• The Journal of the Korea Contents Association
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• v.15 no.7
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• pp.289-299
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• 2015

The purpose of this study is to evaluate and compare the quality of digital X-ray imaging system. The image quality evaluation was conducted By using Modulation transfer function indicating the quantitative resolution of the image and the noise power spectrum showing the noise characteristics. Using a IEC61267 radiation quality was applied to the geometry to be used in clinical and geometry presented in IEC62220-1 and Additional filter, grid, the clinical dose and the MTF value of edge phantom was measured. Result of the MTF corresponding to each item(Grid, Filter, SID, kVp, mAs), the clinical condition 100cm, 180cm, measurements of the spatial frequency of the MTF IEC62220-1Geometry 150cm became similarly apparent, rather spatial frequency was also the case high in clinical conditions 100cm. NPS results, as the dose(mAs) is increased, NPS showed that reduced. The image quality evaluation using IEC61267 the Radiation quality, Image quality of the video using the clinical conditions Geometry than image quality evaluation using IEC62220-1Geometry was better. It shows that MTF and NPC in IEC and clinical condition were not significantly different. In order to apply the evaluation method of image quality applied with clinical conditions rather than the future method, to be presented evaluation of IEC standard, based on the results of the image characterization studies in this paper, the methods that shows good quality of spatial resolution and decrease NPS value as the least dose, used suitable parameters for whether or not using added filter, grid, change SID and clinical quality(kVp), dose(mAs) etc should be found. then It is believed to be able to properly maintain the actual quality of the image of the digital radiographic imaging system in clinical.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.2 s.105
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• pp.139-147
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• 2006

This paper suggests an efficient method of protection ratio calculation and shows some results applicable to frequency coordination in microwave(M/W) relay system networks, and the net filter discrimination(NFD) associated with Tx spectrum mask and overall Rx filter characteristics has been examined to obtain the adjacent channel protection ratio. The protection ratio comprises several factors such as C/N of modulation scheme, noise-to-interference ratio, multiple interference allowance, fade margins of multi-path and rain attenuation, and NFD. According to computed results for 6.7 GHz, 64-QAM, and 60 km at BER $10^{-6}$, fade margin and co-channel protection ratio are 41.1 and 75.2 dB, respectively. NFD for channel bandwidth of 40 MHz reveals 28.9 dB at the first adjacent channel, which results in adjacent channel protection ratio of 46.3 dB. In addition, NFD and protection ratio for different systems with channel bandwidth 20 and 40 MHz have been investigated to be used for actual M/W networks. The proposed method provides some merits of an easy calculation, systematic extension, and applying the same concept to frequency coordination in millimeter wave relay system networks.

• Progress in Medical Physics
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• v.21 no.3
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• pp.239-245
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• 2010

The purpose of this study is to comprehensively compare and evaluate the characteristics of image quality for digital mammography systems which use a direct and indirect conversion detector. Three key metrics of image quality were evaluated for the direct and indirect conversion detector, the modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE), which describe the resolution, noise, and signal to noise performance, respectively. DQE was calculated by using a edge phantom for MTF determination according to IEC 62220-1-2 regulation. The contrast to noise ratio (CNR) was evaluated according to guidelines offered by the Korean Institute for Accreditation of Medical Image (KIAMI). As a result, the higher MTF and DQE was measured with direct conversion detector compared to indirect conversion detector all over spatial frequency. When the average glandular dose (AGD) was the same, direct conversion detector showed higher CNR value. The direct conversion detector which has higher DQE value all over spatial frequency would provide the potential benefits for both improved image quality and lower patient dose in digital mammography system.

• Applied Biological Chemistry
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• v.51 no.2
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• pp.129-135
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• 2008

Berberine is an isoquinoline alkaloid used in traditional Chinese medicine and has been isolated from a variety of plants, such as Coptis chinensis and Phellodendron amurense. It has a wide spectrum of clinical applications such as in anti-tumor, anti-microbial, and anti-inflammatory activities. However, it is still unknown that berberine related with reactive oxygen species (ROS)-mediated apoptosis pathway in human hepatoma HepG2 cells. In the present study, we are examined the molecular mechanism of ROS- and p38 MAP kinase-mediated apoptosis by berberine in HepG2 cells. Berberine increased cytotoxicity effects by time- and does-dependent manner. $LD_{50}$ was detected 50 ${\mu}M$ at 48h of exposure to berberine. Nuclei cleavage and apoptotic DNA fragmentation were observed in cells treated with 50 ${\mu}M$ of berberine for 48h. Moreover, berberine induced the activating of caspase-3, p53, p38 and Bax expression, whereas the expression of anti-apoptotic signaling pathways, Bcl-2, was decreased. Additionally, berberine-treated cells had an increased level of generation of ROS and nitric oxide (NO). These results indicated that berberine induces apoptosis of HepG2 cells may be mediated oxidative injury acts as an early and upstream change, triggers mitochondrial dysfunction, Bcl-2 and Bax modulation, p38 and p53 activation, caspase-3 activation, and consequent leading to apoptosis.

• Korean Journal of Optics and Photonics
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• v.31 no.5
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• pp.223-230
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• 2020

In this paper, we have studied the characteristics of stimulated Brillouin scattering (SBS) and mode instability (MI) in a ytterbium-doped polarization-maintaining fiber laser with master oscillator power amplifier configuration. We measured the laser output power and back-reflection spectrum for a variety of ytterbium-doped fibers and seed lights, to investigate the power-scaling limits of fiber lasers. By optimizing the laser structure, we demonstrated an all-fiber high-power polarization-maintaining fiber laser with near-diffraction-limited beam quality. The output power of 1.5 kW was achieved with a linewidth of 10 GHz, generated by pseudo-random binary sequence (PRBS) phase modulation. The beam quality M² was about 1.15 at the maximum output power. The polarization extinction ratio (PER) was greater than 17 dB.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.8
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• pp.1167-1174
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• 2013

Cancer cells exhibit increased demand for glutamine-derived carbons to support anabolic processes. Indeed, the spectrum of glutamine-dependent tumors and the mechanisms through which glutamine supports cancer metabolism remain areas of active investigation. In the present study, we investigated the effects of glutamine deprivation on the correlation between tightening of tight junctions (TJs) and anti-invasive activity in human prostate carcinoma LnCap cells. Glutamine deprivation markedly inhibited cell motility and invasiveness in a time-dependent manner. The anti-invasive activity of glutamine deprivation was associated with an increased tightness of the TJ, which was demonstrated by an increase in transepithelial electrical resistance (TER). The activities of matrix metalloproteinase (MMP)-2 and MMP-9 were inhibited in a time-dependent fashion by glutamine deprivation, which was correlated with a decrease in expression of their mRNA and proteins and up-regulation of tissue inhibitors of metalloproteinases (TIMPs) expression. Furthermore, glutamine deprivation repressed the levels of the claudin family members, which are major components of TJs that play a key role in the control and selectivity of paracellular transport. Moreover, the levels of E-cadherin, a type I transmembrane glycoprotein, and snail, an epithelial to mesenchymal transition regulator and zinc finger transcription factor, were markedly modulated by glutamine deprivation. Taken together, these findings suggest that TJs and MMPs are critical targets of glutamine deprivation-induced anti-invasion in human prostate carcinoma LnCap cells.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.10a
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• pp.693-697
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• 2007

The SSB modem performs the modulation process which converts the digital voltage level to the audible frequency band signal and the demodulation process which converts reversely the audible frequency signal to the digital voltage level. The modulator and the demodulator are implemented with a single DSP chip. Because of the SSB specific character, the distortion occurs when the frequency is changed. This distortion has no effect on voice communication, but it has an significant effect on data communication. In other words, it is impossible to send data stream with adjacent 2 periods. Therefore, in case of using 2-tone FSK, it is needed to send at least 3 periods to transmit 1 bit. Therefore we implemented the modem using modified phase-delay shift keying to transmit 1 tone signal for high speed transmission. In the 1200[bps] mode, it generates 0, $187{\mu}s$ delay time at 1.3kHz symbol frequency, and in the 2400[bps] mode, 0, $70{\mu}s$, $130{\mu}s$, $200{\mu}s$ delay time at 1.5kHz symbol frequency. Finally, in the maximum 3600[bps] mode, it generates 0, $100{\mu}s$, $160{\mu}s$, $250{\mu}s$ delay time at 2.0kHz symbol frequency. The measured results of the implemented SSB modem shows a good transfer functional characteristic by spectrum analyzer, almost same bandwidth in pass band and 20dB higher SNR comparing the German PACTOR and American CLOVER and in the experimental transmitting test, we verified the transmitted data is received correctly in platform.

• Journal of Nutrition and Health
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• v.41 no.2
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• pp.135-140
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• 2008

Cigarette smoke (CS) induces oxidative and nitrosative stress to the respiratory tract (RT) via both oxidants contained in CS and by CS-induced activation of RT inflammatory-immune pro-oxidant processes. CS exposure has been associated with reduced levels of plasma micronutrient antioxidants, in part due to an increased utilization and turnover of alpha-tocopherol (AT). It has been suggested that gamma-tocopherol (GT) may have an expanded spectrum of antioxidant activation compared to alpha-tocopherol (AT). In order to investigate effects of high GT supplementation as compared to AT, C57 BL/6 mice were fed control AT (35 mg/kg diet) or high GT (1,000 mg/kg diet) diet for 8-10 weeks and then exposed to 60 $mg/m^3$ CS, 6 hr/day for 3 days. AT and GT levels and their metabolites were measured at endpoints. High GT supplementation significantly reduced AT levels in plasma, liver and lung compared to AT. CS increased levels of AT and GT in plasma and lung of control AT group but decreased GT levels in lung of high GT supplemented group. Moreover, CS significantly decreased GT metabolite, gamma-CEHC. The results suggest that high GT supplementation have selective modulation of concentrations of vitamin E and its metabolite in plasma and lung but not in liver against in vivo CS exposure.

• Journal of the Korean Vacuum Society
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• v.19 no.2
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• pp.134-140
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• 2010

We have investigated the contactless electroreflectance (CER) properties of $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs double heterostructures grown by metal-organic chemical vapour deposition (MOCVD). The CER measurements on the sample were studied as a function of temperature, modulation voltage ($V_{ac}$), and dc bias voltage ($V_{bias}$). Five signals observed at room temperature are related to the GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$, and $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ transitions, respectively. From the temperature dependence of CER spectrum, the Varshni coefficients and broadening parameters were determined and discussed. In addition, we found that the behavior of the CER amplitude for the reverse bias is larger than that of the forward.

• Korean Journal of Medicinal Crop Science
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• v.28 no.4
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• pp.276-286
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• 2020

Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with multiple metabolic disorders. The medicinal plant Curcuma longa L. is widely distributed in Asia and has been used to treat a spectrum diseases in clinical practice. To date, there are inadequate reports of the effects of C. longa 50% EtOH extract (CE) on NAFLD. Therefore, in this study, we evaluate the CE on an NAFLD animal and elucidate the mechanism of action. Methods and Results: C57BL/6J mice fed a methionine-choline deficient diet (MCD) were treated with CE or milk thistle, and changes in inflammation and stetosis were assessed. Experimental animals were divided into six group (n = 10); Normal, MCD, MCD + CE 50 mg/kg/day (CE 50), MCD + CE 100 mg/kg/day (CE 100), MCD + CE 150 mg/kg/day (CE 150), and the Control, MCD + Milk thistle 150 mg/kg/day (MT 150). Body weight, liver weight, liver function, and histological changes were assessed in experimental animals. Quantitative real-time polymerase chain reaction and western blot analyses were performed on samples collected after 4 weeks of treatment. We observed that CE administration improved MCD-diet-induced lipid accumulation, and triglyceride (TG) and total cholesterol (TC) levels in serum. Treatment with CE also decreased hepatic lipogenesis through modulation of the sterol regulatory element binding protein-1 (SREBP-1), CCAAT-enhancer binding protein α (C/EBPα), fatty acid synthase (FAS), and peroxisome proliferator-activated receptor γ (PPARγ) expresion. In addition, the use of CE increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and inhibited the up-regulation of toll-like receptor (TLR)-2 and TLR-4 signaling and the production of inflammatory mediators. Conclusions: In this report, we observed that CE regulated lipid accumulation in an MCD dietinduced NAFLD model by decreasing lipogenesis. These data suggeste that CE could effectively protect mice against MCD-induced NAFLD, by inhibiting the TLR-2 and TLR-4 signaling cascades.