• 과학기술학연구
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• 제17권1호
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• pp.71-115
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• 2017

1953년에 이론물리학자 조지 가모프는 "DNA의 염기 서열에 의해 단백질의 아미노산 서열이 암호화된다"는 가설로 단백질 합성 현상을 설명했고, "다이아몬드 코드"라는 핵산-단백질 정보전달 모형을 제안했다. 왓슨, 크릭, 브레너, 스텐트 같은 당대의 생물학자들은 이런 대담한 제안에 관심을 보이며 가모프와 토론했고, 이에 가모프는 이들 간의 의견교환을 활성화하기 위해 RNA 타이 클럽이라는 비공식 연구자 모임을 결성했다. 이후 생물학자들뿐만 아니라 물리학자, 수학자, 컴퓨터엔지니어들이 RNA 타이 클럽에 동참했고, 이들의 다학제적 유전암호 해독 연구는 1950년대 후반까지 활발히 이루어졌다. 본고는 RNA 타이 클럽의 형성, 성장, 와해의 과정을 살피면서 다음과 같은 논제를 다루려 한다. 첫째, 정통 생물학과 거리가 먼 '문자열 간 번역원리를 찾는 가모프의 수학적 접근'은 어떻게 생물학자들의 공동의 연구의제로 채택될 수 있었을까? 둘째, RNA 타이 클럽의 연구의제는 어떻게 다양한 학제의 연구주제들로 풍부하게 확장될 수 있었을까? 셋째, RNA 타이 클럽의 쇠락과 와해를 가져온 요인은 무엇이었을까? 이런 분석을 통해, 본고는 타이 클럽 연구자들의 근본 가정인 "아미노산 서열에 배열 패턴이 존재한다"는 가정이 다양한 학제적 접근방식을 매개하는 연결고리 역할을 했고, 또 이를 통해 당대 생물학의 실험 데이터를 활용할 수 있게 되면서 이들의 번역코드 연구는 유의미한 생물학 연구방법으로 자리 잡을 수 있게 되었음 주장할 것이다. 아울러 위의 논의의 연장선상에서 타이 클럽의 와해 요인을 해명함으로써, 다양한 학제의 연구자들을 성공적으로 매개할 생산적 연구의제가 갖춰야 할 요건은 무엇인지 고찰해 볼 것이다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제36회 동계학술대회 초록집
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• pp.64.2-64.2
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• 2009

• 한국진공학회:학술대회논문집
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• 한국진공학회 2008년도 제34회 동계학술대회 초록집
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• pp.57-57
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• 2008

• Molecules and Cells
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• 제47권2호
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• pp.100032.1-100032.2
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• 2024

• 기술혁신연구
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• 제10권1호
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• pp.22-37
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• 2002

The importance of selecting the strategic research field is increasingly emphasized by research manager and technology policy-maker in perspective of the strategic allocation of R&D resources, employing the R&D personnel, and formulating technology policy. Among various methods for selecting the strategic research field, it is, however, very difficult to find the method that involves the path-dependant trend, and interdisciplinary nature of technology development. This study suggests modified technology cluster analysis (TCA) as a method for selecting strategic research field in order to include the recent technology trend in quantitative approach. TCA is the method that groups the near technologies of which the innovation pattern is similar. TCA model can be a very necessary method for multidisciplinary government research institutes (GRIs) which conduct multi research field with forward oriented positioning. It is more difficult for them to select the strategic research field mainly due to their diversity and intangibility of research scope. In this study, we applied this method to Korea Institute of Science and Technology (KIST) which represents the most adequate research institute in terms of research diversity and forwardness. As a result of the application, we found that seven main technology groups come from TCA analysis, coincide with the technology topics of KIST's recent R&D planning. Even though this method designed for multidisciplinary research institutes, but it also can be used for establishing the research strategy of other (private or public) Research Institute which have the similar mission and scope of research.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2008년도 Asian Magnetics Conference
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• pp.264.2-264.2
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• 2008

• Structural Engineering and Mechanics
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• 제78권2호
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• pp.175-186
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• 2021

Due to the increasing environmental pollution caused by scrap tires, a solution is being sought to recycle and use them in a field of civil engineering, i.e., construction. This paper will provide a brief overview of previous researches that give detailed information on the advantages and disadvantages, considering the microstructural and mechanical characteristics of self-compacting concrete, when waste tire rubber as an aggregate is added. With this aim, a database of 144 different mixtures of self-compacting concrete with partial substitute of natural aggregate with recycled tire rubber (self-compacting rubberized concrete, SCRC) provided by various researchers was created. In this study we show that Gaussian process regression (GPR) modelling is an appropriate method for predicting compressive strength of SCC with recycled tire rubber particles and is in accordance with the results displayed by SEM images.

• 수완나부미
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• 제7권2호
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• pp.57-78
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• 2015

Southeast Asia has been a showcase for democratic transitions in the past 30 years. This paper proposes a conceptual lens for studying political shifts in the Southeast Asian region. The argumentative storyline follows two fundamental propositions about democratic transitions. My first proposition is that during democratic transitions, human phenomena arise on nested analytical layers namely the global arena, the state, prodemocracy movements, and individuals. Each layer is conventionally studied by international relations, political science, sociology, and psychology respectively. I propose a multidisciplinary lens that transverses all these analytical layers. A second proposition is that during political shifts, social conditions are historically-situated. Historicity is anchored on stages of democratization, namely the authoritarian regime, toppling the regime, power shift, state building, and nation building. This paper describes a 4 × 5 matrix (analytical layer × historical stage) that may guide a regional agenda on the empirical study of democratic transitions in the Southeast Asian region. It likewise gives examples of research findings in Philippine-based studies that have already begun to provide empirical data about segments of this research matrix.

• 한국자동차공학회논문집
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• 제11권5호
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• pp.210-218
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• 2003

MDO (multidisciplinary design optimization) technology has been proposed and applied to solve large and complex optimization problems where multiple disciplinaries are involved. In this research. an MDO problem is defined for automobile design which has crashworthiness analyses. Crash model which are consisted of airbag, belt integrated seat (BIS), energy absorbing steering system .and safety belt is selected as a practical example for MDO application to vehicle system. Through disciplinary analysis, vehicle system is decomposed into structure subspace and occupant subspace, and coupling variables are identified. Before subspace optimization, values of coupling variables at given design point must be determined with system analysis. The system analysis in MDO is very important in that the coupling between disciplines can be temporary disconnected through the system analysis. As a result of system analysis, subspace optimizations are independently conducted. However, in vehicle crash, system analysis methods such as Newton method and fixed-point iteration can not be applied to one. Therefore, new system analysis algorithm is developed to apply to crashworthiness. It is conducted for system analysis to determine values of coupling variables. MDO algorithm which is applied to vehicle crash is MDOIS (Multidisciplinary Design Optimization Based on Independent Subspaces). Then, structure and occupant subspaces are independently optimized by using MDOIS.

• 생물정신의학
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• 제20권4호
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• pp.129-135
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• 2013

Aggression can be defined as 'behavior intended to harm another' which can be seen both from humans and animals. However, trying to understand aggression in a simplistic view may make it difficult to develop an integrated approach. So, we tried to explain aggression in a multidisciplinary approach, affected by various factors such as neuroanatomical structures, neurotransmitter, genes, and sex hormone. Parallel with animal models, human aggression can be understood with two phenomena, offensive aggression and defensive aggression. Neurobiological model of aggression give a chance to explain aggression with an imbalance between prefrontal regulatory influences and hyper-reactivity of the subcortical areas involved in affective evaluation, finally in an aspect of brain organization. Serotonin and GABA usually inhibit aggression and norepinephrine while glutamate and dopamine precipitate aggressive behavior. As there is no one gene which has been identified as a cause of aggression, functions between gene to gene interaction and gene to environment interaction are being magnified. Contributions of sex hormone to aggression, especially molecular biologic interaction of testosterone and regulation of estrogen receptor have been emphasized during the research on aggression. This multidisciplinary approach on aggression with types, neurochemical bases, and animal models can bring integrated interpretation on aggression.