• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.12 no.8
• /
• pp.4072-4089
• /
• 2018

This paper introduces a scheme for optimizing the material properties of mass-spring systems of different resolutions to provide coherent behavior for reduced level-of-detail in MSS(Mass-Spring System) meshes. The global optimal material coefficients are derived to match the behavior of provided reference mesh. The proposed method also gives us insight into levels of reduction that we can achieve in the systematic behavioral coherency among the different resolution of MSS meshes. We obtain visually acceptable coherent behaviors for cloth models based on our proposed error metric and identify that this method can significantly reduce the resolution levels of simulated objects. In addition, we have confirmed coherent behaviors with different resolutions through various experimental validation tests. We analyzed spring force estimations through triangular Barycentric coordinates based from the reference MSS that uses a Gaussian kernel based distribution. Experimental results show that the displacement difference ratio of the node positions is less than 10% even if the number of nodes of $MSS^{sim}$ decreases by more than 50% compared with $MSS^{ref}$. Therefore, we believe that it can be applied to various fields that are requiring the real-time simulation technology such as VR, AR, surgical simulation, mobile game, and numerous other application domains.

• Polymer(Korea)
• /
• v.24 no.5
• /
• pp.728-735
• /
• 2000

Fentanyl-loaded biodegradable poly(L-lactide-co-glycolide) (75 : 25 by mole ratio of lactide to glycolide, PLGA) microspheres (MSs) were prepared to study the possibility for long-acting local anesthesia. We developed the fentanyl base (FB, slightly water-soluble)-loaded PLGA MSs by means of conventional O/W solvent evaporation method. The size of MSs was in the range of 10~150 ${\mu}{\textrm}{m}$. The morphology of MSs was characterized by SEM, and the in vitro release amounts of FB were analyzed by HPLC. The lowest porous cross-sectional morphology and the highest encapsulation efficiency were obtained by using gelatin as an emulsifier. The influences of several preparation parameters, such as emulsifier types, molecular weights and concentrations of PLGA, and initial drug loading amount, etc., have been observed in the release patterns of FB. The release of FB in vitro was more prolonged over 25 days, with close to zero-order pattern by controlling the preparation parameters. We also investigated the physicochemical properties of FB-loaded PLGA MSs by X-ray diffraction and differential scanning calorimeter.

• Journal of Biomedical Engineering Research
• /
• v.42 no.6
• /
• pp.251-258
• /
• 2021

Hyaluronic acid (HA) microspheres (MSs) crosslinked with polyethylene glycol diglycidyl ether (PEGDE) are prepared using a simple fluidic device (SFD) to investigate the optimized parameters. A solution mixture of PEGDE in 2-methyl-1-propanol was prepared as a continuous phase in SFD. HA solutions of 1 wt% concentration were introduced into SFD as a discontinuous phase. The HA solution prepared by stirring for more than 48 h exhibited spherical MSs at the needle tip inside the ring cap. As the flow rate of the continuous phase increased from 0.7 to 1.9 mL/min, the diameter of the MS decreased from 173±36 ㎛ to 129±13 ㎛. Although the PEGDE concentration in the range of 0.2 to 1.8 vol% did not affect the diameter of the MS, the microstructure of MS, consisting of inner hollow void and wall, was changed. The inner void and wall size decreased and increased from 79.5 ㎛ to 57.2 ㎛ and from 10.3 ㎛ to 21.4 ㎛, respectively, with increasing PEGDE concentration from 0.2 vol% to 1.8 vol%. FT-IR peaks located around 2867 cm^-1 and 1088 cm^-1 indicated that the HA MS prepared at different PEGDE concentrations were chemically crosslinked. The HA MSs containing different PEGDE concentrations exhibited quantitative cell viability of more than 98%. L-929 cells adhered well to the HA MSs and proliferated continuously with increasing culture time to 48 h regardless of PEGDE concentration, implying that the HA MSs are clinically safe and effective.

• Korean Journal of Clinical Oncology
• /
• v.9 no.2
• /
• pp.80-86
• /
• 2013

Purpose: Hypermethylation of human mut L homologue 1 (hMLH1) promoter region is known to cause sporadic microsatellite instability (MSI) colorectal cancers. 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism, acting as a methyl donor for DNA methylation. In this study, we investigate whether the polymorphism of MTHFR 677C>T plays a role in the alteration of the promoter-specific hypermethylation, predisposing to MSI colorectal cancers. Methods: Total of 487 sporadic colorectal cancer patients in CHA Bundang Medical Center were collected. MSI was identified when two or more are positive among five microsatellite markers (BAT25, BAT26, D17S250, D5S346, D2S123). The others were classified as microsatellite stable (MSS). Polymorphism of MTHFR 677C>T was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: MSI was observed in 65 of 487 patients (12.73%). MSI colorectal cancers showed similar clinicopathological features with previously reported; younger age onset, right-sided preponderance, mucinous and poorly differentiated histology, lower stage, fewer lymph node metastases than MSS tumors (each P<0.05). The frequency of MTHFR 677TT genotype was 17.7% in the MSI group higher than 14.6% in the MSS group (P=0.17). Although not statistically significant, compared to the MTHFR 677CC referent, MTHFR 677 CT+TT genotype was more likely to have MSI than MSS (odds ratio, 1.81; 95% confidence interval, 0.94 to 3.68; P=0.06). Conclusion: This study demonstrated higher frequency of MTHFR 677TT genotype in MSI colorectal cancers. Furthermore, individuals with MTHFR 677CT+TT variant type might potentially develop MSI rather than MSS colorectal cancers.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 2005.04a
• /
• pp.167-174
• /
• 2005

Through time-dependent analyses of RC bridges constructed by a movable scaffolding system (MSS) considering the construction sequence and creep deformation of concrete, structural responses related to the member forces are reviewed. On the basis of the compatibility condition and equilibrium equation at every construction stage, basic equations that can describe the moment variation with time in movable scaffolding construction are derived. By using the introduced relations, the design moment and its variation over time can easily be obtained with only the elastic analysis results and without additional time-dependent analyses considering the construction sequences. In addition, the design moments determined by the introduced equations are compared with the results from a rigorous numerical analysis with the objective of establishing the relative efficiencies of the introduced equations.

• Journal of the Korean Ceramic Society
• /
• v.27 no.1
• /
• pp.127-135
• /
• 1990

Characteristics of the sol-gel derived (Ba1-xPbx)TiO3 powders are compared with those of powders prepared by the calcining ofmixed oxides method (CMO) and molten salt synthesis method(MSS). The sol-gel derived powder has a higher surface area (50$m^2$/g) than those of CMO(3.8$m^2$/g) and MSS(11.5$m^2$/g) derived powders. In the sol-gel method, the (Ba1-xPbx)TiO3 was synthesized at $600^{\circ}C$ for 1hr, indicating that this method has a crystalline temperature 20$0^{\circ}C$-30$0^{\circ}C$ lowr than those of the CMO and MSS methods.

• Journal of electromagnetic engineering and science
• /
• v.9 no.3
• /
• pp.141-145
• /
• 2009

Interference scenarios involving and a methodology for a terrestrial international mobile telecommunication(IMT) system and mobile-satellite service(MSS) system in a co-channel environment are established. Taking into account a practical deployment situation for both systems, a computational simulation of interference in terms of the ratio of interference power to thermal noise(I/N) is performed in order to evaluate the co-frequency interference with the IMT system caused by the MSS system. The methodology and results could be used for planning an IMT deployment without an unacceptable interference impact caused by the MSS system.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.3 no.1
• /
• pp.1-13
• /
• 1985

This study is about the analysis and application of the Satellite(in particular, LANDSAT) Data for the study of urban and region. Land cover maps and change of each classes for a period of years of Seoul, Daejeon, and Incheon cities were extracted by use of LANDSAT MSS Data and MSS Image Analysis System. From the results of this study, it was proved that Satellite data could be used on the study of urban and region to obtain fully fruitful results.

• Journal of Korea Society of Industrial Information Systems
• /
• v.2 no.2
• /
• pp.189-207
• /
• 1997

Recently, we have witnessed a host of emerging tools in the management support systems (MSS) area including the data warehouse/multidimensinal databases (MDDB), data mining, on-line analytical processing (OLAP), intelligent agents, World Wide Web(WWW) technologies, the Internet, and corporate intranets. These tools are reshaping MSS developments in organizations. This article reviews a set of emerging data management technologies in the knowledge discovery in databases(KDD) process and analyzes their implications for decision support. Furthermore, today's MSS are equipped with a plethora of AI techniques (artifical neural networks, and genetic algorithms, etc) fuzzy sets, modeling by example , geographical information system(GIS), logic modeling, and visual interactive modeling (VIM) , All these developments suggest that we are shifting the corporate decision making paradigm form information-driven decision making in the1980s to knowledge-driven decision making in the 1990s.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2007.11a
• /
• pp.195-203
• /
• 2007

In this paper, an analytic model of sleep model operation in the IEEE 802.16e is investigated. A mobile subscribe. station (MSS) goes to sleep mode after negotiations with the base station (BS) and wakes up periodically for a short interval to check whether there is downlink traffic to it. If the arrival of traffic is notified, an MSS returns to wake mode. Otherwise, it again enters increased sleep interval which is double as the previous one. In order to consider the situation more practically, we propose the sleep mode starting threshold, during which MSS should await packets before it enters the sleep mode. By modifying the M/G/1 with multiple vacations model, energy consumption ratio(ECR) and average packet response time are calculated. Our analytic model provides potential guidance in determining the optimal parameters values such as sleep mode starting threshold, minimal sleep and maximal sleep window.