• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.6
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• pp.540-549
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• 2013

An adaptive non-uniform quantization scheme is proposed for soft-decision error correction in NAND flash memory. Even though the conventional maximizing mutual information (MMI) quantizer shows the optimal post-FEC (forward error correction) bit error rate (BER) performance, this quantization scheme demands heavy computational overheads due to the exhaustive search to find the optimal parameter values. The proposed quantization scheme has a simple structure that is constructed by only six parameters, and the optimal values of them are found by maximizing the mutual information between the input and the output symbols. It is demonstrated that the proposed quantization scheme improves the BER performance of soft-decision decoding with only small computational overheads.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.26 no.5
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• pp.21-33
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• 2012

This paper presents the new maximum power point tracking(MPPT) control of the photovoltaic(PV) module integrated converter(MIC) system considering the shadow influence. The output characteristics of the solar cell is a nonlinear and affected by a temperature, the solar radiation and influence of a shadow. Particularly, MIC system is very sensitive to the shadow influence because the capacity is very small. In order to increase an output and efficiency of the solar power generation, the maximum power point(MPP) obeying control are necessary. Conventional perturbation and observation(PO) and Incremental conductance(IC) are the method finding MPP by the continued self-excitation vibration. The MPPT control is unable to be performed by rapid output change affected by the shadow. To solve this problem, the new control algorithm of the multi-level in which the step value changes by output change is presented. In case there are the solar radiation, a temperature and shadow influence, the presented algorithm treats and compares the conventional control algorithm and output error. In addition, the validity of the algorithm is proved. through the output error response characteristics.

• The Transactions of the Korean Institute of Power Electronics
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• v.25 no.2
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• pp.133-141
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• 2020

The use of high-gain-voltage step-up converters for distributed power generation systems is being popularized because of the need for new energy generation and power conversion technologies. In this study, a new constructed high-gain-boost DC-DC converter was proposed to coordinate low voltage output DC sources, such as PV or fuel cell systems, with high DC bus (380 V) lines. Compared with traditional boost DC-DC converters, the proposed converter can create higher gain and has wider input voltage range and lower voltage stress for power semiconductors and passive elements. Moreover, the proposed topology produces multilevel DC voltage output, which is the main advantage of the proposed topology. Steady-state analysis in continuous conduction mode of the proposed converter is discussed in detail. The practicability of the proposed DC-DC converter is presented by experimental results with a 300 W prototype converter.

• Journal of Microbiology and Biotechnology
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• v.34 no.2
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• pp.240-248
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• 2024

In cancer treatment, multi-target approach has paid attention to a reasonable strategy for the potential agents. We investigated whether (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP) could exert an anticancer effect by dual-regulating VEGFR2 and PPARγ. MMPP showed modulating effects in TNBC type (MDA-MB-231 and MDA-MB-468) and luminal A type (MCF7) breast cancer cell lines. MMPP enhanced PPARγ transcriptional activity and inhibited VEGFR2 phosphorylation. MMPP-induced signaling by VEGFR2 and PPARγ ultimately triggered the downregulation of AKT activity. MMPP exhibited anticancer effects, as evidenced by growth inhibition, inducement of apoptosis, and suppression of migration and invasion. At the molecular level, MMPP activated pro-apoptotic proteins (caspase3, caspase8, caspase9, and bax), while inhibiting the anti-apoptotic proteins (bcl2). Additionally, MMPP inhibited the mRNA expressions of EMT-promoting transcription factors. Therefore, our findings showed molecular mechanisms of MMPP by regulating VEGFR2 and PPARγ, and suggested that MMPP has potential to treat breast cancer.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.233-240
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• 2020

Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras-transformed NIH 3T3 cells (Ras-NIH 3T3/Mdr) was generated using the CRISPR/Cas9 technology. The qPCR and LC3 immunoblot confirmed knockout of the gene and protein of ATG5, respectively. The ATG5 KO restored the sensitivity of Ras-NIH 3T3/Mdr cells to paclitaxel. Interestingly, ATG5 overexpression restored autophagy function in ATG5 KO cells, but failed to rescue paclitaxel resistance. These results raise the possibility that low level of resistance to paclitaxel in ATG5 KO cells may be related to other roles of ATG5 independent of its function in autophagy. The ATG5 KO significantly induced a G₂/M arrest in cell cycle progression. Additionally, ATG5 KO caused necrosis of a high proportion of cells after paclitaxel treatment. These data suggest that the difference in sensitivity to paclitaxel between ATG5 KO and their parental MDR cells may result from the disparity in the proportions of necrotic cells in both populations. Thus, our results demonstrate that the ATG5 KO in paclitaxel resistant cells leads to a marked G₂/M arrest and sensitizes cells to paclitaxel-induced necrosis.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.5
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• pp.1077-1083
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• 2015

In this paper, we introduce an energy-efficient opportunistic interference alignment (OIA) scheme that greatly improves the sum-rates in multi-cell uplink networks. Each user employs optimal transmit vector design and power control in the sense of minimizing the amount of generated interference to other-cell base stations while satisfying a required signal quality. As our main result, it is shown that owing to the reduced interference level, the proposed OIA schemes attains larger sum-rates than those of OIA with no power control for almost all signal-to-noise ratio regions. In addition, when both zero-forcing and minimum mean square error (MMSE) detectors are employed at the receiver along with the OIA scheme, it is shown that the OIA scheme with MMSE detection shows superior performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.3
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• pp.127-139
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• 2014

In this paper, we present two signal processing techniques for designing binary error correction codes for Multi-Level Cell(MLC) NAND flash memory. MLC NAND flash memory saves the non-binary symbol at each cell and shows asymmetric channel LLR l-density which makes it difficult to design soft-decision binary error correction codes such as LDPC codes and Polar codes. Therefore, we apply density mirroring and EM algorithm for approximating the MLC NAND flash memory channel to the binary-input memoryless channel. The density mirroring processes channel LLRs to satisfy roughly all-zero codeword assumption, and then EM algorithm is applied to l-density after density mirroring for approximating it to mixture of symmetric Gaussian densities. These two signal processing techniques make it possible to use conventional code design algorithms, such as density evolution and EXIT chart, for MLC NAND flash memory channel.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.4
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• pp.299-310
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• 2020

Alzheimer's disease (AD) is a multi-faceted neurodegenerative disease. Thus, current therapeutic strategies require multitarget-drug combinations to treat or prevent the disease. At the present time, single drugs have proven to be inadequate in terms of addressing the multifactorial pathology of AD, and multitarget-directed drug design has not been successful. Based on these points of views, it is judged that combinatorial drug therapies that target several pathogenic factors may offer more attractive therapeutic options. Thus, we explored that the combination therapy with lower doses of cilostazol and aripiprazole with add-on donepezil (CAD) might have potential in the pathogenesis of AD. In the present study, we found the superior efficacies of donepezil add-on with combinatorial mixture of cilostazol plus aripiprazole in modulation of expression of AD-relevant genes: Aβ accumulation, GSK-3β, P300, acetylated tau, phosphorylated-tau levels, and activation of α-secretase/ADAM 10 through SIRT1 activation in the N2a Swe cells expressing human APP Swedish mutation (N2a Swe cells). We also assessed that CAD synergistically raised acetylcholine release and choline acetyltransferase (CHAT) expression that were declined by increased β-amyloid level in the activated N2a Swe cells. Consequently, CAD treatment synergistically increased neurite elongation and improved cell viability through activations of PI3K, BDNF, β-catenin and α7-nicotinic cholinergic receptors in neuronal cells in the presence of Aβ_1-42. This work endorses the possibility for efficient treatment of AD by supporting the synergistic therapeutic potential of donepezil add-on therapy in combination with lower doses of cilostazol and aripiprazole.

• Nanomaterials
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• v.12 no.11
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• pp.1808-1817
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• 2022

A machine-learning (ML) technique was used to optimize the energetic-trap distributions of nano-scaled charge trap nitride (CTN) in 3D NAND Flash to widen the threshold voltage (V_th) window, which is crucial for NAND operation. The energetic-trap distribution is a critical material property of the CTN that affects the V_th window between the erase and program V_th. An artificial neural network (ANN) was used to model the relationship between the energetic-trap distributions as an input parameter and the V_th window as an output parameter. A well-trained ANN was used with the gradient-descent method to determine the specific inputs that maximize the outputs. The trap densities (N_TD and N_TA) and their standard deviations (σ_TD and σ_TA) were found to most strongly impact the V_th window. As they increased, the V_th window increased because of the availability of a larger number of trap sites. Finally, when the ML-optimized energetic-trap distributions were simulated, the V_th window increased by 49% compared with the experimental value under the same bias condition. Therefore, the developed ML technique can be applied to optimize cell transistor processes by determining the material properties of the CTN in 3D NAND Flash.

• Applied Microscopy
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• v.20 no.1
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• pp.105-119
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• 1990

In order to know the morphological characteristics and changes according to the developmental stage, the comparative observations have been studied by light and electron microscope on the midgut(gastric caecum, stomach) of the grasshopper(Oxya sinuosa Mistshenko). The results obtained are summarized as follow : In light microscopic level, the cuboidal shaped cells of the gastric caecum in the 5th instar nymph are differentiated the columnar epithelium in the adult. A number of pigment granules are appeared in the gastric caecum of the 5th instar nymph, however the pigment granules were absent in the adult. Indistinct or undifferentiated folds of the epithelial layer were appeared in the 5th instar nymph, whereas the well-developed folds were appeared the gastric caecum in the adult. The well-developed muscular layers are seen in the 5th instar numph, however in the adult the muscular layers are appeared thin or a few layers. In electron microscopic level, in the midgut epithelium, a number of well-developed rER, a few lipid droplets, multi vesicular bodies, small vesicles and glycogen granules were found. Two types of the pigment granules in the gastric caecum of the 5th instar nymph were appeared, whereas the whorl-membrane, a few secretory granules and one type of the gastro-entero-endocrine cell were found in the adult midgut. The light and dark cells could be distinguished in the stomach epithelim of the 5th instar nymph.