Sequence for Device-to-Device Communication (D2D 통신 시스템을 위한 CAZAC 시퀀스 기반 링크 스케줄링 기법)

  • Kang, Wipil;Hwang, Won-Jun;Choi, Hyung-Jin
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.38A no.4
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    • pp.325-336
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    • 2013
  • FlashLinQ, one of the typical D2D communication systems developed by Qualcomm, considers a single-tone communication based distributed channel-aware link scheduling method to realize the link scheduling process with low control overheads. However, considering the frequency selective fading effect of practical multi-path channel, the single-tone based SIR estimation causes a critical scheduling error problem because the received single-tone signal has quite different channel gain at each sub-carrier location. In order to overcome this problem, we propose a novel link scheduling method based on CAZAC (Constant Amplitude Zero Auto-Correlation) sequence for D2D communication system. In the proposed method, each link has a unique offset value set for the generation of CAZAC sequences. CAZAC sequences with the cyclic offsets are transmitted using multiple sub-blocks in the entire bandwidth, and then each device can obtain nearly full-band SIR using a good cyclic cross-correlation property of CAZAC sequence.

Metadata Management of a SAN-Based Linux Cluster File System (SAN 기반 리눅스 클러스터 파일 시스템을 위한 메타데이터 관리)

  • Kim, Shin-Woo;Park, Sung-Eun;Lee, Yong-Kyu;Kim, Gyoung-Bae;Shin, Bum-Joo
    • The KIPS Transactions:PartA
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    • v.8A no.4
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    • pp.367-374
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    • 2001
  • Recently, LINUX cluster file systems based on the storage area network (SAN) have been developed. In those systems, without using a central file server, multiple clients sharing the whole disk storage through Fibre Channel can freely access disk storage and act as file servers. Accordingly, they can offer advantages such as availability, load balancing, and scalability. In this paper, we describe metadata management schemes designed for a new SAN-based LINUX cluster file system. First, we present a new inode structure which is better than previous ones in disk block access time. Second, a new directory structure which uses extendible hashing is described. Third, we describe a novel scheme to manage free disk blocks, which is suitable for very large file systems. Finally, we present how we handle metadata journaling. Through performance evaluation, we show that our proposed schemes have better performance than previous ones.

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Biometric Information and OTP based on Authentication Mechanism using Blockchain (블록체인을 이용한 생체정보와 OTP 기반의 안전한 인증 기법)

  • Mun, Hyung-Jin
    • Journal of Convergence for Information Technology
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    • v.8 no.3
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    • pp.85-90
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    • 2018
  • Blockchain technology provides distributed trust structure; with this, we can implement a system that cannot be forged and make Smart Contract possible. With blockchain technology emerging as next generation security technology, there have been studies on authentication and security services that ensure integrity. Although Internet-based services have been going with user authentication with password, the information can be stolen through a client and a network and the server is exposed to hacking. For the reason, we suggest blockchain technology and OTP based authentication mechanism to ensure integrity. In particular, the Two-Factor Authentication is able to ensure secure authentication by combining OTP authentication and biometric authentication without using password. As the suggested authentication applies multiple hash functions and generates transactions to be placed in blocks in order for biometric information not to be identified, it is protected from server attacks by being separate from the server.

Ecological Momentary Assessment Using Smartphone-Based Mobile Application for Affect and Stress Assessment

  • Yang, Yong Sook;Ryu, Gi Wook;Han, Insu;Oh, Seojin;Choi, Mona
    • Healthcare Informatics Research
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    • v.24 no.4
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    • pp.381-386
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    • 2018
  • Objectives: This study aimed to describe the process of utilizing a mobile application for ecological momentary assessment (EMA) to collect data on stress and mood in daily life setting. Methods: A mobile application for the Android operating system was developed and installed with a set of questions regarding momentary mood and stress into a smartphone of a participant. The application sets alarms at semi-random intervals in 60-minute blocks, four times a day for 7 days. After obtaining all momentary affect and stress, the questions to assess the usability of the mobile EMA application were also administered. Results: The data were collected from 97 police officers working in Gyeonggi Province of South Korea. The mean completion rate was 60.0% ranging from 3.5% to 100%. The means of positive and negative affect were 18.34 of 28 and 19.09 of 63. The mean stress was 17.92 of 40. Participants responded that the mobile application correctly measured their affect ($4.34{\pm}0.83$) and stress ($4.48{\pm}0.62$) of 5-point Likert scale. Conclusions: Our study investigated the process of utilizing a mobile application to assess momentary affect and stress at repeated times. We found challenges regarding adherence to the research protocol, such as completion and delay of answering after alarm notification. Despite this inherent issue of adherence to the research protocol, the EMA still has advantages of reducing recall bias and assessing the actual moment of interest at multiple time points that improves ecological validity.

GPU-based Parallel Ant Colony System for Traveling Salesman Problem

  • Rhee, Yunseok
    • Journal of the Korea Society of Computer and Information
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    • v.27 no.2
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    • pp.1-8
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    • 2022
  • In this paper, we design and implement a GPU-based parallel algorithm to effectively solve the traveling salesman problem through an ant color system. The repetition process of generating hundreds or thousands of tours simultaneously in TSP utilizes GPU's task-level parallelism, and the update process of pheromone trails data actively exploits data parallelism by 32x32 thread blocks. In particular, through simultaneous memory access of multiple threads, the coalesced accesses on continuous memory addresses and concurrent accesses on shared memory are supported. This experiment used 127 to 1002 city data provided by TSPLIB, and compared the performance of sequential and parallel algorithms by using Intel Core i9-9900K CPU and Nvidia Titan RTX system. Performance improvement by GPU parallelization shows speedup of about 10.13 to 11.37 times.

Thread Block Scheduling for Multi-Workload Environments in GPGPU (다중 워크로드 환경을 위한 GPGPU 스레드 블록 스케줄링)

  • Park, Soyeon;Cho, Kyung-Woon;Bahn, Hyokyung
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.22 no.2
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    • pp.71-76
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    • 2022
  • Round-robin is widely used for the scheduling of large-scale parallel workloads in the computing units of GPGPU. Round-robin is easy to implement by sequentially allocating tasks to each computing unit, but the load balance between computing units is not well achieved in multi-workload environments like cloud. In this paper, we propose a new thread block scheduling policy to resolve this situation. The proposed policy manages thread blocks generated by various GPGPU workloads with multiple queues based on their computation loads and tries to maximize the resource utilization of each computing unit by selecting a thread block from the queue that can maximally utilize the remaining resources, thereby inducing load balance between computing units. Through simulation experiments under various load environments, we show that the proposed policy improves the GPGPU performance by 24.8% on average compared to Round-robin.