• Journal of Sasang Constitutional Medicine
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• v.22 no.2
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• pp.93-100
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• 2010

1. Objectives: To compare the contents of hazardous substances such as crude, washing solution, crude after washing, decoction and remnant. 2. Methods: The heavy metal contents of each step were measured by inductively coupled plasma (ICP) spectrometer and mercury analyzer (MA-2). In order to analyze pesticides in Yanggyeoksanhwa-tang we used simultaneous multi- residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide (SO2) were performed by Monier-Williams distillation method. 3. Results: 1) The mean values of heavy metal contents (mg/kg) for each steps in Yanggeoksanhwa-tang were as follows: crude (Pb; 1.87, As; 1.29, Cd; 0.28 and Hg; N.D.), washing solution (Pb; 1.98, As; 1.13, Cd; 0.10 and Hg; N.D.), crude after washing (Pb; 1.90, As; 1.40, Cd; 0.22 and Hg; N.D.), decoction (Pb; 1.90, As; 1.14, Cd; 0.11 and Hg; N.D.) and remnant (Pb; 2.39, As; 1.29, Cd; 0.25 and Hg; 0.01). 2) Contents (mg/kg) of residual pesticides in crude and decoction were not detected. 3) Contents (mg/kg) of sulfur dioxide (SO2) in crude, crude after washing and remnant exhibited 3.00, 2.00 and 2.00 mg/kg, respectively. However, contents of sulfur dioxide in washing solution and decoction were not detected. 4. Conclusions: These Results: will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide of each step in Yanggeoksanhwa-tang.

• Journal of Life Science
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• v.21 no.7
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• pp.947-952
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• 2011

A number of epidemiological studies have identified human papillomavirus (HPV) types 1, 2, 3, 4, 7, 10, 27, 57, and 65 in cutaneous common warts. However, identification of the HPV subtype by conventional polymerase chain reaction (PCR) is time consuming with its multi-step laboratory process. In this study, we aim to develop a specific one-step multiplex polymerase chain reaction method which capably identifies six different HPV genotypes related to common warts. By HPV DNA sequence analysis, 6 pairs of specific primers were designed from the intergenic regions of genes L1 to E6, and from genes E2 to L2. DNA sequence analysis with the L1 gene sequence of the sample was performed to measure the specificity of multiplex PCR. HPV-1, -2, -3, -4, -27, and -57 were identified without cross amplification in 109 out of 129 samples. The sensitivity and specificity of our set of primers in detecting HPV were 85% and 99.5%, respectively. For the 20 samples where HPV type was not identifiable by our batch of primer sets, multiplex PCR with an additional set of HPV primers was done, where 7 were found positive for HPV-7 or -65. Our results demonstrate that the newly designed multiplex PCR can rapidly detect the specific HPV subtype involved in common warts with high accuracy.

• The Journal of Korean Academy of Prosthodontics
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• v.45 no.5
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• pp.653-664
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• 2007

Statement of problem: The screw detorque value is a measure of the preload remaining in the screw just before detorquing. Purpose: This study evaluated the effect of different screw tightening sequences and tightening methods on detorque values for a well-fitting implant superstructure. Material and method: An implant superstructure that connected directly to four implants (Astra Tech) was fabricated on a fully edentulous mandibular acrylic resin model. Six well-fitting dental stone casts were made with a pickup impression of the superstructure from the acrylic resin model. To evaluate the effect of three screw tightening sequences (1-2-3-4, 2-4-3-1, and 2-3-1-4) and two tightening methods (2-step and 1-step) on the stability of screw joint, the detorque values for a well-fitting implant superstructure were measured twice after screw tightening using 20 Ncm. Detorque values were analyzed using multi-way analysis of variance and two-way analysis of variance at a .05 level of significance. Results: 1. The mean detorque values for three screw tightening sequences were 12.3 Ncm, 12.6 Ncm, and 12.0 Ncm, respectively. 2. The mean detorque values for two screw tightening methods were 12.0 Ncm, and 12.2 Ncm, respectively. 3. The mean of mimimum detorque values for three screw tightening sequences and for two tightening methods were 10.6 Ncm, 11.1 Ncm, 10.5 Ncm, and 9.8 Ncm, respectively. 4. No statistically significant differences among the variables of screw tightening sequence and tightening method were found (p>.05) for detorque values and for mimimum detorque values. Conclusion: Within the limitations of this study, the screw tightening sequence and tightening method did not have a significant effect on the detorque values for a well-fitting implant superstructure.

• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.218-228
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• 2007

Modem concepts of gait rehabilitation after stroke favor a task-specific repetitive approach. In practice, the required physical effort of the therapists limits the realization of this approach. Therefore, a mechanized gait trainer enabling nonambulatory patients to have the repetitive practice of a gait-like movement without overstraining therapists was constructed. In this study, we developed an active gait training system for patients with gait disorder. This system provides joint movements to patients who cannot carry out an independent gait. It provides a normal stance-swing ratio of 60:40 using an eccentric configuration of two gears. Joint motions of the knee and the ankle were evaluated with using the 3D motion analysis system and compared with the results from the multi-body dynamics simulation. In addition, clinical investigations were also performed for low stroke patients during the 6-week gait training. Results from the dynamics simulation showed that joint movements of the knee and the ankle were affected by the gear size, the step length and the length of the foot plate, except the radius of curvature of the foot guide plate. Also, the 6-week gait training revealed relevant improvements of the gait ability in all low subjects. Functional ambulation category levels of subjects after training were 2 in three patients and 1 in a patient. The developed active gait trainer seems feasible as an adjunctive tool in gait rehabilitation after stroke.

• Journal of KSNVE
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• v.5 no.4
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• pp.515-524
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• 1995

Tubes in heat exchanger of fuel rods in reactor core are supported at intemediate point by support p0lates or springs. Current practice is, in case of heat exchanger, to allow clearance between tube and support plate for design and manufacturing consideration. And in case of fuel rod the clearance in support point can be generated due to the support spring force relaxation. Flow-induced vibration of a tube can cause it to impact or rub against support plate or against adjacent tubes and can result in fretting-wear. The tube-to- support dynamic interaction is used to relate experimental wear data from single-span test rigs to real multi-span heat exchanger configurations. The dynamic interaction cna be measured during experimental wear tests. However, the dynamic interaction is difficult to measure in real heat exchangers and, therefore, analytical techniques are required to estimate this interaction. This paper describels the nonlinear impact model of DAGS(Dynamic Analysis of Gapped Structure) code which simulates the tube response to external sinusodial or step excitation and predicts tube motion and tube-to-support dynamic interaction. Three experimental measurements-two single span rods excited by sinusodial force and a two span rod impacted by a steel ball are compared from the simulation nonlinear model of DAGS code. The simulation results from DAGS code are in good agreement with measurements. Therefore, the developed model of DAGS code is good analytical tool for estimating tube-to-support dynamic interaction in real heat exchangers.

• Transactions of Materials Processing
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• v.29 no.3
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• pp.163-171
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• 2020

We present a multi-step cold drawing for a non-equiatomic Co₁₀Cr₁₅Fe₂₅Mn₁₀Ni₃₀V₁₀ high entropy alloy (HEA) with a simple face-centered cubic (FCC) crystal structure. The distribution of strain in the cold-drawn Co₁₀Cr₁₅Fe₂₅Mn₁₀Ni₃₀V₁₀ HEA wires was analyzed by the finite element method (FEM). The effective strain was expected to be higher as it was closer to the surface of the wire. However, the reverse shear strain acted to cause a transition in the shear strain behavior. The critical effective strain at which the shear strain transition behavior is completely shifted was predicted to be 4.75. Severely cold-drawn Co₁₀Cr₁₅Fe₂₅Mn₁₀Ni₃₀V₁₀ HEA wires up to 96% of the maximum cross-sectional reduction ratio were successfully manufactured without breakage. With the assistance of electron back-scattering diffraction and transmission electron microscope analyses, the abundant deformation twins were found in the region of high effective strain, which is a major strengthening mechanism for the cold-drawn Co₁₀Cr₁₅Fe₂₅Mn₁₀Ni₃₀V₁₀ HEA wire.

• The Korean Journal of Malacology
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• v.31 no.3
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• pp.243-247
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• 2015

A stand-alone BLAST server is available that provides a convenient and amenable platform for the analysis of molluscan sequence information especially the EST sequences generated by traditional sequencing methods. However, it is found that the server has limitations in the annotation of molluscan sequences generated using next-generation sequencing (NGS) platforms due to inconsistencies in molluscan sequence available at NCBI. We constructed a web-based interface for a new stand-alone BLAST, called PANM-DB (Protostome DB) for the analysis of molluscan NGS data. The PANM-DB includes the amino acid sequences from the protostome groups-Arthropoda, Nematoda, and Mollusca downloaded from GenBank with the NCBI taxonomy Browser. The sequences were translated into multi-FASTA format and stored in the database by using the formatdb program at NCBI. PANM-DB contains 6% of NCBInr database sequences (as of 24-06-2015), and for an input of 10,000 RNA-seq sequences the processing speed was 15 times faster by using PANM-DB when compared with NCBInr DB. It was also noted that PANM-DB show two times more significant hits with diverse annotation profiles as compared with Mollusks DB. Hence, the construction of PANM-DB is a significant step in the annotation of molluscan sequence information obtained from NGS platforms. The PANM-DB is freely downloadable from the web-based interface (Malacological Society of Korea, http://malacol.or/kr/blast) as compressed file system and can run on any compatible operating system.

• The Transactions of the Korean Institute of Power Electronics
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• v.14 no.6
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• pp.472-480
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• 2009

This paper describes the overmodulative SVPWM technique and harmonics analyses of three phase NPC type three-level inverter to the modulation index. Three phase NPC type three-level inverter adopted SVPWM to extend the linear region to 0.907, moreover, the following voltage compensation using Fourier series was adopted in the region of overmodulation to make it work to six-step level. PD type of multi carrier method is used with the double Fourier series for the analysis of output power harmonics characteristic. Simulation was performed by PSIM, and the harmonics characteristics of 3-level inverter in each region are analyzed. The side band harmonics of carrier frequency are dominant in the linear region, but these harmonic components are decreased as the inveter goes to overmodulation region, and the harmonics due to the fundamental frequency is increased gradually at the same time. The harmonic analyses are verified through the simulation and experimental results under the same condition.

• Journal of Mechanical Science and Technology
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• v.19 no.5
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• pp.1072-1079
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• 2005

Conceptual design is the first step in the overall process of product design. Its intrinsic uncertainty, imprecision, and lack of information lead to the fact that current conceptual design activities in engineering have not been computerized and very few CAD systems are available to support conceptual design. In most of the current intelligent design systems, approach of principle synthesis, such as morphology matrix, bond graphic, or design catalogues, is usually adopted to deal with the concept generation, in which optional concepts are generally combined and enumerated through function analysis. However, as a large number of concepts are generated, it is difficult to evaluate and optimize these design candidates using regular algorithm. It is necessary to develop a new approach or a tool to solve the concept generation. Generally speaking, concept generation is a problem of concept synthesis. In substance, this process of developing design candidate is a combinatorial optimization process, viz., the process of concept generation can be regarded as a solution for a state-place composed of multi-concepts. In this paper, genetic algorithm is utilized as a feasible tool to solve the problem of combinatorial optimization in concept generation, in which the encoding method of morphology matrix based on function analysis is applied, and a sequence of optimal concepts are generated through the search and iterative process which is controlled by genetic operators, including selection, crossover, mutation, and reproduction in GA. Several crucial problems on GA are discussed in this paper, such as the calculation of fitness value and the criteria for heredity termination, which have a heavy effect on selection of better concepts. The feasibility and intellectualization of the proposed approach are demonstrated with an engineering case. In this work concept generation is implemented using GA, which can facilitate not only generating several better concepts, but also selecting the best concept. Thus optimal concepts can be conveniently developed and design efficiency can be greatly improved.

• Journal of Oriental Neuropsychiatry
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• v.24 no.2
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• pp.163-178
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• 2013

Objectives : The purpose of this study is to investigate the characteristics of Sasang constitutional types in the university students. Methods : One hundred fifty students of Woosuk University participated in this study and their majors were Korean medicine, nursing science and pharmacy. The Sasang constitutional types were determined by the results of Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD). The subjects were also tested by Academic Motivation Tests (AMT), Multi-dimensional Learning Strategy Tests (MLST) and Learning Style Questionnaire of Sasang Constitution (LSQ-SC). The subscale scores of AMT, MSLT and each questions of AMT, MLST, LSQ-SC were compared among the different Sasang constitutions using analysis of variances (ANOVA). Results : There were no significant differences in AMT results between Sasang constitutions. In subscales of AMT, Feeling scales (FTF) scores of Soyangin was significantly higher than Taeeumin. Other subscales of AMT were not different between Sasang constitutions. There were no significant differences in MLST results between Sasang constitutions. Subscales of MLST were not different between Sasang constitutions. There were many questions between Soyangin and other constitutions in the analysis of questions of AMT, MLST, and LSQ-SC, and less between Taeeumin and Soeumin. Conclusions : These results suggest that the characteristics of Soyangin is more prominent compared with other constitutions in the learning style, and there were a little differences between Soeumin and Taeeumin.