• Proceedings of the Plant Resources Society of Korea Conference
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• 2010.10a
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• pp.7-7
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• 2010

전 세계적으로 폭발적으로 증가하고 있는 비만은 만병의 근원이다. 동시에 대사성질환의 발병을 증가시키는 결정적인 역할을 하고 있다. 이러한 상황을 극복할 수 있는 안전하고 효능이 우수한 약의 개발이 매우 시급하다. 시판되는 약들은 예견할 수 없는 지방변으로 실제생활을 매우 불편하게 하는 부작용과 우울증 및 자살충동 등의 심각한 부작용을 유발시키고 있다. 특히 생명을 위협하는 약은 시판이 금지되었다. 200여종의 한약재들을 In vitro screening (pancreatic lipase inhibition, PDE inhibition, c-AMP activity), ex vivo screening (lipolytic action on fat pad), short term animal screening(혈중 TG 함량 분석)을 토대로 long term animal model에서비만 예방 및 치료 효능을 검증하기 위하여 호장근 부탄올 분획을 선정하였다. 고지방 사료로 비만을 유도한 rat (Diet induced obesty (DIO) rat)에서 비만 치료 효능이, 고지방 사료로 비만을 유도한 ICR-mice에서 비만 예방 효능이 우수함을 입증하였다 (체중감소, 지방세포의 크기억제, 지방간 예방/치료(간무게, TG함량, 간 색상, 고지혈증 증상억제), 혈중 TNF-a, IL-6, leptin, adponectin 등, 간 조직에서의 pAMPK, SOCS, NF-${\kappa}B$ DNA biding activity, ACC level, FAS expression, CPT-1 activity의 정상화). 호장근 부탄올 분획의 이러한 효능은 AMPK 작용과 CPT-1 작용을 활성화하고 동시에 지방산 합성 억제와 지방산 산화를 촉진함으로 인함임을 규명하였다. 동시에 비만으로 인한 pancreatic beta cell의 파괴를 예방함으로 인슐린 내성을 예방(치료)함을 입증하였다. 이는 AMPK 활성화와 SOCS-3 단백질 억제와 NF-${\kappa}B$-DNA 결합 억제로 인함임을 증명하였다. 3T3-L1 지방 세포주에서 lipogenesis 예방(치료) 및 lipolytic effect에 관여하는 인자들의 변화를 확인하였다. 이는 Multi-compounds-multi-targets에 의한 시너지 효과임을 알 수 있었다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11A
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• pp.891-897
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• 2009

In the satellite communications, the frequency sharing with other services is important because the service coverage is generally very wide and overlaps with those of other wireless services. This paper introduces a new technique to mitigate interference into the terrestrial stations from the Earth station in the same frequency band by means of band segmentations which are portions of the overall operation frequency band divided by frequency reuse factor. We consider a multi-beam satellite system, where frequency bands are reused in each satellite cell. The terrestrial stations use band segmentations of adjacent satellite cells, and this may decrease the interferences. By this way, the terrestrial and satellite systems can share the same frequency bands efficiently. The simulation is performed at frequency reuse factors, seven and three. The simulation results show that the proposed method can highly reduce the interference level to -168 dBW or -163 dBW depending on the considered frequency reuse factor from -117 dBW at the 90% link availability.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.8
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• pp.4092-4104
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• 2017

In this paper, an efficient 4K and 8K UHD(Ultra High Definition) transmission scheme is proposed on the convergence networks with broadcasting and LTE(Long Term Evolution) by using CoMP(Coordinated Multi-Point). A video data is compressed and divided into BL(Base Layer), E(Enhanced layer)1, E2 and E3 by scalable HEVC(High Efficiency Video Coding). The divided layers can be combined by the scalable HEVC such as mobile HD, full HD, 4K and 8K UHD(Ultra High Definition). The divided layers are transmitted through the convergence networks with DVB-T2(Digital Video Broadcasting-$2^{nd}$ Generation Terrestrial) broadcasting system and LTE CoMP. This scheme transmits mobile HD and full HD layers through DVB-T2 broadcasting system by using M-PLP(Multiple-physical Layer Pipes), and adaptively transmits 4K or 8K UHD layer through LTE CoMP with MMT(MPEG Media Transport) server. An adaptive transmitting and receiving scheme in the LTE CoMP system provides 4K or 8K UHD layer to a user according to the user status. The proposed scheme is verified by showing the system-level simulation results which is better BER(bit-error-rate) performance than the conventional scheme. The results show that the proposed scheme provides the stable video contents to the user especially at the cell edge.

• KSBB Journal
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• v.13 no.3
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• pp.231-237
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• 1998

An attenuated Japanese encephalitis virus (JEV) clone SA-14-14-2(Vero) was obtained through successive adaptation of a primary cell adapted strain, SA-14-14-2(PDK) to Vero cell, a continuous line of monkey kidney cells. The virus titer reached above the 107 plaque forming unit (pfu) per mL of culture supernatant with 3 passages in Vero cells and was maintained close to this level in the further passages. The optimum temperature for the virus growth was $35^{\circ}C$. Growth pattern of the virus indicated that optimum time for the virus harvest is 4 days post infection and the virus accomplished rapid initial propagation even in medium containing no serum supplement. The roller bottle (RB) system and the spinner flask (SF) system using micro-carrier (Cytodex-1) for the JEV cultivation were explored. When RB, SF, and T-flask culture system were compared, there was no significant difference in virus yield. Furthermore, the results indicated that virus could be harvested multiple times from 3 days to 9 days post infection; neither severe cytopathic effect (CPE) in the infected cells nor the decrease in the titer was observed on duration of 9 days.

• Atmosphere
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• v.29 no.4
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• pp.463-480
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• 2019

This study classified heavy rain types from K-means clustering for the hourly relationship between rainfall intensity and cloud top height over the Korean peninsula, and then examined their statistical characteristics for the period of June~August 2013~2018. Total rainfall amount of warm-type events was 2.65 times larger than that of the cold-type, whereas the lightning frequency divided by total rainfall for the warm-type was only 46% of the cold-type. Typical cold-type cases exhibited high cloud top height around 16 km, large reflectivity in the upper layer, and frequent lightning flashes under convectively unstable condition. Phenomenally, the cold-type cases corresponded to cloud cluster or multi-cell thunderstorms. However, two warm-type cases related to Changma and typhoon were characterized by heavy rainfall due to long duration, relatively low cloud top height and upper-level reflectivity, and the absence of lightning under the convectively neutral and extremely humid conditions. This study further confirmed that the forecast skill of rainfall could be improved by applying correction factor with the overestimation for cold-type and underestimation for warm-type cases in the Local Data Assimilation and Prediction System (LDAPS) operational model (e.g., BIAS score was improved by 5%).

• Journal of Pharmaceutical Investigation
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• v.41 no.6
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• pp.381-386
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• 2011

Multi-drug resistance (MDR) has been known as a major hurdle in cancer chemotherapy. One of the most clinically significant causes of MDR was the efflux of anticancer agents mediated by p-glycoprotein (p-gp) over-expressed in MDR cancer cells. To overcome MDR, there have been several strategies such as co-administration with p-gp inhibitors and encapsulation of anticancer drugs into drug delivery systems. In the present study, curcumin was evaluated for its potential as p-gp inhibitor and MDR reversal activity when combined with paclitaxel incorporated into lipid nanoparticles (PTX/LN). Western blot assay showed curcumin did not modulate the level of p-gp expression in MCF-7/ADR which is a MDR variant of human breast cancer cell line, MCF-7, and over-expresses p-gp. However, curcumin inhibited p-gp-mediated efflux of calcein in a dose-dependent manner even though it showed lower activity compared to verapamil, a well-known p-gp inhibitor. Incorporation of paclitaxel into lipid nanoparticles partially recovered the anticancer activity of paclitaxel in MCF-7/ADR. The combined use of curcumin and PTX/LN exhibited further full reversal of MDR, suggesting susceptibility of PTX/LN to the efflux system. In conclusion, combined approach of using p-gp inhibitors and incorporation of the anticancer agents into nano-delivery systems would be an efficient strategy to overcome MDR.

• Proceedings of the KSRS Conference
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• 2006.03a
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• pp.117-120
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• 2006

Heavy rainfall events are occurred exceedingly various forms by a complex interaction between synoptic, dynamic and atmospheric stability. As the results, quantitative precipitation forecast is extraordinary difficult because it happens locally in a short time and has a strong spatial and temporal variations. GOES-9 imagery data provides continuous observations of the clouds in time and space at the right resolution. In this study, an power-law type algorithm(KAE: Korea auto estimator) for estimating rainfall based on the rainfall type was developed using geostationary meteorological satellite data. GOES-9 imagery and automatic weather station(AWS) measurements data were used for the classification of rainfall types and the development of estimation algorithm. Subjective and objective classification of rainfall types using GOES-9 imagery data and AWS measurements data showed that most of heavy rainfalls are occurred by the convective and mired type. Statistical analysis between AWS rainfall and GOES-IR data according to the rainfall types showed that estimation of rainfall amount using satellite data could be possible only for the convective and mixed type rainfall. The quality of KAE in estimating the rainfall amount and rainfall area is similar or slightly superior to the National Environmental Satellite Data and Information Service's auto-estimator(NESDIS AE), especially for the multi cell convective and mixed type heavy rainfalls. Also the high estimated level is denoted on the mature stage as well as decaying stages of rainfall system.

• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.1
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• pp.147-155
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• 2017

A new endurance test-pattern generation on NAND-flash memory is proposed to improve test cost. We mainly focus on the correlation between the data-pattern and the device error-rate during endurance testing. The novelty is the development of testing method using quasi-random pattern based on device architectures in order to increase the test efficiency during time-consuming endurance testing. It has been proven by the experiments using the commercial 32 nm NAND flash-memory. Using the proposed method, the error-rate increases up to 18.6% compared to that of the conventional method which uses pseudo-random pattern. Endurance testing time using the proposed quasi-random pattern is faster than that of using the conventional pseudo-random pattern since it is possible to reach the target error rate quickly using the proposed one. Accordingly, the proposed method provides more low-cost testing solutions compared to the previous pseudo-random testing patterns.

• ETRI Journal
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• v.39 no.2
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• pp.234-244
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• 2017

Research interest in three-dimensional multiple-input multiple-output (3D-MIMO) beamforming has rapidly increased on account of its potential to support high data rates through an array of strategies, including sector or user-specific elevation beamforming and cell-splitting. To evaluate the full performance benefits of 3D and full-dimensional (FD) MIMO beamforming, the 3D character of the real MIMO channel must be modeled with consideration of both the azimuth and elevation domain. Most existing works on the 2D spatial channel model (2D-SCM) assume a wide range for the distribution of elevation angles of departure (eAoDs), which is not practical according to field measurements. In this paper, an optimal FD-MIMO planar array configuration is presented for different practical channel conditions by restricting the eAoDs to a finite range. Using a dynamic network level simulator that employs a complete 3D SCM, we analyze the relationship between the angular spread and sum throughput. In addition, we present an analysis on the optimal antenna configurations for the channels under consideration.

• Atmosphere
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• v.22 no.3
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• pp.331-344
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• 2012

The changes in the Hadley circulation during the second half of the 20th century were examined using observations and the 20C3M (Twentieth Century Climate in Coupled Models) simulations by the 21 IPCC AR4 models. Multi-model ensemble (MME) mean shows that the mean features of the Hadley circulation, such as the intensity, magnitude, and the seasonal variations, are very realistically reproduced, compared to the ERA40 reanalysis. But the long-term trends of the Hadley circulation in 20C3M MME are quite different to those of observations. The observed intensity of the Hadley cell is persistently enhanced, particularly during boreal winter. In comparison, the meridional overturning circulations reproduced in the MME mean remains invariant in time, and even weakened in boreal summer. This discrepancy between the ERA40 and 20C3M MME is consistently shown in the overall structure of the Hadley circulations, such as mass streamfunction, the velocity potential, the vertical shear of meridional wind, and the vertical velocity in the tropical region. This results indicate that the current climate models are skill-less to capture the long-term trend of Hadley circulation yet, and should be improved in simulation of the large-scale features to enhance the confidence level of future climate change projection.