• 한국임상수의학회지
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• 제2권1호
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• pp.121-131
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• 1985

Mouse embryos of 8-cell stage and compacted morulae(approximately 16 cells) containing different number of blastomeres were bisected and cultured in vitro to determine the developmental potentials of the divided embryos compared with those of unmanipulated control embryos. The results were as follows. 1. Micromanipulation was performed successfully by means of a simple manipulator which holds a fine glass, needle, without the use of any micro-instruments for support. 2. The percentage of bisected morulae with 7-9 blastomeres that developed to eu-blastocyst was 94.1% while only 64.8% of the bisected 8-cell embryos with 4 blastomeres developed to eublastocysts (p<0.05). 3. The percentage of eu-blastocysts decreased, while that of pseudoblastocysts and trophectodermal vesicle increased as the number of blastomeres decreased in the bisected embryos of the two stages. 4. The time of the blastocoele re-formation of the bisected and control embryos was not significantly different in morulae stage embryos, but it was significantly delayed in the 8-cell stage embryos (Eu-B, Pseudo-B) compared with control embryos (P<0.01, P<0.05 respectively).

• 한국수정란이식학회지
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• 제6권2호
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• pp.47-51
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• 1991

This study investigated full-term development potential of ultrarap idly frozen and thawed mouse 2-cell embryos. Mouse 2-cell embryos, dehydrated by exposure to freezing medium, were directly immersed into liquid nitrogen and thawed in 37$^{\circ}C$ water. The embryos that were frozen and thawed were cultured in uitro and transferred to foster mothers to examine there developmental potential. As a result, the frozen-thawed 2-cell embryos developed to blastocysts in vitro as a similar rate as control 2-cell embryos did(in vitro 2-cell, 86.4%; in vivo 2-cell, 90.9%; solution control, 89.9%; control, 89.7%). Normal live young were obtained from transfer of frozen-thawed embryos to the oviduct and uterus of pseudopregnant recipients (3l.4~56.7%).

• 혜화의학회지
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• 제17권2호
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• pp.185-198
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• 2008

Wished to examine closely effect that Atopy cream-Jawoongo ointment (A-J) used to atopy dermatitis disease patient get in atopy eruption control experimentally. In this research A-J ointment as treatment result to a NC/Nga mouse by BMAC ointment, clinical skin severity score decreased remarkably than control group. Thus, NC/Nga mice suffered from dermatitis very similar to human AD with IgE hyperproduction. Specially, result that measure IgE and IgG1 level in serum decreased remarkably than control group.

• 한국컴퓨터정보학회지
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• 제14권2호
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• pp.165-174
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• 2006

본 논문은 원격 제어 장치 및 이를 포함하는 디스플레이 원격 제어 시스템에 관한 것이다. 본 논문에 따른 원격 제어 장치는 VOD 등을 위한 마우스 기능과 리모트 콘트롤러 기능을 갖는 와이어리스 원격 포인팅 디바이스이다. 본 장치는 디스플레이장치와의 통신을 위한 신호송신부와 본체 바디 및 상기 본체 바디의 전방의 이미지를 촬상하기 위한 이미지 촬상부로 구성된다. 촬상된 이미지를 분석하여, 전방에 대한 본체 바디의 상대적 움직임의 크기를 나타내는 움직임 데이터를 산출하고, 산출된 움직임데이터를 신호 송신부를 통해 외부 디스플레이장치로 송신하여 외부 디스플레이 장치의 마우스 커서가 이동하도록 제어하는 제어부를 포함한다. 원격 제어 장치에서 전방의 이미지를 촬상하고 이를 분석하여, 전방에 대한 상대적인 움직임에 따라 마우스 커서를 이동시킬 수 있다. 따라서 사용자의 입장에서 만족도를 높인 제품 설계로 제조원가를 절감할 수 있고 특허와 신 설계방식을 이용해서 유비쿼터스 방송 시스템의 원격제어시스템에 획기적인 발전을 이룰 수 있는 계기가 될 것이다.

• 한국HCI학회논문지
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• 제5권2호
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• pp.1-6
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• 2010

본 연구에서는 장애인이나 게이머를 위해 눈의 움직임과 머리의 움직임으로 제어가 가능한 헤드 마우스를 제안하였고, 제안한 마우스를 기존의 마우스와 비교하였다. 마우스 포인터의 이동은 머리 움직임의 회전각도 정보를 활용하였고, 클릭이나 더블 클릭의 이벤트는 눈의 깜빡임을 이용하였다. 기존의 각속도계를 이용한 마우스에서 적분으로 인한 누적오차는 적분을 하지 않고 데드 존을 갖는 비선형 상대 좌표계 방식을 통하여 해결하였고, 추가적으로 이동 거리와 가속도를 함께 고려하여 직관적인 마우스 포인터 제어가 가능하도록 하였다. 주변광의 영향을 최소화하도록 광원 제어 회로를 설계하여 외부 광원의 변화에도 마우스 이벤트 검출에 영향을 받지 않도록 하였다. 제안한 마우스를 응시점을 이용한 마우스(퀵글랜스)와 비교한 결과, 20회 클릭하는 실험에서는 약 21%, Dasher를 이용한 문자입력실험에서도 약 25%, 화상키보드를 이용한 문자입력 실험에서도 약 37% 짧은 입력 시간을 보였다. 그리고 카메라 마우스와의 비교에서도 제안한 헤드 마우스가 우수한 성능을 보였다.

• Clinical and Experimental Reproductive Medicine
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• 제43권3호
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• pp.152-156
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• 2016

Objective: We studied the effect of the site of laser zona opening on the complete hatching of mouse blastocysts and the cell numbers of the completely hatched blastocysts. Methods: Mouse blastocysts were randomly allocated to the inner cell mass (ICM) group (zona opening performed at the site of the ICM, n=125), the trophectoderm (TE) group (zona opening performed opposite to the ICM, n=125) and the control group (no zona opening, n=125). Results: The rate of complete hatching of the blastocysts was not significantly different in the ICM and the TE group (84.8% vs 80.8%, respectively; p=0.402), but was significantly lower in the control group (51.2%, p<0.001). The cell numbers in the completely hatched blastocysts were comparable in the control group, the ICM group, and the TE group ($69{\pm}19.3$, $74{\pm}15.7$, and $71{\pm}16.8$, respectively; p=0.680). Conclusion: These findings indicate that the site of laser zona opening did not influence the rate of complete hatching of mouse blastocysts or their cell numbers.

• Journal of Animal Science and Technology
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• 제58권3호
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• pp.13.1-13.7
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• 2016

Background: In the present study, various freezing containers were tested for mouse embryos of respective developmental stages; embryos were vitrified and then their survival rate and developmental rate were monitored. Mouse two cell, 8 cell, and blastula stage embryos underwent vitrification freezing-thawing and then their recovery rate, survival rate, development rate, and hatching rate were investigated. Methods: EM-grid, OPS, and cryo-loop were utilized for vitrification freezing-thawing of mouse embryos. Results: It was found that recovery rate and survival rate were higher in the group of cryo-loop compared to those of EM-grid (p < 0.05). Embryonic development rate, two cell embryos to blastocyst, as well as hatching rate were higher in the control group compared to the EM-grid group and OPS group (p < 0.05), yet no difference was noted between the control group and cryo-loop group. Development rate and hatching rate of eight cell morulae and blastocysts were all lower in the treatment groups than the control group whilst hatching rate of blastocysts was higher in the control group compared to the groups of EM-grid and OPS (p < 0.05); although the cryo-loop group was shown to be slightly higher than other groups, it was not statistically significant. Conclusions: In the study, we investigate effects of freezing containers on vitrified embryos of respective developmental stages; it was demonstrated that higher developmental rate was shown in more progressed (or developed) embryos with more blastomeres. There was however, no difference in embryonic development rate was shown amongst containers. Taken together, further additional studies are warranted with regards to 1) manipulation techniques of embryos for various vitrification freezing containers and 2) preventive measures against contamination via liquid nitrogen.

• 한국환경보건학회지
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• 제21권4호
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• pp.96-101
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• 1995

To study the immunotoxicity of mouse injected with fungal mycotoxin, T-2 toxin (Fusarium mycotoxin) was treated to 6 week-old female C3H/He mouse and the body, organ weight and morphological change were investigated. The weights of body, liver and kidney of mouse injected the 2 mg/kg of toxin was decreased to 17, 20 and 3%, respectively, compared to control animal and the comsumption of feed was also decreased with lapsing the time. The fat dropleting phenomenon and destruction of Golgi apparatus in liver and histopathological changes of tissue and mitochondria in small intestine were found by scanning electron microscopic observation.

• The Journal of Korean Physical Therapy
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• 제24권2호
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• pp.57-65
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• 2012

Purpose: This study was to investigate the effect of biomechanical intervention, based on the custom seating system on the activities of a mouse click for children with cerebral palsy. Methods: Thirteen children with cerebral palsy participated in this study. We compared reaction time and frequency for proper mouse click in the subject's typical position, in addition to an intervention position. The intervention position conformed to the principle and practice of research on promoting the upper-extremity movement and postural control. The intervention position was achieved through an external postural support, which was based on the custom seating system. Results: Reaction time and frequency for proper mouse click were moderately improved in the intervention position, compared with that of the typical position. There was a statistically significant difference between the typical position and that of the intervention position (p<0.05). Conclusion: Results provide evidence of the positive effects of functional seating on the activities of a mouse click for children with cerebral palsy.

• 약학회지
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• 제43권6호
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• pp.798-801
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• 1999

To investigate the effect of Artemisia apiacea Hance on the hair growth of black mouse (C57BL/6), this study was carried out. We obtained chloroform fraction, ethyl acetate fraction, butanol fraction from ethanol extract. When these fractions were administered to the black mouse by the method of skin paste, chloroform extract increased remarkably the hair growth of black mouse. thus Chloroform fraction was devided into 5 fractions from 20:1 to 1:1 with chloroform : methanol. the detail fractions of chloroform fraction were administered to the black mouse. We obtained the result that fraction I, II, III, IV are superior to minoxidil of positive control. Most of all fraction II have an dramatical effect on hair growth of black mouse.